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Search Results: 1 - 10 of 5282 matches for " Rafaela Antunes Paz "
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Dinamica da distribui o diamétrica de povoamentos de Pinus taeda, na regi o de Ca ador, SC Dynamics of the diameter distribution of Pinus taeda stands, in the region of Ca ador, SC, Brazil
Saulo Jorge Téo,Samara Pozzan da Rocha,Aline Cristina Bortoncello,Rafaela Antunes Paz
Pesquisa Florestal Brasileira , 2011, DOI: 10.4336/2012.pfb.67.183
Abstract: O objetivo deste trabalho foi ajustar as fun es de densidade probabilísticas (fdp’s) Normal e SB de Johnson, para descrever as mudan as, com a idade, na estrutura diamétrica de povoamentos de Pinus taeda L., na regi o de Ca ador, SC. Os dados utilizados foram provenientes de parcelas temporárias e permanentes, com idades variando de 5 a 11,9 anos, agrupadas em classes com intervalos de 1 ano. Foram ajustadas as fdp’s e obtidas as estimativas dos parametros de assimetria e curtose. Por meio do teste de Kolmogorov-Smirnov, verificou-se que, para as idades de 5 a 7,9 anos, as fdp’s Normal e SB de Johnson n o apresentaram aderência satisfatória. As fdp’s SB de Johnson e Normal apresentaram melhor aderência para as idades de 8 a 9,9 e 10 a 11,9 anos, respectivamente. Utilizando a fdp Normal para analisar a dinamica da distribui o diamétrica, verificou-se um deslocamento das curvas de distribui o diamétrica para a direita, um “achatamento” e um “alargamento” destas curvas ao longo dos anos. A assimetria foi negativa para todas as idades, exceto para as idades de 8 a 8,9 anos. A curtose foi leptocúrtica para todas as idades, e platicúrtica para as idades de 8 a 8,9 anos. doi: 10.4336/2011.pfb.31.67.183 The objective of this work was to fit the probability density functions Normal and SB, to describe the changes, with age, in the diameter distribution of loblolly pine (Pinus taeda) stands, in the region of Ca ador, Santa Catarina State, Brazil. The data came from permanent and temporary plots, with ages ranging from 5 to 11,9, grouped in age classes with intervals of 1 year. The probability density functions were fitted and, the Kolmogorov-Smirnov test and the parameters of skewness and kurtosis were calculated. Basing on Kolmogorov-Smirnov test it was verified that, for ages from 5 to 7.9 years old, the Normal and SB functions didn’t show satisfactory adherence. The SB and Normal functions showed better adherence to the ages from 8 to 9.9 and from 10 to 11.9 years old, respectively. Using the Normal probability density functions to analyze the dynamics of the diameter distribution, it was found that there was a shift of the diameter distribution curves to the right, a “flatness” and an “wideness” of these curves, over the years. The skewness was negative for all ages, except for the age from 8 to 8.9 years old. The kurtosis was leptokurtic for all ages, except for age from 8 to 8.9 years old, which was platykurtic. doi: 10.4336/2011.pfb.31.67.183
An Analysis of the Growth Trajectory of Monsanto  [PDF]
Rafaela Di Sabato Guerrante, Adelaide Maria de Souza Antunes, Nei Pereira Jr.
iBusiness (IB) , 2010, DOI: 10.4236/ib.2010.23028
Abstract: The present article aims to present the trajectory of the Monsanto company in light of the main concepts and theories of Chandler, Penrose, Greiner and Fleck related to the growth dynamic of organizations. The analysis of the company’s history from its foundation in 1901 to 2008 allows for the identification of recurring behaviors essential to its trajectory of continuous growth, and offer proof of its propensity to self-perpetuate. The company’s organizational restructurings, decentralization of power, frequent diversification into related areas (foods, pharmaceuticals and genetically modified seeds), acquisition of, or forming of, joint ventures with companies already active in target markets, purchase of technological packages, contracting personnel specialized in areas of interest, long-term planning, use of the versatility and ambition of its leaders in the allocation of idle resources and services, amongst other activities, are hallmarks and characteristics of the journey of Monsanto.
Mapping of the Use of Waste as Raw Materials for Biogas Production  [PDF]
Rafaela Lora Grando, Fabiana Valeria da Fonseca, Adelaide Maria de Souza Antunes
Journal of Environmental Protection (JEP) , 2017, DOI: 10.4236/jep.2017.82010
Abstract: Anthropic methane emissions can largely be prevented or minimized using technologies that are already available. One such technology is anaerobic digestion (AD), which is used commercially around the world, especially in Europe and the United States, where some challenging targets have been set to diversify the energy mix with more renewable energy. This foresight study was designed to identify which technological solutions out of the many options available for biogas production are attracting most interest, for which purpose patent documents and scientific publications were analyzed. The aim is to identify which raw materials are most attractive for AD and biogas production. It was found that the raw materials that have attracted most research and patenting activity are sludge, sewage, and wastewater, livestock waste, and agriculture waste, which together account for 62% of all the patents filed and 74% of all the scientific publications. The countries most engaged in producing biogas from AD plants are China, Germany, and the United States. We also identified a rising trend in the use of biogas around the world, and a steady increase in the number of patents filed on the subject, especially in Japan and South Korea. This growth is driven, amongst other things, by strategic governmental actions, global environmental pacts, and the realization on the part of industry that anaerobic digestion can be used as an efficient method for treating waste and effluents.
