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Search Results: 1 - 10 of 2397 matches for " Rajani Ravi "
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Use of Fibula Bridge Graft Technique to Treat a Distal Tibia Non Union- A Case Report
Amyn Rajani,Chandu J Thakkar,Ravi Shah,Ashok Shyam
Journal of Orthopaedic Case Reports , 2013,
Abstract: Introduction: Compound distal tibia fractures have high incidence of nonunions and have varied presentation as far as status of fibula is concerned. If fibula is sufficiently healthy we can use it for bridging the nonunion of tibia.Case Report: We present a case of 20 year old female with compound and segmental tibia fracture. Primary stablisation by external fixation and later cast brace application achieved union at the proximal end of the segmental fragment with non union at the distal end. This was then treated with bridge grafting of fibula and screw fixation of fibula to the tibia. Five years follow shows good clinical and functional outcome without any complications.Conclusion: Its infrequent to find fibula spanning across the tibia nonunion, however when available this can be used as bridge graft to promote healing.
THE COMPARATIVE STUDY OF AEROBIC CAPACITY IN TRAINED AND UNTRAINED SUBJECTS
Purru Ravi Kumar,Yogananda Reddy Indla,Ragam Ravi Sunder,Rajani Santha Kumari
International Journal of Biomedical Research , 2013, DOI: 10.7439/ijbr.v3i1.272
Abstract: Aim: To evaluate aerobic capacity in trained and untrained subjects by measuring Vo2 max. Methods and Materials: In the present study 40 healthy subjects were selected between the age group 20-30 years. One group is not having any regular specific physical exercise and the second group which includes subjects, who regularly do the cycling in gym since more than two years. Resting pulse rate was recorded with E.C.G. The subjects were asked to peddle the bicycle ergo metre first with a resistance of 2 kg for 5 minutes next with a resistance of 4 kg for 3 minutes there after resistance is increased by 0.5 kg for every 3 minutes until the subject is exhausted. Immediately after the exercise heart rate was recorded with E.C.G. Vo2max =55.23-(0.09xheart rate/min). Results: P-value of Vo2 max is 0.005 which is highly significant. Conclusion: The Vo2 max is higher in trained subjects than in untrained subjects. This is due to cardiac output and total skeletal muscle mass are more in trained subjects.
THE COMPARATIVE STUDY OF ANAEROBIC CAPACITY IN TRAINED AND UNTRAINED SUBJECTS
Ravi Kumar Purru,Yogananda Reddy Indla,Ragam Ravi Sunder,Rajani Santha Kumari
International Journal of Biomedical Research , 2012, DOI: 10.7439/ijbr.v3i2.310
Abstract: Aim: To evaluate anaerobic capacity in trained and untrained subjects Methods and Materials: In the present study 40 healthy male subjects were selected between the age group 20-22 years. Average Weight is 65 kg ±2. Average height is 167 cm ±2. One group is not having any regular specific physical exercise and the second group which includes subjects who regularly do the cycling for 30 minutes all days in a week since 6 months. Subjects attended the physiology department daily between 8-8.30 am without breakfast. The subjects were asked to warm up by peddling the bicycle ergo meter for 2-4 minutes. Next the subjects were asked to rest for 3-5 minutes. Then the subjects were peddled the bicycle ergo meter all-out as fast as they can without any resistance applied to the fly wheel once the subjects reaches full speed now we have applied predetermined resistance to the fly wheel, subjects are peddled the bicycle ergo meter with full speed for 30 seconds. An electrical counter records the number of fly wheel revolutions for 30 seconds. AC = Force x Distance 4 Results: P value of AC is 0.001 Conclusion: AC is higher in trained subjects than in untrained subjects. Keywords: Anaerobic capacity (AC), Bicycle ergo meter (Martin)
THE COMPARATIVE STUDY OF AEROBIC CAPACITY IN TRAINED AND UNTRAINED SUBJECTS
Purru Ravi Kumar,Yogananda Reddy Indla,Ragam Ravi Sunder,Rajani Santha Kumari
International Journal of Biomedical Research , 2012, DOI: 10.7439/ijbr.v3i1.272
Abstract: Aim: To evaluate aerobic capacity in trained and untrained subjects by measuring Vo2 max. Methods and Materials: In the present study 40 healthy subjects were selected between the age group 20-30 years. One group is not having any regular specific physical exercise and the second group which includes subjects, who regularly do the cycling in gym since more than two years. Resting pulse rate was recorded with E.C.G. The subjects were asked to peddle the bicycle ergo metre first with a resistance of 2 kg for 5 minutes next with a resistance of 4 kg for 3 minutes there after resistance is increased by 0.5 kg for every 3 minutes until the subject is exhausted. Immediately after the exercise heart rate was recorded with E.C.G. Vo2max =55.23-(0.09xheart rate/min). Results: P-value of Vo2 max is 0.005 which is highly significant. Conclusion: The Vo2 max is higher in trained subjects than in untrained subjects. This is due to cardiac output and total skeletal muscle mass are more in trained subjects.
