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Search Results: 1 - 10 of 330056 matches for " Raimundo; Arús Soler "
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Influencia de factores epidemiológicos en la progresión de la fibrosis en la hepatitis crónica C
Vilar Gómez,Eduardo; Grá Oramas,Bienvenido; Llanio Navarro,Raimundo; Arús Soler,Enrique;
Revista Cubana de Medicina , 2003,
Abstract: approximately 80 % of hepatitis c evolves to chronicity. the epidemiological and viral factors as well as those of the guest take part in the progression of the disease. the behavior of the epidemiological variables associated with chronic hepatitis c was described and the possible association of these ones with the intensity of fibrosis was identified. 80 patients with hepatitis c were studied and the intensity of fibrosis was determined by the metavir scoring system. they were grouped into absence or little fibrosis (f0-f1) and marked fibrosis (f2-f4) seeking for the possible statistical association with the epidemiological factors. a significant association was found among the infection's oldness estimate, the way it was acquired, the patient's age on catching it and the intensity of fibrosis. the progression of hepatits c may be determined by some epidemiological factors influencing decisively the natural history of the disease.
Bases fisiopatológicas de la insuficiencia hepática aguda
Vilar Gómez,Eduardo; Grá Oramas,Bienvenido; Llanio Navarro,Raimundo; Arús Soler,Enrique;
Revista Cubana de Medicina , 2004,
Abstract: a review was made to explain how the diverse cellular processes occurring in the severely damaged liver tissue and in the mesenteric circulation influence on the different systemic alterations appearing in acute liver failure, and the close relation existing among them. the acute liver failure is a clinical syndrome resulting from a mass liver necrosis generating progressive dysfunction of the organ with the presence of deep alterations in its detoxicating, metabolic, sinthesizing and excreting functions.the hypothesis of critical mass, as well as that on endotoxins-cytokines and vasoactive substances explain somehow the different molecular changes supporting the physiopathological bases of this complex entity.
Influencia de factores epidemiológicos en la progresión de la fibrosis en la hepatitis crónica C
Eduardo Vilar Gómez,Bienvenido Grá Oramas,Raimundo Llanio Navarro,Enrique Arús Soler
Revista Cubana de Medicina , 2003,
Abstract: Aproximadamente 80 % de la hepatitis C evoluciona a la cronicidad. Factores como los epidemiológicos, virales y del huésped intervienen en la progresión de la enfermedad. Se describió el comportamiento de variables epidemiológicas asociadas a la hepatitis crónica C y se identificó la posible asociación de estas con la intensidad de la fibrosis. Se estudiaron 80 pacientes con hepatitis C. Se determinó la intensidad de la fibrosis por el sistema de puntuación METAVIR. Se agruparon en: ausencia o poca fibrosis (F0-F1) y fibrosis marcada (F2 a F4) buscando la posible asociación estadística con los factores epidemiológicos. Se halló asociación significativa entre el estimado de antigüedad de la infección, la vía de adquisición y la edad al contraerla con la intensidad de la fibrosis. La progresión de la hepatitis C puede estar determinada por algunos factores epidemiológicos que influyen de forma decisiva en la historia natural de la enfermedad. Approximately 80 % of hepatitis C evolves to chronicity. The epidemiological and viral factors as well as those of the guest take part in the progression of the disease. The behavior of the epidemiological variables associated with chronic hepatitis C was described and the possible association of these ones with the intensity of fibrosis was identified. 80 patients with hepatitis C were studied and the intensity of fibrosis was determined by the METAVIR scoring system. They were grouped into absence or little fibrosis (f0-F1) and marked fibrosis (F2-F4) seeking for the possible statistical association with the epidemiological factors. A significant association was found among the infection's oldness estimate, the way it was acquired, the patient's age on catching it and the intensity of fibrosis. The progression of hepatits C may be determined by some epidemiological factors influencing decisively the natural history of the disease.
Bases fisiopatológicas de la insuficiencia hepática aguda Physiopathological bases of acute liver failure
Eduardo Vilar Gómez,Bienvenido Grá Oramas,Raimundo Llanio Navarro,Enrique Arús Soler
Revista Cubana de Medicina , 2004,
Abstract: Se hace una revisión para explicar cómo influyen y la estrecha relación que tienen los diversos procesos celulares que ocurren en el tejido hepático, severamente da ado, y en la circulación mesentérica con las distintas alteraciones sistémicas que aparecen en la insuficiencia hepática aguda, síndrome clínico resultado de una necrosis hepática masiva que genera disfunción progresiva del órgano con la presencia de profundas alteraciones en sus funciones detoxificadora, metabólica, sintetizadora y excretora. La hipótesis de la masa crítica, así como la de las endotoxinas-citoquinas y sustancias vasoactivas explican de cierta forma los diferentes cambios moleculares que sustentan las bases fisiopatológicas de esta compleja entidad. A review was made to explain how the diverse cellular processes occurring in the severely damaged liver tissue and in the mesenteric circulation influence on the different systemic alterations appearing in acute liver failure, and the close relation existing among them. The acute liver failure is a clinical syndrome resulting from a mass liver necrosis generating progressive dysfunction of the organ with the presence of deep alterations in its detoxicating, metabolic, sinthesizing and excreting functions.The hypothesis of critical mass, as well as that on endotoxins-cytokines and vasoactive substances explain somehow the different molecular changes supporting the physiopathological bases of this complex entity.