R&D Landscape for Breast Cancer through Patent Documents  [PDF]
Adelaide M. S. Antunes, Iolanda M. Fierro, Rafaela Di Sabato Guerrante, Priscila Rohem dos Santos, Flavia Maria Lins Mendes
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.47A009

Cancer is a leading cause of death worldwide, and is estimated to be the cause of 13.1 million deaths in 2030. Breast cancer is the second cancer in the global mortality ranking, considering both sexes. Due to the burden of breast cancer worldwide, this paper aims to present an overview of the main R&D efforts focusing on breast cancer treatment. Patents were retrieved from the Derwent Innovations Index?, which has a specific code for pharmaceuticals related to breast cancer. A total of 423 patent documents filed in recent years were identified, of which 126 are exclusively for breast cancer, 169 for breast cancer and other cancers, and 128 are inventions related to the treatment of cancer and other diseases. The patent documents were classified into two large groups, the first of which had a predominance of claims for antibodies, proteins and polypeptides for use in medication production, while the second focuses on gene therapy, nucleotides and RNA. The country with the majority of priority patent applications was found to be the United States, followed by China and Japan.

Rafaela Dios Palomares,Jose Miguel Martínez Paz
Revista de Estudios Empresariales. Segunda época , 2010,
Abstract: This paper studies the level of technical efficiency in the olive oil production sector, applying econometric distance functions from a multioutput perspective. It not only regards the olive oil production but also takes into account the quality and environmental impact of the production process. These two latest outputs have been represented by mean of two corresponding indices. All the study has been performed on the basis of information on a 88 olive oil industries sample. Quality index collects different aspects in relation with olive oil proportion on the total production, critical points and traceability and the environmental index includes bad impacts on soil, water, and air, also considering noise and neighborhood disturbances. Three data sources have been used: a comprehensive survey of a sample of olive oil producers, their financial reports and the opinion of a group of experts in olive oil production techniques interviewed by means of the Delphi technique. The inputs are labor, capital and cash flow. Different econometric frontier model specifications have been estimated by maximum likelihood method considering tree orientations: outputs, inputs, and simultaneously both, the later having been carried out by mean of a hyperbolic distance consideration. A tobit model has been also applied in order to detect possible influences of some firm’s characteristics in the efficiency level.
Exame parasitológico de fezes de gatos (Felis catus domesticus) domiciliados e errantes da Regi?o Metropolitana do Rio de Janeiro, Brasil
Serra, Cathia Maria Barrientos;Uch?a, Claudia Maria Antunes;Coimbra, Rafaela Alonso;
Revista da Sociedade Brasileira de Medicina Tropical , 2003, DOI: 10.1590/S0037-86822003000300003
Abstract: in a survey of 131 faecal samples from rio de janeiro domiciliated and stray cats, 63,4% were positive with a higher prevalence among stray animals. ancylostoma sp (43.5%), toxocara sp (19.1%), cystoisospora sp (43.5%), uncinaria sp (1.5%), toxocaris leonine (7.6%), giardia sp (6.1%) and sarcocystis sp (0.8%) were found. this high prevalence suggests the need for improved control measures against cats to protect animal and human health.
Trends in Nanopharmaceutical Patents
Adelaide Antunes,Iolanda Fierro,Rafaela Guerrante,Flavia Mendes,Maria Simone de M. Alencar
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms14047016
Abstract: Investment in nanotechnology is now a given constant by governments, research centers and companies in both more developed countries and emerging markets. Due to their characteristics, such as high stability, ability to enable antigen identification on specific cells in the human body and controlling the release of drugs and, therefore, improving therapies, nanoparticles have been the subject of research and patent applications in the pharmaceutical field. According to the Organization for Economic Co-operation and Development (OCDE), patent data can be used as a source of information in order to measure science and technology activities. Thereby, this paper presents an analysis based on patent documents related to nanotechnology in the pharmaceutical sector. As a result, the analysis of patents demonstrate primarily that nanobiotechnology attracts high levels of R&D investments, including nanoparticle-based chemotherapeutic agents/drugs, monoclonal antibody nanoparticle complexes and their role in drug delivery or contrast agents with non-toxic effects.
