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Search Results: 1 - 10 of 2290 matches for " ROMIEU ISABELLE "
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Uso de los datos de plumbemia para evaluar y prevenir el envenenamiento infantil por plomo en Latinoamérica
Romieu,Isabelle;
Salud Pública de México , 2003, DOI: 10.1590/S0036-36342003000800012
Abstract: exposure to lead is a widespread and serious threat to the health of children in latin america. health officials should monitor sources of exposure and health outcomes to design, implement, and evaluate prevention and control activities. to evaluate the magnitude of lead as a public health problem, three key elements must be defined: 1) the potential sources of exposure, 2) the indicators to evaluate health effects and environmental exposure, and 3) the sampling methods for the population at risk. several strategies can be used to select the study population depending on the study objectives, the time limitations, and the available resources. if the objective is to evaluate the magnitude and sources of the problem, the following sampling methods can be used: 1) population-based random sampling; 2) facility-based random sampling within hospitals, daycare centers, or schools; 3) target sampling of high risk groups; 4) convenience sampling of volunteers; and 5) case reporting (which can lead to the identification of populations at risk and sources of exposures). for all sampling methods, information gathering should include the use of a questionnaire to collect general information on the participants and on potential local sources of exposure, as well as the collection of biological samples. in interpreting data, one should consider the type of sampling used and the non-response rates, as well as factors that might influence blood lead measurements, such as age and seasonal variability. blood lead measurements should be integrated in an overall strategy to prevent lead toxicity in children.
Diet and breast cancer
Romieu,Isabelle;
Salud Pública de México , 2011, DOI: 10.1590/S0036-36342011000500011
Abstract: both diet and nutrition have been studied in relationship with breast cancer risk, as the great variation among different countries in breast cancer incidence could possibly be explained through the inflammatory and immune response, as well as antioxidant intake, among others.to date, no clear association with diet beyond overweight and weight gain has been found, except for alcohol consumption. nonetheless, the small number of studies done in middle to low income countries where variability of food intake is wider,is beginning to show interesting results.
Uso de los datos de plumbemia para evaluar y prevenir el envenenamiento infantil por plomo en Latinoamérica
Romieu Isabelle
Salud Pública de México , 2003,
Abstract: La exposición al plomo es una amenaza seria para la salud de los ni os, que se encuentra ampliamente distribuida en la Región de América Latina. Los funcionarios de salud pública necesitan identificar fuentes de exposición al plomo, así como sus efectos en la salud, para poder dise ar, implantar y evaluar las actividades preventivas y de control. Para evaluar la magnitud del problema del plomo es necesario definir tres elementos clave: a) las fuentes potenciales de exposición, b) los indicadores que se utilizarán para evaluar los efectos en la salud y la exposición en el medio ambiente, y c) las estrategias de muestreo de la población en riesgo. Se pueden utilizar varias estrategias con el fin de seleccionar la población blanco dependiendo de los objetivos del estudio, el tiempo límite y los recursos disponibles. Si el objetivo es evaluar la magnitud y las fuentes del problema pueden emplearse los siguientes métodos de muestreo: a) el muestreo al azar basado en la población; b) el muestreo al azar basado en las facilidades dentro de los hospitales, las guarderías o las escuelas; c) el muestreo objetivo de los grupos de alto riesgo; d) el muestreo de conveniencia (de voluntarios), y e) el reporte de los casos (éste puede conducir a la identificación de las poblaciones en riesgo, además de las fuentes de exposición). Para todos los dise os de muestreo, la información debe incluir tanto el uso de un cuestionario para el informe general de los participantes y de las fuentes potenciales locales de exposición, como la recolección de las muestras biológicas. En la interpretación de los datos se debe considerar el tipo de muestreo utilizado, el porcentaje de falta de respuesta y los factores que pueden influir en las mediciones del plomo en sangre, como la edad y la variación de la temporada. Las mediciones del plomo en la sangre se deben integrar dentro de una estrategia general para la prevención de toxicidad.
The role of obesity, physical activityand dietary factors on the risk for breast cancer: mexican experience
Romieu,Isabelle; Lajous,Martin;
Salud Pública de México , 2009, DOI: 10.1590/S0036-36342009000800007
Abstract: we provide an overview of the role of adiposity, physical activity and diet in the risk for breast cancer in mexican women. lack of physical activity, diets high in carbohydrates and in glycemic load and low intake of folate and vitamin b12 have been shown to increase the risk of breast cancer in mexican women, in particular postmenopausal breast cancer. other dietary factors that may begin to play a more relevant role in breast cancer incidence in mexico are alcohol intake and vitamin d status. recommendations to maintain a healthy weight, practice moderate physical activity, decrease intake of rapidly absorbed carbohydrates and increase consumption of fruits and vegetables could have an important impact on the epidemic of breast cancer in mexico.
