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Search Results: 1 - 10 of 1613 matches for " Rangel-Yagui "
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Farmacologia integrada
Carlota de Oliveira Rangel-Yagui
Revista Brasileira de Ciências Farmacêuticas , 2007, DOI: 10.1590/s1516-93322007000300018
Abstract:
Two-phase aqueous micellar systems: an alternative method for protein purification
Rangel-Yagui, C. O.;Pessoa-Jr, A.;Blankschtein, D.;
Brazilian Journal of Chemical Engineering , 2004, DOI: 10.1590/S0104-66322004000400003
Abstract: two-phase aqueous micellar systems can be exploited in separation science for the extraction/purification of desired biomolecules. this article reviews recent experimental and theoretical work by blankschtein and co-workers on the use of two-phase aqueous micellar systems for the separation of hydrophilic proteins. the experimental partitioning behavior of the enzyme glucose-6-phosphate dehydrogenase (g6pd) in two-phase aqueous micellar systems is also reviewed and new results are presented. specifically, we discuss very recent work on the purification of g6pd using: i) a two-phase aqueous micellar system composed of the nonionic surfactant n-decyl tetra(ethylene oxide) (c10e4), and (ii) a two-phase aqueous mixed micellar system composed of c10e4 and the cationic surfactant decyltrimethylammonium bromide (c10tab). our results indicate that the two-phase aqueous mixed (c10e4/c10tab) micellar system can improve significantly the partitioning behavior of g6pd relative to that observed in the two-phase aqueous c10e4 micellar system.
A 2D-QSPR approach to predict blood-brain barrier penetration of drugs acting on the central nervous system
, Matheus Malta de;Pasqualoto, Kerly Fernanda Mesquita;Rangel-Yagui, Carlota de Oliveira;
Brazilian Journal of Pharmaceutical Sciences , 2010, DOI: 10.1590/S1984-82502010000400016
Abstract: drugs acting on the central nervous system (cns) have to cross the blood-brain barrier (bbb) in order to perform their pharmacological actions. passive bbb diffusion can be partially expressed by the blood/brain partition coefficient (logbb). as the experimental evaluation of logbb is time and cost consuming, theoretical methods such as quantitative structure-property relationships (qspr) can be useful to predict logbb values. in this study, a 2d-qspr approach was applied to a set of 28 drugs acting on the cns, using the logbb property as biological data. the best qspr model [n = 21, r = 0.94 (r2 = 0.88), s = 0.28, and q2 = 0.82] presented three molecular descriptors: calculated n-octanol/water partition coefficient (clogp), polar surface area (psa), and polarizability (α). six out of the seven compounds from the test set were well predicted, which corresponds to good external predictability (85.7%). these findings can be helpful to guide future approaches regarding those molecular descriptors which must be considered for estimating the logbb property, and also for predicting the bbb crossing ability for molecules structurally related to the investigated set.
Can affinity interactions influence the partitioning of glucose-6-phosphate dehydrogenase in two-phase aqueous micellar systems?
Lopes, André M.;Pessoa-Jr., Adalberto;Rangel-Yagui, Carlota de O.;
Química Nova , 2008, DOI: 10.1590/S0100-40422008000500010
Abstract: in this work, we provide an investigation of the role and strength of affinity interactions on the partitioning of the glucose-6-phosphate dehydrogenase in aqueous two-phase micellar systems. these systems are constituted of micellar surfactant solutions and offer both hydrophobic and hydrophilic environments, providing selectivity to biomolecules. we studied g6pd partitioning in systems composed of the nonionic surfactants, separately, in the presence and absence of affinity ligands. we observed that g6pd partitions to the micelle-poor phase, owing to the strength of excluded-volume interactions in these systems that drive the protein to the micelle-poor phase, where there is more free volume available.
Micellar solubilization of ibuprofen: influence of surfactant head groups on the extent of solubilization
Rangel-Yagui, Carlota O.;Hsu, Helen Wei Ling;Pessoa-Jr, Adalberto;Tavares, Leoberto Costa;
Revista Brasileira de Ciências Farmacêuticas , 2005, DOI: 10.1590/S1516-93322005000200012
Abstract: an important property of micelles with particular significance in pharmacy is their ability to increase the solubility of poorly soluble drugs in water, thus increasing their bioavailability. in this work, the solubilization of ibuprofen (ibu) was studied in micellar solutions of three surfactants possessing the same hydrocarbon tail but different hydrophilic head groups, namely sodium dodecyl sulphate (sds), dodecyltrimethylammonium bromide (dtab), and n-dodecyl octa(ethylene oxide) (c12eo8). the results showed that, irrespective of the surfactant type, the solubility of ibu increased linearly with increasing surfactant concentration, as a consequence of the association between the drug and the micelles. the 80 mm dtab and the 80 mm c12eo8 micellar solutions resulted in a 16-fold increase in solubility of ibu when compared to the buffer solution, whereas the 80 mm sds micellar solution resulted in a 5.5-fold increase in ibu solubility. the highest value of molar solubilization capacity (c) was obtained with dtab, c = 0.97, followed by c12eo8 ,c = 0.72, and finally sds, c = 0.23. however, due to the stronger tendency of the nonionic surfactant in forming micelles in solution, at the same surfactant concentration, we obtained the same solubility of ibu in both dtab and c12eo8.
