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Search Results: 1 - 10 of 192934 matches for " Raquel Cristina de Sousa Azevedo "
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Multifunctional Nanostructured Materials Applied in Controlled Radiopharmaceuticals Release  [PDF]
Raquel Cristina de Sousa Azevedo, Daniel Crístian Ferreira Soares, Ricardo Geraldo de Sousa, Edésia Martins Barros de Sousa
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2012, DOI: 10.4236/jbnb.2012.32022
Abstract: The metaiodobenzylguanidine (MIBG) radiopharmaceutical, an analogue of norepinephrine, has been used to diagnose certain diseases in the cardiovascular system when radiolabeled with 123I. This radiopharmaceutical can also be used to treat tumors, such as neuroblastomas and pheochromocytomas, when radiolabeled with 131I. Its clinical use is often accompanied by a slow intravenous administration, where a significant dose of radiation can directly affect workers in nuclear medicine services. To overcome this problem, the incorporation and controlled release of radiopharmaceuticals from the matrix of mesoporous systems based on silica, such as SBA-15 and hybrid [SBA-15/P(N-iPAAm)], can lead to a significant reduction in radiation doses received by workers. In the present study, silica matrices SBA-15 and hybrid [SBA-15/P(N-iPAAm)] containing the radiopharmaceutical MIBG were prepared and physicochemically characterized through FTIR, SEM, and small angle X-ray diffraction techniques. The release profiles of MIBG from SBA-15 and [SBA-15/P(N-iPAAm)] were studied in a simulated body fluid (SBF) to evaluate their potential application as vehicles for controlled releases. Furthermore, in vitro studies were performed to assess the cytotoxicity of matrices as compared to human lung fibroblast cells (MRC-5). The results revealed that the amount of MIBG incorporated within the studied matrices was indeed quite different, showing that only the hybrid [SBA-15/P(N-iPAAm)] system allowed for a more adequate release profile of MIGB. Taking all results into consideration, it can be concluded that the hybrid matrix [SBA-15/P(N-iPAAm)] can be considered a potential alternative material for the controlled release delivery of radio-pharmaceuticals.
Densidade de plantas e número de drenos influenciando a produtividade de roseiras cultivadas em vaso
Viana, Thales VA;Alves, Alexandre M;Sousa, Valdemício F de;Azevedo, Benito M de;Furlan, Raquel Aparecida;
Horticultura Brasileira , 2008, DOI: 10.1590/S0102-05362008000400021
Abstract: the cultivation of flowers in ceará state has expanded during the last years, especially in highland areas with a favorable climate for several crops. however, there exist only limited research in this area, so that producers work empirically with those crops. consequently, this research aimed to evaluate the effects of the number of plants (2, 3 and 4) and the amount of drains (1 and 8) per pot on the number of stems per pot, in a protected environment. the experiment was carried out in s?o benedito, ceará state, brazil, following a 3 x 2 factorial randomized block design with four repetitions. the number of stems with 35, 40, 50, 60 cm and, the total number of stems per pots of 12.0 l were evaluated. the highest number of plants per pot provided the greatest number of stems per pot, but with a predominance of lower commercial value. on the other hand, the least number of plants per pot resulted in few stems per area which were better evaluated commercially. the use of pots having more drains reduced the total number of stems per pot.
Avalia??o preliminar da escala de desempenho em informática educacional com professores
Joly, Maria Cristina Rodrigues Azevedo;Franco, Gisele de Sousa;Nicolau, Adriana Ferreira;
Estudos de Psicologia (Campinas) , 2004, DOI: 10.1590/S0103-166X2004000300007
Abstract: the information technology is an education elementary tool. an instrument able to analyze teachers performance using this technology as an educational tool is very important. this research purpose was to evaluate the psychometrics characteristics of the educational informatics performance scale through an online pilot study. 82 elementary teachers from public and private schools were the subjects of this study. educational informatics performance scale, which was answered online, was composed by 51 items with 4 answer choices each one in order to define every teacher's profile. the results has presented a good internal consistency (αcronbach =0,9678) and a 0,3792 average items correlation. the instrument internal precision has identified the items homogeneity, and it was verified by the split-half method. the factorial analysis has suggested some items rearranges according to the scale definitions. the psychometrics qualities added to the results of factorial analysis has revealed the educational informatics performance scale effectiveness validity.