Envenenamiento infantil por plomo
Romieu Isabelle,Palazuelos Eduardo
Salud Pública de México , 2003,
Abstract:
Role of Obesity in the Risk of Breast Cancer: Lessons from Anthropometry
Amina Amadou,Pierre Hainaut,Isabelle Romieu
Journal of Oncology , 2013, DOI: 10.1155/2013/906495
Abstract:
Role of Obesity in the Risk of Breast Cancer: Lessons from Anthropometry
Amina Amadou,Pierre Hainaut,Isabelle Romieu
Journal of Oncology , 2013, DOI: 10.1155/2013/906495
Abstract: An estimated 1.38 million new cases of breast cancer (BC) are diagnosed each year in women worldwide. Of these, the majority are categorized as invasive ductal cell carcinoma. Subgroups of BC are frequently distinguished into five “intrinsic” subtypes, namely, luminal A, luminal B, normal-like, HER2-positive, and basal-like subtypes. Epidemiological evidence has shown that anthropometric factors are implicated in BC development. Overall consistent positive associations have been observed between high body mass index (BMI) and waist-to-hip ratio (WHR) and the risk of BC among postmenopausal women, while conflicting results persist for premenopausal BC, both for BMI and for other anthropometric parameters as well as across ethnic groups. Furthermore, some evidence suggests that body size, body shape, and weight gain during childhood or adolescence may play a role in the risk of BC. In this paper, we describe the evidence linking anthropometric indices at different ages and BC risk, in order to improve our understanding of the role of body fat distribution in the risk of BC, investigate differences in these associations according to menopausal status and ethnic groups, and discuss the potential biological mechanisms linking body size and BC risk. 1. Introduction Breast cancer (BC) is the most frequently diagnosed cancer in women worldwide, accounting for 23% (1.38 million) of the total new cancer cases in 2008 [1, 2]. The majority of invasive breast neoplasms are categorized as “invasive ductal cell carcinoma, not otherwise specified” (ICD-O 8500/3) [3]. This entity has long been recognized to include tumors with heterogeneous molecular characteristics, characterized by distinct patterns of gene expression [4] and of genomic/genetic alterations [5]. Subgroups of BC are frequently distinguished into luminal A (estrogen/progesterone-positive), luminal B, HER2+, and so-called “triple negative” subtypes [6]. Among these subtypes, HER2+ and basal-like subtypes tend to be more common among premenopausal women, as well as in women of African ancestry. Luminal subtypes are more common in postmenopausal women and among Caucasians [7]. The incidence rates of BC show a heterogeneous distribution, while Western countries present the highest incidence rates, the lowest incidences are observed in low resource countries. BC ranks as the fifth cause of death from cancer overall (458,000 deaths), but is still the most frequent cause of cancer death in women in both developing (269,000 deaths) and developed regions (189,500 deaths) [1]. Incidence and mortality rates have
Particulate air pollution and daily mortality: Can results be generalized to Latin American countries?
ROMIEU,ISABELLE; BORJA-ABURTO,VíCTOR HUGO;
Salud Pública de México , 1997, DOI: 10.1590/S0036-36341997000500002
Abstract: objective. recently, a series of reports, based on ecological analyses of routinely collected data, have shown positive associations between measures of particle concentration and daily mortality counts in various cities of the us and europe. material and methods. we reviewed the process of generalization of these results to latin american countries addressing possible differences in air pollution mixtures, exposure profiles, and population susceptibility. results. a limitation to the process of generalization is the lack of a well-established biological mechanism by which particles may act on daily mortality. also, sources and levels of ambient air pollution as well as population characteristics and habits vary widely between northern communities of europe and the us, and latin american countries, which impairs the process of generalization. however, results of studies conducted in latin american countries suggest a similar effect to that observed in northern countries of europe and the us. conclusions. despite uncertainty about the mechanism, there is sufficient evidence that particles are harmful for health. control measures of particle emission are urgently needed in latin american countries. given the potential of misclassification of exposure, the dose-response relationship observed in northern europe and the us may not be adequate for latin american populations. there is a need for a new generation of epidemiological studies including a specific assessment of exposure to fine particles and of events surrounding death.
