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Search Results: 1 - 10 of 56 matches for " Ravikanth Chintala "
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INFLUENCE OF VERAPAMIL ON PHARMACOKINETICS OF PIOGLITAZONE IN NORMAL AND DIABETIC RATS
Ravikanth Chintala , Chaitanya Gadiko , Bhikku Angoth and Narsimha Reddy Yellu*
International Journal of Pharmaceutical Sciences and Research , 2013,
Abstract: ABSTRACT: The study was undertaken to find out the pharmacokinetic drug interaction of verapamil on pioglitazone in normal and alloxan induced diabetic rats following single and multiple dose treatment. Human oral therapeutic doses of pioglitazone and verapamil were extrapolated to rats based on their body surface area. The serum pioglitazone concentrations were estimated by a sensitive reverse phase – high performance liquid chromatography (RP-HPLC) method. In single and multiple dose study, verapamil significantly increased the pioglitazone exposure (AUC, Cmax) and decreased its elimination by prolongation of t1/2 and mean residence time (MRT) with a relative decrease in clearance (CL). The effect is more significant in diabetic rats. In the present study a pharmacokinetic interaction between verapamil and pioglitazone was observed. The possible interaction may involve both P-glycoprotein and CYP enzymes. Investigating this type of interactions pre-clinically is helpful to avoid drug-drug interactions in actual clinical situation.
SILA: THE FOUNDATION OF BUDDHIST ETHICS AND MIND
CHINTALA VENKATA SIVA SAI
Golden Research Thoughts , 2013, DOI: 10.9780/22315063
Abstract: Buddha contends that suffering (dukkha) arises because of 'craving' (tanha)with the base of 'ignorance' (avijja). Therefore, ignorance is the root cause of allsufferings. It is the ignorance of the true nature of things, that they are impermanent(anicca),essence less (anatta) and full of suffering (dukkha). The ignorant takes them aspermanent (nicca), full of essence (atta) and as the nature of pleasure (sukha). This leadsto 'craving' (tanha) for attachment with the objects. The nerve centre of these falseexperiences of objects as permanent, full of essence and pleasure is the 'mind'(manasi).'Mind' is the master power that moulds and casts 'thought'. In the mind, if, thereare evil thoughts, then the words are evil, and sorrow which results from sin follows thatman as the chariot wheel follows the 'drawer' who drags it.
PHARMACOGNOSTIC STUDIES ON DIOSPYROS MELANOXYLON
Sunitha Chintala et al
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: Diospyros melanoxylon is a medium-sized tree or shrub which belongs to the family Ebenaceae. The whole plant is medicinally important and cures several diseases. Therefore, in this context the detailed pharmacognostic study of various parts like leaf, stem, petiole and root has been carried out with the aim to establish its Pharmacognostical standards. The parameters selected were microscopical studies, proximate analysis, fluorescence analysis and preliminary phytochemical screening. The microscopical studies of leaf,stem and root revealed the presence of branched trichomes,spiral xylem vessel. In physicochemical evaluation the ash values and extractive values were studied. Fluorescence analysis performed showed the wide range of fluorescence colors for the crude powder. The Diospyros melanoxylon powder was successively extracted with hexane, benzene, chloroform, ethylacetate, ethanol and water for the identification of the best solvent. Preliminary phytochemical screening was carried out for all the extracts and maximum chemical constituents were observed in the ethanolic extract.
Test Effort Estimation Using Neural Network  [PDF]
Chintala Abhishek, Veginati Pavan Kumar, Harish Vitta, Praveen Ranjan Srivastava
Journal of Software Engineering and Applications (JSEA) , 2010, DOI: 10.4236/jsea.2010.34038
Abstract: In software industry the major problem encountered during project scheduling is in deciding what proportion of the resources has allocated to the testing phase. In general it has been observed that about 40%-50% of the resources need to be allocated to the testing phase. However it is very difficult to predict the exact amount of effort required to be allocated to testing phase. As a result the project planning goes haywire. The project which has not been tested sufficiently can cause huge losses to the organization. This research paper focuses on finding a method which gives a measure of the effort to be spent on the testing phase. This paper provides effort estimates during pre-coding and post-coding phases using neural network to predict more accurately.
