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Search Results: 1 - 10 of 24 matches for " Redouan Nakache "
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Synthesis and Influence of Two Quinoxalinone Derivatives on Anxiety- and Depressive-Like Responses in Wistar Rat  [PDF]
Redouan Nakache, Brahim Lakhrissi, Fatima Zahra El Mrabet, Aboubaker Elhessni, Ali Ouichou, Bouchra Benazzouz, Abdelhalem Mesfioui
Neuroscience & Medicine (NM) , 2012, DOI: 10.4236/nm.2012.34039
Abstract: Two new quinoxalinone derivatives have been synthesized adopting the HONG method, and investigated for some neuropharmacological effects (anxiety- and depressive-like responses) in rats. The present experiment sought to determine whether treatment with these compounds produces changes in affective responses. We found that the chronic injection of 6-nitro-2(1H)-quinoxalinone (NQu) showed obvious anxiolytic- and antidepressant-like effects, respectively, measured in the behavioral tests of Elevated Plus Maze (EPM) and Forced Swim Test (FST). At the dose of 30 mg/kg, NQu showed a comparative anxiolytic-like effect in rats as diazepam (Dz) (1 mg/kg), and a comparative antidepressant effect as clomipramine (Clmp) (2 mg/kg; i.p). The 2(1H)-quinoxalinone (Qu) significantly reduced depressive-like responses as evaluated in FST, whereas no anxiolytic-like effect was found as measured by open field test (OF). Additionally, the locomotor activity levels were unaffected by treatment as measured by OF and EPM.
Les Israéliens d’aujourd’hui et la Shoah ou le r le de la troisième génération dans l’élaboration de nouvelles pratiques mémorielles
Guila Sylvie Nakache
Bulletin du Centre de Recherche Fran?ais de Jérusalem , 2007,
Abstract: En élaborant une problématique générale de la mémoire historique contemporaine, Pierre Nora a fait surgir un nouvel objet d'histoire : le lieu de mémoire auquel il accorde l’aptitude d’engendrer une autre histoire . Dans l’article de 1992 L’ère de la commémoration , Pierre Nora convient de l’étrange destinée de ces Lieux de mémoire : Ils se sont voulus, par leur démarche, leur méthode et leur titre même, une histoire de type contre-commémoratif, mais la commémoration les a rattra...
Today’s Israelis and the Shoah or the Role of the “Third Generation” in the Development of New Memory Practices
Guila Sylvie Nakache
Bulletin du Centre de Recherche Fran?ais de Jérusalem , 2007,
Abstract: While looking into general issues of contemporary historical memory, Pierre Nora brought to light a new object of history: the “place of memory,” to which he grants the faculty of generating “another history”. In his 1992 article, “The age of commemoration,” Pierre Nora reflects on “the strange fate of these places of memory: by their approach, their method, their very name, they sought to be a kind of counter-commemorative history, but commemoration has caught up with them”. These “places of...
Individual Differences in Foraging Strategies of Parasitic Sabre-Tooth Blennies
Andrea Bshary, Redouan Bshary
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0045998
Abstract: Originally, evolutionary game theory typically predicted that optimal behaviour in a given situation is uniform or bimodal. However, the growing evidence that animals behave more variably while individuals may differ consistently in their behaviour, has led to the development of models that predict a distribution of strategies. Here we support the importance of such models in a study on a coral reef fish host–parasite system. Parasitic blennies (Plagiotremus sp.) regularly attack other fishes to bite off scales and mucus. Individuals of some victim species react to being bitten with punishing the parasite through aggressive chasing. Our field observations and laboratory experiments show that individual blennies differ markedly in how they incorporate being punished into their foraging decisions. We discuss how these differences may affect the payoff structure and hence the net effect of punishment on punishers and on the appearance of a public good for look-alikes.
Versatile Route to Synthesize Heterobifunctional Poly(ethylene glycol) of Variable Functionality for Subsequent Pegylation
Redouan Mahou,Christine Wandrey
Polymers , 2012, DOI: 10.3390/polym4010561
Abstract: Pegylation using heterotelechelic poly(ethylene glycol) (PEG) offers many possibilities to create high-performance molecules and materials. A versatile route is proposed to synthesize heterobifunctional PEG containing diverse combinations of azide, amine, thioacetate, thiol, pyridyl disul?de, as well as activated hydroxyl end groups. Asymmetric activation of one hydroxyl end group enables the heterobifunctionalization while applying selective monotosylation of linear, symmetrical PEG as a key step. The azide function is introduced by reacting monotosyl PEG with sodium azide. A thiol end group is obtained by reaction with sodium hydrosulfide. The activation of the hydroxyl end group and subsequent reaction with potassium carbonate/thioacetic acid yields a thioacetate end group. The hydrolysis of the thioester end group by ammonia in presence of 2,2′-dipyridyl disulfide provides PEG pyridyl disul?de. Amine terminated PEG is prepared either by reduction of the azide or by nucleophilic substitution of mesylate terminated PEG using ammonia. In all cases, >95% functionalization of the PEG end groups is achieved. The PEG derivatives particularly support the development of materials for biomedical applications. For example, grafting up to 13% of the Na-alg monomer units with α-amine-ω-thiol PEG maintains the gelling capacity in presence of calcium ions but simultaneous, spontaneous disulfide bond formation reinforces the initial physical hydrogel.