Exame parasitológico de fezes de gatos (Felis catus domesticus) domiciliados e errantes da Regi o Metropolitana do Rio de Janeiro, Brasil
Serra Cathia Maria Barrientos,Uch?a Claudia Maria Antunes,Coimbra Rafaela Alonso
Revista da Sociedade Brasileira de Medicina Tropical , 2003,
Abstract: Foram estudadas 131 amostras de fezes de gatos de comportamento domiciliado e errante da Regi o Metropolitana do Rio de Janeiro, obtendo-se uma positividade de 63,4% das amostras, com maior ocorrência no grupo de animais errantes. Foi observado predomínio de parasitismo por Ancylostoma sp (43,5%), Toxocara sp (19,1%) e Cystoisospora sp (43,5%) em ambos os grupos. Também foram encontrados ovos de Uncinaria sp (1,5%), Toxascaris leonina (7,6%), cistos de Giardia sp (6,1%) e esporocistos de Sarcocystis sp (0,8%). A alta prevalência de enteroparasitas na amostra estudada ressalta a importancia de um maior controle parasitológico nesses animais, para prote o da saúde animal e humana.
Screening Test for Antibiotics in Medicinal Plants (STAMP): Using Powdered Plant Materials Instead of Extracts  [PDF]
Marielle Cascaes Inácio, Fabio Carmona, Tiago Antunes Paz, Maysa Furlan, Fernando Arcanjo da Silva, Bianca Waléria Bertoni, Suzelei de Castro Fran?a, Ana Maria Soares Pereira
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.412290

Plants are a rich source of antibiotics, but screening all the existing plant species for biological activity using current methods can be time and resource consuming. The present study is to investigate whether powdered plant materials would perform as well as plant extracts in the screening of plants with antimicrobial activity. In the new method proposed (STAMP), we compared in vitro antimicrobial activity of powdered plant materials from 12 species against bacteria and fungi. We confirmed these results with their corresponding aqueous (wet) and hydro-alcoholic extracts and one species testing the antimicrobial activity of two isolated compounds. Compared with hydro-alcoholic extracts, screening using the powdered plant materials correctly identified the majority of the species with antimicrobial activity against Candida albicans (sensitivity 91%, specificity 86%), C. parapsilosis (sensitivity 100%, specificity 67%), and Staphylococcus aureus (sensitivity 64%, specificity 86%). For bacteria, the method performed better in a pH of 9.0. The antimicrobial activity of two compounds isolated from one species (maytenin and netzahualcoyone) confirmed the results. In conclusion, the use of powdered plant materials for screening plants with antimicrobial properties is a cheap, widely available, technically easy, time sparing, reproducible, and sensitive method and can significantly shorten the time and money spent during drug development.

PinetoninaTM, an Intranasally Administered Essential Oil Preparation, Is Effective in Decrease of Cortisol Levels and on the Glutamate Release Modulation  [PDF]
Maira Jardim, Fernando Amaral, Valeria Maria de Souza Antunes, Fernando Rodrigues, Mariana Soares Alves de Souza, Fernanda Rossi Siqueto, Luiza Melanie Silva, Rafaela Alves Bertolino, Victor Cavalaro, Carlos Rocha Oliveira
Neuroscience & Medicine (NM) , 2018, DOI: 10.4236/nm.2018.93014
Abstract: Background: Most anxiety complaints are treated with pharmacological measures involving barbiturates and benzodiazepines, in which they may end up causing tolerance and pharmacological dependence. Integrative approaches such as aromatherapy are used in addition to medications to improve sleep quality and reduce anxiety. Thus, PinetoninTM, a phytocomplex obtained from a blend of essential oils aims to aid in the symptoms of stress and anxiety. Methods: The cytotoxicity of PinetoninTM was evaluated MTT assay using fibroblasts and astrocytes showed reduction in the cell viability only at high concentrations. Evaluation of intracellular calcium and determination of residual glutamate in the supernatant of astrocyte cultures showed agonist action of dihydroxyphenylglycine (DHPG) increasing linearly the concentration of intracellular calcium and the glutamate levels in the supernatants of the cultures. On the other hand, cultures of astrocytes treated with PinetoninTM showed residual glutamate levels in the supernatants reducing proportionally, as well as, intracellular calcium reduction. The determination of salivary cortisol showed a significant reduction in salivary cortisol levels in the group that received PinetoninTM. The evaluation of the electroencephalogram in patients treated with PinetoninTM had a significant increase (P < 0.05) in the frequency (Hz) of the alpha and beta waves. Results: A reduction in dose-dependent cell viability was observed when compared to cultures of PinetoninTM treated fibroblasts with control culture. When PinetoninTM and linole are administered in astrocytic cells, there was a reduction of the intracellular concentration of Ca2+ against a control group treated with DHPG agonist. The evaluation of salivary cortisol demonstrated a reduction when the patient group was treated with PinetoninTM
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