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Search Results: 1 - 10 of 401388 matches for " Rajadurai M. "
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EFFECT OF VIMLIV ON LIPID PEROXIDES AND ANTIOXIDANTS IN ETHANOL INDUCED HEPATOTOXICITY IN ALBINO WISTER RATS
M. Samundeeswari and M. Rajadurai*
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: This study was carried out to investigate the hepatoprotective and antioxidant properties of vimliv in ethanol-induced hepatotoxicity in rats. The liver toxicity was induced by the administration of ethanol to the animals at dose of 3 g/kg orally for 35 days. During the period of vimliv was co-administered to the rats at doses of 25 and 50 mg/kg for 35 days. The levels of lipidperoxidative products significantly increased and the levels of antioxidants decreased in ethanol induced rats. Co-administration of vimliv to ethanol-induced rats were significantly minimized the alterations in the levels of lipidperoxidation and antioxidatns. Administration of vimliv protected the liver against ethanol-induced toxicity, possibly by reducing the rate of lipidperoxidation and increasing the antioxidant defense mechanism in rats.
Compositional analysis of protein sequences of different species
Vinobha C.S.,Rajasekaran E.,Rajadurai M.
International Journal of Bioinformatics Research , 2010,
Abstract: We describe several protein sequence statistics designed to evaluate distinctive attributes ofresidue content and arrangement in primary structure. As per the global consideration, thecompositional biases of clustering different residue types (charged residues, hydrophobic residues) oflong runs of charged or uncharged residues, periodic patterns, counts and distribution ofhomooligopeptides, and unusual spacing between particular residue types. The computer programSEQUANA (statistical analysis of protein sequences) calculates all the statistics for any individualprotein sequence input and is available for the WINDOWS environment through electronic mail onrequest to csvinobha@gmail.com
Optical Waveguiding Organic Nanorods Coated with Reversibly Switchable Fe(II) Spin Transition Nanoparticles
Supratim Basak,Ajay Kumar Botcha,M. Thameem Ansari,Rajadurai Chandrasekar
Indian Journal of Materials Science , 2013, DOI: 10.1155/2013/136178
Abstract: A dual functional nanohybrid object combining photonic and magnetic properties was successfully prepared through a “bottom-up” self-assembly approach. In this method, spin transition Fe(II) coordination nanoparticles and optical wave guiding organic nanorods were generated in situ and successfully integrated together in a single pot through self-assembly. The Fe(II) nanoparticles coated on organic nanorods (nanohybrids) display temperature dependent reversible spin transition (Paramagnetic; diamagnetic; ) behavior. The nano-hybrids show efficient optical wave guiding behavior, which demonstrates the future possibility to perform light induced excited spin state trapping (LIESST) experiments on a single spin transition nanoparticle level. These photonic and magnetic “nanohybrids” offer promising option to externally manipulate spin state of the spin transition nanoparticles using temperature as well as remote laser light. 1. Introduction Bottom-up nanofabrication of self-assembled multifunctional nanoobjects and study of their uncharted physical properties at the nanoscale level are an active and sophisticated research area of nanoscience and technology [1–13]. Particularly programming the in situ growth of self-assembled organic and inorganic nanostructures from different molecular components and also their integration to form hybrid nanoscale objects in the same pot is a less explored area. A successful groundwork in this discipline might lead to new advanced functional hybrid nanomaterials capable of performing a sensing, electronic, photonic, and mechanical function [1–13]. For example integration of magnetically bistable inorganic nanoparticles (NPs) and optical wave guiding organic nanostructures could facilitate remote manipulation of the light sensitive spin states of individual NPs through guided laser light. Recently, we have reported for the first time on the passive wave guiding behavior of organic tubes and also demonstrated the remote electronic excitation of a mesotetratolylporphyrin nanosheet using a 20? m long optical wave guiding organic tube [14–16]. Hence we intended to study the propensity of the 1D organic solids coated with spin transition NPs [17–37] (ST-NPs) to guide source laser light under laser confocal microscope setup. It was anticipated that the dielectric difference between the 1D nano-hybrid solid and the surrounding medium would guide the optical wave along the growth axis of the waveguide. Among NPs, Fe(II) ST-NPs are of interest due to their switchable bistable magnetic spin states between paramagnetic high-spin state
The Effect of Muscle Energy Technique on Temporomandibular Joint Dysfunction: A Randomized Clinical Trail
Viswas Rajadurai
Asian Journal of Scientific Research , 2011,
Abstract: Limited research has been done to assess the effectiveness of Muscle Energy Technique (MET) on Temporomandibular Joint Dysfunction (TMD) patients. The present study was a randomized clinical trial that aimed to evaluate the effectiveness of MET in reducing pain and improving Maximal Mouth Opening (MMO) in patients with TMD. The sample consisted of forty participants; aged 20-30 years (mean age 25.5±2.96) diagnosed with TMD of less than three months duration were recruited. Participants were treated with MET, which includes post isometric relaxation and reciprocal inhibition, given on alternate days for 5 weeks. Before the commencement of the treatment and at the end of each week, subjects were evaluated for pain intensity using Visual Analogue Scale (VAS) and MMO by measuring the inter-incisal distance. The intra group comparison showed that there was a significant reduction of pain (p<0.05) at the end of each week as measured by the VAS. The MMO measurements showed significant improvement in range of motion (p<0.05) at the end of each week when compared to the baseline measurements. Results may have important implications for physiotherapy practice in suggesting that MET is effective in reducing pain and improving MMO in patients with TMD.
