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Search Results: 1 - 10 of 146 matches for " Renuka Suravajhala "
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Synthesis of C-8 alkyl xanthines by pentaamminecobalt(III) complex  [PDF]
Renuka Suravajhala
Advances in Biological Chemistry (ABC) , 2013, DOI: 10.4236/abc.2013.36058

Alkyl xanthines underwent selective homolytic aromatic substitution at C-8 position with alkyl groups of pentaamminecobalt(III) complex. In this process of synthesis, we used monoalkyl hydrazines as the radical source in aqueous ammonia solution. Evidence supporting coordination of the alkyl hydrazine to pentaamminecobalt(III) complex by radical trapping was in good agreement with literature. The products were characterized using GC-MS and 1H, 14N and 59Co NMR spectroscopy.


Biological evaluation of 8-alkyl xanthines as potential cytotoxic agents  [PDF]
Renuka Suravajhala, Nitasha Suri, Madhulika Bhagat, Ajit Kumar Saxena
Advances in Biological Chemistry (ABC) , 2013, DOI: 10.4236/abc.2013.33035

A series of 8-substituted alkyl xanthines were evaluated in vitro to test the cytotoxocity in cells. For this experiment, we utilized different mammalian cancer cell lines primarily representing prostrate and lung. One of the compounds synthesized, viz. 8-tertbutyl caffeine showed potent anticancer activity at low concentrations against DU145 when compared to adriamycin. Further experiments were carried out to check the cell cycle arrest in the DU145 cells treated with adriamycin, caffeine and 8-tert butyl caffeine. We observed that there was an arrest in G1 phase of cell cycle at 24 hours while at 48 hours of incubation, the cells were constantly distributed (59.71% -70.79%). We conclude that the effect of 8-tertbutyl caffeine is relatively comparable to caffeine whereas in adriamycin treated cells, we observed the cells underwent G2 arrest. We evaluate the studies on these effects by showing potent analogues which could be used as promising anticancer agents.

The Making of the Women in Biology Forum (WiB) at Bioclues
Reeta Rani Singhania,Dhatri Madduru,Pranathi Pappu,Sameera Panchangam,Renuka Suravajhala,Mohanalatha Chandrasekharan
PLOS Computational Biology , 2014, DOI: doi/10.1371/journal.pcbi.1003436
Abstract: The Women in Biology forum (WiB) of Bioclues (India) began in 2009 to promote and support women pursuing careers in bioinformatics and computational biology. WiB was formed in order to help women scientists deprived of basic research, boost the prominence of women scientists particularly from developing countries, and bridge the gender gap to innovation. WiB has also served as a platform to highlight the work of established female scientists in these fields. Several award-winning women researchers have shared their experiences and provided valuable suggestions to WiB. Headed by Mohanalatha Chandrasekharan and supported by Dr. Reeta Rani Singhania and Renuka Suravajhala, WiB has seen major progress in the last couple of years particularly in the two avenues Mentoring and Research, off the four avenues in Bioclues: Mentoring, Outreach, Research and Entrepreneurship (MORE). In line with the Bioclues vision for bioinformatics in India, the WiB Journal Club (JoC) recognizes women scientists working on functional genomics and bioinformatics, and provides scientific mentorship and support for project design and hypothesis formulation. As a part of Bioclues, WiB members practice the group's open-desk policy and its belief that all members are free to express their own thoughts and opinions. The WiB forum appreciates suggestions and welcomes scientists from around the world to be a part of their mission to encourage women to pursue computational biology and bioinformatics.
Hypo, hype and ’hyp’ human proteins
Prashanth Suravajhala
Bioinformation , 2007,
Abstract: Genes with unknown function are called orphan genes while their transcripts and peptides are called hypothetical proteins. There are many genes and their associated proteins that remain uncharacterized in the human genome. A database of human hypothetical proteins with ascribed functions could be helpful for biologists to search for potential proteins of interest. In recent years, the rapid completion of genome sequences has created essential information to link genes to gene products. In order to better explain functions for un-annotated proteins we designed BioinformaTRICKS (an open source) and used it to develop a database called HYPO. The database is available for free at http://pc-dugong.ruc.dk:8080.
Toward understanding the role of p53 in cardiovascular diseases  [PDF]
Mohanalatha Chandrasekharan, Silvia Vasquez, Rajesh Kumar Galimudi, Prashanth Suravajhala
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.62A025

Tumour suppressor protein 53 (TP53 or simply p53) is a well known protein linked to apoptosis, cell signalling, cascading and several myriad functions in cells. Many diseases are linked to p53 though analysis show only 216 interaction partners. Whether p53 plays an important role in cardiovascular diseases (CVD) remains uncertain. Through this bioinformatical analysis, we propose that p53 might play a major role in CVD whilst being linked to Hypoxia and Lupus. There could be evidence by pull down assay studies. Whether its interactants play a role in CVD remains to be studied using experiments, though the interaction maps show possible affect on other diseases.

