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匹配条件: “Remus MOLDOVAN” ,找到相关结果约293条。
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Influence of the Administration of a TNF-α Inhibitor on the Oxidant/Antioxidant Balance in Chronic Venous Insufficiency
Cristina Maria VAIDA VOEVOD,Remus MOLDOVAN,Nicoleta DECEA,Adriana MURE?AN
Applied Medical Informatics , 2012,
Abstract: Purpose: many studies in experimental models have evidenced the presence of inflammation in venous vascular dysfunction and the implication of TNF-α in vascular pathology, through its prooxidant and proinflammatory effect. Starting from these studies, we experimentally investigated the effect of treatment with a TNF-α inhibitor, etanercept, on the oxidant/antioxidant balance in rats, with the partial obstruction of the common femoral vein. Methods: the researches were carried out in 7 groups of animals (n=10 rats/group), 6 groups undergoing surgery and a control group. In 3 groups, the ligation of the common femoral vein was performed (groups 1, 2, 3), 3 groups underwent the ligation of the common femoral vein and received etanercept (groups 4, 5, 6), in a dose of 1 mg/kg, one dose per week, according to data found in literature. The serum indicators of the O/AO balance were determined: indicators for oxidative stress (malondialdehyde (MDA), protein carbonyls (PC)), indicators for non-enzymatic AO defense (thiol groups (SH), hydrogen donors (HD ), glutathione (GSH)) at weeks 1, 2 and three. Results and Conclusions: chronic venous insufficiency with and without anti-TNF-α treatment induced changes in the oxidant/antioxidant balance compared to the control group; after the administration of the anti-TNF-α preparation, oxidative stress was maintained on account of MDA that increased significantly, and decreased significantly on account of PC compared to the untreated groups; after the administration of the anti-TNF-α preparation, at two and three weeks there was an insignificant increase in antioxidant defense on account of HD and GSH compared to the untreated groups; the administered anti-TNF-α preparation had late and insignificant effects in chronic venous insufficiency.
Influence of Acute Ozone Exposure on the Tissue Oxidant/Antioxidant Balance in Physical Exercise
ágnes UGRON,Cristina BIDIAN,Remus MOLDOVAN,Nicoleta DECEA
Applied Medical Informatics , 2012,
Abstract: Aims: The influence of acute ozone (O3) exposure on the tissue oxidant/antioxidant (O/AO) balance in the brain, myocardium, lungs and striated muscles was studied at rest and during exercise. Material and Methods: The research was performed in 3 groups of white male Wistar rats with a weight of 280-300 g: Group I – control group, sedentary rats under normoxia conditions; Group II – sedentary rats, acutely exposed to O3; Group III – animals acutely exposed to O3, followed by exercise under normoxia conditions. The rats were exposed to ozone for 3 days, 5 min/day. Group III was trained daily for 3 days under normoxia conditions by the swimming test. In order to determine the indicators of the oxidant/antioxidant balance, tissue samples from the brain, myocardium, lungs and quadriceps muscle of the anesthetized animals were taken. On the third day the following were measured: malondialdehyde (MDA), protein carbonyls (PC), hydrogen donor capacity (HD) and total sulfhydryl (thiol) group content (SH). Results: Between the indicators of the tissue O/AO balance, significant correlations were evidenced in the brain, myocardium, lungs and muscles. Conclusions: Acute combined stress through O3 pre-exposure and exercise causes OS on account of PC in the brain, myocardium and muscles, a decrease in AO defense capacity on account of HD in the brain, lungs and muscles, and an increase in AO defense capacity in the myocardium.
Postnatal Development of the Retina in Rats Exposed to Hyperoxia: A Fractal Analysis
Anne Claudia ?tef?nu?,?tefan ??lu,Viorel Micl?u?,Adriana Mure?an,Remus Moldovan,Bianca Szabo
ISRN Biomedical Imaging , 2013, DOI: 10.1155/2013/589327
Abstract: Purpose. The aim of this study was to investigate and quantify changes in the newborn rats retinal layers during the hyperoxia (80% O2) exposure using fractal analysis. Materials and Methods. This study was conducted on two groups of 20 newborn rats: a control (normal) group (10 rats) and an experimental group (10 rats). The control group was composed of 10 newborn rats, which were placed at 12 hours after birth, in a pediatric incubator, together with their mother, in conditions of normoxia for 21 days. The experimental group consisted of 10 newborn rats, which were placed at 12 hours after birth, in a pediatric incubator with their mother, in conditions of normoxia for 7 days, then 7 days of hyperoxia (80% O2) for 22.5 hours/day, and then 7 days in conditions of normoxia. Slaughtering of the rats was performed on day 21 and the eye globes were harvested in order to perform histopathological examinations. The fractal analyses of the retinal digital images were performed using the fractal analysis software Image J, and the fractal dimensions were calculated using the standard box-counting method. Results. Microscopic examination revealed a normal development of the retina in the control group. In the experimental group, all the animals exposed to hyperoxia revealed both structural and vascular abnormalities on entire retina. Conclusions. The results showed that the fractal analysis is a valuable tool to quantify histoarchitectural changes in the newborn rats retinal layers during the hyperoxia (80% O2). 1. Introduction In the last few decades important efforts have been directed to understand various aspects of the newborn rats retinal layers, for clinical diagnostics and treatment [1–4]. The rat’s retina is immature at birth, being comparable with that from human fetuses of 26 weeks, and allows tracking its development postnatally [1]. Exposure to oxigen of rat pups retina, during the first days after birth, develops an oxygen-induced retinopathy (OIR), similar to human retinopathy of prematurity (ROP) [2–4]. Retinopathy of prematurity is a leading cause of blindness in children [5–9]. Newborn rat model represents a solution to study normal and abnormal development of primary visual system of human subjects [4]. The cycle hyperoxia-normoxia mimics ischemia-reperfusion and leads to retinal neovascularization [2–4, 10–12]. This experimental model could be useful in the study of angiogenesis occurring in other potentially blinding retinal diseases (e.g., diabetes), cancer, and degenerative diseases and in the study of the effect of some substances with
POLICY DIALOG: THE MISSING LINK IN THE 2008 ROMANIAN HUMAN PAPILLOMAVIRUS (HPV) VACCINATION PROGRAM
Remus PRICOPIE
Transylvanian Review of Administrative Sciences , 2009,
Abstract: The model of the traditional decision-making deciding behind the closed doors of power is strongly eroded by the new perception of democracy, as it is gradually replaced by a model dominated not by managers, but by the management of decision. This article analyzes from the social sciences perspective a) why the Romanian 2008 HPV vaccination campaign turned out to be a failure, b) what generated the strong public rejection of a policy that the Ministry of Public Health supposed would be easily accepted by the population, and especially by the targeted group – the 10-11 years old girls and their parents. The article also seeks to offer recommendations, from the public communication perspective, regarding how policy dialogue and public participation might support the promotion of large-scale policies by involving the stakeholders at all stages of the decision-making process, and hence, avoiding unfounded social tensions and waste of valuable resources.
