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Search Results: 1 - 10 of 92 matches for " Rema Razdan "
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Descri??o de um novo método de ooforectomia em ratas
Khajuria, Deepak Kumar;Razdan, Rema;Mahapatra, D Roy;
Revista Brasileira de Reumatologia , 2012, DOI: 10.1590/S0482-50042012000300016
Abstract: rats are currently the most used laboratory animals to investigate osteoporosis. we report an efficient method of ovariectomy and compared this method with the two other operative methods of ovariectomy (i.e., midline dorsal skin incision and double dorsolateral approach, which are used commonly for inducing experimental osteoporosis. female wistar rats, 12 weeks old, were divided into three groups. ovariectomy was preceded by a single midline dorsal skin incision, 3 cm long, in the group a; double dorsolateral incisions, approximately 1 cm long, in the group b; and a single ventral transverse incision of 0.4-0.6 cm at the middle abdominal region in the group c. animals in groups a, b, and c had a mean weight of 258.12 ± 0.54 g, 255.78 ± 0.42 g, and 254.55 ± 1.69 g, respectively. there were significant differences in the duration (in minutes) of surgery in the groups b (9.65 ± 0.86) and c (7.55 ± 0.11, p < 0.001) when compared to the group a (15.52 ± 0.30) and in the group b (p < 0.01) when compared to the group c. wound healing time (in days) for groups b (9.22 ± 0.67) and c (8.01 ± 0.93) was significantly shorter than that for group a (11.58 ± 1.2, p < 0.001), with the wound healing time for group c being slightly shorter than that for group b. the surgery, as conducted in the group c, was technically easier, less time consuming and showed less wound healing duration.
Medicamentos para o tratamento da osteoporose: revis?o
Khajuria, Deepak Kumar;Razdan, Rema;Mahapatra, D.Roy;
Revista Brasileira de Reumatologia , 2011, DOI: 10.1590/S0482-50042011000400008
Abstract: osteoporosis is characterized by low bone mass with micro architectural deterioration of bone tissue leading to enhance bone fragility, thus increasing the susceptibility to fracture. osteoporosis is an important public health problem leading to an increased risk of developing spontaneous and traumatic fractures. in india osteoporotic fractures occur more commonly in both sexes, and may occur at a younger age than in the western countries. although exact numbers are not available, based on available data and clinical experience, 36 million indians may be affected by osteoporosis by 2013. this would be associated with enormous costs and considerable consumption of health resources. pharmacological therapies that effectively reduce the number of fractures by improving bone mass are now available widely in markets. at present most drugs available in the markets decrease bone loss by inhibiting bone resorption, but the upcoming therapies may increase bone mass by directly increasing bone mass as is the case of parathyroid hormone. current treatment alternatives include bisphosphonates, calcitonin, selective estrogen receptor modulators and inhibitors of rank pathway but sufficient calcium and vitamin d are a prerequisite. newer osteoclast targeted agents like cathepsin k and c-src kinase are under clinical development. the therapies which target osteoblasts include the agents acting through the wnt-β catenin signaling pathway like dkk-1 inhibitors and sclerostin antagonists. to further improve pharmacological interventions and therapeutical choices in this field, improvement of knowledge is very necessary
The Combination Therapy with Zoledronic Acid and Propranolol Improves the Trabecular Microarchitecture and Mechanical Property in an Rat Model of Postmenopausal Osteoporosis
Deepak Kumar Khajuria,Rema Razdan,D. Roy Mahapatra
Journal of Osteoporosis , 2014, DOI: 10.1155/2014/586431
Abstract: We conducted the present study to investigate the therapeutic effects of propranolol (PRO), alone and in combination with the antiresorptive agent ZOL, in a rat model of postmenopausal osteoporosis. Female Wistar rats were OVX or sham-operated at 3 months of age. Twelve weeks after surgery, rats were randomized into six groups: (1) sham + vehicle, (2) OVX + vehicle, (3) OVX + ZOL (100?μg/kg, i.v. single dose), (4) OVX + ZOL (50?μg/kg, i.v. single dose), (5) OVX + PRO (0.1?mg/kg, s.c. 5 days per week), and (6) OVX + ZOL (50?μg/kg, i.v. single dose) + PRO (0.1?mg/kg, s.c. 5 days per week) for 12 weeks. At the end of treatment study, various bone parameters were evaluated. With respect to improvement in the mechanical strength of the lumbar spine and the femoral mid-shaft, the combination treatment of ZOL and PRO was more effective than each drug administered as a monotherapy. Moreover, combination therapy using ZOL and PRO preserved the trabecular microarchitecture better than single-drug therapy using ZOL or PRO in OVX rats. These data suggest that combination therapy with ZOL plus PRO represents a potentially useful therapeutic option for patients with osteoporosis. 