A classification scoring schema to validate protein interactors
Prashanth Suravajhala*,Vijayaraghava Seshadri Sundararajan
Bioinformation , 2012,
Abstract: Hypothetical protein [HP] annotation poses a great challenge especially when the protein is putatively linked or mapped to another protein. With protein interaction networks (PIN) prevailing, many visualizers still remain unsupported to the HP annotation. Through this work, we propose a six-point classification system to validate protein interactions based on diverse features. The HP data-set was used as a training data-set to find putative functional interaction partners to the remaining proteins that are waiting to be interacting. A Total Reliability Score (TRS) was calculated based on the six-point classification which was evaluated using machine learning algorithm on a single node. We found that multilayer perceptron of neural network yielded 81.08% of accuracy in modelling TRS whereas feature selection algorithms confirmed that all classification features are implementable. Furthermore statistical results using variance and co-variance analyses confirmed the usefulness of these classification metrics. It has been evaluated that of all the classification features, subcellular location (sorting signals) makes higher impact in predicting the function of HPs.
Sinonasal Undifferentiated Carcinoma—A Case Report  [PDF]
C. Aparna, I. V. Renuka
International Journal of Otolaryngology and Head & Neck Surgery (IJOHNS) , 2014, DOI: 10.4236/ijohns.2014.36068
Abstract: Sinonasal tumors with neuroendocrine differentiation are uncommon. They arise from schneiderian epithelium. The authors reported a case in a fifty-six years old female patient who came with complaints of headache and epistaxis. Differential diagnosis and review of literature are presented in detail. This case is presented in view of its rarity.
Mathematics, Devan, and project work
Renuka Vithal
South African Journal of Education , 2004,
Abstract: I analyse the efforts of one learner, Devan, and a student teacher, Sumaiya Desai, in whose class he participated, as she attempted to realise what may be referred to as a social, cultural, political approach to the school mathematics curriculum through the practice of project work. The focus is specifically on the actions and reflections of Devan as he participated in the project work experience and overturned his casting as a "failing" mathematics learner in a Grade 6 mathematics classroom. I theorise the practice of project work through the data related to Devan and the conceptual tools of project work: problem-orientation; participant-directed; inter-disciplinarity; and exemplarity, and use this framework to organise the structure of this paper. Through this conceptual framing, the challenges and possibilities that such classrooms pose, for learners like Devan but also for the theoretical ideas and associated practice, are made visible and I discuss the potentiality that remained unexplored. South African Journal of Education Vol.24(3) 2004: 225-232
Mathematics education, democracy and development: Exploring connections
Renuka Vithal
Pythagoras , 2012,
Abstract: Mathematics education and its links to democracy and development are explored in this article, with specific reference to the case of South Africa. This is done by engaging four key questions. Firstly, the question of whether mathematics education can be a preparation for democracy and include a concern for development, is discussed by drawing on conceptual tools of critical mathematics education and allied areas in a development context. Secondly, the question of how mathematics education is distributed in society and participates in shaping educational possibilities in addressing its development needs and goals is used to examine the issues emerging from mathematics performance in international studies and the national Grade 12 examination; the latter is explored specifically in respect of the South African mathematics curriculum reforms and teacher education challenges. Thirdly, the question of whether a mathematics classroom can be a space for democratic living and learning that equally recognises the importance of issues of development in contexts like South Africa, as a post-conflict society still healing from its apartheid wounds, continuing inequality and poverty, is explored through pedagogies of conflict, dialogue and forgiveness. Finally the question of whether democracy and development can have anything to do with mathematics content matters, is discussed by appropriating, as a metaphor, South Africa’s Truth and Reconciliation Commission’s framework of multiple ‘truths’, to seek links within and across the various forms and movements in mathematics and mathematics education that have emerged in the past few decades.
Developing Mathematical Literacy through project work: A teacher/teaching perspective
Renuka Vithal
Pythagoras , 2011, DOI: 10.4102/pythagoras.v0i64.97
Abstract: The implementation of the new Mathematical Literacy curriculum in South Africa is assuming several different conceptions of mathematics and therefore also being realised through a range of different pedagogies. In this paper I begin from a particular privileging of a critical perspective in mathematics education, which I argue is one (among others) of the forces shaping the new South African curriculum reforms, particularly the Mathematical Literacy curriculum. If so, then the case for a specific pedagogy, that of project work, can be shown to support the development of a mathematical literacy from a critical perspective. In this paper a particular set of conceptual tools, principles and practices associated with project work, as developed in the Scandanavian context but researched in South Africa, are elaborated from the perspective of teachers/teaching of mathematical literacy.
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