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Search Results: 1 - 10 of 2806 matches for " Raymond Dory "
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La transformation de la Défense : une étape aboutie ?
Raymond Dory
Pyramides : Revue du Centre d'Etudes et de Recherches en Administration Publique , 2012,
Abstract: De par sa situation géographique et son histoire, la Belgique n’a qu’en périodes exceptionnelles considéré la problématique défense comme prioritaire, voire vitale. La planification capacitaire en matière de défense reste un exercice difficile mais pourtant essentiel à la bonne marche de l’outil militaire, lequel pour sa part, se doit d’affronter les défis du moment et ceux du futur. Les plans stratégiques adoptés ces dix dernières années ont profondément modifié le profil opérationnel de la Défense. Ces choix politiques ont engagé et engagent le pays par rapport à ses partenaires et ses alliances de fa on profonde et durable. Une réalisation ne fut-ce que partielle ou incomplète de ces plans a des conséquences très importantes sur la viabilité de l’outil militaire à court et moyen termes et ne peut que déclencher un nouveau cycle de planification stratégique. Les défis qui se posent actuellement à la Défense, que ce soit en matière de personnel ou d’investissements, méritent que les questions de fond soient abordées clairement afin que les choix qui engagent l’avenir soient faits en parfaite connaissance de cause.
Allele-Specific Effects on Extracellular Superoxide Dismutase Synthesis and Secretion  [PDF]
Sujung Jun, Ladislav Dory
Journal of Biomedical Science and Engineering (JBiSE) , 2017, DOI: 10.4236/jbise.2017.104011
Abstract: Plasma extracellular superoxide dismutase (ecSOD) concentrations are significantly (2 - 3-fold) higher in 129 mice than in the C57 strain. We reported earlier that the 129 strain carries a different allele of this enzyme, characterized by two amino acid substitutions and a 10 bp deletion in the 3’UTR of the mRNA. One of the substitutions is at the signal peptide cleavage site (position 21) while the other is within the catalytic site. Since the differences in plasma enzyme concentrations persist in congenic mice expressing the different alleles, the differences in plasma concentrations appear to be largely allele-driven and independent of the remainder of the genome. As expected, in vitro translation using rabbit reticulocyte lysate showed no differences in translational efficiency of transcripts and processing of the newly synthesized enzymes. Determinations of the rates of synthesis and secretion of the two isoforms of this enzyme in stably transfected CHO cells clearly demonstrate that the mature 129 variant is synthesized at rates nearly twice those of the wild-type isoform and has an intracellular pool size twice as large. However, both isoforms are secreted at the same fractional rate and have identical intracellular T1/2 as well as similar extent of degradation. These data explain, at least partially, the higher levels of ecSOD in congenic mice expressing the 129 variant, as well as enzyme levels in the 129 strain of mice. In silico calculations support this conclusion and indicate that the aa change at the signal peptide cleavage site (N21D) results in a substantial increase in cleavage probability at this site for the 129 variant. Our results also highlight the importance of signal peptide cleavage in determining steady-state levels of secretory proteins.
Un gong muet au fond de l’homme : A gong of silence inside of a man: a few words in memory of Avrom Sutzkever
Dory Manor
Yod : Revue des études Hébra?ques et Juives , 2011, DOI: 10.4000/yod.653
Abstract: In this homage to one of the greatest Jewish poets of the XXth century, the Israeli poet Dory Manor explains how he discovered the work of Avrom Sutzkever and recounts the personal discussions that he later had with the Yiddish poet. This article is a reflexion on the place of Yiddish literature in Israeli collective imagination as well as about two roads that never met: the one of Israeli culture and the one of this great creator who lived and wrote in Tel-Aviv over the course of sixty-three years. , , 20 “ . – , , – 63 .
Dory Manor
Yod : Revue des études Hébra?ques et Juives , 2011, DOI: 10.4000/yod.378
Abstract: Rencontre avec Sutzkever – Dory Manor , – ( - , – - - ) ( ) . .– , ? – - : . - .– , ? – ...
