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Search Results: 1 - 10 of 500513 matches for " Renata L. S. Gon?alves "
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Festas e rituais religiosos: a performance como perspectiva de análise
Renata de Sá Gonalves
Religi?o & Sociedade , 2009, DOI: 10.1590/s0100-85872009000100011
Mitochondrial Reactive Oxygen Species Modulate Mosquito Susceptibility to Plasmodium Infection
Renata L. S. Gonalves, Jose Henrique M. Oliveira, Giselle A. Oliveira, John F. Andersen, Marcus F. Oliveira, Pedro L. Oliveira, Carolina Barillas-Mury
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0041083
Abstract: Background Mitochondria perform multiple roles in cell biology, acting as the site of aerobic energy-transducing pathways and as an important source of reactive oxygen species (ROS) that modulate redox metabolism. Methodology/Principal Findings We demonstrate that a novel member of the mitochondrial transporter protein family, Anopheles gambiae mitochondrial carrier 1 (AgMC1), is required to maintain mitochondrial membrane potential in mosquito midgut cells and modulates epithelial responses to Plasmodium infection. AgMC1 silencing reduces mitochondrial membrane potential, resulting in increased proton-leak and uncoupling of oxidative phosphorylation. These metabolic changes reduce midgut ROS generation and increase A. gambiae susceptibility to Plasmodium infection. Conclusion We provide direct experimental evidence indicating that ROS derived from mitochondria can modulate mosquito epithelial responses to Plasmodium infection.
Blood-Feeding Induces Reversible Functional Changes in Flight Muscle Mitochondria of Aedes aegypti Mosquito
Renata L. S. Gonalves,Ana Carolina L. Machado,Gabriela O. Paiva-Silva,Marcos H. F. Sorgine,Marisa M. Momoli,Jose Henrique M. Oliveira,Marcos A. Vannier-Santos,Antonio Galina,Pedro L. Oliveira,Marcus F. Oliveira
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0007854
Abstract: Hematophagy poses a challenge to blood-feeding organisms since products of blood digestion can exert cellular deleterious effects. Mitochondria perform multiple roles in cell biology acting as the site of aerobic energy-transducing pathways, and also an important source of reactive oxygen species (ROS), modulating redox metabolism. Therefore, regulation of mitochondrial function should be relevant for hematophagous arthropods. Here, we investigated the effects of blood-feeding on flight muscle (FM) mitochondria from the mosquito Aedes aegypti, a vector of dengue and yellow fever.
Cádmio no leite materno: concentra??o e rela??o com o estilo de vida da puérpera
Gonalves, Renata Moreira;Gonalves, José Rubens;Fornés, Nélida Schmid;
Revista Brasileira de Ginecologia e Obstetrícia , 2010, DOI: 10.1590/S0100-72032010000700006
Abstract: purpose: to relate the cadmium concentration of colostrum with the lifestyle of women in the puerperium period. methods: a cross-sectional study was conducted in goiania, goiás (mid-western region of brazil). eighty women, according to inclusion criteria, were interviewed about their socioeconomic characteristics and lifestyle. they answered a questionnaire about food frequency consumption (ffq). the colostrum samples collected were analyzed by flame atomic absorption spectrometry to quantify cadmium levels. for statistical analysis, central tendency measures were obtained, and the mann-whitney and kruskal-wallis tests were performed, as well as correlation and regression tests. results: the average cadmium concentration was 2.3 μg/l and the median was 0.9 μg/l. variables such as age and parity showed a nonsignificant positive correlation with cadmium. smoking habit was not significantly associated with cadmium. conclusions: postpartum food intake influences the level of cadmium in colostrum, especially vegetables such as cereals.
Rela??o entre níveis de chumbo no colostro, consumo alimentar e características socioecon?micas de puérperas em Goiania, Brasil
Gonalves,Renata Moreira; Gonalves,José Rubens; Fornés,Nélida Schmid;
Revista Panamericana de Salud Pública , 2011, DOI: 10.1590/S1020-49892011000400003
Abstract: objective: to estimate the levels of lead in human colostrum and investigate whether they are correlated with dietary intake and socioeconomic factors in puerperal women. method: this cross-sectional study was carried out with 80 puerperal women from a maternity hospital in goiania, brazil. data were collected between july and december 2008. a questionnaire was used to collect socioeconomic and lifestyle information. a dietary intake frequency questionnaire was also applied. after that, colostrum samples were collected and analyzed using flame atomic absorption spectrometry to quantify lead levels. the correlation between lead levels, socioeconomic variables, and dietary intake was calculated. results: the mean concentration of lead in colostrum samples was 6.88 μg/l, and the median concentration was 4.65 μg/l. there was no association between socioeconomic aspects and lead levels. the intake of saturated fatty acids, eggs, pork meats, chicken, and chicken products (r = -0.26 and p = 0.020) was inversely correlated with the levels of lead in human colostrum, whereas the intake of squash (r = 0.26; p = 0.019) and eggplant (r = 0.27; p = 0.015) was positively correlated with the levels of lead. the correlation observed for cooked squash, eggs, pork and chicken meats, and chicken products was maintained after logistic regression adjustment. conclusions: the presence of lead was detected in human colostrum in this sample, probably as a result of dietary exposure. in addition to a correlation between presence of lead and dietary intake, the present findings suggest that specific nutrients may result in increased or decreased levels of lead, without a direct relationship with socioeconomic factors.
