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Search Results: 1 - 10 of 324202 matches for " ROSSI Nádia F. "
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Análise dos critérios diagnósticos dos distúrbios do metabolismo de glicose e variáveis associadas à resistência insulínica
Costa, Augusto C. F.;Rossi, Adriana;Garcia, Nádia B.;Moreira, Ayrton C.;Foss, Milton C.;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2003, DOI: 10.1590/S1676-24442003000200006
Abstract: the diagnostic criteria of the glucose metabolism disorders had been established by the world health organization (who)/national data group (nddg) in the beginning of the 1980's. in 1997, the american diabetes association (ada) suggested new criteria, based upon the interpretation of the fasting glucose. in this study, 56 subjects underwent an oral glucose tolerance test (ogtt), and we have applied both criteria to estimate the prevalence of the glucose metabolism disorders. out of 56 subjects, 11 (19,6% - group 1) had been considered glucose intolerants by the criteria of the who/nddg and 6 (10,7% - group 2) as impaired fasting glycemia (ifg) by the ada new criteria. we have compared clinical and biochemical variables (age, bmi, insulin peak during ogtt, area under the insulin curve during ogtt and serum concentrations of igfbp-1) between both groups, not observing differences in any of the variables (43 ± 13 x 46 ± 4.4 years, 29.5 ± 3.2 x 27.2 ± 2.6kg/m2, 153.7 ± 100.7 x 171.3 ± 145.6μui/ml, 12,040 ± 8,488 x 13,970 ± 12,170 e 14.4 ± 9.3 x 19.4 ± 11.8ng/ml, respectively, p = ns). however, when we compare these same variables between the subjects considered normal by the ada criteria and intolerants by the who/nddg (n = 8, group 3) and the subjects considered normal by both criteria (n = 42, group 4), we observed that it also did not have difference in relation to age (42 ± 15 x 38 ± 10 years, respectively, ns), however, group 3 presents bmi (29.5 ± 3.9 x 24.5 ± 3.5kg/m2, respectively, p < 0.02), insulin peak (115.2 ± 29.1 x 84.4 ± 56.5μui/ml, respectively, p < 0.02) and area under the insulin curve (9,112 ± 2,323 x 6,649 ± 4,438, respectively, p < 0.007)with higher values than group 4. group 3 still presented serum concentration of igfbp-1 with lower values than group 4 (14.9 ± 10.1 x 28.9 ± 17.6ng/ml, respectively, p < 0.03).
Análise dos critérios diagnósticos dos distúrbios do metabolismo de glicose e variáveis associadas à resistência insulínica
Costa Augusto C. F.,Rossi Adriana,Garcia Nádia B.,Moreira Ayrton C.
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2003,
Abstract: Os critérios diagnósticos dos distúrbios do metabolismo de glicose foram estabelecidos pela Organiza o Mundial de Saúde (OMS)/National Diabetes Data Group (NDDG) no início da década de 1980. Em 1997, a American Diabetes Association (ADA) sugeriu novos critérios diagnósticos, baseados na interpreta o da glicemia de jejum. Neste estudo, 56 indivíduos foram submetidos ao teste de tolerancia à glicose oral (oGTT) (75g) e aplicamos ambos os critérios diagnósticos para estimar a prevalência de distúrbios de metabolismo de glicose. Dos 56 indivíduos, 11 (19,6% - grupo 1) foram considerados intolerantes pelos critérios da OMS/NDDG e seis (10,7% - grupo 2), como glicemia de jejum alterada (GJA) pelos novos critérios da ADA. Comparamos variáveis clínicas e bioquímicas (idade, índice de massa corporal, pico de insulina durante o oGTT, área sob a curva de insulina durante o oGTT e concentra es séricas basais da proteína carreadora dos fatores de crescimento insulina-símiles 1 (IGFBP-1) entre ambos os grupos, n o observando diferen a significativa em nenhuma das variáveis (43 ± 13 x 46 ± 4,4 anos, 29,5 ± 3,2 x 27,2 ± 2,6kg/m2, 153,7 ± 100,7 x 171,3 ± 145,6μUI/ml, 12.040 ± 8.488 x 13.970 ± 12.170 e 14,4 ± 9,3 x 19,4 ± 11,8ng/ml, respectivamente, p = NS). Entretanto, quando comparamos estas mesmas variáveis entre o grupo de indivíduos considerados normais pelos critérios da ADA e intolerantes pelos critérios da OMS/NDDG (n = 8, grupo 3) e o grupo de indivíduos considerados normais por ambos os critérios (n = 42, grupo 4), observamos que n o houve também diferen a em rela o à idade (42 ± 15 x 38 ± 10 anos, respectivamente, NS); entretanto o grupo 3 apresenta índice de massa corporal (IMC) (29,5 ± 3,9 x 24,5 ± 3,5kg/m2, respectivamente, p < 0,02), pico de insulina durante o oGTT (115,2 ± 29,1 x 84,4 ± 56,5μUI/ml, respectivamente, p < 0,02) e área sob a curva de insulina durante o oGTT (9.112 ± 2.323 x 6.649 ± 4.438, respectivamente, p < 0,007) com valores médios superiores ao grupo 4. O grupo 3 apresentou ainda concentra es séricas basais de IGFBP-1 com valores em média inferiores ao grupo 4 (14,9 ± 10,1 x 28,9 ± 17,6ng/ml, respectivamente, p < 0,03).