Social Transparency through Recommendation Engines and its Challenges: Looking Beyond Privacy
Remus TITIRIGA
Informatica Economica Journal , 2011,
Abstract: Our knowledge society is quickly becoming a 'transparent' one. This transparency is acquired, among other means, by 'personalization' or 'profiling': ICT tools gathering contextualized information about individuals in men–computers interactions. The paper begins with an overview of these ICT tools (behavioral targeting, recommendation engines, 'personalization' through social networking). Based on these developments the analysis focus a case study of developments in social network (Facebook) and the trade-offs between 'personalization' and privacy constrains. A deeper analysis will reveal unexpected challenges and the need to overcome the privacy paradigm. Finally a draft of possible normative solutions will be depicted, grounded in new forms of individual rights.
EVOLUTION TENDENCIES SPECIFIC TO THE FIELD OF QUALITY IN THE CONTEXT OF KNOWLEDGE BASED ECONOMY
Rosca Remus
Annals of the University of Oradea : Economic Science , 2010,
Abstract: In the actual rivalry environment characterised by the exacerbation of the competition, quality is getting the most important factor. Sequel every organization has to consider a priority the improvement of their products quality. Set going from these realities, we consider convenient and interesting to present the most important tendencies in the field of quality, which understanding depends on the turning to account of numerous improvement opportunities.
A note on cocycle-conjugate endomorphisms of von Neumann algebras
Remus Floricel
Mathematics , 2003,
Abstract: We show that two cocycle-conjugate endomorphisms of an arbitrary von Neumann algebra that satisfy certain stability conditions are conjugate endomorphisms, when restricted to some specific von Neumann subalgebras. As a consequence of this result, we obtain a new criterion for conjugacy of Powers shift endomorphisms acting on factors of type $\rm{I}\sb{\infty}.$
A finiteness result for commuting squares of matrix algebras
Remus Nicoara
Mathematics , 2004,
Abstract: We consider a condition for non-degenerate commuting squares of matrix algebras (finite dimensional von Neumann algebras) called the \emph{span condition}, which in the case of the $n$-dimensional standard spin models is shown to be satisfied if and only if $n$ is prime. We prove that the commuting squares satisfying the span condition are isolated among all commuting squares (modulo isomorphisms). In particular, they are finiteley many for any fixed dimension. Also, we give a conceptual proof of previous constructions of certain one-parameter families of biunitaries.
The epidermal study of sweet chestnut-tree Leaf (Castanea sativa Mill.)
I. MOLDOVAN,Aurelia MOLDOVAN
Notulae Botanicae Horti Agrobotanici Cluj-Napoca , 1992,
Abstract: This paper is part of a broader study on the ontogenetic evolution of C. sativa. On detached epidermis, obtained by different methods, the following structural aspects have been studied: the shape and size of the cells of each sample and their number on surface unity, the type of stomata, the size of stomata, the number of stomata on surface unity and the stomatic index. At the same time remarks have been made concerning the protecting and secretive hairs of each sample.
Spectrophotometric determination of nitrite by its catalytic effect on the oxidation of congo red with bromate
Zenovia Moldovan
Bulletin of the Chemical Society of Ethiopia , 2012,
Abstract: A novel simple, sensitive and rapid kinetic-spectrophotometric method for the determination of trace amounts of nitrite is proposed. The method is based on its catalytic effect on the oxidation of congo red (CR) by potassium bromate in acidic solution. The oxidation reaction is monitored spectrophotometrically by measuring the decrease in the absorbance of CR at a suitable λmax= 570 nm for the first 10–40 s from the start of the reaction. Under the optimum experimental conditions (sulfuric acid, 0.3 M; CR, 0.75x10-4 M; potassium bromate, 5x10-4 M and 25 oC), nitrite can be determined in the range of 0.015–0.75 μg mL 1 with the detection limit of 0.006 μg mL 1. The relative standard deviation of five replicate determination of 0.25 μg mL 1 nitrite was 2.5%. The proposed method was applied satisfactorily to the determination of nitrite in spiked drinking water samples. KEY WORDS: Nitrite, Catalytic effect, Congo red, Spectrophotometry, Drinking water Bull. Chem. Soc. Ethiop. 2012, 26(2), 159-169. DOI: http://dx.doi.org/10.4314/bcse.v26i2.1
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