Hydrogen Bonds between Acidic Protons from Alkynes (C–H···O) and Amides (N–H···O) and Carbonyl Oxygen Atoms as Acceptor Partners
Pierre Baillargeon,Tommy Lussier,Yves L. Dory
Journal of Crystallography , 2014, DOI: 10.1155/2014/371629
Abstract: Crystals of tert-butyl (2S)-2-(prop-2-yn-1-ylcarbamoyl)pyrrolidine-1-carboxylate (Boc-L-Pro-NHCH2CCH) have been obtained. The title compound crystallizes easily as sharp needles in orthorhombic system, space group P 21 21 21 with a = 9.2890(2), b = 9.7292(2), c = 15.7918(4)??, V = 1427.18(6)??3, and Z = 4. The main feature of the structure is the orientation of the carbamate and amide. Their dipoles add up and the molecule displays an electric dipole moment of 5.61?D from B3LYP/6-31G(d) calculations. The antiparallel H bonding of amides and the alignment of dipoles induce columnar stacking (the dipole moment along the columnar a axis is 4.46?D for each molecule). The other components across the other axes are, therefore weaker, (3.17?D and 1.23?D along the b and c axes, resp.). The resulting anisotropic columns pack side by side, in an antiparallel fashion mostly by (alkyne) CH···O=C (carbamate) interactions. 1. Introduction The design of organic solid (crystal or supramolecular engineering) is still today challenging and of great importance [1, 2]. Understanding the details of weak intermolecular interactions plays definitely a major role in the rational design of ordered organic crystals. In our lab, we already achieved great molecular macroscopic order with specially designed peptides, macrocycles as precursors to organic nanotubes [3–5] or supramolecular walls [6]. Here, we present the crystal structure of the proline derivative 1 (Figure 1) which alkyne, amide, and carbamate functionalities are all involved in hydrogen bonding. Figure 1: Structure of the proline derivative 1 (Boc-L-ProNHCH 2CCH). 2. Materials and Methods 2.1. Synthesis To Boc-L-proline N-hydroxysuccinimide ester (2.0?g, 6.4?mmol) in CH2Cl2 (40?mL) was added, at 0°C, propargylamine (0.46?g, 8.4?mmol) and K2CO3 (1.43?g, 10.3?mmol). The reaction mixture was allowed to warm up to RT and was stirred for 72?h. Water (30?mL) was added and the organic phase was isolated. The remaining aqueous layer was extracted again with CH2Cl2 ( ?mL). The combined organic layers were filtrated through a cotton plug and the solvent was removed under reduced pressure. The residue was purified by flash chromatography on silica gel, eluted with Et2O/Hexane (75?:?25), to yield the title product as a white solid (1.654?g, 78%). (Et2O/Hexane 75?:?25); Tfus (108–111°C); IR (NaCl, ? cm?1): 3242, 3055, 2982, 2288, 2117, 1688, 1536, 1402, 1324, 1258, 919, 885, and 718. NMR1H (300?MHz, CDCl3, δ ppm): 6.20 (br, 1H), 4.30–3.90 (m, 3H), 3.50–3.30 (m, 2H), 2.40–2.00 (m, 2H), 2.20 (brs, 1H), 2.00–1.80 (m, 2H), and 1.45
A Characterization of the Optimal Management of Heterogeneous Environmental Assets under Uncertainty  [PDF]
Frank Raymond
Theoretical Economics Letters (TEL) , 2012, DOI: 10.4236/tel.2012.25093
Abstract: The application herein involves the optimal management of renewable and nonrenewable resources within the context of a stochastic model of optimal control. By characterizing the two dimensional Bellman solution, three rules with respect to resource management are established. Within the context of coastal development, this analysis may help to explain why renewable resources may become increasingly vulnerable to random external shocks as nonrenewable resources are depleted. Although existence of an optimal closed form solution to the multi-sector Bellman model remains an open mathematical question, this analysis offers a characterization which can be applied to other scenarios in economics or finance in which two assets following stochastic processes interact.
Influence of Hot Spring Phages on Community Carbon Metabolism: Win, Lose or Draw?  [PDF]
Raymond Kepner
Advances in Microbiology (AiM) , 2015, DOI: 10.4236/aim.2015.59066
Abstract: Abundant virus-like particles were concentrated from large-volume samples from two hot springs. Both addition of viral concentrates and addition of samples induced by addition of mitomycin-C changed patterns of carbon source utilization by hot spring microbial communities. Specific effects of the two treatments depended upon both temperature and incubation period. Increased metabolic capability with greater exposure to free phages, consistent with the view that phages are major lateral transporters of metabolic genes, was observed most clearly in microbes incubated at a temperature lower than that encountered in situ. On the other hand, decreases in the diversity of utilizable C sources upon exposure to phages may have been due to lytic activity in which susceptible bacterial populations were differentially reduced by infective viruses, consistent with the “killing the winner” hypothesis. Treatment of cultures with MC-treated culture extracts, assumed to increase exposure to excised prophages, resulted in higher average metabolic rates after 18 h, but lower rates after 48 h of incubation. With incubation at in situ temperature, this same treatment led to an initial increase in the number of readily utilized C sources, followed by a decrease in community metabolic diversity relative to controls in samples from both hot springs. Thus, treatments designed to increase the interaction between hot spring microbes and either free or newly-excised phages had observable time- and temperature-dependent effects on community metabolism, demonstrating an important, yet complex, ecological role for phages in hot spring waters.
