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Search Results: 1 - 10 of 446541 matches for " Raoni S.B. Gon?alves "
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In vitro anti-mycobacterial activity of (E)-N′-(monosubstituted-benzylidene) isonicotinohydrazide derivatives against isoniazid-resistant strains
Tatiane S. Coelho,Jessica B. Cantos,Marcelle L.F. Bispo,Raoni S.B. Gonalves
Infectious Disease Reports , 2012, DOI: 10.4081/idr.2012.e13
Abstract: A series of twenty-three N-acylhydrazones derived from isoniazid (INH 1-23) have been evaluated for their in vitro antibacterial activity against INH- susceptible strain of M. tuberculosis (RG500) and three INH-resistant clinical isolates (RG102, RG103 and RG113). In general, derivatives 4, 14, 15 and 16 (MIC=1.92, 1.96, 1.96 and 1.86 mM, respectively) showed relevant activities against RG500 strain, while the derivative 13 (MIC=0.98 mM) was more active than INH (MIC=1.14 mM). However, these derivatives were inactive against RGH102, which displays a mutation in the coding region of inhA. These results suggest that the activities of these compounds depend on the inhibition of this enzyme. However, the possibility of other mechanisms of action cannot be excluded, since compounds 2, 4, 6, 7, 12-17, 19, 21 and 23 showed good activities against katG-resistant strain RGH103, being more than 10-fold more active than INH.
Fraturas vertebrais em grandes animais: estudo retrospectivo de 39 casos (1987-2002)
Borges A.S.,Silva D.P.G.,Gonalves R.C.,Chiacchio S.B.
Arquivo Brasileiro de Medicina Veterinária e Zootecnia , 2003,
Abstract: Realizou-se estudo retrospectivo (1987-2002) dos aspectos clínicos das fraturas vertebrais em eqüinos, bovinos, ovinos, caprinos e suínos atendidos no hospital veterinário da FMVZ-Unesp de Botucatu. Todos os casos tiveram confirma o radiográfica ou post-mortem. Segundo a espécie, a ordem de acometimento foi: bovina, eqüina, ovina, caprina e suína. As les es ocorreram desde os 12 dias de idade até os 10 anos, com maior freqüência até os 12 meses. O segmento torácico foi o mais comprometido seguido dos segmentos lombar, cervical e sacral. As fraturas vertebrais devem fazer parte da lista de diagnósticos diferenciais de animais em decúbito, independente da espécie, sexo ou idade.
Pênfigo foliáceo em eqüino: relato de caso
Oliveira Filho, J.P.;Gonalves, R.C.;Chiacchio, S.B.;Amorim, R.M.;Concei??o, L.G.;Borges, A.S.;
Arquivo Brasileiro de Medicina Veterinária e Zootecnia , 2007, DOI: 10.1590/S0102-09352007000500007
Abstract: pemphigus foliaceus was diagnosed in a four-year-old arabian equine gelding, with generalized dermatitis characterized by scaling and crusting plaques and acantholytic subcorneal pustular dermatitis.
Inventário da família Orchidaceae na Amaz?nia Brasileira: parte I
Silva, Manoela F.F. da;Silva, Jo?o B.F. da;Rocha, Antonio E.S;Oliveira, Francisco P.M;Gonalves, Lúcia S.B;Silva, Mary F. da;Queiroz, Odete H.A. de;
Acta Botanica Brasilica , 1995, DOI: 10.1590/S0102-33061995000100009
Abstract: a total of 378 species of 99 genera were registered, some of these species are new to science while and others are new records for the brazilian flora.
Artrópodes-praga e predadores (Arthropoda) associados à cultura da mangueira no Vale do S?o Francisco, nordeste do Brasil
Barbosa, Flávia R.;Gonalves, Manoel E. de C.;Moreira, Wellington A.;Alencar, José A. de;Souza, Eduardo A. de;Silva, Cherre S.B. da;Souza, Adriano de M.;Miranda, Ismênia da G.;
Neotropical Entomology , 2005, DOI: 10.1590/S1519-566X2005000300016
Abstract: in order to identify and evaluate the occurrence of arthropods-pest and predators on mangoes at "vale do s?o francisco", northestern brazil, studies were carried out in eight commercial plantations of the cv. tommy atkins, from february 2000 to january 2002. in each area, fruit flies were collected using mcphail and jackson traps; other pests and predators were evaluated on samples of branches, panicles and fruits. the arthropods-pest occurrence in decreasing order were: aceria mangiferae (sayed) (acari: eriophyidae) - 87.0%; pseudaonidia tribitiformis (green) (hemiptera: diaspididae) - 70.1%; ceratitis capitata wied. (diptera: tephritidae) - 66.1%; erosomyia mangiferae felt (diptera: cecidomyiidae) - 64.6%; pleuroprucha asthenaria walker (lepidoptera: geometridae) - 42.9%; polyphagotarsonemus latus (banks) (acari: tarsonemidae) - 39.3%; anastrepha spp. (diptera: tephritidae) - 33.0%; selenothrips rubrocinctus (giard) (thysanoptera: thripidae) - 26.4%; oligonychus sp. (acari: tetranychidae) - 16.6%; frankliniella schultzei (trybom) (thysanoptera: thripidae) - 13.1%; unidentified mirid - 9.1%, and aphids [aphis craccivora koch; toxoptera aurantii (boyer de fonscolombe), a. gossypii glover (hemiptera: aphididae)] - 7.2%. the predators were: euseius concordis (chant) and e. citrifolius (denmark & muma) (acari: phytoseiidae) - 32.7%; cheletogenes ornatus (canestrini & fanzago) (acari: cheyletidae) - 32.3%; rubroscirus sp. (acari: cunaxidae) - 17.7%; unidentified arachnids - 16.6%, and chrysoperla externa (hagen) and ceraeochrysa cubana (hagen) (neuroptera: chrysopidae) - 3.7%.
