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Search Results: 1 - 10 of 167802 matches for " Rajasekaran E. "
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Carbon Distribution in Protein Structure Might Influences Thermostability of Modified Form
Rajasekaran E.
Advanced Biotech , 2013,
Abstract: Hydrophobic interaction is the dominant force in proteins that arises from carbon. The carbon content and distribution make a protein to fold in form to have stability and function. The science of carbon in toxic protein, thermolabile protective antigen in native and mutant form is studied. The CARd analysis program is used for this purpose. The results reveal that carbon distribution in local structure is responsible for thermolability. The CARd analysis is able explain this phenomena of protein stabilisation. It also suggests that before going for protein engineering, this simple carbon distribution study can be performed for validation. This can be utilised for production of stable proteins.
The nature of proteins in influenza  [PDF]
K. Akila, P. Balamurugan, E. Rajasekaran
Health (Health) , 2012, DOI: 10.4236/health.2012.430151
Abstract: Mutation can alter the structure of viral proteins to form different structure. Carbon distribution is responsible for these changes in structure. The carbon distribution in proteins of human Influenza A virus is analyzed here. Results reveal that the carbon contents are high in surface proteins, optimum in polymerase proteins and less in nuclear proteins. Polymerase proteins have better carbon distribution pattern than the other proteins. Thymine distribution in different frames of mRNAs are checked as it has link with carbon distribution pattern in the corresponding proteins. Results show that frame 4 is violating from thymine distribution. This is responsible for production of protein with different carbon distribution. Unusual thymine distribution in frame 3 are observed. The thymine distributions are different in viral mRNA compared to normal one. Minimizing the excess thymine in H1N1 mRNAs might improve the protein performance. Mutational study based on carbon distribution should be better exploited for further improving the protein stability, activity and ultimately for gene therapy.
What Might be the Difference in Viral Proteins?
Akila K.,Rajasekaran E.
International Journal of Bioinformatics Research , 2009,
Abstract: The difference between normal and viral proteins is the way the amino acids organized in someform. Though both proteins use same 20 naturally occurring amino acids, it differs in arrangements. Thisdifference cannot be felt by merely comparing the amino acid sequence but at atom level. This is analysedand compared in terms of carbon distribution as carbon is the only element that contributes towards thedominant force, hydrophobic interaction. For this purpose the arenaviruses have been selected here forstudy. The protein sequences of 7 arenaviruses are analysed. Our results show that the carbon distributionin viral proteins is different from the normal proteins. Either the carbon content is different or the distributionis not uniform. This carbon distribution analysis uses our earlier report of 31.44% of carbon for its structureand activity.
International Journal of Bioinformatics Research , 2011,
Abstract: Alanine aminotransferase (ALT) is an enzymatic protein involved in catabolism of amino acids. The carbondistribution study on this clinically important protein is carried out here. The study reveals that the carbon content is generallyhigher than the expected values of 31.45%. The alteration in carbon content other than the active site might improve theactivity of this enzymatic protein. Particularly the reduction at the carboxyl end of the sequence is more appropriate. Carbondistribution analysis clearly locates the active site of ALT protein, which is reported here.
Rajasekaran E.,Asha Jacob,Klaus Heese
International Journal of Bioinformatics Research , 2012,
Abstract: Thymine is the one and only base transcribed into uracil during production of proteins. Thymine in DNA and uracil in mRNA plays a major role in producing proteins with appropriate carbon content for stability and activity. Thymine distribution is different frames of coding nucleic acids are investigated statistically. The results confirm that frame 1 supposed to have definite thymine content. Frame 3 prefers to have least thymine content. Frames 4 & 5 maintain some degree of thymine while 2 & 6 have a variable fraction of thymine
A Parameter Estimation Model of G-CSF: Mathematical Model of Cyclical Neutropenia  [PDF]
S. Balamuralitharan, S. Rajasekaran
American Journal of Computational Mathematics (AJCM) , 2012, DOI: 10.4236/ajcm.2012.21002
Abstract: We investigate the FFT (Fast Fourier Transform) model and G-CSF (granulocyte colony-stimulating factor) treatment of CN (Cyclical Neutropenia). We collect grey collies and normal dog’s data from CN and analyze the G-CSF treatment. The model develops the dynamics of circulating blood cells before and after the G-CSF treatment. This is quite natural and useful for the collection of laboratory data for investigation. The proposed interventions are practical. This reduces the quantity of G-CSF required for potential maintenance. This model gives us good result in treatment. The changes would be practical and reduce the risk side as well as the cost of treatment in G-CSF.