Geographical Asynchronous Information Access for Distributed Systems
Ali Elouafiq,Redouan Abid
Computer Science , 2014,
Abstract: Non-relational databases are the common means of data storage in the Cloud, and optimizing the data access is of paramount importance into determining the overall Cloud system performance. In this paper, we present GAIA, a novel model for retrieving and managing correlated geo-localized data in the cloud environment. We survey and compare the existing models used mostly in Geographical Information Systems (GIS), mainly the Grid model and the Coordinates Projection model. Besides, we present a benchmark comparing the efficiency of the models. Using extensive experimentation, we show that GAIA outperforms the existing models by its high efficiency which is of O(log(n)), and this mainly thanks to its combination of projection with cell decomposition. The other models have a linear efficiency of O(n). The presented model is designed from the ground up to support GIS and is designed to suit both cloud and parallel computing.
Infective endocarditis and motivation to an oral health check-up
Guillaud M,Blatier J-F,Chabert R,Nakache P
Pratiques et Organisation des Soins , 2010,
Abstract: Aim: The Rh ne-Alpes Union régionale des caisses d’Assurance maladie (URCAM) sent information about oral health to patients at risk of infective endocarditis (IE) and information with audit-feedback to general practitioners. Our objective was to assess the effectivenessof this action.Methods: In 2004, 5 to 70 year-old chronic patients at risk of infective endocarditis were included. We randomized 25 geographical clusters in two groups: a control and an intervention group. Several documents were sent to patients and physicians of the interventiongroup. We studied for one year the dental treatments performed to analyse the oral health check-ups (OHCU).Results: The biannual OHCU was 13,6% in the intervention group versus 14,1% in the control group (p unilateral = 0,44). With adjusted logistic regression models, we found no association between the intervention and a biannual OHCU (OR = 0,95; CI 95% = [0,55; 1,65]).For the annual OHCU, there was no statistical association between the intervention and annual OHCU (OR = 1,22; CI 95% = [0,90; 1,65]) with logistic regression models. When the physicians had mentioned the OHCU on the medical claim, we observed a statistical associationwith the annual OHCU (OR = 4,30; CI 95% = [1,36 ; 13,54]). High risk patients were less often cared than patients at lower risk (OR = 0,70 ; CI 95% = [0,53; 0,94]).Conclusion: Prevention should encourage general practitioners to prescribe regular OHCU, especially for high risk patients.
Third-Party Ranks Knowledge in Wild Vervet Monkeys (Chlorocebus aethiops pygerythrus)
Christèle Borgeaud, Erica van de Waal, Redouan Bshary
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0058562
Abstract: The Machiavellian/Social Intelligence Hypothesis proposes that a complex social environment selected for advanced cognitive abilities in vertebrates. In primates it has been proposed that sophisticated social strategies like obtaining suitable coalition partners are an important component of social intelligence. Knowing the rank relationships between group members is a basic requirement for the efficient use of coalitions and the anticipation of counter-coalitions. Experimental evidence for such knowledge currently exists in only few species. Here, we conducted rank reversal playback experiments on adult females belonging to three different groups of free-ranging vervet monkeys (Chlorocebus aethiops pygerythrus) to test their knowledge of the female hierarchy. Playbacks simulating rank reversals (subordinate aggressing a dominant) induced longer looking times than playbacks simulating a dominant aggressing a subordinate. Vervet monkey females therefore seem to compute the rank relationships between other females. Our results suggest that detailed social knowledge about rank relationships may be widespread in primates and potentially also in other species living in stable groups.
Sistemas de aprendizajes e inclusión educativa: Procesos cognitivos interactividad
Elichiry,Nora Emilce; Arrúe,Carola; Aizencang,Noemí; Maddonni,Patricia; Nakache,Débora; Scavino,Carolina;
Anuario de investigaciones , 2005,
Abstract: the purpose of this line of research in educational psychology is to identify the elements that favor school's inclusion. this study aims to examine activities and learning systems permitting to describe the relationships between two different quotidian educational environments: school and family. it undertakes the description and analysis of the continuity-discontinuity lines that exist between them. in order to do that, two different topics have been given a special significance: "homework" and existing "tutoring practices". both of them are considered as daily interaction spaces between students, teachers and parents. here, a special care is given to the psychological analysis referred to the cognitive processes involved in different learning activities in their contexts. the investigation is focused on the study of the firsts levels of elementary and high school education, given the high ratio of "school failure" found there.
A Low-Cost Time-Hopping Impulse Radio System for High Data Rate Transmission
Molisch Andreas F,Li Ye Geoffrey,Nakache Yves-Paul,Orlik Philip
EURASIP Journal on Advances in Signal Processing , 2005,
Abstract: We present an efficient, low-cost implementation of time-hopping impulse radio that fulfills the spectral mask mandated by the FCC and is suitable for high-data-rate, short-range communications. Key features are (i) all-baseband implementation that obviates the need for passband components, (ii) symbol-rate (not chip rate) sampling, A/D conversion, and digital signal processing, (iii) fast acquisition due to novel search algorithms, and (iv) spectral shaping that can be adapted to accommodate different spectrum regulations and interference environments. Computer simulations show that this system can provide 110 Mbps at 7–10 m distance, as well as higher data rates at shorter distances under FCC emissions limits. Due to the spreading concept of time-hopping impulse radio, the system can sustain multiple simultaneous users, and can suppress narrowband interference effectively.
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