Haematological Profile and Growth Performance of Goats under Transportation Stress
Ambore,B.,Ravikanth,K.
Veterinary World , 2009,
Abstract: Stress in caprine lowers overall growth, performance and induces various haematological alterations. A study was conducted in 24 Osmanabadi goats divided randomly into four groups; negative control (I), positive control (II), treated groups III & IV. Group III was given Restobal liquid@20 ml/animal bid & group IV, Stresomix premix@5gm/day/animal with gur for 10 days. Group II, III, IV were subjected to transportation stress on day 10th. Pre-load and post-load transported goats were weighed to assess the weight loss during the journey and blood samples were collected for haematological evaluation. Administration of both the antistressor, immunomodulator and performance enhancer formulations to goats prior to their transportation was found safe and efficacious as evident by significantly lesser shrinkage of body weight and normalization of physiological and haematological parameters. [Vet. World 2009; 2(5.000): 195-198]
Inhibition of Reactive Gliosis Attenuates Excitotoxicity-Mediated Death of Retinal Ganglion Cells
Bhagyalaxmi S. Ganesh,Shravan K. Chintala
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0018305
Abstract: Reactive gliosis is a hallmark of many retinal neurodegenerative conditions, including glaucoma. Although a majority of studies to date have concentrated on reactive gliosis in the optic nerve head, very few studies have been initiated to investigate the role of reactive gliosis in the retina. We have previously shown that reactive glial cells synthesize elevated levels of proteases, and these proteases, in turn, promote the death of retinal ganglion cells (RGCs). In this investigation, we have used two glial toxins to inhibit reactive gliosis and have evaluated their effect on protease-mediated death of RGCs. Kainic acid was injected into the vitreous humor of C57BL/6 mice to induce reactive gliosis and death of RGCs. C57BL/6 mice were also treated with glial toxins, alpha-aminoadipic acid (AAA) or Neurostatin, along with KA. Reactive gliosis was assessed by immunostaining of retinal cross sections and retinal flat-mounts with glial fibrillary acidic protein (GFAP) and vimentin antibodies. Apoptotic cell death was assessed by TUNEL assays. Loss of RGCs was determined by immunostaining of flat-mounted retinas with Brn3a antibodies. Proteolytic activities of matrix metalloproteinase-9 (MMP-9), tissue plasminogen activator (tPA), and urokinase plasminogen activator (uPA) were assessed by zymography assays. GFAP-immunoreactivity indicated that KA induced reactive gliosis in both retinal astrocytes and in Muller cells. AAA alone or in combination with KA decreased GFAP and vimentin-immunoreactivity in M?ller cells, but not in astrocytes. In addition AAA failed to decrease KA-mediated protease levels and apoptotic death of RGCs. In contrast, Neurostatin either alone or in combination with KA, decreased reactive gliosis in both astrocytes and M?ller cells. Furthermore, Neurostatin decreased protease levels and prevented apoptotic death of RGCs. Our findings, for the first time, indicate that inhibition of reactive gliosis decreases protease levels in the retina, prevents apoptotic death of retinal neurons, and provides substantial neuroprotection.
Impact of New Financial Products on Financial Performance of Public Sector Banks in India
Chintala Balaji,Syed Mobasheer,G. Praveen Kumar
International Business and Management , 2012, DOI: 10.3968/j.ibm.1923842820120402.1125
Abstract: In this paper, we analyze the performance of public sector banks in India during the period 1999-2000 to 2008-09. This period covers the old financial products period and new financial products period. Specifically, the paper examines the impact of new financial products on financial performance of public sector banks in India. The empirical results show that impact of new financial product on public sector banks has intensified. The financial performance of public sector banks is greater in new financial products than the old financial products period. Key words: Banking; Public sector banks; New financial products period; Old financial products period
Effect of salt stress on growth and accumulation of proline and soluble sugars on plantlets of Pistacia atlantica Desf. subsp. atlantica used as rootstocks
Chintala, R.,McDonald, LM.,Bryan, WB.
