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Search Results: 1 - 10 of 188569 matches for " RIBEIRO MARLISE DE CASTRO "
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Paraplegia como manifesta??o inicial de medula presa: relato de caso
GUARDIOLA, ANA;PRATES, LISIANDRA ZILIO;RIBEIRO, MARLISE DE CASTRO;FERREIRA, MARCELO PAGLIOLI;
Arquivos de Neuro-Psiquiatria , 1999, DOI: 10.1590/S0004-282X1999000100020
Abstract: tethered spinal cord (tsc) is a rare disorder; it occurs when the conus medularis is anchored to the base of the vertebral canal by thickened filum terminale cysts, lipoma and spinal dysraphia. this disorder may cause paraplegia, sensory and sphincter disturbance. we report a twenty-two months-old girl presenting with paraplegia. tsc diagnostic was confirmed by myelotomography. the patient was submitted to surgical relief of tethered filum terminale.
The role of apoptosis, cell proliferation index, bcl-2, and p53 in glioblastoma prognosis
Ribeiro, Marlise de Castro;Coutinho, Lígia M. Barbosa;Hilbig, Arlete;
Arquivos de Neuro-Psiquiatria , 2004, DOI: 10.1590/S0004-282X2004000200014
Abstract: glioblastoma is the most common neuroectodermic tumor. it is also the most malignant one. many genetic changes are found in glioblastomas, among them, the presence of oncoproteins p53 and blc-2, as well as a high mitotic level and the presence of apoptosis. the utility of such findings through immunohistochemistry for the prognosis of patients remains uncertain. our objectives in this study were to verify the presence of apoptosis, blc-2, p53, and the proliferative index (mib-1), through immunohistochemistry, in 30 glioblastomas obtained by surgical resection between august 2000 and august 2001, as well as correlations between those immunohistochemical variables and the patient's age and survival time. correlations between immunohistochemical variables themselves were also examined. for correlation calculations, pearson's and spermann's correlations were used and the time of survival was calculated with the kaplan-meier method. results: no correlation was found between immunohistochemical variables and survival time. there was also no correlation between those variables and the patients' age. a moderate inverse correlation was found between the apoptotic index (ai) and the mitotic index (mi) (p = 0.058), besides an inverse correlation between blc-2 and mi. conclusion: our study has not demonstrated any of the examined immunohistochemical findings as having a predictive value in the prognosis of glioblastomas. a reverse correlation was found between ai and mi, which has already been demonstrated by a few studies, as well as an inverse correlation between blc-2 and mi. this finding can demonstrate blc-2 as having a pro-apoptotic role in this group of tumors.
The role of apoptosis, cell proliferation index, bcl-2, and p53 in glioblastoma prognosis
Ribeiro Marlise de Castro,Coutinho Lígia M. Barbosa,Hilbig Arlete
Arquivos de Neuro-Psiquiatria , 2004,
Abstract: Glioblastoma is the most common neuroectodermic tumor. It is also the most malignant one. Many genetic changes are found in glioblastomas, among them, the presence of oncoproteins p53 and blc-2, as well as a high mitotic level and the presence of apoptosis. The utility of such findings through immunohistochemistry for the prognosis of patients remains uncertain. Our objectives in this study were to verify the presence of apoptosis, blc-2, p53, and the proliferative index (MIB-1), through immunohistochemistry, in 30 glioblastomas obtained by surgical resection between August 2000 and August 2001, as well as correlations between those immunohistochemical variables and the patient's age and survival time. Correlations between immunohistochemical variables themselves were also examined. For correlation calculations, Pearson's and Spermann's correlations were used and the time of survival was calculated with the Kaplan-Meier method. RESULTS: No correlation was found between immunohistochemical variables and survival time. There was also no correlation between those variables and the patients' age. A moderate inverse correlation was found between the apoptotic index (AI) and the mitotic index (MI) (p = 0.058), besides an inverse correlation between blc-2 and MI. CONCLUSION: Our study has not demonstrated any of the examined immunohistochemical findings as having a predictive value in the prognosis of glioblastomas. A reverse correlation was found between AI and MI, which has already been demonstrated by a few studies, as well as an inverse correlation between blc-2 and MI. This finding can demonstrate blc-2 as having a pro-apoptotic role in this group of tumors.