Análise da adultera o de méis por a úcares comerciais utilizando-se a composi o isotópica de carbono
ROSSI Nádia F.,MARTINELLI Luiz A.,LACERDA Tais H.M.,CAMARGO Plínio B. de
Ciência e Tecnologia de Alimentos , 1999,
Abstract: O mel é um alimento apreciado por seu sabor característico e pelo seu considerável valor nutritivo. Devido a oferta do produto ser menor que a procura, seu pre o é relativamente alto, incentivando sua adultera o. Geralmente, a adultera o do mel é feita através da adi o de a úcares comerciais, derivados de cana-de-a úcar e milho. Como essas plantas têm uma composi o isotópica do carbono distinta das plantas utilizadas pelas abelhas como fonte de néctar (flores silvestres, citros e eucaliptos), é possível utilizar a composi o isotópica do carbono de amostras de mel para se avaliar a adultera o desse produto por a úcares comerciais oriundos da cana e do milho. Foram analisadas amostras de plantas pertencentes ao ciclo fotos-sintético C3, subprodutos de plantas C4 (a úcares comerciais) e 61 amostras de mel obtidas no mercado. As plantas C3 analisadas apresentaram valores de d13C de -28,9±1,1? (n=8), enquanto os a úcares apresentaram valores de -11,1±0,7? (n=3). Das 61 amostras de mel analisadas, cerca de 8% (5 amostras) tiveram sinais claros de adultera o. A amostra de número 34 teve um valor igual a -12,9?, indicando que a úcar puro de cana-de-a úcar ou milho estaria sendo comercializado como mel. As amostras 13, 14, 33 e 54 apresentaram valores iguais a -21,0; -19,9; -21,9 e -17,6?, respectivamente. Esses valores indicam também adi o de a úcares de cana-de-a úcar ou milho, no entanto em menor propor o. A metodologia testada neste trabalho foi aprovada como um método simples, confiável e complementar aos métodos químicos e físicos convencionais visando detectar adultera o de mel.
Análise da adultera??o de méis por a?úcares comerciais utilizando-se a composi??o isotópica de carbono
ROSSI, Nádia F.;MARTINELLI, Luiz A.;LACERDA, Tais H.M.;CAMARGO, Plínio B. de;VICTóRIA, Reynaldo L.;
Ciência e Tecnologia de Alimentos , 1999, DOI: 10.1590/S0101-20611999000200008
Abstract: honey is a known product for its nutritional value. considering that offer is smaller than the market demand, honey is relatively expensive. this fact contribute to the incentive of its adulteration by commercial sugars derived from sugar cane and corn. as these plants have a distinct stable carbon isotope composition than plants commonly used by bees as sources of nectar, it is possible to use the stable carbon isotope composition of honey to detect addition of commercial sugar cane and corn sugars. in this study we analyzed samples of c3 plants commonly used by bees, subproducts of c4 plants, and 61 samples of honey. the d13c of c3 plants values had on average of -28.9±1.1? (n=8), while the commercial sugars had an average value of -11.1±0.7? (n=3). approximately 8% (5 samples) of the 61 samples analyzed had d13c values that clearly indicated the addition of commercial sugars (adulteration). the sample number 5 had a d13c valor equal to -12.9?, indicating that it was all made of commercial sugars. the samples numbers 13, 14, 33, and 54 had values equal to -21.0, -19.9, -21.9 and -17.6?, respectively. these values also indicated the addition of commercial sugars. the methodology used in this study proved to be a valuable and simple complement to the conventional chemical and physical methods normally used to detect honey adulteration.