Biotechnologie, Agronomie, Société et Environnement , 2012,
Abstract: In Appalachian grasslands, soil acidity and highly variable topography are the main factors negatively affecting the productivity. There was a need to develop a yield response function and determine nutritive value of grasslands. Soil factors such as water potential (WP), soil pH, nitrogen (N) and phosphorus (P) levels are highly variable across mountainous grasslands. A greenhouse study was conducted to study the effects of WP, soil pH, N, and P levels on the herbage production and nutrient concentration of Kentucky bluegrass (Poa pratensis L.) and white clover (Trifolium repens L.) mixed sward. Central composite rotatable design was used to conduct this pot study. The effects of two levels of WP and five levels each of pH, N, and P fertilizers were evaluated. WP, pH, N and P levels as their interactions WP x pH, WP x N, pH x N, and N x P explained a significant part of sward accumulation in our trial. The importance of the different factors in explaining herbage accumulation variations was, in decreasing order, WP > pH > WP x pH > WP x N > P > N > N x P > pH x N. Optimum conditions for the production of bluegrass and white clover crop system were predicted, from this pot experiment, as follows WP of -422 to -171 kPa, 5.5 to 6.1 soil pH, 50 to 68 N mg·kg-1, and 38 to 40 P mg·kg-1. Concentration (%) of nitrogen (N), phosphorus (P), potassium (K), calcium (Ca), and magnesium (Mg) were determined in shoot tissue to understand the impact of the different factors on nutrient content of forage. WP and soil pH had shown significant influence on concentration of all elements. Effects of soil pH and N level had significant effect on N concentration in plant tissue. Plant P concentration was significantly influenced by interaction of P level with WP and soil pH. Yield response function of Kentucky bluegrass and white clover mixture from this case study should be evaluated in field trials to obtain practical significance. Effect of WP, soil pH, and N and P levels on herbage accumulation of grasslands and nutritive value should be understood to harmonize productivity across this undulating landscape.
A VALIDATED REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF DOXOFYLINE IN PURE AND PHARMACEUTICAL FORMULATIONS
Lanka Venkateswararao,Golkonda Ramu,Chintala Rambabu
International Research Journal of Pharmacy , 2013,
Abstract: A novel reverse phase high performance liquid chromatographic method (RP-HPLC) was developed and validated for the determination of doxofylline (DXF) in pharmaceutical formulations. Agilent 1100 series HPLC instrument equipped with variable wavelength programmable UV-Visible detector and a chromosil C18 (250mm x 4.6mm, 5μm) column with an auto injector was used for the present investigation. A volume of 20μL of working standard of concentration 25μg/mL was injected into the chromatographic system, the component was separated by using the mobile phase of the mixture of potassium dihydrogen phosphate buffer of pH 5.5 and acetonitrile in the ratio 75:25(v/v) at a flow rate of 1.0 mL/min and the detection of the components was carried out at a wavelength of 275nm. Chemstation software was used for the data acquisition through out the analysis. The system suitable parameters such as number of theoretical plates, tailing factor and resolution were found to be satisfactory. The retention time of the component was found to be at 4.814 minutes. The proposed method was validated in terms of precision, accuracy, linearity, limit of detection, limit of quantification, robustness and ruggedness. The developed method was found to be rapid, simple and sensitive hence it could be used as an alternative method in assay of the doxofylline in any pharmaceutical industries.
Unsupervised Representation Learning with Deep Convolutional Generative Adversarial Networks
Alec Radford,Luke Metz,Soumith Chintala
Computer Science , 2015,
Abstract: In recent years, supervised learning with convolutional networks (CNNs) has seen huge adoption in computer vision applications. Comparatively, unsupervised learning with CNNs has received less attention. In this work we hope to help bridge the gap between the success of CNNs for supervised learning and unsupervised learning. We introduce a class of CNNs called deep convolutional generative adversarial networks (DCGANs), that have certain architectural constraints, and demonstrate that they are a strong candidate for unsupervised learning. Training on various image datasets, we show convincing evidence that our deep convolutional adversarial pair learns a hierarchy of representations from object parts to scenes in both the generator and discriminator. Additionally, we use the learned features for novel tasks - demonstrating their applicability as general image representations.
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