Two-phase aqueous micellar systems: an alternative method for protein purification
Rangel-Yagui C. O.,Pessoa-Jr A.,Blankschtein D.
Brazilian Journal of Chemical Engineering , 2004,
Abstract: Two-phase aqueous micellar systems can be exploited in separation science for the extraction/purification of desired biomolecules. This article reviews recent experimental and theoretical work by Blankschtein and co-workers on the use of two-phase aqueous micellar systems for the separation of hydrophilic proteins. The experimental partitioning behavior of the enzyme glucose-6-phosphate dehydrogenase (G6PD) in two-phase aqueous micellar systems is also reviewed and new results are presented. Specifically, we discuss very recent work on the purification of G6PD using: i) a two-phase aqueous micellar system composed of the nonionic surfactant n-decyl tetra(ethylene oxide) (C10E4), and (ii) a two-phase aqueous mixed micellar system composed of C10E4 and the cationic surfactant decyltrimethylammonium bromide (C10TAB). Our results indicate that the two-phase aqueous mixed (C10E4/C10TAB) micellar system can improve significantly the partitioning behavior of G6PD relative to that observed in the two-phase aqueous C10E4 micellar system.
Growth and content of Spirulina platensis biomass chlorophyll cultivated at different values of light intensity and temperature using different nitrogen sources
Danesi, Eliane Dalva Godoy;Rangel-Yagui, Carlota Oliveira;Sato, Sunao;Carvalho, Jo?o Carlos Monteiro de;
Brazilian Journal of Microbiology , 2011, DOI: 10.1590/S1517-83822011000100046
Abstract: the effects of light intensity and temperature in s. platensis cultivation with potassium nitrate or urea as nitrogen source were investigated, as well as the biomass chlorophyll contents of this cyanobacteria, through the response surface methodology. experiments were performed at temperatures from 25 to 34.5oc and light intensities from 15 to 69 μmol photons m-2 s-1, in mineral medium. in cultivations with both sources of nitrogen, kno3 and urea, statistic evaluation through multiple regression, no interactions of such independent variables were detected in the results of the dependent variables maximum cell concentration, chlorophyll biomass contents, cell and chlorophyll productivities, as well as in the nitrogen-cell conversion factor. in cultivation performed with both sources of nitrogen, it was possible to obtain satisfactory adjustments to relate the dependent variables to the independent variables. the best results were achieved at temperature of 30oc, at light intensity of 60 μmol photons m-2s-1, for cell growth, with cell productivity of approximately 95 mg l-1 d-1 in cultivations with urea. for the chlorophyll biomass content, the most adequate light intensity was 24 μmol photons m-2 s-1.
Polymeric micelles and molecular modeling applied to the development of radiopharmaceuticals
Grallert, Sibila Roberta Marques;Rangel-Yagui, Carlota de Oliveira;Pasqualoto, Kerly Fernanda Mesquita;Tavares, Leoberto Costa;
Brazilian Journal of Pharmaceutical Sciences , 2012, DOI: 10.1590/S1984-82502012000100002
Abstract: micelles composed of amphiphilic copolymers linked to a radioactive element are used in nuclear medicine predominantly as a diagnostic application. a relevant advantage of polymeric micelles in aqueous solution is their resulting particle size, which can vary from 10 to 100 nm in diameter. in this review, polymeric micelles labeled with radioisotopes including technetium (99mtc) and indium (111in), and their clinical applications for several diagnostic techniques, such as single photon emission computed tomography (spect), gamma-scintigraphy, and nuclear magnetic resonance (nmr), were discussed. also, micelle use primarily for the diagnosis of lymphatic ducts and sentinel lymph nodes received special attention. notably, the employment of these diagnostic techniques can be considered a significant tool for functionally exploring body systems as well as investigating molecular pathways involved in the disease process. the use of molecular modeling methodologies and computer-aided drug design strategies can also yield valuable information for the rational design and development of novel radiopharmaceuticals.
Obesidade infantil ontem e hoje: importancia da avalia??o antropométrica pelo enfermeiro
Marchi-Alves, Leila Maria;Yagui, Cíntia Megumi;Rodrigues, Cíntia Sim?es;Mazzo, Alessandra;Rangel, Elaine Maria Leite;Gir?o, Fernanda Berchelli;
Escola Anna Nery , 2011, DOI: 10.1590/S1414-81452011000200004
Abstract: studies have shown relation between the incidence of chronic diseases in adults and obesity in infancy. this research aimed to determine and compare the indexes of overweight and infant obesity in the years 1983/1984 and 2003/2004. secondary data related to child growth and development were collected through consults in patient files, of users who had been under follow-up at the pediatrics service in the unit located in the state of s?o paulo, brazil. the percentile was adopted for classification of the nutritional status. absolute and percentage frequencies were considered for descriptive analysis. data analysis was done using t test for comparisons of means. it was observed greater risk of overweight and significant difference in the weight of children born in 2003/2004 compared to users born in 1983/1984. anthropometric assessment carried out by nurses has a fundamental importance in child nutritional diagnosis, to accurately identify abnormalities and define efficient action strategies.
La agenda nacional de investigación en recursos humanos en salud: generando evidencias para mejorar las competencias en el sector salud National agenda for research in human resources for health: generating evidence for improving the health sector competences
Martín Yagui,Javier Vargas
Revista Peruana de Medicina Experimental y Salud Pública , 2011,
Abstract:
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