Blood Meal-Derived Heme Decreases ROS Levels in the Midgut of Aedes aegypti and Allows Proliferation of Intestinal Microbiota
Jose Henrique M. Oliveira,Renata L. S. Gonalves,Flavio A. Lara,Felipe A. Dias,Ana Caroline P. Gandara,Rubem F. S. Menna-Barreto,Meredith C. Edwards,Francisco R. M. Laurindo,Mário A. C. Silva-Neto,Marcos H. F. Sorgine,Pedro L. Oliveira
PLOS Pathogens , 2011, DOI: 10.1371/journal.ppat.1001320
Abstract: The presence of bacteria in the midgut of mosquitoes antagonizes infectious agents, such as Dengue and Plasmodium, acting as a negative factor in the vectorial competence of the mosquito. Therefore, knowledge of the molecular mechanisms involved in the control of midgut microbiota could help in the development of new tools to reduce transmission. We hypothesized that toxic reactive oxygen species (ROS) generated by epithelial cells control bacterial growth in the midgut of Aedes aegypti, the vector of Yellow fever and Dengue viruses. We show that ROS are continuously present in the midgut of sugar-fed (SF) mosquitoes and a blood-meal immediately decreased ROS through a mechanism involving heme-mediated activation of PKC. This event occurred in parallel with an expansion of gut bacteria. Treatment of sugar-fed mosquitoes with increased concentrations of heme led to a dose dependent decrease in ROS levels and a consequent increase in midgut endogenous bacteria. In addition, gene silencing of dual oxidase (Duox) reduced ROS levels and also increased gut flora. Using a model of bacterial oral infection in the gut, we show that the absence of ROS resulted in decreased mosquito resistance to infection, increased midgut epithelial damage, transcriptional modulation of immune-related genes and mortality. As heme is a pro-oxidant molecule released in large amounts upon hemoglobin degradation, oxidative killing of bacteria in the gut would represent a burden to the insect, thereby creating an extra oxidative challenge to the mosquito. We propose that a controlled decrease in ROS levels in the midgut of Aedes aegypti is an adaptation to compensate for the ingestion of heme.
Morphology and Thermal Properties of Core-Shell PVA/PLA Ultrafine Fibers Produced by Coaxial Electrospinning  [PDF]
Raquel P. Gonalves, Flavia F. F. da Silva, Paulo H. S. Picciani, Marcos L. Dias
Materials Sciences and Applications (MSA) , 2015, DOI: 10.4236/msa.2015.62022
Abstract: Coaxial electrospinning process was used to produce biodegradable membranes made of coreshell fibers of a poly(lactic acid) (PLA) shell and a poly(vinyl alcohol) (PVA) core. Scanning electron microscopy analyses of these structures showed that the PLA shell can present certain porosity depending on the process condition. FTIR-ATR and contact angle measurements also suggested imprisonment of the PVA core within the PLA shell. This type of structure was also confirmed by means of transmissions electron microscopy. The morphology of these fibers was dependent on the flow rate of both core and shell solutions, and homogeneous and smooth surface was only attained when the flow rate of the external PLA solution was 4 times the flow rate of the internal PVA solution. The increase in the PLA solution flow rate increases the diameter of the core-shell fiber which reaches up to 1.7 μm. Nevertheless, fibers with smaller average diameter could also be produced (200 nm). These core-shell fibers presented improved hydrophilicity as compared with monolithic PLA fibers.
