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Search Results: 1 - 10 of 1144 matches for " Renu Chauhan "
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Congenital malformation of fifth lumbar vertebra: A case report
Jugesh Khanna,Renu Chauhan
International Journal of Research in Medical Sciences , 2013, DOI: 10.5455/2320-6012.ijrms20130524
Abstract: Fifth lumbar vertebra is an atypical vertebra as it has widely separated inferior articular processes and thick transverse processes projecting out from the body and pedicles of the vertebra. On routine examination of osteology specimens we found a fifth lumbar vertebra in two separate parts. One part consisted of body, pedicles, transverse and superior articular processes. The other part consisted of lamina, spinous and inferior articular processes. Knowledge of this variation may be of importance to the clinicians for diagnosis of certain neurological deficits in the lower limb and to orthopaedic surgeons and neurosurgeons during the surgical intervention of that area. [Int J Res Med Sci 2013; 1(2.000): 153-155]
Anatomical variations and clinical relevance of dorsal sacral foramina in North Indians
Jugesh Khanna,Renu Chauhan
International Journal of Research in Medical Sciences , 2013, DOI: 10.5455/2320-6012.ijrms20130820
Abstract: Lateral side of each intermediate crest has four dorsal sacral foramina for the passage of posterior division of the sacral nerves. Not only they serve as an important landmark in placement of spinal instrumentation but are also of great importance in transsacral block of sacral nerves for producing analgesia and anesthesia in pelvic surgeries. Therefore a study on the variation in number of dorsal sacral foramina was conducted in 60 adult dry North Indian sacra. Three dorsal sacral foramina were seen on the lateral side of each intermediate crest in four sacra (6.6%) and five in 6 sacra (10%) amongst all the sacra examined. Either a single pair, double pair or totally absent foramina were not observed in any of the sacra seen. This study revealed that there is variation in the number of dorsal sacral foramina. Anaesthetists should be aware of this disparity to be able to perform trans-sacral nerve block successfully. Radiologists must also know about this variation to interpret the radiographs of lumbosacral region. Neurologist and orthopedist should also be cognizant of this fact to diagnose patients presenting with bizarre clinical findings. [Int J Res Med Sci 2013; 1(3.000): 263-266]
Incomplete development of second sacral lamina: a case report
Renu Chauhan,Jugesh Khanna
International Journal of Research in Medical Sciences , 2013, DOI: 10.5455/2320-6012.ijrms20130823
Abstract: Sacrum is made up of large fused 5 sacral vertebra forming posterior wall of pelvis. On routine examination of the bones present in the bone bank of our department we noticed a sacrum in which sacral canal was incompletely formed due to imperfect formation of second sacral laminae. Knowledge of such type of variation may be of importance to the clinicians in dealing with patients presenting with bladder and or bowel disturbances or presenting with some neurological deficit of the lower limb. Orthopaedic surgeons should also be aware of this anomaly while operating in the sacral region. [Int J Res Med Sci 2013; 1(3.000): 278-280]
Absence of costal element of the foramen transversarium of atlas vertebrae
Renu Chauhan,Jugesh Khanna
International Journal of Research in Medical Sciences , 2013, DOI: 10.5455/2320-6012.ijrms20130505
Abstract: Background: Since scanty literature is available on the absence of costal element forming foramen transversarium of atlas vertebra therefore this study was undertaken. Atlas vertebrae were examined to see the presence of foramen transversarium and their boundaries. Methods: Hundred foramina transversaria of 50 atlas vertebrae were examined grossly. Results: Foramen transversarium was seen to be present in all the transverse processes of the atlas vertebrae examined. Costal element was found to be missing in seven foramina tranversaria out of 100 foramina seen. It was found to be absent on the right side in three vertebrae and in two it was absent bilaterally. Conclusions: In case the costal element of the foramen transversarium is absent, the second part of vertebral artery passing through this foramen is liable to be damaged while operating at the level of atlanto-occipital joint the operating surgeon should be aware of such variations so as to avoid injury of second part of vertebral artery and subsequently preventing any kind of neurological involvement. Radiologists must also know about such variations so as to correctly interpret radiological image of the craniovertebral region. [Int J Res Med Sci 2013; 1(2.000): 66-68]
Pareto optimal solutions of small fixed-charge bicriterion transportation problems using a heuristic method
Renu Tuli,Sudhir Kumar Chauhan
International Journal of Knowledge and Research in Management and E-Commerce , 2011,
Abstract: In this paper a heuristic method is developed to find Pareto optimal solutions of small fixed-charge bicriterion transportation problems (FCTP’s). The two objectives are minimization of cost and time. We have applied the Vogel’s approximation method and then used a new entry criterion method to solve such problems. The solid waste management problem falls in the category of such problems. In comparison with the already existing approximate, exact and heuristic methods, our method is easier to understand and implement. It also saves time and computational work. A numerical example is presented to illustrate the proposed method.
