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Search Results: 1 - 10 of 27882 matches for " Ramesh Kumar Rao Takallapally "
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An Electrooculographic Method for the Evaluation of Psychotropic Drugs on Saccadic Eye Movements in Healthy Subjects
Raveendranadh Pilli,Naidu M.U.R,Usha Rani Pingali,Ramesh Kumar Rao Takallapally
International Journal of Psychological Studies , 2012, DOI: 10.5539/ijps.v4n2p75
Abstract: Recording of saccadic eye movements has proved to be a valuable tool for investigation of brain function and dysfunction and is very sensitive to centrally acting drugs. Since there is a lack of agreement concerning velocity–amplitude characteristics of saccadic eye movements, the present study obtained saccadic eye movements from 24 healthy subjects using indigenously developed electro-oculographic recording and analysis system in forward and countdown sequence. The validity of the system was further tested by evaluating the psychotropic effects of 5mg zolpidem and 500mg caffeine in randomized, double blind, placebo controlled three way cross over design on 24 healthy subjects. Saccadic eye movements were measured at baseline and 1, 2 and 3 hrs after administration of study medication. Mean (±SD) values for peak saccadic velocity (PSV) over saccades of ±10, ±20, ±30, ±40, ±50 & ±60 degrees were in agreement with those previously reported. Zolpidem produced statistically significant decrease in PSV compared to placebo at all the angular displacements at 1 & 2 hrs. In contrast, caffeine produced non-significant increase in PSV at all angular displacements at 1hr. Similarly latency period (LP) increased with zolpidem and decreased with caffeine compared to placebo. The electro-oculographic recording and analysis system is simple, sensitive to centrally acting drug effects and therefore has potential for future experimental psychomotor assessment studies.
Determination of Capsaicin Induced Increase in Dermal Blood Flow Using Laser Doppler Flowmetry Technique  [PDF]
Sunil Kumar Reddy Khambam, Madireddy Umamaheshwar Rao Naidu, Pingali Usha Rani, Takallapalli Ramesh Kumar Rao
Pharmacology & Pharmacy (PP) , 2011, DOI: 10.4236/pp.2011.23022
Abstract: In the present study, we evaluated laser Doppler flowmetry technique using LDF100C (Biopac systems) by determining blood flow changes following acute application of capsaicin on 12 healthy human subjects. Capsaicin applied locally (topical application) at a dose of 0.075% produced significant increase in mean dermal blood flow from 31.4 ± 3.1 Blood Perfusion Units (BPU) to 115. 7 ± 24.6 Blood Perfusion Units (BPU) after 30 minutes, also there was significant difference in dermal blood flow change between placebo (32.1 ± 2.7 BPU) and capsaicin (115.7 ± 24.6 BPU) applica- tion. Capsaicin application produced significant percentage change in dermal blood flow by 291.0 ± 85.3% from baseline, while the change was insignificant with placebo (13.2 ± 7.4%). Therefore, it is suggested that this technique which is technically sound, non-invasive and inexpensive can be adopted in various fields of research to determine blood flow changes and this technique can also be utilized to determine the antagonists of the mediators involved in capsaicin induced vasodilatation.
Automated Measurement of Immature Granulocytes: Performance Characteristics and Utility in Routine Clinical Practice
Balamurugan Senthilnayagam,Treshul Kumar,Jayapriya Sukumaran,Jeya M.,Ramesh Rao K.
