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Search Results: 1 - 10 of 406698 matches for " Renato; Müller "
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Traditional and Modern Biomedical Prospecting: Part I—the History
Werner E. G. Müller,Renato Batel,Heinz C. Schr der,Isabel M. Müller
Evidence-Based Complementary and Alternative Medicine , 2004, DOI: 10.1093/ecam/neh013
Abstract: Nature, especially the marine environment, provides the most effective drugs used in human therapy. Among the metazoans, the marine sponges (phylum Porifera), which are sessile filter feeders, produce the most potent and highly selective bioactive secondary metabolites. These animals (or their associated symbiotic microorganisms) synthesize secondary metabolites whose activity and selectivity has developed during their long evolutionary history (evochemistry). The exploitation of these resources has become possible due to the progress in molecular and cell biology. BIOTECmarin, the German Center of Excellence follows this rationale. In the past, these animals have been successfully and extensively utilized to isolate bioactive compounds and biomaterials for human benefit. Pharmaceuticals prepared from marine animals, primarily sponges, have been applied since ancient times (Hippocrates, Aristotle and later Plinius). It has been reported that extracts and/or components from sponges can be used for the treatment of specific diseases. For a systematic and applied-oriented exploitation, the successful development of effective compounds largely depends on quality of the institutional infrastructure of marine stations and more so on the biodiversity. The Center for Marine Research in Rovinj (Croatia) fulfils these prerequisites. Founded in 1891, this institute has to its credit major discoveries related to exploitation of secondary metabolites/biomaterials from sponges for therapeutical application and to obtain biomaterials for general wellbeing.This is the first part of a review focusing on biomedical prospecting. Here, we have mainly described the historic background. The details of techniques, substances, approaches and outlooks will be discussed in the second part.
Sistemas de preparo de solo: altera??es na estrutura do solo e rendimento das culturas
Mazurana, Michael;Levien, Renato;Müller, J?natan;Conte, Osmar;
Revista Brasileira de Ciência do Solo , 2011, DOI: 10.1590/S0100-06832011000400013
Abstract: the introduction and intensification of no-tillage systems in brazilian agriculture in recent decades have created a new scenario, increasing concerns about soil physical properties. the objective of this study was to assess the effects of different tillage systems on some physical properties of an ultisol previously under native grassland. five tillage methods were tested: no-tillage (nt), chiseling (ch), no-tillage with chiseling every two years (ntch2), chiseling using an equipment with a clod-breaking roller (chr) and chiseling followed by disking (chd). the bulk density, macroporosity, microporosity and total porosity, mechanical resistance to penetration, water infiltration into the soil and crop yields were evaluated. the values of soil bulk density, mechanical resistance to penetration and microporosity increased as macroporosity decreased. soil bulk density was lower in tillage systems with higher levels of tillage/soil mobilization; highest values were observed in nt and the lowest in the chd system. the water infiltration rate was highest in the chr system, followed by the systems chd, nt and ntch2, while crop yields were higher in systems with less soil mobilization.
Extrato de alho como alternativa na quebra de dormência de gemas em macieiras cv. Fuji Kiku
Botelho, Renato Vasconcelos;Müller, Marcelo Marques Lopes;
Revista Brasileira de Fruticultura , 2007, DOI: 10.1590/S0100-29452007000100010
Abstract: this study aimed to examine the effects of garlic extract (bioalho?) on bud break of 'fuji kiku' apple trees in comparison to the conventional use of hydrogen cyanamide (h2cn2) at the region of guarapuava-pr, brazil. soon after winter pruning, in september 2005, the following treatments were sprayed on plants at dormant bud stage: 1) control (untreated); 2) 1% ge (garlic extract); 3) 5% ge; 4) 10% ge; 5) 2% mo (mineral oil); 6) 1% ge + 2% mo; 7) 5% ge + 2% mo; 8) 10% ge + 2% mo; 9) 0.4% h2cn2 + 4% mo. the treatments with garlic extract and mineral oil showed similar effects in comparison to the hydrogen cyanamide treatment, achieving up to 90% of bud sprouting at 50 dat, while only 2% mineral oil and control, attained only 62.5 and 42.7%, respectively. the treatments with 5 or 10% garlic extract presented the lowest values for number of fruits, yield per plant and yield per area, not because the ineffectivenessof break dormancy, but probably due to the antecipation of the flowering which coincided to a very much rainy period at the beginning of the spring.