Emerging Functions of Transcription Factors in Malaria Parasite
Renu Tuteja,Abulaish Ansari,Virander Singh Chauhan
Journal of Biomedicine and Biotechnology , 2011, DOI: 10.1155/2011/461979
Abstract: Transcription is a process by which the genetic information stored in DNA is converted into mRNA by enzymes known as RNA polymerase. Bacteria use only one RNA polymerase to transcribe all of its genes while eukaryotes contain three RNA polymerases to transcribe the variety of eukaryotic genes. RNA polymerase also requires other factors/proteins to produce the transcript. These factors generally termed as transcription factors (TFs) are either associated directly with RNA polymerase or add in building the actual transcription apparatus. TFs are the most common tools that our cells use to control gene expression. Plasmodium falciparum is responsible for causing the most lethal form of malaria in humans. It shows most of its characteristics common to eukaryotic transcription but it is assumed that mechanisms of transcriptional control in P. falciparum somehow differ from those of other eukaryotes. In this article we describe the studies on the main TFs such as myb protein, high mobility group protein and ApiA2 family proteins from malaria parasite. These studies show that these TFs are slowly emerging to have defined roles in the regulation of gene expression in the parasite.
‘DEAD-box’ helicase from Plasmodium falciparum is active at wide pH and is schizont stage-specific
Arun Pradhan,,Virander S. Chauhan,Renu Tuteja
Journal of Vector Borne Diseases , 2007,
Abstract: Background & objectives: DNA helicases catalyse unwinding of duplex DNA in an ATP-dependentmanner and are involved in all the basic genetic processes. In order to study these important enzymesin the human malaria parasite we have recently cloned the first full-length ‘DEAD-box’ helicasegene from Plasmodium falciparum (3D7). In the present study, we report some of the importantactivities of the encoded protein.Methods: We have expressed the P. falciparum helicase in Escherichia coli and characterised theencoded biochemically active helicase protein. The characterisation of the protein was carried outusing radioactively labeled substrate and the standard strand displacement assay. The localisation ofthe enzyme was studied using immunofluorescence assay.Results & conclusion: P. falciparum helicase gene is 1551 bp in length and encodes for a proteinconsisting of 516 amino acid residues with a predicted molecular mass of 59.8 kDa. The protein isdesignated as Plasmodium falciparum DEAD-box helicase 60 kDa in size (PfDH60). Purified PfDH60showed ATP and Mg2+ dependent DNA unwinding, ssDNA-dependent ATPase and ATP-bindingactivities. Interestingly, this is a unique helicase because it works at a wide pH range (from5.0–10.0). The peak expression of PfDH60 is mainly in schizont stages of the development of P.falciparum, where DNA replication is active. The cell-cycle dependent expression suggests thatPfDH60 may be involved in the process of DNA replication and distinct cellular processes in theparasite and this study should make an important contribution in our better understanding of DNAmetabolic pathways in the parasite.