Matrix Metalloproteinase MMP-9 Promotes K/BxN Serum Induced Arthritis in Mice  [PDF]
Narendiran Rajasekaran, Harald Illges
Open Journal of Rheumatology and Autoimmune Diseases (OJRA) , 2014, DOI: 10.4236/ojra.2014.41003
Abstract: Matrix metalloproteinases (MMPs) are matrix-degrading enzymes that are over-expressed in joints of rheumatoid arthritis (RA) patients. However, the contribution of specific MMPs for the development of arthritic joints is unknown. This study is aimed at studying the role of matrix metalloproteinase-9 (MMP-9) in mice, using the K/BxN serum-transfer model of RA. Arthritis was induced in Balb/c mice by injecting K/BxN serum. Development of arthritis was followed in these mice by measuring ankle thickness and clinical index score. MMP-9 expression in the joints of mice killed at various time points during the disease progression was determined by gelatin zymography using ankle lysates. We found that MMP-9 expression increased with the severity of arthritis. Importantly MMP-9 deficient mice injected with K/BxN serum showed a milder form of arthritis in comparison to the control C57BL/6 mice injected with K/BxN serum. We therefore conclude that MMP-9 promotes arthritis in mice.
Fuzzy Based Intelligent Monitoring of Critical Lines in the Restructured Power Market  [PDF]
S. Rajasekaran, S. Sathiyamoorthy
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.79191
Abstract: Restructured electric market environment allows the power wheeling transactions between the power producers and customers to meet the growing load demand. This will lead to the possible of congestion in the transmission lines. The possible contingencies of power components further worsen the scenario. This paper describes the methodology for the identification of critical transmission line by computing the real power and reactive power performance indices. It also demonstrates the importance of fuzzy logic technique used to rank the transmission lines according to the severity and demonstrated on IEEE-30 bus system.
Economically Precise Water Resource Management for Domestic Usage in India  [PDF]
P. Babu, C. Rajasekaran
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.710240
Abstract: In the present years water resource that can be utilized for domestic usage is getting reduced dramatically. In order to have sufficient water for the utilization of future generation, it is our duty to conserve and utilize the available water in a very efficient way. This paper is aimed to help the people to conserve water; it is done with the help of an embedded system that is reconfigurable depending on the number of persons in the family. The system consists of three modules. Each has a different purpose, one module senses the water level present in the tank and intimates the user regarding when the water is needed to be restored. The second module deals with the division of water based on the type of application for which is intended. The third module deals with intimating the municipality regarding the availability of water. All the three modules combine to work in conserving the water; as a result, we can consume nearly 30% per year per head. So this would result in a large amount of conservation of water. Thus the saved water can be reused for several applications.
Improved PLL Tuning of Shunt Active Power Filter for Grid Connected Photo Voltaic Energy System  [PDF]
Rajmohan Rajalakshmi, Vairamani Rajasekaran
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.710261
Abstract: This research work brings out the unique predictive current control method for attaining an efficient grid connected Photo Voltaic (PV) system by Shunt Active Power Filter (SAPF) as grid connected converter. The major objective of the research work is to address the presence of Direct Current (DC) component, frequency improvement, quicker theta response, voltage magnitude estimation in the input signal of the Phase Locked Loop (PLL) which is challenging. This work focuses on tuning the PLL block (Kp,?Ki,?Kv?and Ko)?through Artificial Bee Colony (ABC) optimization algorithm. The proposed ABC based modified three-phase PLL method is based on adding a new loop inside the PLL structure. In power converters, ABC algorithm is used to select the optimal switching states. The voltage vector which minimizes a cost optimization function is selected. Simulation is carried out for both balanced and unbalanced system and the results validate that the performance of the proposed approach is better in terms of harmonic compensation as per the IEEE standards within ±5%, power factor improvement of the system, quicker theta tracking and suppression of frequency jump with the interconnection of PV system.
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