Traditional and Modern Biomedical Prospecting: Part II—The Benefits
Werner E. G. Müller,Heinz C. Schr der,Matthias Wiens,Sanja Perovi -Ottstadt,Renato Batel,Isabel M. Müller
Evidence-Based Complementary and Alternative Medicine , 2004, DOI: 10.1093/ecam/neh030
Abstract: The progress in molecular and cell biology has enabled a rational exploitation of the natural resources of the secondary metabolites and biomaterials from sponges (phylum Porifera). It could be established that these natural substances are superior for biomedical application to those obtained by the traditional combinatorial chemical approach. It is now established that the basic structural and functional elements are highly conserved from sponges to the crown taxa within the Protostomia (Drosophila melanogaster and Caenorhabditis elegans) and Deuterostomia (human); therefore, it is obvious that the molecular etiology of diseases within the metazoan animals have a common basis. Hence, the major challenge for scientists studying natural product chemistry is to elucidate the target(s) of a given secondary metabolite, which is per se highly active and selective. After this step, the potential clinical application can be approached. The potential value of some selected secondary metabolites, all obtained from sponges and their associated microorganisms, is highlighted. Examples of compounds that are already in medical use (inhibition of tumor/virus growth [arabinofuranosyl cytosine and arabinofuranosyl adenine]), or are being considered as lead structures (acting as cytostatic and anti-inflammatory secondary metabolites [avarol/avarone], causing induction of apoptosis [sorbicillactone]) or as prototypes for the interference with metabolic pathways common in organisms ranging from sponges to humans (modulation of pathways activated by fungal components [aeroplysinin], inhibition of angiogenesis [2-methylthio-1,4-napthoquinone], immune modulating activity [FK506]) are discussed in this study. In addition, bioactive proteins from sponges are listed (antibacterial activity [pore-forming protein and tachylectin]). Finally, it is outlined that the skeletal elements—the spicules—serve as blueprints for new biomaterials, especially those based on biosilica, which might be applied in biomedicine. These compounds and biomaterials have been isolated/studied by members of the German Center of Excellence BIOTECmarin. The goal for the future is to successfully introduce some of these compounds in the treatment of human diseases in order to raise the public awareness on the richness and diversity of natural products, which should be sustainably exploited for human benefit.
A memória histórica de Getúlio Vargas e o Palácio do Catete
, Celso Pereira de;Castro, Ricardo Vieiralves de;Mller, Renato Cesar;Perez, Juliana Aieta;
Estudos de Psicologia (Natal) , 2008, DOI: 10.1590/S1413-294X2008000100006
Abstract: the article deals with the historical memory of getúlio vargas (1883-1954) - who governed brazil from 1930 to 1945 and from 1951 to 1954 -, in its close association to the catete palace, in rio de janeiro, which was the republic presidency's seat during that period. such a memory was investigated in terms of the social representations about getúlio which were manifested by 410 visitors to an exhibition held in the palace - republic museum, nowadays - in honor to the fiftieth anniversary of his death. results, which were obtained from responses to a free association task and to a concise questionnaire, evidence that the memory which was built about the historical trajectory of vargas is a complex and controversial one, but it tends sharply for the positive pole, since the evaluations that getúlio did more good than bad things and that he deserves to be remembered as "father of the poor people" and as "brazil's greatest statesman" prevail.
Secondary zoospores in the algal endoparasite Maullinia ectocarpii (Plasmodiophoromycota)
Parodi,Elisa R.; Cáceres,Eduardo J.; Westermeier,Renato; Müller,Dieter G.;
Biocell , 2010,
Abstract: the present paper deals with the ultrastructure of zoospores produced by the plasmodiophorid maullinia ectocarpii, living in the marine algal host ectocarpus siliculosus. the zoospores described here are very similar to secondary zoospores of polymyxa graminis and phagomyxa sp.(the latter an algal endoparasite, also). our results indicate that m. ectocarpii produces two types of plasmodia, and suggest that is a species with a complete life cycle, as it is known for all the plasmodiophormycota that have been studied. sporogenic and sporangial plasmodia produce, respectively, primary zoospores with parallel flagella within thick walled resting sporangia, and secondary zoospores with opposite flagella within thin walled sporangia.