Pathology Research International , 2012, DOI: 10.1155/2012/483670
Abstract: The granulocytic “shift to left” reflects marrow response to bacterial infection, and this may be quantified as band count or immature granulocyte count (IGC). The former value, used widely in neonatal sepsis, has been notoriously difficult to measure accurately and precisely. A reproducible, precise, and accurate counting of immature granulocyte counts may be possible with automation. This study of 200 febrile patients aimed at analysing the performance characteristics of automated immature granulocytes (AIGs) in predicting blood culture and their clinical utility. The absolute (IGC) and relative IG count (IG%) had area under curve (AUC) of 0.69 and 0.66. Moreover, the means of IGC and IG% between culture positive and negative groups were statistically significant suggesting that they are potential markers for bacteremia. IGC of 0.03?×?103?cu·mm and IG% of 0.5% offered sensitivity of 86.3% and 92.2%, respectively, and may be used for screening for bacteremia. Higher values, IGC?>?0.3, and IG%?>?3 had specificity greater than 90%, although the values were infrequent. It may not be long before that these automated hemograms are put into regular diagnostic use. 1. Introduction Early detection of bacteremia facilitates timely initiation of antimicrobial therapy, reduces morbidity and mortality, and decreases healthcare costs thereby making it a relevant clinical objective. However, there is a considerable timelag before the blood culture results are available for the physician to act upon. This has necessitated studies to address the usefulness of various parameters to predict infection earlier [1]. The manual “band count” used widely in pediatric practice as a marker for bacterial infection has been notoriously difficult to measure accurately and precisely [2, 3]. Therefore, a more reproducible measurement of immature granulocytes might be a useful parameter to predict infection or sepsis. Automated hematology analysers have undergone numerous technical innovations during the last few years. Recent developments permit not only flagging of samples with abnormal cell population but also categorisation and counting of those cells [4]. The Coulter Act Diff 5 counter can perform a 5-part differential leucocyte count and can also enumerate the percentage and absolute number of immature granulocytes (IG% and IGC) using a technology that combines cytochemistry, focused flow impedance, and light absorbance [5, 6]. At this time, automated immature granulocyte measurements are still being evaluated in the research arena and do not form part of routine reporting.
Diversity of Ethnomedicinal Plants in Boridand Forest of District Korea, Chhattisgarh, India  [PDF]
Ramesh Kumar Ahirwar
American Journal of Plant Sciences (AJPS) , 2015, DOI: 10.4236/ajps.2015.62047
Abstract: Present study deals with an extensive ecological assessment of natural forest areas under several in-situ conservation plots which have resulted from high rate of grazing and biotic pressure. Over-exploitation of forest and unwanted incidental fire cases decreased the diversity of several ethnomedicinally and economically valuable plants species from the Boridand forest region in Korea district, Chhattisgarh. The total number of plants reported in all three study sites, 41 plants species belonging to 26 families and 37 plant genera were identified. A field survey was conducted at three different study sites in Boridand forest, district Korea, Chhattisgarh as Plot A, Plot B and Plot C, during months March 2013 to February 2014 to identify the diversity of ethnomedicinal plants.
Digital Equity: Causes and measurement
Ramesh Rao
International Journal of Asian Social Science , 2012,
Abstract: Digital divide among students has become a concern to many governments. Previously digital divide (DD) is seen as the difference between those who own a computer with those who don’t. But this has changed to how much technology access is done by someone. Thus measuring this digital divide has moved from computer ownership to technology accessing. This has also caused the issues involved in measuring DD to change, and leads to terms such as Digital Equity (DE). In this paper, the issues which should be included when measuring DE are discussed. Along with this, Gini coefficient, an approach commonly used in measuring income distribution is shown on how it can be used in measuring DE.
Digital Divide: Issues Facing Adult Learners
Ramesh Rao
Computer and Information Science , 2009, DOI: 10.5539/cis.v2n1p132
Abstract: Technology had enabled many adult to pursue their education. However, technology changes in terms of type and accessing had caused “digital divide” (DD) to exist among students of all ages. In this paper, issues which should be incorporated in measuring digital divide for adult learners are discussed. The issues which are discussed in this paper are age, gender and income. Why these issues should be included in evaluating DD are examined.
Regulation of Glioblastoma Progression by Cord Blood Stem Cells Is Mediated by Downregulation of Cyclin D1
Kiran Kumar Velpula,Venkata Ramesh Dasari,Andrew J. Tsung,Christopher S. Gondi,Jeffrey D. Klopfenstein,Sanjeeva Mohanam,Jasti S. Rao
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0018017
Abstract: The normal progression of the cell cycle requires sequential expression of cyclins. Rapid induction of cyclin D1 and its associated binding with cyclin-dependent kinases, in the presence or absence of mitogenic signals, often is considered a rate-limiting step during cell cycle progression through the G1 phase.