THE COMPARATIVE STUDY OF ANAEROBIC CAPACITY IN TRAINED AND UNTRAINED SUBJECTS
Ravi Kumar Purru,Yogananda Reddy Indla,Ragam Ravi Sunder,Rajani Santha Kumari
International Journal of Biomedical Research , 2013, DOI: 10.7439/ijbr.v3i2.310
Abstract: Aim: To evaluate anaerobic capacity in trained and untrained subjects Methods and Materials: In the present study 40 healthy male subjects were selected between the age group 20-22 years. Average Weight is 65 kg ±2. Average height is 167 cm ±2. One group is not having any regular specific physical exercise and the second group which includes subjects who regularly do the cycling for 30 minutes all days in a week since 6 months. Subjects attended the physiology department daily between 8-8.30 am without breakfast. The subjects were asked to warm up by peddling the bicycle ergo meter for 2-4 minutes. Next the subjects were asked to rest for 3-5 minutes. Then the subjects were peddled the bicycle ergo meter all-out as fast as they can without any resistance applied to the fly wheel once the subjects reaches full speed now we have applied predetermined resistance to the fly wheel, subjects are peddled the bicycle ergo meter with full speed for 30 seconds. An electrical counter records the number of fly wheel revolutions for 30 seconds. AC = Force x Distance 4 Results: P value of AC is 0.001 Conclusion: AC is higher in trained subjects than in untrained subjects. Keywords: Anaerobic capacity (AC), Bicycle ergo meter (Martin)
Adenylate Kinase 3 Sensitizes Cells to Cigarette Smoke Condensate Vapor Induced Cisplatin Resistance
Xiaofei Chang,Rajani Ravi,Vui Pham,Atul Bedi,Aditi Chatterjee,David Sidransky
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0020806
Abstract: The major established etiologic risk factor for bladder cancer is cigarette smoking and one of the major antineoplastic agents used for the treatment of advanced bladder cancer is cisplatin. A number of reports have suggested that cancer patients who smoke while receiving treatment have lower rates of response and decreased efficacy of cancer therapies.
Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy
Savita Bisht, Georg Feldmann, Sheetal Soni, Rajani Ravi, Collins Karikar, Amarnath Maitra, Anirban Maitra
Journal of Nanobiotechnology , 2007, DOI: 10.1186/1477-3155-5-3
Abstract: We have synthesized polymeric nanoparticle encapsulated formulation of curcumin – nanocurcumin – utilizing the micellar aggregates of cross-linked and random copolymers of N-isopropylacrylamide (NIPAAM), with N-vinyl-2-pyrrolidone (VP) and poly(ethyleneglycol)monoacrylate (PEG-A). Physico-chemical characterization of the polymeric nanoparticles by dynamic laser light scattering and transmission electron microscopy confirms a narrow size distribution in the 50 nm range. Nanocurcumin, unlike free curcumin, is readily dispersed in aqueous media. Nanocurcumin demonstrates comparable in vitro therapeutic efficacy to free curcumin against a panel of human pancreatic cancer cell lines, as assessed by cell viability and clonogenicity assays in soft agar. Further, nanocurcumin's mechanisms of action on pancreatic cancer cells mirror that of free curcumin, including induction of cellular apoptosis, blockade of nuclear factor kappa B (NFκB) activation, and downregulation of steady state levels of multiple pro-inflammatory cytokines (IL-6, IL-8, and TNFα).Nanocurcumin provides an opportunity to expand the clinical repertoire of this efficacious agent by enabling ready aqueous dispersion. Future studies utilizing nanocurcumin are warranted in pre-clinical in vivo models of cancer and other diseases that might benefit from the effects of curcumin.Curcumin or diferuloylmethane is a yellow polyphenol extracted from the rhizome of turmeric (Curcuma longa), a plant grown in tropical Southeast Asia [1]. For centuries, turmeric has been used as a spice and coloring agent in Indian food, as well as a therapeutic agent in traditional Indian medicine. Enthusiasm for curcumin as an anti-cancer agent evolved based on the wealth of epidemiological evidence suggesting a correlation between dietary turmeric and low incidence of gastrointestinal mucosal cancers [2,3]. A plethora of experimental data has unequivocally established that free curcumin induces cell cycle arrest and/or apoptosis in h
Drug Resistance Pattern of MTB Isolates from PTB Patients
Rajani Ranganath,Vijay G. S. Kumar,Ravi Ranganath,Gangadhar Goud,Veerabhadra Javali
Tuberculosis Research and Treatment , 2013, DOI: 10.1155/2013/862530