A Fast Quad-Tree Based Two Dimensional Hierarchical Clustering
Priscilla Rajadurai and Swamynathan Sankaranarayanan
Bioinformatics and Biology Insights , 2012, DOI: 10.4137/BBI.S10383
Abstract: Recently, microarray technologies have become a robust technique in the area of genomics. An important step in the analysis of gene expression data is the identification of groups of genes disclosing analogous expression patterns. Cluster analysis partitions a given dataset into groups based on specified features. Euclidean distance is a widely used similarity measure for gene expression data that considers the amount of changes in gene expression. However, the huge number of genes and the intricacy of biological networks have highly increased the challenges of comprehending and interpreting the resulting group of data, increasing processing time. The proposed technique focuses on a QT based fast 2-dimensional hierarchical clustering algorithm to perform clustering. The construction of the closest pair data structure is an each level is an important time factor, which determines the processing time of clustering. The proposed model reduces the processing time and improves analysis of gene expression data.
A Fast Quad-Tree Based Two Dimensional Hierarchical Clustering
Priscilla Rajadurai,Swamynathan Sankaranarayanan
Bioinformatics and Biology Insights , 2012,
Abstract:
BIOFFORC: Tool development for biological file format conversion
Chinnaiah Swaminathan Vinobha,Maruthamuthu Rajadurai,Ekambaram Rajasekaran
Bioinformation , 2008,
Abstract: The use of bioinformatics tools require different sequence formats at various instances. Every tool uses specific set of formats for processing. Sequence in one format is often required in another format. Thus, there is a need for sequence format conversion. A number of such tools are available in the public domain. Here, we describe BIOFFORC as a file format converter. The tool is developed with a graphical user interface in PERL.
Effect of Aegle marmelos Leaf Extract and -Tocopherol on Lipid Peroxidation and Antioxidants in Isoproterenol Induced Myocardial Infarction in Rats
Murugan Rajadurai,Mannangatti Padmanabhan,Ponnaian Stanely Mainzen Prince
The Cardiology , 2011,
Abstract: The present study investigates the effect of oral administration of an aqueous Aegle marmelos leaf extract (AMLEt) on lipid peroxidation and antioxidants in isoproterenol (ISO) treated rats. A significant increase in the activities of marker enzymes such as creatine kinase, lactate dehydrogenase, aspartate transaminase and alanine transminase in serum of isoproterenol treated rats was observed. The levels of thiobarbituric acid reactive substances and hydroperoxides increased but the levels and activities of nonenzymic (vitamin C, reduced glutathione and ceruloplasmin) and enzymic (glutathione peroxidase, superoxide dismutase and catalase) antioxidants decreased in isoproterenol administered rats. Pretreatment with aqueous AMLEt at doses of 100 and 200 mg/kg orally for a period of 35 days exerted a significant effect on isoproterenol treated rats. The effect of AMLEt at a dose of 200 mg/kg showed a similar effect as that of ?-tocopherol (60 mg/kg). Thus the results of our study show the cardioprotective activity of Aegle marmelos leaf extract in isoproterenol induced myocardial infarction in rats.
BCDB - A database for breast cancer research and information
Jayashree Mohandass,Saranya Ravichandran,Koganti Srilakshmi,Chinnasamy Perumal Rajadurai
Bioinformation , 2010,
Abstract: In pursuit of a better updated source including ‘omics’ information for breast cancer, Breast Cancer Database (BCDB) has been developed to provide the researcher with the quick overview of the Breast cancer disease and other relevant information. This database comprises of myriad of information about genes involved in breast cancer, its functions and drug molecules which are currently being used in the treatment of breast cancer. The data available in BCDB is retrieved from the biomedical research literature. It facilitates the user to search information on gene, its location in chromosome, functions and its importance in cancer diseases. Broadly, this can be queried by giving gene name, protein name and drug name. This database is platform independent, user friendly and freely accessible through internet. The data present in BCDB is directly linked to other on-line resources such as NCBI, PDB and PubMed. Hence, it can act as a complete web resource comprising gene sequences, drug structures and literature information related to breast cancer, which is not available in any other breast cancer database.
A database for medicinal plants used in treatment of asthma
Balaji Kasirajan,Rajadurai Maruthamuthu,Vidhya Gopalakrishnan,Krithika Arumugam
Bioinformation , 2007,
Abstract: The knowledge of most plants used in the treatment of asthma, the plant part which is effective in treatment is confined to very few persons who are engaged in folklore medicine. However, this form of medicine is not very popular. Therefore, it is of considerable interest to ethno-botanical community to understand the plants and the parts used for treatment. Here, we describe AsthmaPlantBase, a database containing information of medicinal plants for treatment of asthma.
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