Altera??es de linguagem em pacientes idosos portadores de demência avaliados com a Bateria MAC
Koehler, Cristine;Gindri, Gigiane;Bós, Angelo José Gonalves;Mancopes, Renata;
Revista da Sociedade Brasileira de Fonoaudiologia , 2012, DOI: 10.1590/S1516-80342012000100005
Abstract: purpose: to identify language deficits in a group of elderly patients with dementia in tasks of free lexical retrieval, lexical retrieval with orthographic and semantic criteria, interpretation of metaphors and of narrative discourse, from the montreal communication evaluation battery - mac battery, as well as to verify the frequency of deficits. methods: participants were 13 patients with mild to moderate dementia, treated at the neurology sector of the ambulatory of movement disorders and dementia of the hospital santa clara of the irmandade santa casa de misericórdia de porto alegre (iscmpa). the neuropsychological assessment instrument was the mac battery, and the tasks were applied in the following order: free lexical retrieval, lexical retrieval based on orthographic criteria, lexical retrieval based on semantic criteria, interpretation of metaphors, and interpretation of narrative discourse. results: the group of patients with dementia showed impaired performance in all tasks from mac battery that were evaluated, with significant difference. furthermore, participants presented higher frequency of deficits, in descending order, in partial retelling of narrative discourse tasks (essential and present information), followed by the tasks of lexical retrieval with orthography and semantic criteria, and full retelling of narrative discourse. at least two patients showed deficits in some of the five tasks performed from the mac battery. conclusion: language evaluation using the mac battery allowed the verification of language processing deficits in elderly with dementia, characterizing that this instrument is also applicable to this clinical population.
Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi
Soares Milena B. P.,Gonalves Renata,Pyrrho Alexandre S.,Costa Deise A.
Anais da Academia Brasileira de Ciências , 2003,
Abstract: We have previously demonstrated that inoculation of BALB/c mice with trypomastigotes of CL-14, an avirulent Trypanosoma cruzi clone, prevents the development of parasitemia and mortality after challenge with virulent CL strain. In this report, we investigated the cytokine and antibody profiles induced by inoculation with CL-14 clone. Groups of mice were inoculated with trypomastigotes of CL-14 clone and challenged with infective CL strain. Challenged CL-14-inoculated mice had lower levels of IFN-g and higher production of IgG1 antibodies as compared to CL strain-infected mice. Previous inoculation with CL-14 clone partially prevented the suppression of IL-2 production caused by CL strain infection. No significant differences were found regarding IL-4 production by splenocytes from CL-14-inoculated or control groups after challenge with CL-strain. Our results show that protection against acute T. cruzi infection induced by CL-14 inoculation correlates with a balanced T1/T2 cytokine production, a profile likely to be beneficial for the host.
Alimentos e Nutri??o , 2008,
Abstract: O consumidor moderno est cada vez mais exigente em rela § £o aos produtos que ingere, tornando o processo de sele § £o e consumo de alimentos mais complexo. Quest μes relacionadas ao meio ambiente e sa ode podem influenciar o processo de escolha e compra de alimentos. O conhecimento de tal atitude que composta por cren §as e valores, pode contribuir para um melhor direcionamento e organiza § £o do mercado de alimentos. H , portanto, a necessidade de avaliar o efeito de quest μes relacionadas sa ode na atitude do consumidor, que pode ser feito atrav s de instrumentos simples e pr ticos. Para tal, foram desenvolvidas escalas, como a Health and Taste Attitude Scales (HTAS), que investiga o interesse do consumidor por alimentos saud veis e o efeito do sabor no processo de escolha e inten § £o de compra de produtos. Outra quest £o que vem ganhando import ¢ncia, refere- se atitude do consumidor frente aos produtos org ¢nicos. Neste caso, investigar a atitude do consumidor em rela § £o s poss -veis conseq ancias da compra de alimentos org ¢nicos, atrav s da aplica § £o de question rio apropriado, dever contribuir para o conhecimento deste mercado. Tais instrumentos est £o dispon -veis na l -ngua inglesa, n £o podendo, portanto, ser aplicados em estudos com consumidores brasileiros. O presente estudo objetivou traduzir e validar, para o portugu as, o question rio sobre as Poss -veis Conseq ancias da Compra de Org ¢nicos e as sub-escalas de atitude em rela § £o sa ode (Health Attitude Scale). A metodologia utilizada foi a back-translation, capaz de estabelecer equival ancia conceitual e sem ¢ntica entre duas l -nguas distintas, ap 3s o processo de tradu § £o. Os resultados foram analisados estatisticamente atrav s do teste t e correla § £o de Pearson. Tais an lises permitiram concluir que a tradu § £o e a valida § £o dos instrumentos Escalas de Atitude em Rela § £o Sa ode e as Poss -veis Conseq ancias da Compra de Org ¢nicos foram adequadas, e que podem ser utilizados em estudos com consumidores, cuja l -ngua m £e o portugu as.
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