Preven o de queimaduras: percep o de pacientes e de seus familiares
Rossidia Aparecida,Ferreira Enéas,Costa Elaine C.F.B.,Bergamasco Ellen C.
Revista Latino-Americana de Enfermagem , 2003,
Abstract: Os objetivos deste estudo foram investigar os meios de preven o de queimaduras identificados por pacientes vítimas de queimaduras e por seus familiares. Os dados foram coletados na Unidade de Queimados do Hospital das Clínicas da Faculdade de Medicina de Ribeir o Preto, mediante a realiza o de entrevistas com pacientes e seus familiares. Os dados foram categorizados por quatro juízes. Para verificar a existência de concordancia entre os juízes, quanto à categoriza o, foi utilizada a medida n o paramétrica de correla o - Coeficiente de Contingência. Foram entrevistados: 24 familiares de pacientes que sofreram queimaduras e 33 pacientes. Dos 33 pacientes entrevistados, 18 sofreram acidentes em ambiente doméstico. Dos 57 entrevistados, 11 afirmaram que n o poderiam ter contribuído para evitar o acidente. Vinte pacientes e 12 familiares identificaram situa es de risco no ambiente doméstico ou no trabalho, e 13 pacientes e 12 familiares n o identificaram qualquer tipo de situa o de risco. Os familiares e pacientes apontaram como medidas preventivas de acidentes por queimaduras: estar atento às atividades realizadas e ter cuidado com o manuseio de produtos inflamáveis.
Isolation of xylose isomerases by sequence- and function-based screening from a soil metagenomic library
Nádia Parachin, Marie F Gorwa-Grauslund
Biotechnology for Biofuels , 2011, DOI: 10.1186/1754-6834-4-9
Abstract: A soil metagenomic library was constructed and two screening methods based on protein sequence similarity and enzyme activity were investigated to isolate novel XI encoding genes. These two screening approaches identified the xym1 and xym2 genes, respectively. Sequence and phylogenetic analyses revealed that the genes shared 67% similarity and belonged to different bacterial groups. When xym1 and xym2 were overexpressed in a xylA-deficient Escherichia coli strain, similar growth rates to those in which the Piromyces XI gene was expressed were obtained. However, expression in S. cerevisiae resulted in only one-fourth the growth rate of that obtained for the strain expressing the Piromyces XI gene.For the first time, the screening of a soil metagenomic library in E. coli resulted in the successful isolation of two active XIs. However, the discrepancy between XI enzyme performance in E. coli and S. cerevisiae suggests that future screening for XI activity from soil should be pursued directly using yeast as a host.The soil habitat is an immensely diverse environment. One gram of soil may harbour up to ten billion bacteria belonging to more than 4,000 to 7,000 different species [1], although this value varies according to the soil type [2]. However, only 1% of the soil bacterial flora can be cultivated under standard laboratory conditions [3]. Metagenomics, which consists of the extraction, cloning and analysis of the entire genetic material in a given habitat [4,5], has emerged as a tool for assessing the genetic information from uncultivable microorganisms. Metagenomic libraries are a powerful source for discovering new biological activities and have already been successfully used to isolate novel hydrolytic enzymes such as amylases, cellulases and xylanases [6,7].The screening of metagenomic libraries, which is a critical step for the successful isolation of new and improved biological activities, can be performed by sequence homology or activity-based assays [8]. In
New diterpenoids from leaves of Guarea macrophylla (Meliaceae)
Lago, Jo?o Henrique G.;Roque, Nídia F.;
Journal of the Brazilian Chemical Society , 2005, DOI: 10.1590/S0103-50532005000400024
Abstract: the hexane phase from the ethanol extract from leaves of guarea macrophylla (meliaceae) was submitted to chromatographic separation. these procedures allowed the isolation of one new diterpenoid: 7a-hydroperoxy-isopimara-8(14),15-diene-2a,3b-diol, one new nor-diterpenoid: 19-nor-isopimara-7,15,4(18)-trien-3-one besides seven known diterpenoids. their structures were deduced by analysis of spectrometric data and comparison of data described in the literature.
