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Search Results: 1 - 10 of 8521 matches for " Regina Stieber "
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The Cayman Crab Fly Revisited — Phylogeny and Biology of Drosophila endobranchia
Marcus C. Stensmyr, Regina Stieber, Bill S. Hansson
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0001942
Abstract: Background The majority of all known drosophilid flies feed on microbes. The wide spread of microorganisms consequently mean that drosophilids also can be found on a broad range of substrates. One of the more peculiar types of habitat is shown by three species of flies that have colonized land crabs. In spite of their intriguing lifestyle, the crab flies have remained poorly studied. Perhaps the least investigated of the three crab flies is the Cayman Island endemic Drosophila endobranchia. Apart from its life cycle very little is known about this species, including its phylogenetic position, which has remained unresolved due to a cryptic set of characteristics. Principal Findings Based on molecular data, corroborated by a re-analysis of the morphological make up, we have resolved the phylogenetic position of D. endobranchia and show that it somewhat surprisingly belongs to the large Neotropical repleta radiation, and should be considered as an aberrant member of the canalinea species group. Furthermore we also provide additional data on the behavior of these remarkable flies. Conclusion Our findings reveal that the two Caribbean crab flies are not as distantly related as first thought, as both species are members of the derived repleta radiation. That this lineage has given rise to two species with the same odd type of breeding substrate is curious and prompts the question of what aspects of their shared ancestry has made these flies suitable for a life on (and inside) land crabs. Knowledge of the phylogenetic position of D. endobranchia will allow for comparative explorations and will aid in efforts aimed at understanding processes involved in drastic host shifts and extreme specialization.
Pro-Gastrin-Releasing Peptide (ProGRP) –A Diagnostic Biomarker for Small-Cell Lung Cancer
Chinese Journal of Lung Cancer , 2009,
Sex-Specific Odorant Receptors of the Tobacco Hornworm Manduca Sexta
Ewald Gro?e-Wilde,Regina Stieber,Maike Forstner,Jürgen Krieger,Dieter Wicher,Bill S. Hansson
Frontiers in Cellular Neuroscience , 2010, DOI: 10.3389/fncel.2010.00022
Abstract: As odor information plays a vital role in the life of moths, their olfactory sense has evolved into a highly specific and sensitive apparatus relevant to reproduction and survival. The key players in the detection of odorants are olfactory receptor (OR) proteins. Here we identify four OR-encoding genes differentially expressed in the antennae of males and females of the sphingid moth Manduca sexta. Two male-specific receptors (the previously reported MsexOR-1 and the newly identified MsexOR-4) show great resemblance to other male moth pheromone ORs. The putative pheromone receptors are co-expressed with the co-receptor involved in general odorant signal transduction, the DmelOr83b homolog MsexOR-2. One female-specific receptor (MsexOR-5) displays similarities to BmorOR-19, a receptor in Bombyx mori tuned to the detection of the plant odor linalool.
Priorities for people living with dementia: education, counseling, research
Kerstin Stieber Roger
Clinical Interventions in Aging , 2008,
Abstract: Kerstin Stieber RogerDepartment of Family Social Sciences, Faculty of Human Ecology, University of Manitoba, Winnipeg, CanadaAbstract: Hearing the voices of people living with dementia assists in a better understanding of their experiences. This understanding can pave the way for improved community-based service delivery such as education and counseling, as well as including them more frequently as research participants. The voices of people living with dementia have not been well represented in research, resulting in very few data describing their experiences. This paper describes empirical qualitative data from a study that asked people with Alzheimer’s and Huntington’s disease about their experiences. Recommendations are provided on education, counseling, and research.Keywords: counseling, dementia, education, family, personhood, research
Living with Parkinson's disease—managing identity together
Kerstin Stieber Roger,Maria I. Medved
International Journal of Qualitative Studies on Health & Well-Being , 2010, DOI: 10.3402/qhw.v5i2.5129
Abstract: The specific aim of this paper is to discuss how individuals living with Parkinson's disease and their main family supports perceive communications with each other, with a focus on their roles related to care. The paper is based on individual interviews conducted with individuals and their main family support person. The transcripts were analyzed based on grounded theory and “managing identity together” emerged as the core category. This is discussed in terms of independence, a sense of self-sufficiency and an overall sense of personhood. Implications for other populations conclude the paper.
Detection of prostate cancer with complexed PSA and complexed/total PSA ratio - is there any advantage?
