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Search Results: 1 - 10 of 7959 matches for " Raiees Ahmad "
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A Prospective Study of Cholilithiasis in Children  [PDF]
Raiees Ahmad, Alfer Nafae, Shahnawaz Bashir, Pervaze Salam, Qayoom Khan, Malik Suhail, Umer Mushtaq, Javid Ahmad
Surgical Science (SS) , 2015, DOI: 10.4236/ss.2015.63024

Background: Gallstones are generally uncommon in infants and children. Formation of gallstone is a very poorly understood phenomenon. In general, the risk factors for cholithiasis in infants include patients who are ill, are receiving hyperalimentation, are premature, have congenital anomalies and have necrotizing enterocolitis. Children aged 1 - 5 years most frequently have hemolysis as the underlying condition [1]. Materials and Methods: From Jan 2012 to Feb 2014, a study entitled “A Prospective Study of Cholelithiasis in Children” was conducted in Postgraduate Department of General Surgery Govt. Medical College Srinagar. The patients selected for the study were in the age group of 1 to 14 years of either sex. There were a total of 141 cases, out of which only 38 had ultrasound documented gallstones. All the patients included in the study were evaluated for prevalence, clinical presentation, and pathological features of gallstones, and were analysed for metabolic causes of gallstones. Results: The prevalence of chliothiasis in symptomatic patients was found to be 26.95% higher than the prevalence of gallstones in children in other parts of world, also the mean age of presentation was 9.3 years ranging from 6 - 14 years. Male to female ratio was 3:2 and male predominance was found in all age groups contrary to female predominance in adults. Most common presenting symptom was right upper quadrant pain followed by vomiting and nausea similar to presentation of symptomatic gallstones in adults. 4 patients had a positive family history of cholithiasis in the first degree relatives; 25 (65.7%) patients had no underlying risk factor for gallstones contrary to presumption that gallstones in children are mostly secondary to some hematological disorder or other predisposing factors. Chronic cholecystities was found in 81% of patients with gallstones and composition of gallstones retrieved was different from those of adult gallstones with calcium carbonate gallstones relatively common in children but composition of black and brown stones was almost similar to adult stones. Conclusion: Gallstone disease was increasingly gaining recognition in peadiatic practice due to significant documented increase in non-heamolytic cases

D1 versus Modified D2 Gastrectomy for Ca Stomach—A Prospective and Comparative Study  [PDF]
Alfar Nafae, Raiees Ahmad, Amber Aliya, Yawar Nisar, Pervaze Salam, Imtiyaz Ahmad
Surgical Science (SS) , 2016, DOI: 10.4236/ss.2016.71002
Abstract: Background: Carcinoma stomach remains a major malignancy and accounts for 10.4% of cancer related deaths globally. Despite improvement in chemo-radiotherapy, surgery remains the primary curative modality with special emphasis on lymphadenectomy. However the extent of lymphadenectomy performed by surgeons all over the world differs. Generally speaking, in Japan and Korea, the standard curative protocol would entail a “D2” lymphadenectomy whereas in the western world it would be considered unnecessary and the standard protocol would entail a standard “D1” lymphadenectomy. Thus prompting a newer surgical therapy of modified D2 in dissection in which pancreas and spleen are preserved. Lymph nodes surrounding stomach are divided into 20 stations and these are classified into three groups depending upon the location of the primary tumour. Aims & Objectives: The aims and objectives are to compare: 1) operative time of modified D2 gastrectomy with that of D1 gastrectomy; 2) operative morbidity and mortality of modified D2 gastrectomy with that of D1 gastrectomy; 3) the disease recurrence between modified D2 & D1 gastrectomy. Materials & Method: The study entitled D1 versus modified D2 gastrectomy for Ca stomach—a prospective, comparative study was conducted in the Postgraduate Department of General Surgery, Government Medical College, Srinagar as a prospective, comparative study over a period of three years 2012-2014. Patients with resectable gastric cancer were taken as subjects for the study and were divided in 2 groups that were closely matched to avoid any bias. Assessment of both the groups was done in identical fashion as per standard protocol. One group underwent gastrectomy with D1 lymph node dissection whereas the other group underwent gastrectomy with a modified D2 lymph node dissection (spleen and pancreas preservation). The type of lymphadenectomy was decided on randomization (simple random sampling). Results: After comparing the two procedures, it was noted that: 1) modified D2 lymphadenectomy took on an average 2 hours more than D1 gastrectomy; 2) operative mortality was same in both the procedures. Operative morbidity was seen more in modified D2 group than D1 group however this difference was statistically insignificant; 3) number of recurrence was quite significant in D1 group but no recurrence was seen in modified D2 group. Conclusion: On the basis of the study, we recommend that modified D2 gastrectomy is a better procedure than D1
Isolated Blunt Traumatic Diaphragmatic Rupture in a Case of Situs Inversus  [PDF]
Raiees Ahmad, Malik Suhail, Alfer Nafae, Qayoom Khan, Pervaze Salam, Shahnawaz Bashir, Yawar Nisar
Surgical Science (SS) , 2015, DOI: 10.4236/ss.2015.63021

Situs inversus, a very rare congenital anomaly of reversal site of thoracic and abdominal organs, can be very problematic to surgeon while dealing with a case of trauma in emergency. Surgical procedures are considered difficult, complex and more challenging in patients with this condition due to the anatomical difference and position of organs. We came across an interesting and very rare case of isolated blunt traumatic diaphragmatic injury in a case of situs inversus. Traumatic injuries of the diaphragm are uncommon and isolated blunt traumatic injuries of diaphragm are very rare. Our case is very unique of its kind of situs inversus with isolated right sided diaphragmatic rupture in a 60-year-old male patient presenting 4 hours after blunt trauma to chest and abdomen.

A Point-Specific Site for Placement of Epigastric Port in Iaparoscopic Management of Gallbladder Disease: An Observational Study  [PDF]
Mushtaq Chalkoo, Shahnawaz Ahangar, Faud Sadiq Baqal, Alfar Ah Nafae, Muntakhab Nafae, Raiees Ahmad Malla, Ajaz Ahmad Mallar
Surgical Science (SS) , 2013, DOI: 10.4236/ss.2013.47060

Backgound: Laparoscopic cholecystectomy has revolutionized the world in the surgical management of benign gallbladder disease. However, for any procedure to learn properly, anatomy becomes a major concern. Aims and Objectives: We present a point, a convenient site, speedily accessible by our maneuver of placing epigastric port on the patient. Materials and Methods: This is an outcome of an observation with the prospective study of 100 patients irrespective of age, sex, body habitus and severity of gallstone disease. Our point for epigastric port satisfies all the criteria for an ideal port. Results: Our general observation with majority of patients with this point specific epigastric port placement was that it is easy to locate, needs less thrust on trocar for creation, stays on the linea alba, is easily maneuverable facilitates safe, easy and speedy dissection, causes less portal bleeds and is easy to angulate towards the right of falciform ligament. Conclusion: The point specific epigastric port conveys many benefits to the operating surgeon in terms of easy location, adds safety and speed to the procedure, causes less portal bleeds, needs less thrust and is easy to angulate to the right of the falciform ligament adding technical ease to the surgeon. It is easy to be learnt, taught and practiced by the young surgeons.