Efectos agudos de las partículas respirables y del dióxido de azufre sobre la salud respiratoria en ni os del área industrial de Puchuncaví, Chile
Sánchez Juan,Romieu Isabelle,Ruiz Silvia,Pino Paulina
Revista Panamericana de Salud Pública , 1999,
Abstract: Se investigó el efecto agudo de la contaminación atmosférica sobre la salud respiratoria en 114 ni os de 6 a 12 a os de edad residentes en la zona industrial de Puchuncaví, V Región de Chile: 57 con síntomas respiratorios crónicos y 57 asintomáticos. Durante 66 días se midieron diariamente los niveles de partículas respirables de tama o < 10 mym (PM10) y de dióxido de azufre (SO2) en el aire. Los participantes fueron seleccionados y clasificados según su susceptibilidad a la enfermedad respiratoria crónica, para lo cual se utilizó un cuestionario de síntomas respiratorios aplicado a un total de 882 ni os residentes en el área de influencia de las emisiones de una fundición de cobre y de una central termoeléctrica. Diariamente se registraron el flujo espiratorio máximo (FEM) y la incidencia de síntomas respiratorios. La asociación de los niveles de PM10 y SO2 con el FEM y la incidencia de tos, expectoración, sibilancias, disnea y uso de broncodilatadores fue estimada por modelos de regresión (ecuaciones estimativas generalizadas). En los ni os inicialmente sintomáticos, un incremento de 50 myg/m3 en el nivel medio diario de SO2 dio lugar a una reducción de -1,42 L/min (intervalo de confianza de 95% (IC95%): -2,84 a -0,71) en el FEM del día siguiente, mientras que un aumento de 30 myg/m3 en la concentración acumulada de tres días de PM10 produjo una disminución de -2,84 L/min (IC95%: -4,26 a 0,00). Con respecto a los síntomas, un aumento de 30 myg/m3 en el nivel medio semanal de PM10 se relacionó con un incremento de 26% (razón de posibilidades (RP) = 1,26; IC95%: 1,01 a 1,57) en la incidencia de tos y de 23% (RP = 1,23; IC95%: 1,00 a 1,50) en la incidencia de expectoración, un aumento de 50 myg/m3 en el nivel medio de SO2 durante tres días se asoció a un incremento de 5% (RP = 1,05; IC95%: 1,00 a 1,10) en la incidencia de expectoración y un aumento de 30 (myg/m3 en el promedio diario de PM10 incrementó el uso de broncodilatadores dos días más tarde en 10% (RP = 1,10; IC95%: 1,03 a 1,18). En los ni os inicialmente asintomáticos solo se registraron efectos significativos por la exposición a las PM10: tras un incremento de 30 myg/m3 en su nivel medio diario se observó una reducción de -1,34 L/min (IC95%: -2,68 a -0,67) en el FEM del día siguiente y un incremento similar en la exposición acumulada de tres días se asoció a un aumento de 9% en la incidencia de sibilancias (RP = 1,09; IC95%: 1,01 a 1,31). Se concluye que la salud respiratoria de los ni os residentes en el área industrial de Puchuncaví se ve afectada por los altos niveles de PM10 y SO2.
Particulate air pollution and daily mortality: Can results be generalized to Latin American countries?
ROMIEU ISABELLE,BORJA-ABURTO VíCTOR HUGO
Salud Pública de México , 1997,
Abstract: Objective. Recently, a series of reports, based on ecological analyses of routinely collected data, have shown positive associations between measures of particle concentration and daily mortality counts in various cities of the US and Europe. Material and methods. We reviewed the process of generalization of these results to Latin American countries addressing possible differences in air pollution mixtures, exposure profiles, and population susceptibility. Results. A limitation to the process of generalization is the lack of a well-established biological mechanism by which particles may act on daily mortality. Also, sources and levels of ambient air pollution as well as population characteristics and habits vary widely between Northern communities of Europe and the US, and Latin American countries, which impairs the process of generalization. However, results of studies conducted in Latin American countries suggest a similar effect to that observed in Northern countries of Europe and the US. Conclusions. Despite uncertainty about the mechanism, there is sufficient evidence that particles are harmful for health. Control measures of particle emission are urgently needed in Latin American countries. Given the potential of misclassification of exposure, the dose-response relationship observed in Northern Europe and the US may not be adequate for Latin American populations. There is a need for a new generation of epidemiological studies including a specific assessment of exposure to fine particles and of events surrounding death.
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