Repellent activity of DEET against Amblyomma cajennense (Acari: Ixodidae) nymphs submitted to different laboratory bioassays Atividade repelente do DEET contra ninfas de Amblyomma cajennense (Acari: Ixodidae) em bioensaio laboratorial
Sara Fernandes Soares,Raquel de Sousa Braga,Lorena Lopes Ferreira,Carla Cristina Braz Louly
Revista Brasileira de Parasitologia Veterinária , 2010, DOI: 10.1590/s1984-29612010000100004
Abstract: This study was developed to evaluate the repellent activity of N,N-diethyl-3-methylbenzamide (DEET) against Amblyomma cajennense nymphs. Two repellent bioassays were compared and the effective concentration and repellent time were calculated. The fingertip test was accomplished to evaluate in vivo four concentrations of the compound (0.200; 0.100; 0.050 and 0.025 mg.cm-2) and the filter-paper bioassay to evaluate in vitro the two highest concentrations. The compound provided repellence higher than 90% in all concentrations and at least 95% repellency in the highest concentration over 5 hours. The effective concentration against 50% of tested nymphs (EC50) was 0.006 mg.cm-2 and the EC99 was 0.036 mg.cm-2. Those concentrations were lower than the ones obtained against other tick species, denoting the effectiveness of DEET against A. cajennense. The repellency time against 50% of the ticks (RT50) was 4.8 hours and the RT90 was 2.7 hours. Both bioassays were adequate to evaluate A. cajennense repellency and provided similar results; however the in vivo test is more appropriate to estimate the effective concentration and repellency time. Este estudo foi conduzido com o objetivo de avaliar a atividade repelente do N,N-diethyl-3-methylbenzamide (DEET) sobre ninfas de Amblyomma cajennense. Dois bioensaios para a avalia o de repelência foram comparados e cálculos da concentra o eficaz e do tempo de repelência foram realizados. Foram empregados o bioensaio da ponta do dedo, para avalia o in vivo de quatro concenta es do químico (0,200; 0,100; 0,050 e 0,025 mg.cm-2) e o bioensaio do papel filtro, para a avalia o in vitro das duas concentra es mais altas. O composto conferiu mais de 90% de repelência em todas as concentra es utilizadas e 95% de repelência por mais de cinco horas na maior concentra o. A concentra o do composto efetiva contra 50% das ninfas testadas (CE50) foi de 0,006 mg.cm-2 e a CE99 foi de 0,036 mg.cm-2. Estas concentra es s o mais baixas do que as observadas em outras espécies de carrapatos, denotando a efetividade do princípio contra A. cajennense. O tempo de repelência de 50% dos carrapatos (TR50) foi de 4,8 horas e o TR90 de 2,7 horas. Os dois bioensaios avaliados permitiram a observa o de percentuais de repelência igualmente altos e se mostraram adequados para tal avalia o, sendo que o teste in vivo é mais indicado para cálculo da concentra o eficaz e da dura o da repelência.
Produtividade do meloeiro fertirrigado com potássio em ambiente protegido
Viana, Thales Vinícius de Araújo;Sales, Inêz Gifone Maia;Sousa, Valdemício Ferreira de;Azevedo, Benito Moreira de;Furlan, Raquel Aparecida;Costa, Solerne Caminha;
Horticultura Brasileira , 2007, DOI: 10.1590/S0102-05362007000300027
Abstract: we studied the effects of three kalium doses applied via fertigation on the yield of melon plants (cucumis melo l.). the experiment was carried out in a greenhouse installed in limoeiro do norte county, ceará state, brazil. plants were irrigated from april to august, 2002 by a regular or a subsurface drip irrigation system. seeds of the hybrid bonus 2 were sown at 0.5 x 1.0 m. streaks were installed to induce the vertical growth of the plants, up to 2.0 m height. the experimental design followed a 2 x 3 factorial random blocks design. the treatments consisted of the combination of three kalium doses (40; 120 and 200 kg ha-1) and tof two depths of application (0.0 m - surface and 0.20 m - subsurface) with four replications per treatment. the total dry matter, leaf dry matter, average fruit weight, soluble solid content of fruits and yield of fruits were evaluated. the subsurface drip irrigated plants produced higher total dry matter and leaf dry matter. the applied kalium levels, however, resulted in no statistic difference for all evaluated variables.
Repellent activity of DEET against Amblyomma cajennense (Acari: Ixodidae) nymphs submitted to different laboratory bioassays
Soares, Sara Fernandes;Braga, Raquel de Sousa;Ferreira, Lorena Lopes;Louly, Carla Cristina Braz;Sousa, Lorena Alessandra Dias de;Silva, Andrea Caetano da;Borges, Lígia Miranda Ferreira;
Revista Brasileira de Parasitologia Veterinária , 2010, DOI: 10.4322/rbpv.01901003
Abstract: this study was developed to evaluate the repellent activity of n,n-diethyl-3-methylbenzamide (deet) against amblyomma cajennense nymphs. two repellent bioassays were compared and the effective concentration and repellent time were calculated. the fingertip test was accomplished to evaluate in vivo four concentrations of the compound (0.200; 0.100; 0.050 and 0.025 mg.cm-2) and the filter-paper bioassay to evaluate in vitro the two highest concentrations. the compound provided repellence higher than 90% in all concentrations and at least 95% repellency in the highest concentration over 5 hours. the effective concentration against 50% of tested nymphs (ec50) was 0.006 mg.cm-2 and the ec99 was 0.036 mg.cm-2. those concentrations were lower than the ones obtained against other tick species, denoting the effectiveness of deet against a. cajennense. the repellency time against 50% of the ticks (rt50) was 4.8 hours and the rt90 was 2.7 hours. both bioassays were adequate to evaluate a. cajennense repellency and provided similar results; however the in vivo test is more appropriate to estimate the effective concentration and repellency time.
