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Search Results: 1 - 10 of 164 matches for " Raskin "
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On the notion of spectral decomposition in local geometric Langlands
Sam Raskin
Mathematics , 2015,
Abstract: The geometric Langlands program is distinguished in assigning spectral decompositions to all representations, not only the irreducible ones. However, it is not even clear what is meant by a spectral decomposition when one works with non-abelian reductive groups and with ramification. The present work is meant to clarify the situation, showing that the two obvious candidates for such a notion coincide. More broadly, we study the moduli space of (possibly irregular) de Rham local systems from the perspective of homological algebra. We show that, in spite of its infinite-dimensional nature, this moduli space shares many of the nice features of an Artin stack. Less broadly, these results support the belief in the existence of a version of geometric Langlands allowing arbitrary ramification. Along the way, we give some apparently new, if unsurprising, results about the algebraic geometry of the moduli space of connections, using Babbitt-Varadarajan's reduction theory for differential equations.
Coherent sheaves on formal complete intersections via DG Lie algebras
Sam Raskin
Mathematics , 2012,
Abstract: We establish a criterion for sheaves on an adically complete DG scheme to be coherent. We deduce a description of coherent sheaves on an adically complete lci singularity in terms of modules for a DG Lie algebra.
A Geometric Proof of the Feigin-Frenkel Theorem
Sam Raskin
Mathematics , 2011,
Abstract: We reprove the theorem of Feigin and Frenkel relating the center of the critical level enveloping algebra of the Kac-Moody algebra for a semisimple Lie algebra to opers (which are certain de Rham local systems with extra structure) for the Langlands dual group. Our proof incorporates a construction of Beilinson and Drinfeld relating the Feigin-Frenkel isomorphism to (more classical) Langlands duality through the geometric Satake theorem.
Vascular effects of rapid-acting insulin analogs in the diabetic patient: a review
Steve Fordan, Philip Raskin
Vascular Health and Risk Management , 2009, DOI: http://dx.doi.org/10.2147/VHRM.S3402
Abstract: scular effects of rapid-acting insulin analogs in the diabetic patient: a review Review (13814) Total Article Views Authors: Steve Fordan, Philip Raskin Published Date February 2009 Volume 2009:5 Pages 225 - 231 DOI: http://dx.doi.org/10.2147/VHRM.S3402 Steve Fordan, Philip Raskin Department of Medicine, Division, of Endocrinology, University of Texas, Southwestern Medical Center, Dallas, TX, USA Abstract: The insulin analogs lispro, aspart, and glulisine are the only commercially available rapid-acting insulins to treat diabetes. We review the evidence for treating hyperglycemia, using insulin, and specifically using rapid-acting analogs in diabetic individuals, on the prevention of vascular events. We review the beneficial effects of insulin on the vascular system, which include vasodilation and anti-inflammatory actions. The effects of treating hyperglycemia and intensive blood glucose control on vascular outcomes are reviewed.
Vascular effects of rapid-acting insulin analogs in the diabetic patient: a review
Steve Fordan,Philip Raskin
Vascular Health and Risk Management , 2009,
Abstract: Steve Fordan, Philip RaskinDepartment of Medicine, Division, of Endocrinology, University of Texas, Southwestern Medical Center, Dallas, TX, USAAbstract: The insulin analogs lispro, aspart, and glulisine are the only commercially available rapid-acting insulins to treat diabetes. We review the evidence for treating hyperglycemia, using insulin, and specifically using rapid-acting analogs in diabetic individuals, on the prevention of vascular events. We review the beneficial effects of insulin on the vascular system, which include vasodilation and anti-inflammatory actions. The effects of treating hyperglycemia and intensive blood glucose control on vascular outcomes are reviewed.Keywords: lispro, aspart, glulisine, nitric oxide synthetase, nuclear factor kappa B
Tidal Tail Ejection as a Signature of Type~Ia Supernovae from White Dwarf Mergers
Cody Raskin,Daniel Kasen
Physics , 2013, DOI: 10.1088/0004-637X/772/1/1
Abstract: The merger of two white dwarfs may be preceded by the ejection of some mass in "tidal tails", creating a circumstellar medium around the system. We consider the variety of observational signatures from this material, which depend on the lag time between the start of the merger and the ultimate explosion (assuming one occurs) of the system in a Type Ia supernova. If the time lag is fairly short, the interaction of the supernova ejecta with the tails could lead to detectable shock emission at radio, optical, and/or x-ray wavelengths. At somewhat later times, the tails produce relatively broad NaID absorption lines with velocity widths of order the white dwarf escape speed ($\sim 1000$ \kms). That none of these signatures have been detected in normal SNe Ia constrains the lag time to be either very short ($\lesssim 100$ s) or fairly long ($\gtrsim 100$ yr). If the tails have expanded and cooled over timescales $\sim 10^4$ yr, they could be observable through narrow NaID and CaII H&K absorption lines in the spectra, which are seen in some fraction of SNe Ia. Using a combination of 3D and 1D hydrodynamical codes, we model the mass-loss from tidal interactions in binary systems, and the subsequent interactions with the interstellar medium, which produce a slow-moving, dense shell of gas. We synthesize NaID line profiles by ray-casting through this shell, and show that in some circumstances tidal tails could be responsible for narrow absorptions similar to those observed.