F Strittmatter, P Stieber, D Nagel, C Füllhase, S Walther, CG Stief, R Waidelich
European Journal of Medical Research , 2011, DOI: 10.1186/2047-783x-16-10-445
Abstract: Frozen sera of 442 patients have been analysed for tPSA, free PSA (fPSA) and cPSA. 131 patients had prostate cancer and 311 patients benign prostatic hyperplasia.Differences in the distribution of the biomarkers were seen as follows: tPSA, cPSA and c/tPSA were significantly higher in the PC group, and f/tPSA was significantly higher in the BPH group. In the tPSA-range of 0-4 ng/ml none of the biomarkers showed a significant difference in the distribution between both groups. In the tPSA-ranges of 0-10 ng/ml, 2-10 ng/ml, 4-10 ng/ml and <10 ng/ml, f/tPSA showed the highest specificity at high sensitivtities, followed by c/tPSA, cPSA, and tPSA, respectively. In tPSA-ranges greater than 10 ng/ml, cPSA offered the best discriminatory ability. GPSA compared to tPSA offered better specificity at high sensitivities in all tPSA-ranges.F/tPSA offers the best ability to distinguish between both groups in lower tPSA-ranges, followed by c/tPSA. CPSA compared to tPSA offers a better ability to discriminate between both groups in all PSA-ranges and could be used as an initial test for PC.Prostate cancer (PC) is the most diagnosed cancer in men. In the European Union, prostate cancer accounts for approximately 11% of all cancers and 9% of all cancers deaths [1]. The diagnosis of PC is based on a combination of digital-rectal examination (DRE), testing of the prostate specific antigen (PSA) and the transrectal ultrasound guided biopsy (TRUS-biopsy). Testing of PSA and the digital-rectal examination are both limited with regard to their low sensitivity and specificity. Consequently, patients are often undergoing histological examination by prostate biopsy because of an elevated PSA or an abnormal DRE without having prostate cancer. A serum PSA measurement of 4 ng/ml is often still regarded as the threshold above which prostate biopsy is performed. With this cut-off of PSA, sensitivities of 80% to 91% and specificities from 28% to 85% can be found. Nevertheless there are several studi
Predictive and prognostic value of circulating nucleosomes and serum biomarkers in patients with metastasized colorectal cancer undergoing Selective Internal Radiation Therapy
Yvonne Fahmueller, Dorothea Nagel, Ralf-Thorsten Hoffmann, Klaus Tatsch, Tobias Jakobs, Petra Stieber, Stefan Holdenrieder
BMC Cancer , 2012, DOI: 10.1186/1471-2407-12-5
Abstract: Blood samples were prospectively and consecutively taken from 49 colorectal cancer patients with extensive hepatic metastases before, three, six, 24 and 48 h after SIRT to analyze the concentrations of nucleosomes and further laboratory parameters, and to compare them with the response to therapy regularly determined 3 months after therapy and with overall survival.Circulating nucleosomes, cytokeratin-19 fragments (CYFRA 21-1), carcinoembryonic antigen (CEA), C-reactive protein (CRP) and various liver markers increased already 24 h after SIRT. Pretherapeutical levels of CYFRA 21-1, CEA, cancer antigen 19-9 (CA 19-9), asparate-aminotransferase (AST) and lactate dehydrogenase (LDH) as well as 24 h values of nucleosomes were significantly higher in patients suffering from disease progression (N = 35) than in non-progressive patients (N = 14). Concerning overall survival, CEA, CA 19-9, CYFRA 21-1, CRP, LDH, AST, choline esterase (CHE), gamma-glutamyl-transferase, alkaline phosphatase, and amylase (all 0 h, 24 h) and nucleosomes (24 h) were found to be prognostic relevant markers in univariate analyses. In multivariate Cox-Regression analysis, the best prognostic model was obtained for the combination of CRP and AST. When 24 h values were additionally included, nucleosomes (24 h) further improved the existing model.Panels of biochemical markers are helpful to stratify pretherapeutically colorectal cancer patients for SIR-therapy and to early estimate the response to SIR-therapy.Colorectal cancer is the third most common cancer in women and men worldwide [1] and accounts for almost 9% of all cancer deaths in the USA [2]. At time of detection of the primary tumor, 15-20% of the patients will already present with liver metastases, another 20% will develop these metastases following treatment of the primary tumor [3]. In 20% of these patients the liver will be the only site of metastases at the time of death [4]. Despite new treatment options nowadays, patients with distant
Relevance of circulating nucleosomes and oncological biomarkers for predicting response to transarterial chemoembolization therapy in liver cancer patients
Nikolaus Kohles, Dorothea Nagel, Dietrich Jüngst, Jürgen Durner, Petra Stieber, Stefan Holdenrieder
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-202
