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Search Results: 1 - 10 of 2866 matches for " Ravi Bhatia "
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Experiences of refugees and asylum seekers in general practice: a qualitative study
Ravi Bhatia, Paul Wallace
BMC Family Practice , 2007, DOI: 10.1186/1471-2296-8-48
Abstract: Qualitative study of adult asylum seekers and refugees who had entered the UK in the last 10 years. The study was set in Barnet Refugee Walk in Service, London. 11 Semi structured interviews were conducted and analysed using framework analysis.Access to GPs may be more difficult for failed asylum seekers and those without support from refugee agencies or family. There may be concerns amongst some in the refugee community regarding the access to and confidentiality of professional interpreters. Most participants stated their preference for GPs who offered advice rather than prescriptions. The stigma associated with refugee status in the UK may have led to some refugees altering their help seeking behaviour.The problem of poor access for those with inadequate support may be improved by better education and support for GPs in how to provide for refugees. Primary Care Trusts could also supply information to newly arrived refugees on how to access services. GPs should be aware that, in some situations, professional interpreters may not always be desired and that instead, it may be advisable to reach a consensus as to who should be used as an interpreter. A better doctor-patient experience resulting from improvements in access and communication may help to reduce the stigma associated with refugee status and lead to more appropriate help seeking behaviour. Given the small nature of our investigation, larger studies need to be conducted to confirm and to quantify these results.The increasing refugee [throughout this report, the term "refugee" is used to denote "refugee and asylum seeker"] population in the UK has led to increased research and debate about their health and social needs [1]. Most studies have been based on health professionals' views of how refugees should be managed and the problems encountered by these professionals when dealing with them. They have exposed how healthcare for refugees is patchy and often inappropriate [2] with inequalities in relation to a
Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing: Response to antiepileptic dual therapy
Gupta Ravi,Bhatia Manjeet
Neurology India , 2008,
Abstract: Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) is included among trigeminal autonomic cephalalgias in the International Classification of Headache Disorders-2. Available literature suggests that it responds to anticonvulsants, particularly lamotrigine. However, management of partial responders is difficult and antiepileptic duo-therapy may be an answer to it. Nonetheless, to our knowledge, anticonvulsant combination has never been tried in partial responders to monotherapy. We are presenting a case of SUNCT that had overlapping symptoms with Short-lasting Unilateral Neuralgiform headache attacks with cranial Autonomic features and responded well only to the combination of lamotrigine with carbamazepine. However, lamotrigine had to be stopped as patient developed leucopenia and it resulted in partial recurrence of symptoms.
Drug Induced Parkinsonism Presenting As Isolated Jaw Tremors
Ravi Gupta,Manjeet Singh Bhatia
Online Journal of Health & Allied Sciences , 2006,
Abstract: We describe a case of drug induced parkinsonism (DIP) that presented with isolated mandibular tremors despite prophylactic anticholinergic therapy. Varied presentations of DIP may be explained by anatomical & functional neuro-circuitry of striatum.
Granulocytes Affect Double-Strand Break Repair Assays in Primary Human Lymphocytes
Sandrine Lacoste, Ravi Bhatia, Smita Bhatia, Timothy R. O'Connor
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0093185
Abstract: Patients who develop therapy-related myelodysplasia/acute myeloid leukemia after autologous-hematopoietic stem cell (aHCT) transplant show lower expression levels of DNA repair genes in their pre-aHCT CD34+ cells. To investigate whether this leads to functional differences in DNA repair abilities measurable in patients, we adapted two plasmid-based host-cell reactivation assays for use in primary lymphocytes. Prior to applying these assays to patients who underwent aHCT, we wanted first to verify whether sample preparation affected repair measurements, as patient samples were simply depleted of erythrocytes (with hetastarch) prior to freezing, which is not the classical way to prepare lymphocytes prior to DNA repair experiments (with a density gradient). We show here that lymphocytes from healthy donors freshly prepared with hetastarch show systematically a higher level of double-strand break repair as compared to when prepared with a density gradient, but that most of this difference disappears after samples were frozen. Several observations points to granulocytes as the source for this effect of sample preparation on repair: 1) removal of granulocytes makes the effect disappear, 2) DSB repair measurements for the same individual correlate to the percentage of granulocytes in the sample and 3) nucleofection in presence of granulocytes increases the level of reactive oxygen species (ROS) in neighboring lymphocytes in a dose-dependent manner (R2 of 0.95). These results indicate that co-purified granulocytes, possibly through the release of ROS at time of transfection, can lead to an enhanced repair in lymphocytes that obfuscates any evaluation of inter individual differences in repair as measured by host-cell reactivation. As a result, hetastarch-prepared samples are likely unsuitable for the assessment of DSB repair in primary cells with that type of assay. Granulocyte contamination that exists after a density gradient preparation, although much more limited, could have similar effects, but might be circumvented by freezing cells prior to analysis.