Acyclic complexes and 1-affineness
Dennis Gaitsgory,Sam Raskin
Mathematics , 2015,
Abstract: This short note is an erratum to arXiv:1306.4304, correcting the proof of one of its main results. It includes some counterexamples regarding infinite-dimensional unipotent groups and affine spaces that may be of independent interest.
Correlation between Obesity and Inflammation in Cardiovascular Diseases—Evaluation of Leptin and Inflammatory Cytokines  [PDF]
Rajagopal Raskin Erusan, Devarajan Nalini, Ganesan Manohar, Raghunathan Malathi
Open Journal of Endocrine and Metabolic Diseases (OJEMD) , 2012, DOI: 10.4236/ojemd.2012.22002
Abstract: Obesity, an important risk factor for cardiovascular disease (CVD), is currently viewed as a pro-inflammatory state with an increase in the expression of inflammatory cytokines including Tumor Necrosis Factor-α (TNF-alpha) and Interleukin-6 (IL-6) along with the increased secretion of leptin. Serum leptin was estimated in 150 CVD patients (belonging to the age group of 35 - 75 years) of different Body Mass Index (BMI) and its correlation to various biochemical parameters including lipids, glucose and CRP was analyzed to study the association of leptin with CVD. Further to understand the relationship between obesity, inflammation and CVD, serum leptin, TNF-alpha, IL-6 was evaluated in 50 CVD and 50 non-CVD subjects. Results were presented as mean ± SD. A distinct correlation between leptin, TNF-alpha, IL-6 and BMI was observed and these cytokines were elevated in CVD subjects. The protein expression of the monomeric form of CRP which is known to be expressed in pathological condition was found to be highly expressed in serum of CVD subjects. Further, to substantiate the role of inflammation in obesity related CVD, different concentrations of leptin were added to Peripheral Blood Mononuclear Cells (PBMC) isolated from twenty healthy volunteers of different BMI and the gene expression of TNF-alpha, IL-6 and Ob-Rb were studied. A significant increase in the level of these cytokines was observed with increasing leptin concentration. The results obtained from the present analysis suggest that inflammation may be a crucial factor involved in obesity associated CVD.
PCR Biases Distort Bacterial and Archaeal Community Structure in Pyrosequencing Datasets
Ameet J. Pinto,Lutgarde Raskin
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0043093
Abstract: As 16S rRNA gene targeted massively parallel sequencing has become a common tool for microbial diversity investigations, numerous advances have been made to minimize the influence of sequencing and chimeric PCR artifacts through rigorous quality control measures. However, there has been little effort towards understanding the effect of multi-template PCR biases on microbial community structure. In this study, we used three bacterial and three archaeal mock communities consisting of, respectively, 33 bacterial and 24 archaeal 16S rRNA gene sequences combined in different proportions to compare the influences of (1) sequencing depth, (2) sequencing artifacts (sequencing errors and chimeric PCR artifacts), and (3) biases in multi-template PCR, towards the interpretation of community structure in pyrosequencing datasets. We also assessed the influence of each of these three variables on α- and β-diversity metrics that rely on the number of OTUs alone (richness) and those that include both membership and the relative abundance of detected OTUs (diversity). As part of this study, we redesigned bacterial and archaeal primer sets that target the V3–V5 region of the 16S rRNA gene, along with multiplexing barcodes, to permit simultaneous sequencing of PCR products from the two domains. We conclude that the benefits of deeper sequencing efforts extend beyond greater OTU detection and result in higher precision in β-diversity analyses by reducing the variability between replicate libraries, despite the presence of more sequencing artifacts. Additionally, spurious OTUs resulting from sequencing errors have a significant impact on richness or shared-richness based α- and β-diversity metrics, whereas metrics that utilize community structure (including both richness and relative abundance of OTUs) are minimally affected by spurious OTUs. However, the greatest obstacle towards accurately evaluating community structure are the errors in estimated mean relative abundance of each detected OTU due to biases associated with multi-template PCR reactions.
CONTROVERSIAS EN LOS CRITERIOS éTICOS DE LOS CUIDADOS EN GERIATRíA
Daichman Raskin,Lía Susana;
Acta bioethica , 2001, DOI: 10.4067/S1726-569X2001000100009
Abstract: resolving about resource allocation and the ethical dilemmas daily arising in geriatric care is becoming the pattern that will dominate health care during next decades. if elderly care in the community increasingly becomes the norm, the ethical dimensions of this kind of care giving will generate essential questioning on frailty, dependence, autonomy, competence, and the controversial relationship between the elderly and those who care and sustain them. shared decision-making requires that the professional seeks not only to understand and meet the person's needs but also to provide him/her with reasonable alternatives, thus allowing the patient to choose what they prefer. it is through this process of shared decision-making that caregiver's knowledge and professional expertise can come together with the older person's expressed values. the development of a coherent and understandable dialogue as well as necessary strategies stand as a crucial task and commitment for those concerned with the ethical criteria of geriatric care
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