Historia natural de la infección por el virus de la hepatitis C
Arús Soler,Enrique;
Revista Cubana de Medicina , 2006,
Abstract: the acute stage of infection goes by inadvertently in most of the patients. the disease has a marked trend of evolution towards chronicity and it evolves very slowly. the chronic persistence of the virus ranges from 54 to 86 % of the cases. the evolution towards liver cirrhosis fluctuates between 2.6 and 42 % of the cases, depending on the study method used to evaluate the natural history. the youngest patients at the moment of infection and the females had the lowest progression rates. the coinfection with hivand hbv favor a rapid progression. some associated diseases as the non-alcoholic steatohepatitis, type ii diabetes mellitus, obesity, and the increase of the iron deposit in the liver have also been related to a rapid progression. alcoholism plays an important role on accelerating the course of the disease to liver cirrhosis and to hepatocellular carcinoma. the transfusion-acquired infection has been considered as a fibrosis-accelerating factor.
Historia natural de la infección por el virus de la hepatitis C Natural history of HCV infection
Enrique Arús Soler
Revista Cubana de Medicina , 2006,
Abstract: La fase aguda de la infección transcurre de forma desapercibida en la mayoría de los enfermos. La enfermedad tiene marcada tendencia de evolución a la cronicidad y evoluciona muy lentamente. La persistencia crónica del virus oscila entre un 54 y 86 % de los casos. La evolución a la cirrosis hepática oscila entre 2,6 y 42 % de los casos, en dependencia del método de estudio que se haya utilizado para evaluar la historia natural. Los pacientes con edades más jóvenes al momento de la infección y del sexo femenino tienen las tasas más bajas de progresión. La coinfección con los virus de la inmunodeficiencia humana y de la hepatitis B favorece una rápida progresión. Algunas enfermedades asociadas como son la esteatohepatitis no alcohólica, la diabetes mellitus tipo II, la obesidad, el aumento del depósito de hierro en el hígado, también se han asociado a una rápida progresión. El alcoholismo desempe a un papel importante en acelerar el curso de la enfermedad tanto a la cirrosis hepática como al carcinoma hepatocelular . La vía transfusional de adquisición de la infección se ha se alado como factor que acelera la fibrosis. The acute stage of infection goes by inadvertently in most of the patients. The disease has a marked trend of evolution towards chronicity and it evolves very slowly. The chronic persistence of the virus ranges from 54 to 86 % of the cases. The evolution towards liver cirrhosis fluctuates between 2.6 and 42 % of the cases, depending on the study method used to evaluate the natural history. The youngest patients at the moment of infection and the females had the lowest progression rates. The coinfection with HIVand HBV favor a rapid progression. Some associated diseases as the non-alcoholic steatohepatitis, type II diabetes mellitus, obesity, and the increase of the iron deposit in the liver have also been related to a rapid progression. Alcoholism plays an important role on accelerating the course of the disease to liver cirrhosis and to hepatocellular carcinoma. The transfusion-acquired infection has been considered as a fibrosis-accelerating factor.
Evolución histórica de las terapias antivirales en hepatitis crónica C
Sánchez Rodríguez,Yoan Antonio; Arús Soler,Enrique;
Revista Cubana de Medicina , 2010,
Abstract: a bibliographic review on the more significant features of historical course experienced by the antiviral therapies used in treatment of chronic hepatitis c virus was carried out due to the increasing incidence and prevalence of this disease with infection estimates about 3% of the world population. a updating was carried out on this subject matter from its origins with special emphasis on future perspectives of this therapeutics, nowadays under consideration by the international scientific community. for the carrying out of present work 69 bibliographic references were reviewed including the meta-analyses available in medline from 1998 up to present time, as well as the publications of researches results performed in our country on this subject.