Dehumanization, Racial Minority and Female Leadership: An Analysis of Global Trends  [PDF]
Simon Raymond
Advances in Applied Sociology (AASoci) , 2016, DOI: 10.4236/aasoci.2016.68022
Abstract: Purpose: The use of dehumanization, directed toward racial minorities, impresses as a global trend of significance, spanning from broad generalisations with regards to black community members holding a lower status through to Russian politicians terming Barack Obama and Michelle Obama as mammalian apes (or, monkeys). This report analyses the use of dehumanization and the validity of racial degradation. Female leadership is also analysed. Methods: A comparative analysis was performed assessing the achievements of African Americans in comparison with white (including caucasian) society, with a gender comparison to assess for consistency across genders. The categorisation of racial minorities based on the satisfying of criteria for conscious being recognition was also considered. Results: African Americans have held positions, and achieved success, equally respectable with that of the white (including caucasian) community. These members of society also satisfy the criteria for conscious beings. There appears to be no validity to support black or Asian people as representative of a being less than that of a human being. Conclusion: There appears to be no validity behind categorisation of certain races as lesser members of society. Furthermore, there appears no validity behind the use of dehumanization.
Causes of Death in Patients with Aortic Aneurysmal Disease (1987-2014)  [PDF]
Raymond Englund
Surgical Science (SS) , 2017, DOI: 10.4236/ss.2017.81001
Abstract: Introduction: This study examined the cause of death of patients with aortic aneurysms treated for this disease between 1987 and 2014 to understand the current natural history of this condition. Methods: This study results from analysis of a prospectively maintained data base of patients treated by the author. Data points were obtained from practice records and supplemented by data made available through CHeRL (Centre for electronic Health Record Linkage). Six hundred and twenty two patients were treated consecutively between 1987 and 2014. At closure of the study in 2014, 402 patients had died and date of death was available. Cause of death was available by ICD (International Classification of Diseases) 9 or 10 in 89% of patients. Method of treatment of aneurysmal disease was available in all patients. Ethics approval for this study was obtained from the Centre for Health Research, Cancer Institute, New South Wales Department of Health. Statistical analysis was conducted by comparison of mean ±95% conference interval. Where appropriate contingency table analysis was constructed. Statistical significance was accepted at P < 0.05. Results: Mean age at presentation was 75.6 years (95%C.I. 74.8 - 76.3). Mean age at death was 81 years (95%C.I. 80.2 - 81.7). Predicted age at death based on Australian Bureau of Statistics life tables was 86.25 years (95%C.I. 85.8 - 86.8). Between 1987 and 1999, mean age at presentation was 74.5 years (95%C.I. 73.3 - 75, n = 304, Females = 78). Between 2000 and 2014, mean age at presentation was 75.3 years (95%C.I. 74.1 - 75, n = 318, females = 54). The difference for females presenting 1987 to 1999 compared 2000 to 2014 was significant, p < 0.01. Death was due to the following causes unknown 11%, cardiovascular disease 27.7%, pulmonary related disease 9.7% and aortic related disease 20.6%. Patients died of aortic related causes significantly earlier (within 2 years) compared to patients with other causes of death (5 to 8 years) due to presentation with ruptured aortic aneurysm. Cardiovascular related causes of death, malignancy and pulmonary related causes of death accounted for the majority of deaths post-treatment. There was no significant difference in length of survival among patients dying from these causes. Conclusion: Patients with successfully treated aneurysmal disease can expect to survive 5 - 8 years post-treatment. Presentation with aortic aneurysm rupture results in significantly shortened life expectancy. Patients presenting in the ninth
Towards a Classification of Left Common Iliac Vein Compression Based on Triplanar Phlebography  [PDF]
Raymond Englund
Surgical Science (SS) , 2017, DOI: 10.4236/ss.2017.81003
Abstract: Introduction: There is currently no consistent classification of the extent of left common iliac vein compression syndromes such that clinicians working in the area have a common terminology. Hypothesis: To create a classification of left common iliac vein compression based on the end point of triplanar pelvic phlebogrpahy. Methods: Based on 61 consecutive patients found to have left common iliac vein compression on triplanar phlebography in the course of treatment of venous disease, clinical presentation and symptomatology were retrospectively used to create a classification of left common iliac vein compression. Treatment of left common iliac vein compression was also retrospectively correlated with staging. Results: The following classification was arrived at: Stage 0, no compression and no intraluminal fibrous bands; Stage 1, evidence of compression by surrounding anatomical structures with or without the presence of fibrous bands; Stage 2: evidence of compression with or without fibrous bands as evidenced by cross-pelvic collaterals; Stage 3: compression of the left common iliac vein. Fibrous bands replaced by localised occlusion, with collateralisation and no involvement of adjacent venous segments; Stage 4a: as for Stage 3 but with the addition of thrombotic involvement of adjacent venous segments; Stage 4b: as for Stage 4a but with involvement of distal venous segments, femoral and popliteal. Stages 3, 4a or 4b correlated well with clinical presentations of DVT, PE, venous ulceration, vulval or cross-pelvic collaterals, ipsilateral limb swelling and claudication. The presence of varicose veins or recurrent varicose veins was a common finding amongst all groups. Conclusion: Acceptance of this classification system would provide a common terminology to allow more transparent assessment of modalities of treatment for this condition.
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