Estudo fitoquímico da madeira de Guarea macrophylla (Meliaceae)
Lago, Jo?o Henrique G.;Roque, Nídia F.;
Química Nova , 2009, DOI: 10.1590/S0100-40422009000900022
Abstract: in the present work, the crude ethanol extract from wood of g. macrophylla was submitted to liquid/liquid partition between hexane, ch2cl2, etoac and n-buoh. each phase was individually chromatographed over silica gel, sephadex lh-20 or amberlite xad-2 to give eight terpene derivatives, such as five sesquiterpenoids (caryophyllene oxide, guai-6-en-10β-ol, spathulenol, aromadendrane-4β,10α-diol and aloaromadendrane-4α,10β-diol) as well as three triterpenoids (cicloart-24-ene-3β,23(r*)-diol, cicloart-24-ene-3β,23(s*)-diol, and cicloart-23e-ene-3β,25-diol). additionally, were isolated three fatty acids (linolenic, linoleic and stearic), two steroids (sitosterol and stigmasterol) and sacarose. the structures of all these compounds were characterized by spectrometric analysis, mainly mass spectrometry and nmr and comparison of these data described in the literature.
Evidence of inadequate docosahexaenoic acid status in Brazilian pregnant and lactating women
Torres,Alexandre G; Trugo,Nádia M F;
Revista de Saúde Pública , 2009, DOI: 10.1590/S0034-89102009000200018
Abstract: recently published data concerning dietary intake of fat and food sources of (n-3) long-chain polyunsaturated fatty acids (lcpufa) in brazil are reviewed together with data on biochemical indices of pufa status during pregnancy and lactation and pufa composition of breast milk in brazilian adolescents and adults. potential inadequacies of docosahexaenoic acid (dha) status among brazilian pregnant and lactating women have not yet been thoroughly evaluated. the data reviewed show that dietary intake of food sources of n-3 lcpufa is low and possibly deficient in brazil, and that biochemical indices of maternal dha status and breast milk dha content are low compared to the international literature. these data indicate inadequate dha status among brazilian women during pregnancy and lactation, but this evidence needs confirmation through comprehensive and specific population-based studies.
Effets pharmacologiques d’un extrait aqueux de Mirabilis jalapa L. (Nyctaginaceae) sur le système cardiovasculaire, la respiration et l’activité mécanique intestinale de mammifères
K Ndia, F Traore, K Kouakou, E Ehile
Afrique Science: Revue Internationale des Sciences et Technologie , 2009,
Abstract: L’extrait aqueux brut de Mirabilis jalapa (Mj) a des effets hypotenseurs, il active l’amplitude et la fréquence respiratoires du Lapin de 2,19.10-3 à 1,75.10-2 g/kg de P.C. De 4,27.10-4 à 1,54.10-2 g/kg de P.C., cette substance provoque une diminution de l’amplitude des ondes P, QRS et T de l’ECG ainsi qu’une baisse de la fréquence du coeur du Lapin. Ces effets, ainsi que les arythmies enregistrées à 1,54.10-2 g/kg de P.C. de Mj sont pratiquement abolis par l’Atropine à 1,28.10-6 g/kg de P.C. Cet extrait diminue le tonus de base de l’aorte de Cobaye entre 10-10 et 10-1 mg/mL et augmente l’amplitude des contractions rythmiques du duodénum de Lapin à partir de 2.10-4 g/mL. Ces effets rappellent ceux de l’acétylcholine. On en conclut que l’extrait aqueux de Mirabilis jalapa L. (Nyctaginaceae) contient des substances cholinomimétiques, ce, d’autant plus que les effets de Mirabilis jalapa sur l’ECG sont en grande partie abolis par l’Atropine, un inhibiteur compétitif de l’Acetylcholine. Mots-clés : Mirabilis jalapa, Acetylcholine, récepteurs muscariniques
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