Production and characterization of human anti-V3 monoclonal antibodies from the cells of HIV-1 infected Indian donors
Andrabi Raiees,Kumar Rajesh,Bala Manju,Nair Ambili
Virology Journal , 2012, DOI: 10.1186/1743-422x-9-196
Abstract: Background Analysis of human monoclonal antibodies (mAbs) developed from HIV-1 infected donors have enormously contributed to the identification of neutralization sensitive epitopes on the HIV-1 envelope glycoprotein. The third variable region (V3) is a crucial target on gp120, primarily due to its involvement in co-receptor (CXCR4 or CCR5) binding and presence of epitopes recognized by broadly neutralizing antibodies. Methods Thirty-three HIV-1 seropositive drug naive patients (18 males and 15 females) within the age range of 20–57 years (median = 33 years) were recruited in this study for mAb production. The mAbs were selected from EBV transformed cultures with conformationally constrained Cholera-toxin-B containing V3C (V3C-CTB) fusion protein. We tested the mAbs for their binding with HIV-1 derived proteins and peptides by ELISA and for neutralization against HIV-1 viruses by TZM-bl assays. Results We isolated three anti-V3 mAbs, 277, 903 and 904 from the cells of different individuals. The ELISA binding revealed a subtype-C and subtype-A specific binding of antibody 277 and 903 while mAb 904 exhibited cross reactivity also with subtype-B V3. Epitope mapping of mAbs with overlapping V3 peptides showed exclusive binding to V3 crown. The antibodies displayed high and low neutralizing activity against 2/5 tier 1 and 1/6 tier 2 viruses respectively. Overall, we observed a resistance of the tier 2 viruses to neutralization by the anti-V3 mAbs, despite the exposure of the epitopes recognized by these antibodies on two representative native viruses (Du156.12 and JRFL), suggesting that the affinity of mAb might equally be crucial for neutralization, as the epitope recognition. Conclusions Our study suggests that the anti-V3 antibodies derived from subtype-C infected Indian patients display neutralization potential against tier 1 viruses while such activity may be limited against more resistant tier 2 viruses. Defining the fine epitope specificities of these mAbs and further experimental manipulations will be helpful in identification of epitopes, unique to clade C or shared with non-clade C viruses, in context of V3 region.
A novel strategy for efficient production of anti-V3 human scFvs against HIV-1 clade C
Kumar Rajesh,Andrabi Raiees,Tiwari Ashutosh,Prakash Somi Sankaran
BMC Biotechnology , 2012, DOI: 10.1186/1472-6750-12-87
Abstract: Background Production of human monoclonal antibodies that exhibit broadly neutralizing activity is needed for preventing HIV-1 infection, however only a few such antibodies have been generated till date. Isolation of antibodies by the hybridoma technology is a cumbersome process with fewer yields. Further, the loss of unstable or slowly growing clones which may have unique binding specificities often occurs during cloning and propagation and the strongly positive clones are often lost. This has been avoided by the process described in this paper, wherein, by combining the strategy of EBV transformation and recombinant DNA technology, we constructed human single chain variable fragments (scFvs) against the third variable region (V3) of the clade C HIV-1 envelope. Results An antigen specific phage library of 7000 clones was constructed from the enriched V3- positive antibody secreting EBV transformed cells. By ligation of the digested scFv DNA into phagemid vector and bio panning against the HIV-1 consensus C and B V3 peptides followed by random selection of 40 clones, we identified 15 clones that showed V3 reactivity in phage ELISA. DNA fingerprinting analysis and sequencing showed that 13 out of the 15 clones were distinct. Expression of the positive clones was tested by SDS-PAGE and Western blot. All the 13 anti-V3 scFvs showed cross-reactivity against both the clade C and B V3 peptides and did not show any reactivity against other unrelated peptides in ELISA. Preliminary neutralization assays indicated varying degrees of neutralization of clade C and B viruses. EBV transformation, followed by antigen selection of lines to identify specific binders, enabled the selection of phage from un-cloned lines for scFv generation, thus avoiding the problems of hybridoma technology. Moreover, as the clones were pretested for antigen binding, a comparatively small library sufficed for the selection of a considerable number of unique antigen binding phage. After selection, the phage clones were propagated in a clonal manner. Conclusions This strategy can be efficiently used and is cost effective for the generation of diverse recombinant antibodies. This is the first study to generate anti-V3 scFvs against HIV-1 Clade C.