Hereditary Leukemia Due to Rare RUNX1c Splice Variant (L472X) Presents with Eczematous Phenotype  [PDF]
April Sorrell, Carin Espenschied, Wei Wang, Jeffrey Weitzel, Su Chu, Pablo Parker, Juan-Sebastian Saldivar, Ravi Bhatia
International Journal of Clinical Medicine (IJCM) , 2012, DOI: 10.4236/ijcm.2012.37110
Abstract:

Deleterious mutations in the RUNX1 gene cause hereditary leukemia due to a rare syndrome called Familial platelet Disorder with Associated Myeloid Malignancy (FPDMM). We describe the characteristics of a family with FPDMM due to a novel RUNX1 mutation (L472X), located in the most 3-prime end of the gene reported to date. Our 36-year-old proband presented with incidentally detected thrombocytopenia and a family history suggestive of FPDMM. Contrary to previously described families, affected members of our kindred express an eczematous phenotype, reportedly most severe in members who develop leukemia. Pedigree analysis shows that the L472X mutation tracks with thrombocytopenia, acute leukemia, and eczema. The L472X mutation produces a stably expressed RUNX1 protein product with a corresponding decrease in wild type RUNX1 expression. Our data supports the inclusion of eczema in the FPDMM phenotype and suggests the possibility that the RUNX1 L472X mutant causes the type of dominant negative affect that is associated with an elevated risk of leukemia in FPDMM families.

Benign Ancient Schwannoma of the abdominal wall: An unwanted birthday present
Ravi K Bhatia, Ayan Banerjea, Manisha Ram, Bryony E Lovett
BMC Surgery , 2010, DOI: 10.1186/1471-2482-10-1
Abstract: A healthy 64 year old lady received a privately funded whole body CT scan for her birthday which revealed an incidental mass in the right iliac fossa. This was investigated with further imaging and colonoscopy and as confident diagnosis could not be made, eventually excised. Histology demonstrated this to be a benign ancient schwannoma and we believe this to be the first reported case of an abdominal wall schwannoma in the English literatureAncient schwannomas are rare tumours of the peripheral nerve sheaths more usually found in the head, neck and flexor surfaces of extremities. They are a subtype of classical schwannomas with a predominance of degenerative changes. Our case highlights the pitfalls of such screening tests in demonstrating benign disease and subjecting patients to what turns out to be unnecessary invasive investigation and treatment. It provides evidence as to the consequences of the large number of false positive results that are created by blind CT scanning of asymptomatic patients i.e. its tendency to detect pseudodiesease rather than affect survival rates. Should the number of scans increase there may be an unnecessary burden on NHS resources due to the large numbers of benign lesions picked up, that are then referred for further investigation.In recent years private entrepreneurs have recognised, some might say exploited, a market for radiological screening tests [1,2]. One of these tests, Computerised Tomography (CT), in particular whole body CT, is tendered as a possible tool to identify asymptomatic thoracic and abdominal disease. However, before any procedure is adopted to screen for disease, its cost, benefit and risk should all be taken into account and before this happens the value of the test must remain unproven and unknown[3] To date, this evaluation has not been carried out with whole body CT screening in asymptomatic individuals [4]. This may be due to the huge cost and long follow up period required for such a trial as well as the
Impact of primary headaches on subjective sleep parameters among adolescents
Gupta Ravi,Bhatia Manjeet,Dahiya Devendra,Sharma Sameer
Annals of Indian Academy of Neurology , 2008,
Abstract: Context: Headache patients commonly report sleep disruption and sleep disorders. Available literature suggests that the sleep pattern of headache sufferers is different from the control group. Patients in these studies were recruited from headache clinics; they did not include tension type headache. Aims: The aim of this study is to find out whether primary headaches affect sleep patterns. Settings and Design: Community based cross sectional study Materials and Methods: This study was conducted in three high schools. Children in the 12-19 age group were allowed to participate. They were given a questionnaire in the presence of at least one of the authors, who assisted them in filling it. They were asked to provide responses based on most severe recurrent headache that they had experienced rather than the more frequent ones. The questionnaire included questions regarding demographic data