Outputs, cost and efficiency of public sector centres for prevention of mother to child transmission of HIV in Andhra Pradesh, India
Lalit Dandona, SG Prem Kumar, YK Ramesh, M Chalapathi Rao, Elliot Marseille, James G Kahn, Rakhi Dandona
BMC Health Services Research , 2008, DOI: 10.1186/1472-6963-8-26
Abstract: Cost and output data were collected at 16 sampled PMTCT centres in the south Indian state of Andhra Pradesh using standardized methods. The services provided were analysed, and the relation of unit cost of services with scale was assessed.In the 2005–2006 fiscal year, 125,073 pregnant women received PMTCT services at the 16 centres (range 2,939 to 20,896, median 5,679). The overall HIV positive rate among those tested was 1.67%. Of the total economic cost, the major components were personnel (47.3%) and recurrent goods (31.7%). For the 16 PMTCT centres, the average economic cost per post-HIV-test counselled pregnant woman was Indian Rupees (INR) 98.9 (US$ 2.23), ranging 2.7-fold from INR 71.4 (US$ 1.61) to INR 189.9 (US$ 4.29). The economic cost per mother-neonate pair who received nevirapine had a higher variation, ranging 41-fold for the 16 centres from INR 4,354 (US$ 98) to INR 179,175 (US$ 4,047), average INR 10,210 (US$ 231), with very high unit cost at some centres where HIV prevalence among pregnant women and the total volume of services were both low. Scale had a significant inverse relation with both of the unit costs, per post-HIV-test counselled pregnant woman and per mother-neonate pair who received nevirapine. In addition, HIV prevalence among pregnant women had a significant inverse relation with unit cost per mother-neonate pair who received nevirapine.Although the variation between PMTCT centres for unit cost per post-HIV-test counselled pregnant woman was modest that per mother-neonate pair receiving nevirapine was over 40-fold. The extremely high unit cost for each mother-neonate pair receiving nevirapine at some centres suggests that the new approach of combining PMTCT services with voluntary counselling and testing services that has recently been started in India could potentially offer better efficiency.Although the estimate of the number of people living with HIV in India has been reduced to less than half recently based on new population-based
Bioequivalence Study of two Long Acting Isosorbide Mononitrate Formulations Assessed by Digital Pulse Plethysmography
Mohsin Mohd, M.U.R. Naidu, Jaydip Bhadun,Aravinda Babu P,T. Ramesh Kumar Rao
JK Science : Journal of Medical Education & Research , 2000,
Abstract: Not available
Improved Automotive CAN Protocol Based on Payload Reduction and Selective Bit Stuffing  [PDF]
B. Vinodh Kumar, J. Ramesh
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.710291
Abstract: In this research paper, the implementation strategies of automotive controller area network protocol are investigated and the short messaging scheme with selective bit stuffing method to improve the effective utilization of its bandwidth has been proposed. There would be a sharp decrease in the performance of traditional CAN protocol because of considerable increase in the number of ECUs (Electronic Control Units) and infotainment gadgets connected in the vehicle architecture. The demand for safety, emission, diagnostics and comfort norms has steeply increased the number of messages in the 250 Kbps CAN network as the computational power of ECUs has gone up. To overcome this problem, the short CAN method has been proposed and the work is benchmarked with SAEJ1939 Heavy commercial vehicle CAN standard. The Matlab Simulink based short CAN has been modeled and the performance of the proposed system has evaluated using virtual instrument cluster. Experimental results have shown that compared to the traditional CAN, the proposed method has reduced the worst case response time of CAN extended frame from 160 μ sec to 144 μ sec. Selective bit stuffing technique has reduced the impact of bit stuffing over the payload and improved the utilization factor for the CAN bus without affecting the CAN message ID properties. The proposed algorithm has been modeled and simulated using CAN Matlab model Simulink and it has been verified using virtual CAN tool and real time CAN bus hardware.
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