Desulphurization of Transportation Fuels by Per-Formic Acid Oxidant Using MoOx Loaded on ZSM-5 Catalyst  [PDF]
Waqas Ahmad, Imtiaz Ahmad
Journal of Power and Energy Engineering (JPEE) , 2017, DOI: 10.4236/jpee.2017.512011
Desulphurization of model and real oil samples was investigated using performic acid as oxidant assisted by air as co-oxidant. The catalysts used were Mo-oxide supported on ZSM-5 zeolite, which was synthesized in the laboratory and characterized by FT-IR, XRD, SEM and SSA analysis. In case of model oil, the optimum condition determined for complete oxidation of all the model compounds including thiophene, DBT and 4,6-DMDBT were; 60?C, 60 min, ambient pressure and air flow rate of 100 mL/min. The oxidation reactivity decreased from 4,6-DMDBT to DBT and thiophene, which was found to follow pseudo first order kinetics. The real oil sample used in the study included untreated naphtha (NP), light gas oil (LGO), heavy gas oil (HGO) and Athabasca bitumen (Bit.). In case of NP and LGO the sulfur removal of above 78% was attained whereas in case of HGO and Bit. samples about 60% of desulfurization was achieved.
Efficiency and Duality in Nondifferentiable Multiobjective Programming Involving Directional Derivative  [PDF]
Izhar Ahmad
Applied Mathematics (AM) , 2011, DOI: 10.4236/am.2011.24057
Abstract: In this paper, we introduce a new class of generalized dI-univexity in which each component of the objective and constraint functions is directionally differentiable in its own direction di for a nondifferentiable multiobjective programming problem. Based upon these generalized functions, sufficient optimality conditions are established for a feasible point to be efficient and properly efficient under the generalised dI-univexity requirements. Moreover, weak, strong and strict converse duality theorems are also derived for Mond-Weir type dual programs.
Visco-Elastic Boundary Layer Flow past a Stretching Plate and Heat Transfer with Variable Thermal Conductivity  [PDF]
Naseem Ahmad
World Journal of Mechanics (WJM) , 2011, DOI: 10.4236/wjm.2011.12003
Abstract: In the present paper, the boundary layer flow of Walters Liquid B Model over a stretching plate has been considered to solve heat flow problem with variable conductivity. First, using similarity transformation, the velocity components of velocity have been obtained. Then, the heat flow problem has been considered in two ways: 1) prescribed surface temperature (PST), and 2) prescribed stretching plate heat flux (PHF) in case of variable conductivity. Due to variable conductivity, temperature profile has its two part- one mean tempera-ture and other temperature profile induced due to variable conductivity. The related results have been dis-cussed with the help of graphs.
Intelligent MSW Biocell Approach for Efficient Methane Production  [PDF]
Ahmad Qasaimeh
Computational Water, Energy, and Environmental Engineering (CWEEE) , 2012, DOI: 10.4236/cweee.2012.12003
Abstract: The aim of this research is to provide approach to enhance methane production and to convert CO2 released into methane via anaerobic degradation. Despite CH4 has more global warming potential than CO2 but it is less available in the environment and it has fuel value. This research suggests approach that methane is being stimulated and carbon dioxide is being converted to methane. The methane enhancement herein is achieved via technical and intelligent processes. The technical processes entail leachate and carbon dioxide recirculation. The recirculated leachate is controlled via fuzzy intelligent system that acquires values of abiotic factors such as C:N:P, pH, temperature, and moisture content, and then these values are introduced to trained fuzzy system to decide the value of methane production quality. The fuzzy logic proceeds in systematic sequence as input, inference through rules, and output. If the fuzzy logic output decision indicates bad production, then the value of aboitic factors are dynamically altered with optimized combination of values. Carbon dioxide is being re-circulated in order to convert it biologically to methane by hydrogenotrophic methanogens. The hydrophobic permeable membranes are used as planes through the solid waste. These selective membranes are used to separate biogas and to have smooth and fast transfer of biogas from waste to the storage. The approach of this research is believed to be as a new generation of sustainable green bio-fuel biocells.
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