and the characteristics of headache according to International Classification of Headache Disorders-2 criteria. Part B of the questionnaire contained questions regarding sleep habits. The children were asked to provide data regarding sleep habits on a normal school day. Diagnosis was based upon the information contained in the questionnaire. A telephonic interview was also done, where the information provided was found inadequate. Statistical Analysis Used: Analysis was done with the help of SPSS v. 11.0., descriptive analysis, Chi square, and one way ANOVA with post hoc analysis. Kruskall-Wallis tests were run. Results: A total of 1862 subjects were included in the study. Migraineurs and tension type headache sufferers comprised 35.7% and 13.4% of the group respectively. Migraineurs had the highest prevalence of nocturnal awakenings ( P < 0.001), abnormal movements ( P =0.001) and breathing problems during sleep ( P < 0.001). Approximately half the migraineurs felt sleepy during the day ( P < 0.001) and spent around 1.17 hours in sleep during the day ( P = 0.007). Similarly, values for frequency of nocturnal awakenings per week ( P < 0.001), wake time after sleep onset and offset ( P < 0.001 and 0.002 respectively) were the maximum in migraineurs. Only 32.8% migraineurs reported refreshing sleep ( P < 0.001). Post hoc analysis revealed that migraineurs were different from the other two groups on most of the parameters. Conclusions: Sleep disruption is more common in migraineurs than those in the tension type headache sufferers and the control group.
Biaxial strain effect of spin dependent tunneling in MgO magnetic tunnel junctions
Ajeesh M. Sahadevan,Ravi K. Tiwari,Gopinadhan Kalon,Charanjit S. Bhatia,Mark Saeys,Hyunsoo Yang
Physics , 2012, DOI: 10.1063/1.4738787
Abstract: We study the effect of strain on magnetic tunnel junctions (MTJ) induced by a diamond like carbon (DLC) film. The junction resistance as well as the tunnel magnetoresistance (TMR) reduces with the DLC film. Non-equilibrium Green's function quantum transport calculations show that the application of biaxial strain increases the conductance for both the parallel and anti-parallel configurations. However, the conductance for the minority channel and for the anti-parallel configuration is significantly more sensitive to strain, which drastically increases transmission through a MgO tunnel barrier, therefore, the TMR ratio decreases with biaxial strain.
Keystroke Dynamics Based Authentication Using Information Sets  [PDF]
Aparna Bhatia, Madasu Hanmandlu
Journal of Modern Physics (JMP) , 2017, DOI: 10.4236/jmp.2017.89094
Abstract: This paper presents keystroke dynamics based authentication system using the information set concept. Two types of membership functions (MFs) are computed: one based on the timing features of all the samples and another based on the timing features of a single sample. These MFs lead to two types of information components (spatial and temporal) which are concatenated and modified to produce different feature types. Two Component Information Set (TCIS) is proposed for keystroke dynamics based user authentication. The keystroke features are converted into TCIS features which are then classified by SVM, Random Forest and proposed Convex Entropy Based Hanman Classifier. The TCIS features are capable of representing the spatial and temporal uncertainties. The performance of the proposed features is tested on CMU benchmark dataset in terms of error rates (FAR, FRR, EER) and accuracy of the features. In addition, the proposed features are also tested on Android Touch screen based Mobile Keystroke Dataset. The TCIS features improve the performance and give lower error rates and better accuracy than that of the existing features in literature.
Keystroke Dynamics Based Authentication Using Possibilistic Renyi Entropy Features and Composite Fuzzy Classifier  [PDF]
Aparna Bhatia, Madasu Hanmandlu
Journal of Modern Physics (JMP) , 2018, DOI: 10.4236/jmp.2018.92008
Abstract: This paper presents the formulation of the possibilistic Renyi entropy function from the Renyi entropy function using the framework of Hanman-Anirban entropy function. The new entropy function is used to derive the information set features from keystroke dynamics for the authentication of users. A new composite fuzzy classifier is also proposed based on Mamta-Hanman entropy function and applied on the Information Set based features. A comparison of the results of the proposed approach with those of Support Vector Machine and Random Forest classifier shows that the new classifier outperforms the other two.
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