Corpora amylacea in temporal lobe epilepsy associated with hippocampal sclerosis
Ribeiro Marlise de Castro,Barbosa-Coutinho Lígia,Mugnol Fabiana,Hilbig Arlete
Arquivos de Neuro-Psiquiatria , 2003,
Abstract: Hippocampal sclerosis (HS) is the commonest pathology in epileptic patients undergoing temporal lobe epilepsy surgery. Beside, there are an increased density of corpora amylacea (CA) founded in 6 to 63% of those cases. OBJECTIVE: verify the presence of CA and the clinical correlates of their occurrence in a consective series of patients undergoing temporal surgery with diagnosis of HS. METHOD: We reviewed 72 hippocampus specimens from January 1997 to July 2000. Student's t test for independent, samples, ANOVA and Tukey test were performed for statistical analysis. RESULTS: CA were found in 35 patients (49%), whose mean epilepsy duration (28.7 years) was significantly longer than that group of patients without CA (19.5 years, p= 0.001). Besides, when CA were found, duration was also significantly correlated with distribution within hippocampus: 28.7 years with diffuse distribution of CA, 15.4 with exclusively subpial and 17.4 years with distribution subpial plus perivascular (p= 0.001). CONCLUSION: Our findings corroborate the presence of CA in patients with HS and suggest that a longer duration of epilepsy correlate with a more distribution of CA in hippocampus.
Paraplegia como manifesta o inicial de medula presa: relato de caso
GUARDIOLA ANA,PRATES LISIANDRA ZILIO,RIBEIRO MARLISE DE CASTRO,FERREIRA MARCELO PAGLIOLI
Arquivos de Neuro-Psiquiatria , 1999,
Abstract: A medula presa (MP) é entidade pouco frequente que ocorre quando há restri o da migra o normal do cone medular por cistos, lipomas ou disrafismos espinhais. Esta patologia pode levar a paraplegia, distúrbios sensoriais e esficterianos. Relatamos o caso de uma menina de 22 meses que consultou com quadro de paraplegia. O diagnóstico de medula presa foi confirmado pela mielotomografia e a paciente foi submetida à cirurgia para libera o do filo terminal.
Disfagia e acidente vascular cerebral: rela??o entre o grau de severidade e o nível de comprometimento neurológico
Itaquy, Roberta Baldino;Favero, Samara Regina;Ribeiro, Marlise de Castro;Barea, Liselotte Menke;Almeida, Sheila Tamanini de;Mancopes, Renata;
Jornal da Sociedade Brasileira de Fonoaudiologia , 2011, DOI: 10.1590/S2179-64912011000400016
Abstract: the aim of this case study was to verify the occurrence of dysphagia in acute ischemic stroke within 48 hours after the onset of the first symptoms, in order to establish a possible relationship between the level of neurologic impairment and the severity degree of dysphagia. after emergency hospital admission, three patients underwent neurological clinical evaluation (general physical examination, neurological examination, and application of the national institute of health stroke scale - nihss), and clinical assessment of swallowing using the protocolo fonoaudiológico de avalia??o do risco para disfagia (pard - speech-language pathology protocol for risk evaluation for dysphagia). one of the patients presented functional swallowing (nihss score 11), while the other two had mild and moderate oropharyngeal dysphagia (nihss scores 15 and 19, respectively). the service flow and the delay on the patients' search for medical care determined the small sample. the findings corroborate literature data regarding the severity of the neurological condition and the manifestation of dysphagia.
Expression of nestin and vimentin in gliomatosis cerebri
Hilbig, Arlete;Barbosa-Coutinho, Lígia Maria;Toscani, Nadima;Ribeiro, Marlise de Castro;Cunha, Bartira Silveira Campos da;
Arquivos de Neuro-Psiquiatria , 2006, DOI: 10.1590/S0004-282X2006000500015
Abstract: gliomatosis cerebri (gc) is a rare form of cns neoplasia in which there is diffuse involvement of the nervous tissue with or without the presence of tumor mass. the origin of the tumor is unknown, nor whether it represents a disease with diffuse onset or infiltration from a neoplastic focus. here we studied the histopathologic characteristics of 6 cases with a diagnosis of gc and performed an immunohistochemical analysis using glial fibrillary acidic protein (gfap), synaptophysin, nestin and vimentin. most tumor cells were negative for gfap, even though there were foci of positivity for this marker in all cases. we detected the presence of many positive cells for nestin and vimentin in all studied samples. the presence of these cells may indicate origin of the tumor from undifferentiated cells with a high degree of mobility.