Antileishmanial Activity of Coumarin from Amburana cearensis Seeds  [PDF]
Roxeane Martins Monteiro, Igor de Sá Carneiro, Felipe Domingos de Sousa, Maria Jania Teixeira, Regina Claudia Matos Dourado, Renato de Azevedo Moreira, Ana Cristina de Oliveira Monteiro Moreira
Open Access Library Journal (OALib Journal) , 2017, DOI: 10.4236/oalib.1103829
Abstract:
Visceral leishmaniasis is caused by parasites of the genus Leishmania. Prevalent in developing countries, the disease is on the list of the world’s most neglected diseases. Most cases (90%) in Latin America occur in Brazil, especially in the Northeast. The condition is treated mainly with pentavalent antimonials, an expensive and relatively inefficient drug known to induce resistance. In search of new antileishmanial drugs, much attention has been given to the medicinal properties of coumarin. In this study, coumarin was isolated from seeds of Amburana cearensis, purified and evaluated with regard to its ability to inhibit Leishmania chagasi promastigotes using the MTT test. The cell viability of macrophages treated with coumarin was also evaluated. The findings were submitted to one-way ANOVA for paired data, followed by the Bonferroni correction. The level of statistical significance was set at 5% (p < 0.05). Coumarin displayed low toxicity to macrophages in the MTT test (p > 0.05), but was toxic to Leishmania chagasi promastigotes (p < 0.05). Our results represent a contribution to the development of new drugs for the control or prophylaxis of visceral leishmaniasis.
Bem-estar espiritual e transtornos psiquiátricos menores em estudantes de psicologia: estudo transversal
Gastaud, Marina Bento;Souza, Luciano Dias de Mattos;Braga, Laryssa;Horta, Cristina Lessa;Oliveira, Flávio Martinez de;Sousa, Paulo Luis Rosa;Silva, Ricardo Azevedo da;
Revista de Psiquiatria do Rio Grande do Sul , 2006, DOI: 10.1590/S0101-81082006000100003
Abstract: introduction: religiosity/spirituality and mental health seem to be positively associated. this study examines associations between spiritual well-being and psychiatric disorders in psychology students. methods: a spiritual well-being scale - the self-reporting questionnaire (srq-20) - and sociodemographic information were used to all psychology students (n = 351) from universidade católica de pelotas, rs, brazil, during the year of 2002. current scores were compared to those obtained from medical and law students of the same university in 2001 (n = 464). results: 84.6% of psychology students presented negative spirituality, compared to 68.8% of medical and 68.5% of law students (p discussion: the findings coincide with the international experience. it is a matter of concern that psychology students define themselves more distant from spiritual/religious issues, considering the association spirituality/health-illness. conclusion: spirituality-religiosity appeared as a factor inversely associated to minor psychiatric disorders among psychology students.
Associa??o entre a analgesia epidural e o trauma perineal no parto vaginal
Monteiro, Juliana Cristina dos Santos;Pitangui, Ana Carolina Rodarti;Sousa, Ligia de;Beleza, Ana Carolina Sartorato;Nakano, Ana Márcia Spanó;Gomes, Flávia Azevedo;
Escola Anna Nery , 2009, DOI: 10.1590/S1414-81452009000100019
Abstract: the aim of this study was to analyze the association between the epidural analgesia and the perineal laceration in women submitted to a vaginal childbirth. a descriptive and transversal study was realized with 109 archives of women attended during the childbirth process in a maternity located in ribeir?o preto. the data was collected in march and april 2003. to analyze the correlation between the variables, the chi-square test was applied. was realized normal childbirth in 91,7% of the parturient and forceps labor in 8,2%. in the data analysis, 74.3% of the sample received epidural analgesia, 26.5% had some degree of laceration perineal and 9.1% had intact perineum. the results demonstrated none association between the mentioned variables. no statistical significance was found in this study to affirm that the conditions of the perineum after the vaginal childbirth and the use of the epidural analgesia are associates (x24gl= 3,1).
Oz?nio na esteriliza??o de produtos para assistência à saúde: revis?o integrativa da literatura
Sousa, Cristina Silva;Torres, Lilian Machado;Azevedo, Marcela Padilha Facetto;Camargo, Tamara Carolina de;Graziano, Kazuko Uchikawa;Lacerda, Rúbia Aparecida;Turrini, Ruth Natalia Teresa;
Revista da Escola de Enfermagem da USP , 2011, DOI: 10.1590/S0080-62342011000500030
Abstract: the objective of this integrative literature review was to find evidence to support using ozone as a sterilizing agent for health products. the search was performed on the following bases: medline, scopus, cochrane, compendex, inspec and engineering research database; using ozone and sterilization as descriptors. five articles were found between 1990 and 2008, which tested ozone as a sterilizer. all studies used the same type of investigation (experimental laboratory study) and achieved sterilization with ozone, but with different scopes and products, besides using different methodological procedures. considering the ever-growing technology for new products, with the vast range of forms and materials, the findings point at ozone sterilization as a promising method, but still in an initial phase of investigation. further experimental studies are needed to provide broader evidence regarding the possibilities and limitations of ozone sterilization.
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