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Search Results: 1 - 10 of 7346 matches for " Rachna Gupta "
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Formulation and evaluation of enteric coated tablets of proton pump inhibitor
Anroop B Nair,Rachna Gupta,Rachna Kumria,Shery jacob
Journal of Basic and Clinical Pharmacy , 2010,
Abstract: The present study was an attempt to formulate and evaluate enteric coated tablets for esomeprazole magnesium trihydrate. Different core tablets were prepared and formulation (F-1) was selected for further enteric coating, based on the disintegration time. Seal coating was applied to achieve 3% weight gain using opadry . Enteric coating was carried out using different polymers like Eudragit L-30 D-55, hydroxy propyl methylcellulose phthalate, cellulose acetate phthalate and Acryl-EZE to achieve 5% weight gain. Disintegration studies showed that the formulations failed in 0.1 N HCl media. Hence the quantity of enteric coating was increased to 8% w/w. In vitro analysis of the developed tablets was carried out. Results from disintegration time and dissolution rate studies indicate that all the esomeprazole enteric tablets prepared possess good integrity, desirable for enteric coated tablets. Among the polymers studied, the methacrylic polymers exhibited better dissolution rate than the cellulose polymers. Stability studies indicate that the prepared formulations were stable for a period of three months. This study concluded that enteric coated tablets of esomeprazole can be prepared using any of the enteric coating polymer studied using a minimal weight gain of 8%.
Evaluation of a single-dose of intravenous magnesium sulphate for prevention of postoperative pain after inguinal surgery
Kiran Shashi,Gupta Rachna,Verma Deepak
Indian Journal of Anaesthesia , 2011,
Abstract: This study was undertaken to study efficacy of single dose of intravenous magnesium sulphate to reduce post-operative pain in patients undergoing inguinal surgery. One hundred patients undergoing inguinal surgery were divided randomly in two groups of 50 each. The patients of magnesium sulphate group (Group-I) received magnesium sulphate 50 mg/kg in 250 ml of isotonic sodium chloride solution IV whereas patients in control group (Group-II) received same volume of isotonic sodium chloride over 30 minutes preoperatively. Anaesthesia was induced with propofol (2 mg/kg) and pethidine (1 mg/kg). Atracurium besylate (0.5 mg/kg) was given to facilitate insertion of LMA. Pain at emergence from anaesthesia and 2, 4, 6, 12 and 24 hours after surgery was evaluated. The timing and dosage of rescue analgesic during first 24 hrs after operation was noted. Pain in postop period was significantly lower in magnesium sulphate group in comparison to control group at emergence from anaesthesia and 2, 4, 6, 12 and 24 hrs postop [1.86 vs. 1.96 (P=0.138), 1.22 vs. 1.82 (P=0.001), 1.32 vs. 1.88 (P=0.000), 2.74 vs. 3.84 (P=0.000), 1.36 vs. 2.00 (P=0.000) and 0.78 vs 1.30 (P=0.000), respectively]. Patients in group-I were more sedated as compared to group-II [sedation score 1.86 vs. 1.40 (P=0.000)]. Rescue analgesia requirement postoperatively in first 4, 8 and 16 hrs was significantly lower in patients of group-1 than in group- II [1.9 vs. 3.8 (P<0.05), 25.50 vs. 52.50 (P<0.05) and 0.000 vs. 7.5 (P<0.05)]. Preoperative magnesium sulphate infusion decreases postop pain and requirement of rescue analgesia.
Cerebrovascular complications in pediatric intensive care unit
Sachdev Anil,Sharma Rachna,Gupta Dhiren
Indian Journal of Critical Care Medicine , 2010,
Abstract: Cerebrovascular complications are being frequently recognized in the pediatric intensive care unit in the recent few years. The epidemiology and risk factors for pediatric stroke are different from that of the adults. The incidence of ischemic stroke is almost slightly more than that of hemorrhagic stroke. The list of diagnostic causes is increasing with the availability of newer imaging modalities and laboratory tests. The diagnostic work up depends on the age of the child and the rapidity of presentation. Magnetic resonance imaging, computerized tomography and arteriography and venography are the mainstay of diagnosis and to differentiate between ischemic and hemorrhagic events. Very sophisticated molecular diagnostic tests are required in a very few patients. There are very few pediatric studies on the management of stroke. General supportive management is as important as the specific treatment. Most of the treatment guidelines and suggestions are extrapolated from the adult studies. Few guidelines are available for the use of anticoagulants and thrombolytic agents in pediatric patients. So, our objective was to review the available literature on the childhood stroke and to provide an insight into the subject for the pediatricians and critical care providers.
Recent Updates on Free Radicals Scavenging Flavonoids: An Overview
Vivek Kumar Gupta,Rachna Kumria,Munish Garg,Monika Gupta
Asian Journal of Plant Sciences , 2010,
Abstract: Flavonoids are low molecular weight, polyphenolic compounds present in majority of vascular plants, possessing many therapeutic activities vis a vis antioxidant activity. The present review discuss the chemical nature, mechanism of action, current status, pharmacodynamic/pharmacokinetic studies, industrial significance, nutritive value in health system and analysis of flavonoids with the recent technology.