Abstract: Here, sera of 50 prospectively and consecutively included HCC patients undergoing 71 TACE therapies were taken before and 3 h, 6 h and 24 h after TACE application to analyze concentrations of circulating nucleosomes, cytokeratin-19 fragments (CYFRA 21-1), alpha fetoprotein (AFP), C-reactive protein (CRP) and several liver biomarkers, and to compare these with radiological response to therapy.While nucleosomes, CYFRA 21-1, CRP and some liver biomarkers increased already 24 h after TACE, percental changes of nucleosome concentrations before and 24 h after TACE and pre- and posttherapeutic values of AFP, gamma-glutamyl-transferase (GGT) and alkaline phosphatase (AP) significantly indicated the later therapy response (39 progression versus 32 no progression). In multivariate analysis, nucleosomes (24 h), AP (24 h) and TACE number were independent predictive markers. The risk score of this combination model achieved an AUC of 81.8% in receiver operating characteristic (ROC) curves and a sensitivity for prediction of non-response to therapy of 41% at 97% specificity, and of 72% at 78% specificity.Circulating nucleosomes and liver markers are valuable tools for early estimation of the efficacy of TACE therapy in HCC patients.Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third most common cause of cancer-related death with approximately 500,000 deaths each year [1]. In recent years, incidence of HCC has been increasing in western countries [2]. The major risk factors of HCC are liver cirrhosis, alcohol abuse, and hepatitis B and C virus infections [3-5]. Most patients have at least two concomitant diseases, such as chronic liver disease and HCC, while complex interactions between these have major implications for diagnosis, prognosis and management of HCC. The clinical course of patients is determined by both liver function and the extent of HCC. Curative therapy options include resection, liver transplantation and radiofrequency ablation
Early prediction of therapy response in patients with acute myeloid leukemia by nucleosomal DNA fragments
Susanne Mueller, Stefan Holdenrieder, Petra Stieber, Torsten Haferlach, Andreas Schalhorn, Jan Braess, Dorothea Nagel, Dietrich Seidel
BMC Cancer , 2006, DOI: 10.1186/1471-2407-6-143
Abstract: We investigated the course of nucleosomal DNA, thymidine kinase, lactate dehydrogenase and leukocytes in sera of 25 patients with acute myeloid leukemia during the first cycle of induction chemotherapy and tested their power to distinguish between patients with complete remission and those with no remission.Almost all patients showed strongly decreasing levels of nucleosomal DNA during the first week, in some cases after initial peaks. In overall analysis of variance, DNA levels could clearly distinguish between patients with complete remission, who had higher DNA values, and those with insufficient response (p = 0.017). The area under the curve of DNA values of days 2–4 after start of therapy (AUC 2–4) discriminated between both groups with a sensitivity of 56% at a specificity of 100%. Further, pretherapeutic levels and AUC 2–4 of nucleosomal DNA correlated significantly with blast reduction after 16 days. A tendency to higher levels in patients with complete response was also found for thymidine kinase, lactate dehydrogenase and leukocytes, however the difference did not reach the level of significance (p = 0.542, p = 0.260, and p = 0.144, respectively).Our results indicate that nucleosomal DNA fragments are valuable markers for the early prediction of therapeutic efficacy in patients with acute myeloid leukemia.The incidence of acute myeloid leukemia (AML) has remained stable over the last decades and has averaged between 1998 and 2002 at about 3.8 per 100,000 persons and year. The age-adjusted incidence rates showed a distinct difference between patients under 65 years with 1.8 per 100,000 and those over 65 years with 17.9 per 100,000 [1]. With regard to the treatment of AML, a standardized procedure has been established including induction chemotherapy to eliminate the blasts and to achieve remission followed by a consolidation therapy to stabilize the remission status [2,3]. Unfortunately the rate of complete remission after induction therapy, particularly in
The Reality in the Surveillance of Breast Cancer Survivors—Results of a Patient Survey
Stemmler Hans-Joachim,L?ssig Dorit,Stieber Petra,Bauerfeind Ingo
Breast Cancer: Basic and Clinical Research , 2008,
Abstract: Background: International guidelines for the surveillance of breast cancer patients recommend a minimized clinical follow-up including routine history and physical examination and regularly scheduled mammograms. However, the abandonment of scheduled follow-up examinations in breast cancer survivors remains a contradiction to established follow-up guidelines for other solid tumours.Patients and Methods: We report the patients’ view on the basis of a survey performed in two separate geographical areas in Germany. The questionnaires were sent out to 2.658 patients with a history of breast cancer.Results: A total of 801 patients (30.1%) responded to the questionnaire. The results of the survey can be summarized in two major categories: First, necessity for surveillance was affi rmed by a majority (>95%), and 47.8% of the organized patients answered that there was a need for more intensive diagnostic effort during follow-up. The main expectation from an intensified follow-up was the increased feeling of security as expressed by >80% of the women. Second, the present survey indicates that most of the regularly scheduled follow-up visits were expanded using extensive laboratory and imaging procedures exceeding the quantity of examinations recommended in the present follow-up guidelines.Conclusion: Despite the fact that only one third of the patients responded to the questionnaire, the survey indicates that a majority of physicians who treated these patients still do not accept the present follow-up guidelines. To some extent this may be explained by the observation that patients and possibly also their doctors trust that intensified follow-up increases diagnostic security and survival. Since considerable changes in the treatment options of breast cancer have been made during the last decades a new trial of investigations in follow-up is warranted.
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