tert-Butyl 2-{[2,8-bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidine-1-carboxylate
Raoni S. B. Gonçalves,Marcus V. N. de Souza,James L. Wardell,Solange M. S. V. Wardell
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811047726
Abstract: The title molecule, C22H24F6N2O3, adopts a folded conformation whereby the carboxylate residue lies over the quinolinyl residue, with the dihedral angle between the carbamate and quinoline planes being 41.64 (7)°. Helical supramolecular C(7) chains sustained by O—H...O hydrogen bonds propagating along the a-axis direction feature in the crystal packing. The F atoms of one of the CF3 groups are disordered over two orientations; the major component has a site occupancy of 0.824 (7).
Benzyl 2-{[2,8-bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidine-1-carboxylate
Marcus V. N. de Souza,Raoni S. B. Gonçalves,James L. Wardell,Solange M. S. V. Wardell
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811047738
Abstract: The title molecule, C25H22F6N2O3, adopts an open conformation whereby the quinoline and carboxylate ester groups are orientated in opposite directions but to the same side of the piperidine ring so that the molecule has an approximate U-shape. The piperidine ring adopts a distorted boat conformation. In the crystal, inversion dimers linked by pairs of O—H...O hydrogen bonds generate R22(14) loops.
(R*,S*)-(±)-1-(2-{[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-yl)ethanone methanol monosolvate
Raoni S. B. Gonçalves,Marcus V. N. de Souza,Solange M. S. V. Wardell,James L. Wardell
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811038128
Abstract: The title mefloquine derivative has been crystallized as its 1:1 methanol solvate, C19H18F6N2O2·CH3OH. Each of the methinehydroxyl residue [the C—C—C—O torsion angle is 16.35 (17) °] and the piperidinyl group [distorted chair conformation] lies to one side of the quinolinyl ring system. The hydroxyl and carbonyl groups lie to either side of the molecule, enabling their participation in intermolecular interactions. Thus, the hydroxyl and carbonyl groups of two centrosymmetrically related molecules are bridged by two methanol molecules via O—H...O hydrogen bonds, leading to a four-molecule aggregate. These are linked into a supramolecular chain along the a axis via C—H...O interactions involving the hydroxyl-O atom. The chains assemble into layers that interdigitate along the c axis being connected by C—H...F interactions.
2-{1-[2,8-Bis(trifluoromethyl)quinolin-4-yl]-3,5,6,7,8,8a-hexahydro-1H-1,3-oxazolo[3,4-a]pyridin-3-yl}phenol
Raoni S. B. Gonçalves,Carlos R. Kaiser,Marcus V. N. de Souza,James L. Wardell
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811022379
Abstract: In the title mefloquine–oxazolidine derivative, C24H20F6N2O2, the oxazoline ring adopts an envelope conformation (the flap atom is N) and the piperidine ring has a chair conformation. The oxazoline and benzene residues lie away from the C6 ring of the quinoline group and, to a first approximation, to one side of the plane through the ten atoms (r.m.s. deviation = 0.025 ). An intramolecular O—H...N(piperidine) hydrogen bond is present. The crystal packing features C—H...O, C—H...F and C—H...π(hydroxybenzene) interactions.
Fraturas vertebrais em grandes animais: estudo retrospectivo de 39 casos (1987-2002)
Borges, A.S.;Silva, D.P.G.;Gonalves, R.C.;Chiacchio, S.B.;Amorim, R.M.;Kuchembuck, M.R.G.;Vulcano, L.C.;Bandarra, E.P.;Lopes, R.S.;
Arquivo Brasileiro de Medicina Veterinária e Zootecnia , 2003, DOI: 10.1590/S0102-09352003000200001
Abstract: it was performed a retrospective study (1987-2002) of clinical features of spinal fractures in the equine, bovine, ovine, caprine and swine referred to the veterinary hospital - fmvz-unesp in botucatu, sp, brazil. all the cases were confirmed by necropsy or radiographic evaluation. bovines were the most affected species, followed by horses, sheep, goats and swines, and lesions occurred from 12 days to 10 years of age, being more frequent up to 12 months of age. thoracic vertebrae were the most affected, followed by lumbar, cervical and sacral segments. vertebral fractures should be included for differential diagnosis of recumbent animals, independently on species, sex or age.
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