IDENTIFICATION OF T-CELL EPITOPE FOR PROTECTIVE ANTIGEN AND LETHAL FACTOR OF Bacillus anthracis - AN IMMUNOINFORMATICS APPROACH
Anuraj Nayarisseri, Mukesh Yadav, Sheaza Ahmed, Jyoti Sahu, Priyanka Gupta, Rachna Chourasia and Deepti Mittal
International Journal of Drug Discovery , 2012,
Abstract: Anthrax is an infectious disease caused by spores of the bacterium, Bacillus anthracis. The B. anthracis spores are highly resistant to inactivation and may be present in the soil, for example, for decades, occasionally infecting grazing animals that ingest the spores. Goats, sheep and cattle are examples of animals that may become infected. Human infection may occur by three routes of exposure to anthrax spores: cutaneous (through the skin), gastrointestinal (by ingestion) and pulmonary (inhalation). A major factor in the virulence of Bacillus anthracis is its secretion of three binary toxins, protective antigen, lethal toxin and edema toxin. These toxins possess a common cell receptor-binding (B) component but have distinct biochemically active (A) components. In traditional vaccine approaches made researchers to produce vaccine very easy. The current approach was based upon the insilico identification of T-Cell Epitopes and its binding affinity with MHC Class II. The T-Cell Epitope was identified using the HLAPred which identifies the peptide class that binds with both MHC Class I and II. Further the Epitope was analyzed for peptide characteristics such as antigenic nature, lipophilicity and solvent assessable. Out of all peptides the peptide which shows all the character for further analyzed for protein peptide interaction to find the high affinity binding peptide with low energy.
Financial Analysis Of Bharti Airtel
Rachna Bajaj
Golden Research Thoughts , 2013, DOI: 10.9780/22315063
Abstract: Financial analysis is done to evaluate capability, stability and profitability of a company. It is done through various financial ratios calculated from the financial statements of a company. Financial analysis helps investors to appraise whether they should invest in a particular company or not. The main objective of this study is to analyze the financial position of Bharti Airtel from the investors' point of view. It is done through various ratios calculated through financial statements of company for the period from 2005 to 2012. There are various tools and techniques of financial analysis out of these techniques Investigator has used ratio analysis for the analysis of financial statements of Bharti Airtel based on the secondary data including balance sheet and profit and loss account . Investigator has calculated various types of liquidity ratio, activity ratio and profitability ratio which helped to analyze and interpret real profit and liquidity position of the company. BHARTI AIRTELhas the largest market share from subscriber and revenue based in the telecom sector.
Batch, Fed Batch Production and Characterization of Glutaminase Free L-Asparaginase II of Pectobacterium carotovorum MTCC 1428 in Escherichia coli  [PDF]
Rachna Goswami, Krishnamoorthy Hegde, Venkata Dasu Veeranki
Advances in Microbiology (AiM) , 2014, DOI: 10.4236/aim.2014.410072
Abstract: The present study describes the production optimization of recombinant L-asparaginase II of Pectobacterium carotovorum MTCC 1428 in Escherichia coli BL21 (DE3) at batch and fed batch bioreactor level. Production of recombinant L-asparaginase II in batch and fed batch mode was found to be 1.34 and 5.38 folds higher, respectively as compared to shake flask culture. SDS-PAGE and native PAGE of the purified enzyme revealed that molecular mass of the subunits and native enzyme are ~37.5 kDa and ~150 kDa, respectively. Optimum range of pH and temperature for hydrolysis of L-asparagine were found to be 7.5 - 8.5 and 47°C - 52°C, respectively. The recombinant enzyme is very specific for its natural substrate, L-asparagine. The activity of recombinant L-asparaginase II is improved by mono cations and diverse effectors including Na+, K+, L-cystine, L-histidine, glutathione and 2-mercaptoethanol whereas, it is moderately inhibited by different divalent cations and thiol group blocking reagent. The kinetic parameters Km, Vmax, kcat and K
Achievement Motivation across Gender and Different Academic Majors
Chandra Shekhar,Rachna Devi
Journal of Educational and Developmental Psychology , 2012, DOI: 10.5539/jedp.v2n2p105
Abstract: Achievement motivation is considered a prerequisite for success in academic settings. The present study was carried out with the objectives to investigate the gender related differences and differences across academic majors on achievement motivation among college students. The study was carried on 80 undergraduate students of various colleges from Jammu region, 40 males and 40 females (ages 18-23 years) selected by purposive sampling method. As per research plan all 80 subjects were selected on the basis of gender (males and females) and academic majors (arts and sciences) using Achievement Motivation Scale. t- Test was used for deriving the results. Significant difference was found between the achievement motivation of sciences and arts stream students and achievement motivation among male and female college students. The differences indicate significant role of gender and academic majors in achievement motivation of college students.
Awareness and knowledge of mothers of under five children regarding immunization in Ahmedabad
Rachna Kapoor,Sheetal Vya
Healthline , 2010,
Abstract: Research question: What is the level of knowledge of mothers of Under Five Children, attending the Immunization centre of Postpartum Unit , VS General Hospital, Ahmedabad regarding immunization? Objective: To assess the awareness & knowledge of mothers of Under Five children regarding Immunization. Study Design: Cross sectional descriptive study. Study Area/ Setting: Immunization centre of Post Partum Unit, VS General Hospital, Ahmedabad. Participants & Sample size : 100 mothers of Under Five children were studied from March 2009 to May 2009. Results: Mean age of the respondents was 28.4 years. 72% of the respondents were housewives & 65% of them were Hindus. 83% of the literate mothers had some knowledge about VPDs. 85% of the respondents knew about poliomyelitis & only 15% knew about Hepatitis B. 80% of respondents had no knowledge about Vitamin A. Main sources of information of mothers about VPD’s was Anganwadi Worker 47% & Television 35%.
Negative pressure pulmonary oedema after rhinoplasty
Wadhwa Rachna,Kalra Seema
Indian Journal of Anaesthesia , 2010,
Abstract:
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