Evolución histórica de las terapias antivirales en hepatitis crónica C Historical course of antiviral therapies in chronic hepatitis C
Yoan Antonio Sánchez Rodríguez,Enrique Arús Soler
Revista Cubana de Medicina , 2010,
Abstract: Dada la creciente incidencia y prevalencia de la infección crónica por el Virus de la hepatitis cónica C, con estimados de infección de alrededor del 3 % de la población mundial, se realizó una revisión bibliográfica sobre los aspectos más relevantes de la evolución histórica que han experimentado las terapias antivirales utilizadas en el tratamiento de esta enfermedad. Se realizó una puesta al día sobre esta temática desde sus orígenes, con especial énfasis en las perspectivas futuras de esta terapéutica, actualmente en estudio por parte de la comunidad científica internacional. Para la realización de esta obra fueron consultadas 69 citas bibliográficas que incluyen metanálisis disponibles en MEDLINE desde 1998 hasta la actualidad, así como las publicaciones de los resultados de las investigaciones realizadas en nuestro país sobre este tema. A bibliographic review on the more significant features of historical course experienced by the antiviral therapies used in treatment of Chronic Hepatitis C virus was carried out due to the increasing incidence and prevalence of this disease with infection estimates about 3% of the world population. A updating was carried out on this subject matter from its origins with special emphasis on future perspectives of this therapeutics, nowadays under consideration by the international scientific community. For the carrying out of present work 69 bibliographic references were reviewed including the meta-analyses available in MEDLINE from 1998 up to present time, as well as the publications of researches results performed in our country on this subject.
Hepatitis autoinmune
Infante Velázquez,Mirtha; Arús Soler,Enrique;
Revista Cubana de Medicina , 2000,
Abstract: this necroinflammatory liver disease of unknown origin was reported for the first time in 1950. it was mainly described in young women. this nosological entity has had several denominations through history. at present, it is known as autoimmune hepatitis. it appears in individuals with certain genetic predisposition when they are exposed to some environmental agent that has not been identified yet, giving rise to an autoimmune mechanism directed to the liver, where a necroinflammatoy process takes place leading to fibrosis and, finally, to cirrhosis. there are 3 types of autoimmune hepatitis: type1 is characterized by the presence of antinuclear antibodies, smooth antimuscle and antiactin; type 2, by the existance of anti- liver/kidney chromosome antibodies; and type 3, by the appearance of antibodies against the soluble antigen. the diagnosis is based on the histological study of the liver and on the presence of the above mentioned antibodies. monoclonal hypergammaglobulinemia is a laboratory alteration that characterizes the disease. other lab findings were the elevation of aminotranferases, alkaline phosphatase and bilirubin. the response to the treatment with glucocorticoids is common in this affection. azathioprine associated with corticosteroids is used in the maintenance therapy in order to prescribe low doses and to avoid their side effects. azathioprine may be also used alone as a maintenance therapy.
Hepatitis autoinmune
Mirtha Infante Velázquez,Enrique Arús Soler
Revista Cubana de Medicina , 2000,
Abstract: Se reportó, por primera vez, esta enfermedad necroinflamatoria del hígado de causa desconocida en el a o 1950. Se describió principalmente en mujeres jóvenes. Se han conocido a través de la historia, varias denominaciones para esta entidad nosológica. En la actualidad, se conoce con el nombre de hepatitis autoinmune. Se desarrolla en individuos con cierta predisposición genética cuando se exponen a algún agente ambiental que aún no ha sido identificado, a partir de lo cual se desencadena un mecanismo autoinmune dirigido contra el hígado, donde tiene lugar un proceso necroinflamatorio que conduce a la fibrosis y finalmente, a la cirrosis. Se reconocen 3 tipos de hepatitis autoinmune; el tipo I se caracteriza por la presencia de anticuerpos antinucleares, antimúsculo liso y antiactina; en el tipo II están presentes anticuerpos antimicrosomas contra hígado y ri ón y el tipo III se caracteriza por la existencia de anticuerpos contra el antígeno soluble. El diagnóstico se basa en el estudio histológico del hígado y la presencia de los autoanticuerpos antes se alados. La hipergammaglobulinemia monoclonal es una alteración de laboratorio que caracteriza la enfermedad. Otros hallazgos de laboratorio son la elevación de las aminotransferasas, la fosfatasa alcalina y la bilirrubina. Es característica de esta afección la respuesta al tratamiento con glucocorticoides. La azathioprina asociada a los corticosteroides se utiliza en los tratamientos de mantenimiento con el fin de prescribir dosis bajas de éstos y evitar sus efectos secundarios. También la azathioprina puede usarse sola como terapia de sostén. This necroinflammatory liver disease of unknown origin was reported for the first time in 1950. It was mainly described in young women. This nosological entity has had several denominations through history. At present, it is known as autoimmune hepatitis. It appears in individuals with certain genetic predisposition when they are exposed to some environmental agent that has not been identified yet, giving rise to an autoimmune mechanism directed to the liver, where a necroinflammatoy process takes place leading to fibrosis and, finally, to cirrhosis. There are 3 types of autoimmune hepatitis: type1 is characterized by the presence of antinuclear antibodies, smooth antimuscle and antiactin; type 2, by the existance of anti- liver/kidney chromosome antibodies; and type 3, by the appearance of antibodies against the soluble antigen. The diagnosis is based on the histological study of the liver and on the presence of the above mentioned antibodies. Monoclonal hypergam
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