Isolation and Characterization of Type I Signal Peptidase of Different Malaria Parasites
Sutikshan Sharma,Arun Pradhan,Virander S. Chauhan,Renu Tuteja
Journal of Biomedicine and Biotechnology , 2005, DOI: 10.1155/jbb.2005.301
Abstract: Type I signal peptidases are important membrane-bound serine proteases responsible for the cleavage of the signal peptide of the proteins. These enzymes are unique serine proteases that carry out catalysis using a serine/lysine catalytic dyad. In the present study, we report the isolation of type I signal peptidase from the malaria parasites Plasmodium falciparum, Plasmodium knowlesi, and Plasmodium yoelii and some characterization of type I signal peptidase of Plasmodium falciparum. We show that these enzymes are homologous to signal peptidases from various sources and also contain the conserved boxes present in other type I signal peptidases. The type I signal peptidase from P falciparum is an intron-less and a single-copy gene. The results also show that the enzyme from Plasmodium falciparum is subject to self-cleavage and it has been demonstrated to possess type I signal peptidase activity in E coli preprotein processing in vivo by complementation assay. This study will be helpful in understanding one of the important metabolic pathways “the secretory pathway” in the parasite and should make an important contribution in understanding the complex process of protein targeting in the parasite.
Meige Syndrome: An Eternal Diagnostic Confusion  [PDF]
Amit Chauhan, Shravani Chauhan
Open Journal of Psychiatry (OJPsych) , 2015, DOI: 10.4236/ojpsych.2015.53033
Abstract: Meige syndrome is an idiopathic dystonia characterized by combination of blepharospasm and involuntary movements of the lower facial and/or masticatory (jaw) muscles. The condition is rare and has a variety of clinical presentations which often lead to its misdiagnosis. We report a case of Meige syndrome repeatedly misdiagnosed and treated unsuccessfully as conversion disorder.
Knowledge Attitude and Practice towards Infection Control Measures amongst Medical Students in a Medical Teaching Tertiary Care Hospital  [PDF]
Keshvi Chauhan
International Journal of Clinical Medicine (IJCM) , 2017, DOI: 10.4236/ijcm.2017.89050
Abstract: Introduction: Health care associated infections (HAIs) are likely to be the most common complication of hospital care. World Health Organization (WHO) estimates these infections to occur among 7% - 12% of the hospitalized patients globally, with more than 1.4 million people suffering from infectious complications acquired in the hospital at any time. Keeping this in mind, the present study was conducted to delineate the level of knowledge, attitudes, and practices (KAP) for the use of proper disinfection procedures among the final year undergraduate medical students in a tertiary care hospital and teaching institute. Methodology: Present study was conducted at Government Medical College, Surat, a tertiary care hospital and teaching institute. The participants who gave consent were provided with a pre-tested questionnaire that included several questions on knowledge attitude and practices on hospital acquired infections and its control practices. Analysis of the answers was done based on KAP score. Result: 80 students who consented were included in the study. 75% of the study population had correct knowledge about the most common health care associated infections (HAIs), being infection of venous access, urinary tract infection, respiratory infections and surgical site infections, based on their current knowledge on hospital acquired infections. Majority of study participants agreed with the fact that the inappropriate application of disinfection procedures increases the risk for a health care worker of either acquiring or transmitting a HAI from/to a patient. >90% participants had a good attitude towards risk of getting or transmitting any infectious disease by a Health care worker (HCW) while working and the utility of the application of disinfection procedures during work would reduce the rates of HAI. Practices of the students towards disinfection during performance of certain medical procedures ranged from 10% to 88% of the times showing poor practices of the medical students in following disinfection practices. Conclusion: In the present study the knowledge of medical students for the most common cause of hospital acquired infection was satisfactory. The overall attitude of the students was satisfactory as the mean score was 8. The practices of the students for the application of disinfection during performance of certain medical procedures were also satisfactory, although time to time training and tutorials of these students can help in increasing their knowledge, attitude and
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