Corpora amylacea in temporal lobe epilepsy associated with hippocampal sclerosis
Ribeiro, Marlise de Castro;Barbosa-Coutinho, Lígia;Mugnol, Fabiana;Hilbig, Arlete;Palmini, André;Costa, Jaderson Costa da;Paglioli Neto, Eliseu;Paglioli, Eduardo;
Arquivos de Neuro-Psiquiatria , 2003, DOI: 10.1590/S0004-282X2003000600010
Abstract: hippocampal sclerosis (hs) is the commonest pathology in epileptic patients undergoing temporal lobe epilepsy surgery. beside, there are an increased density of corpora amylacea (ca) founded in 6 to 63% of those cases. objective: verify the presence of ca and the clinical correlates of their occurrence in a consective series of patients undergoing temporal surgery with diagnosis of hs. method: we reviewed 72 hippocampus specimens from january 1997 to july 2000. student's t test for independent, samples, anova and tukey test were performed for statistical analysis. results: ca were found in 35 patients (49%), whose mean epilepsy duration (28.7 years) was significantly longer than that group of patients without ca (19.5 years, p= 0.001). besides, when ca were found, duration was also significantly correlated with distribution within hippocampus: 28.7 years with diffuse distribution of ca, 15.4 with exclusively subpial and 17.4 years with distribution subpial plus perivascular (p= 0.001). conclusion: our findings corroborate the presence of ca in patients with hs and suggest that a longer duration of epilepsy correlate with a more distribution of ca in hippocampus.
Immunohistochemical expression of markers Ki-67, neun, synaptophysin, p53 and HER2 in medulloblastoma and its correlation with clinicopathological parameters
Meurer, Rosalva Thereza;Martins, Daniele Tondolo;Hilbig, Arlete;Ribeiro, Marlise de Castro;Roehe, Adriana Vial;Barbosa-Coutinho, Ligia Maria;Fernandes, Marilda da Cruz;
Arquivos de Neuro-Psiquiatria , 2008, DOI: 10.1590/S0004-282X2008000300020
Abstract: medulloblastoma (mb) is the most common malignant brain tumor in childhood. the alterations found include: presence of oncoproteins p53 and her2, elevated mitotic index, and presence of neuronal differentiation. the aim of this study was to determine the immunohistochemical expression of markers ki-67, neun, synaptophysin, her2 and p53 in 40 mb samples and their correlation with clinicopathologic parameters and survival. in 29 patients (72.5%), >20% of cells were positive for ki-67. males showed greater ki-67 expression (p=0.02) and smaller survival rates (p=0.002). neun and synaptophysin were negative in 16 (40%) and 8 (20%) cases, respectively. p53 was positive in 18 (45%) cases, with 11 (61%) weakly positive and 7 (39%) strongly positive. her2 was positive in 23 (57.5%) of the samples and did not show statistical association with survival (p=0.07).
Caso Ouro Fino Saúde Animal
Castro, Bernardo Hauch Ribeiro de;
REAd. Revista Eletr?nica de Administra??o (Porto Alegre) , 2012, DOI: 10.1590/S1413-23112012000100010
Abstract: the present teaching case illustrates a decision-making by company executives, on entry into a new market of vaccines for cattle. faced with the need to take a major step toward sustainable growth, ouro fino saúde animal could not fail, as long as it represented more than half the market of veterinary products. however, it was a risky step. the main issue of the case is to evaluate wether to buy third-part vaccines or to produce internally their own vaccines. the case company is ouro fino saúde animal, a brazilian industry of veterinary products, located in the state of s?o paulo, with sales over r$ 100 million annually. the two main characters of this case are the financial and industrial directors. the situation is set in 2005. as a teaching tool, the case was designed for teaching strategy in post-graduate in management, leading students to assess the advantages and disadvantages of each alternative. as a secondary objective, the case provides some elements for an estimate of the viability of the option to start a new production unit and the possibility of reflecting on a decision already made, to enter the new market. finally, the case has a lot of information about the brazilian and the global market for veterinary products. it is possible, based on these data, work on segmentation and positioning topics, left to the discretion of the teacher such use.
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