Dormência e dominancia apical de diferentes tamanhos de tubérculos de batata
Müller, Douglas Renato;Bisognin, Dilson Antonio;Morin, Glademir Roque;Gnocato, Francisco Saccol;
Ciência Rural , 2010, DOI: 10.1590/S0103-84782010001200003
Abstract: the size of potato tubers produced in the same hill is an indicator of the physiological age and the time required to break dormancy and apical dominance, which is essential for the proper post-harvest management. the objective of this study was to evaluate the period of dormancy and apical dominance of different tuber sizes of three potato clones produced in the fall and submitted to two storage temperatures. field produced tubers were harvested from ten hills per clone. the tubers were individually identified and assessed for fresh weight, length and major and minor diameters. one lot of five hills per clone was stored at 10°c and other at 20°c±2 and 85±5% relative humidity for 170 days. breaking of dormancy and apical dominance were recorded when the tuber produced, respectively, one or two sprouts. the experiment was a factorial of three clones (sminia00017-6, smij461-1 and asterix), two storage temperatures (10 and 20°c) and three types of tubers (smaller diameter less than 35mm, between 35 and 45mm and larger than 45mm) in a completely randomized design. in conclusion, the results showed that physiological age varies with the size of the potato tubers, and tubers with diameter smaller than 35mm have longer dormancy than those larger than 35mm. moreover, the storage temperature of 20°c is more effective to break the dormancy than the apical dominance.
Dinamica das rela??es em famílias com um membro portador de dermatite atópica: um estudo qualitativo
Ferreira, Vinícius Renato Thomé;Müller, Marisa Campio;Jorge, Hericka Zogbi;
Psicologia em Estudo , 2006, DOI: 10.1590/S1413-73722006000300018
Abstract: atopic dermatitis is a skin allergic disease, which increases its incidence each year, thus, demands more researches in order to minimize its social impact. the influence of psychological factors, when developing such an illness is known. stress and anxiety are usual factors that affect the immunological system in a severe way; such psychological factors characterize atopic dermatitis as a psychosomatic illness. three families were investigated in a qualitative framework, through the use of a semi-structured interview. family perceptions and elements related to the family dynamics, concerning atopic dermatitis, were studied, once one child in each family bears the illness. the families reported that atopic dermatitis had damaged the whole family in psychological and social aspects, consequently, influencing the family relationship and influencing in the intensity and frequency of symptoms due to the increasing stress, besides interfering in the family communication and relationship.
Estado nutricional de diferentes cultivares de pereira nas condi??es edafoclimáticas de Guarapuava-PR
Botelho, Renato Vasconcelos;Müller, Marcelo Marques Lopes;Basso, Clori;Suzuki, Atsuo;
Revista Brasileira de Fruticultura , 2010, DOI: 10.1590/S0100-29452010005000087
Abstract: the fertilizer applications in deciduous fruit trees are usually recommended in function of chemical soil and leaves analysis interpretation, but they are not specific for the different scion and rootstock cultivars. in this context, a trial was carried out aiming to evaluate the nutritional status of different pear cultivars grafted on rootstock quince 'cp' by two consecutive years, in guarapuava, paraná state, brazil. the pear cultivars cascatense, tenra, hosui, packham's triumph and williams were planted in 2004 at the density planting of 2.500 plants ha-1. samples of leaves and fruits were collected in 2006 and 2007 for chemical analysis of nutrient contents. complete and normal leaves were sampled in the end of january, token from the middle part of one-year shoots. the fruits were collected when the total soluble solids content reached 10o brix. the pear cultivars showed differences in relation to nutrient content in leaves and fruits, indicating distinct nutritional requirements. the cv. cascatense presented the highest n and p contents in fruits at least in one of the years, and the cv hosui the highest k content. the nutrient extraction by fruits ranged from 0.366 to 0.825 kg n; 0.097 to 0.205 kg p, 0.996 to 1.302 kg k, 0.049 to 0.085 kg ca and 0.041 to 0.095 kg mg per fruit ton.
Secondary zoospores in the algal endoparasite Maullinia ectocarpii (Plasmodiophoromycota)
Elisa R. Parodi,Eduardo J. Cáceres,Renato Westermeier,Dieter G. Müller
Biocell , 2010,
Abstract: The present paper deals with the ultrastructure of zoospores produced by the plasmodiophorid Maullinia ectocarpii, living in the marine algal host Ectocarpus siliculosus. The zoospores described here are very similar to secondary zoospores of Polymyxa graminis and Phagomyxa sp.(the latter an algal endoparasite, also). Our results indicate that M. ectocarpii produces two types of plasmodia, and suggest that is a species with a complete life cycle, as it is known for all the Plasmodiophormycota that have been studied. Sporogenic and sporangial plasmodia produce, respectively, primary zoospores with parallel flagella within thick walled resting sporangia, and secondary zoospores with opposite flagella within thin walled sporangia.
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