Abstract: Background. TB is a global pandemic disease. All TB control programs were not successful due to the emergence of multidrug resistance in M. tuberculosis strains. Objective of the present study was to detect the rate of MDR-MTB in this part of India. Methods. One hundred and thirty clinical MTB strains isolated from patients on treatment and confirmed as MTB by MPT64 antigen detection were tested for drug susceptibility against Streptomycin, INH, Rifampicin, and Ethambutol by MBBact automated system. Result. Thirty-two were MDRs (25.61%). 31.2%, 28%, 17.6%, and 21.6% were resistant to INH, RIF, Ethambutol, and Streptomycin, respectively. Resistance to either INH or Rifampicin was 20.8% and 13.88%, respectively. Combined INH and Rifampicin resistance was seen in 18.05% isolates. Conclusion. Drug resistance rate is high in patients treated previously and who have been irregular on treatment. 1. Introduction Tuberculosis (TB) is the second leading cause of death from an infectious disease worldwide after human immunodeficiency virus (HIV). Inspite of free supply of drugs, 1.4 million TB deaths occurred worldwide in 2011. Recently, World Health Organization has estimated that 3.7% of new TB cases are MDRs. MDR-TB global average rate is 20%. About 9% of these cases also are resistant to at least one injectable second line antitubercular drugs. These strains are called extensively drug resistant (XDR) TB cases [1]. During the middle of twentieth century, tuberculosis rate in Europe and North America decreased to an extent that it was thought as totally eradicated. Health care providers started to announce that TB is eradicated. TB sanatoriums were closed. But M. tuberculosis bounced back in 1980s with a vengeance and has spread all over the world. Unholy nexus between TB and HIV has further increased not only TB rate but also mortality. Drug resistance (DR) in MTB is a manmade problem. Defaulting by the patient, poor quality of drugs and lack of awareness have contributed to the present grim situation of TB management. In 1993, increasing reports of MDRTB were noted from USA [2] and WHO declared TB as global emergency [3]. WHO’s millennium development goal to reduce TB by 2015 has failed. Drug resistance in MTB is manmade and is a consequence of suboptimal regimens and treatment interruptions [4]. MTB strains exhibiting resistance to INH and Rifampicin, the two main first line drugs, are designated as MDRTB strains. These MDR strains require prolonged treatment using second line drugs which are highly toxic and less effective [5, 6]. WHO and International
Automated Pulse-Based Diagnosis: Role of TIM Diagnostic Features  [PDF]
Rajani R. Joshi
Journal of Biomedical Science and Engineering (JBiSE) , 2014, DOI: 10.4236/jbise.2014.710076
Abstract: Emanated from the idea of reinvestigating ancient medical system of Ayurveda—Traditional Indian Medicine (TIM), our recent study had shown significant applications of analysis of arterial pulse waveforms for non-invasive diagnosis of cardiovascular functions. Here we present results of further investigations analyzing the relation of pulse-characteristics with some clinical and pathological parameters and other features that are of diagnostic importance in Ayurveda.
Commiphora wightii (Arnott) Bhandari—A Natural Source of Guggulsterone: Facing a High Risk of Extinction in Its Natural Habitat  [PDF]
Neeraj Jain, Rajani S. Nadgauda
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.46A009
Abstract:

The plants are the primary producers and an indispensible source of food and nutrition, medicine and fuel/biofuel. Unsustainable overharvesting and indiscriminate felling of plants due to ever increasing needs of population pressure are causes of great concern. The IUCN includes, the species facing a high risk of extinction in the wild as threatened, and “endangered” is one of the sub-categories under “threatened” category. Commiphora wightii (Arnott) Bhandari is an arid region plant, highly valued for its medicinally important guggul gum-resin as a source of guggulsterone. It is listed in IUCN’s Red Data List of threatened plants and now it is becoming endangered. Its population is fast depleting in its natural habitat, primarily due to over-exploitation, unsustainable and destructive methods of gum-extraction coupled with natural dry-arid habitat, slow growth and poor regeneration of the plant. Several other reasons have also been indicated for its declining population. Therefore, it demands severe measures for its conservation before we completely lose this important medicinal plant. A lot of research and study is underway but has vast scope for improvement, requiring efforts to supplement with such information that would aid transgenic development and breeding programmes for production and cultivation of improved varieties. The article presents the importance of this plant and its conservation in a nut-shell.

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