1. Introduction Osteoporosis is a degenerative disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and increased fracture risk. Osteoporosis is considered an important public health issue increasing rapidly in the elderly population [1, 2]. The fractures caused by osteoporosis have clinical and public health impacts, as they are often associated with increased morbidity, mortality, and enormous healthcare expenditure [1]. For those already affected by osteoporosis, timely diagnosis of bone loss, assessment of fracture risk, and selection of optimal treatment at appropriate stages of the disease are very important for effective management of osteoporosis. Zoledronic acid (ZOL) is a third generation nitrogen-containing bisphosphonate that has been shown to significantly reduce the risk of fractures in patients who receive the once-yearly dosing regimen for the treatment of postmenopausal osteoporosis [3]. ZOL interferes with osteoclastic activity by inhibiting osteoclast formation and osteoclast bone resorptive activities and by inducing osteoclast apoptotic cell death. On osteoclast stimulation of bone resorption, the bisphosphonate is released and internalized by the osteoclasts, interfering with osteoclast formation, function, and survival [4–6]. Moreover, the results obtained from several histologic and
The Next Page Access Prediction Using Makov Model
Deepti Razdan
International Journal of Electronics Communication and Computer Technology , 2011,
Abstract: Predicting the next page to be accessed by the Webusers has attracted a large amount of research. In this paper, anew web usage mining approach is proposed to predict next pageaccess. It is proposed to identify similar access patterns from weblog using K-mean clustering and then Markov model is used forprediction for next page accesses. The tightness of clusters isimproved by setting similarity threshold while forming clusters.In traditional recommendation models, clustering by nonsequentialdata decreases recommendation accuracy. In thispaper involve incorporating clustering with low order markovmodel which can improve the prediction accuracy. The main areaof research in this paper is pre processing and identification ofuseful patterns from web data using mining techniques with thehelp of open source software.
On Debye temperature anomaly observed in Ge-Se-Ag glasses
Ashok Razdan
Physics , 2008, DOI: 10.1016/j.physb.2008.04.005
Abstract: Anomalous Values of Debye temperature have been obtained from Lamb Mossbauer factor measurements of Ge-Se-Ag glasses. We show that this anomaly may arise due to the presence of anharmonic potential at the high spin ferrous site. In this paper, we use q Lamb Mossbauer factor and anharmonic Lamb Mossbauer factor to study this anharmoncity.
Transfer matrix method to study electromagnetic shower
Ashok Razdan
Physics , 2008, DOI: 10.1016/j.chaos.2008.11.014
Abstract: Transfer matrix method gives underlying dynamics of a multifractal. In the present studies transfer matrix method is applied to multifractal properties of Cherenkov image from which probabilities of electromagnetic components are obtained.
Non-extensivity in magnetic systems: possible impact on Mossbauer results
Ashok Razdan
Physics , 2009, DOI: 10.1016/j.physb.2009.01.031
Abstract: Energy positions of pure magnetic transitions in Mossbauer Spectroscopy are calculated using non-extensive approach. It is observed that these new calculated energy positions so obtained, may have strong overlap with those energy positions obtained from combined effect of magnetic and quadrupole interactions using standard statistical physics.
Low temperature specific heat of glasses: a non-extensive approach
Ashok Razdan
Physics , 2005, DOI: 10.1016/j.physleta.2005.04.027
Abstract: Specific heat is calculated using Tsallis statistics. It is observed that it is possible to explain some low temperature specific heat properties of glasses using non-extensive approach. A similarity between temperature dependence of non-extensive specific heat and fractal specific heat is also discussed.
Lamb Mossbauer factor using non-extensive Statistics
Ashok Razdan
Physics , 2003, DOI: 10.1016/j.physleta.2003.10.068
Abstract: Lamb Mossbauer factor is derived using Tsallis Statistics. Recoil free factor so obtained, has weak temperature dependence which is similar to the temperature dependence observed for Lamb Mossbauer factor of a fractal
Crab pulsar spectrum: a non-extensive approach
Ashok Razdan
Physics , 2014, DOI: 10.1016/j.newast.2014.11.001
Abstract: Non extensive statistical physics has been applied to various problems in physics including astrophysics. In this paper we explore the possibility of using non extensive approach to explain the recently observed pulsed $\gamma$-ray from Crab pulsar above 100 GeV observed by VERITAS $\gamma$-ray telescope.
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