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Search Results: 1 - 10 of 1437 matches for " RAMON "
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Waning Sovereignty? The Kindred Myths of “Origins” and “Vanishing” of the State  [PDF]
Ramon Maiz
Open Journal of Political Science (OJPS) , 2017, DOI: 10.4236/ojps.2017.73032
Abstract: This article discusses, from an historical-neo-institutionalist and relational-strate- gic perspective, the postmodern thesis of the end of the state due to the increasing processes of world globalization. The main hypothesis is that the arguments which predict the structural crisis or the disappearance of the State in the age of neo-liberal globalization have their roots in a theoretically and historically implausible concept of sovereignty that ignores and distorts central aspects of statehood and state-building in terms of both institutional structure and political action. The myth of the “origins” of the State in Medieval or Renaissance times shares with the postmodern vision of the “vanishing” of the state, the same underlying misconception of the scope and limits of the state power. Sovereignty (the monopolization of political power) was always a claim, a desiderata, a contested andunfinished political project not an accomplished empirical fact.
Investigating the robustness of the classical enzyme kinetic equations in small intracellular compartments
Ramon Grima
BMC Systems Biology , 2009, DOI: 10.1186/1752-0509-3-101
Abstract: Starting from a master equation description of enzyme reaction kinetics and assuming metabolic steady-state conditions, we derive novel mesoscopic rate equations which take into account (i) the intrinsic molecular noise due to the low copy number of molecules in intracellular compartments (ii) the physical nature of the substrate transport process, i.e. diffusion or vesicle-mediated transport. These equations replace the conventional macroscopic and deterministic equations in the context of intracellular kinetics. The latter are recovered in the limit of infinite compartment volumes. We find that deviations from the predictions of classical kinetics are pronounced (hundreds of percent in the estimate for the reaction velocity) for enzyme reactions occurring in compartments which are smaller than approximately 200 nm, for the case of substrate transport to the compartment being mediated principally by vesicle or granule transport and in the presence of competitive enzyme inhibitors.The derived mesoscopic rate equations describe subcellular enzyme reaction kinetics, taking into account, for the first time, the simultaneous influence of both intrinsic noise and the mode of transport. They clearly show the range of applicability of the conventional deterministic equation models, namely intracellular conditions compatible with diffusive transport and simple enzyme mechanisms in several hundred nanometre-sized compartments. An active transport mechanism coupled with large intrinsic noise in enzyme concentrations is shown to lead to huge deviations from the predictions of deterministic models. This has implications for the common approach of modeling large intracellular reaction networks using ordinary differential equations and also for the calculation of the effective dosage of competitive inhibitor drugs.The inside of a cell is a highly complex environment. In the past two decades, detailed measurements of the chemical and biophysical properties of the cytoplasm have es
Use of intravenous antiarrhythmics to identify concealed Brugada syndrome
Ramon Brugada
Trials , 2000, DOI: 10.1186/cvm-1-1-045
Abstract: Over the past 50 years, the survival and quality of life of patients with cardiac disease has improved tremendously. Despite continued progress in technology and drug therapy, it seems that progress may have reached a plateau. The majority of our patients suffer from structural heart diseases, such as atherosclerosis and primary myocardial disease, that often progress despite our best efforts.The situation is completely different, however, when cardiac arrest strikes a healthy young person with no previous medical history. In this case, there is pressure not only on the patient and physician but also on family members, as there is a higher likelihood that the patient is suffering from a genetically determined disease predisposing to sudden death. It is at this point that there is a clash between the bench and the bedside, with physicians and family demanding a genetic test that will provide a definite diagnosis. The advances in molecular cardiology and genetics have been spectacular if one thinks that it has been only 10 years since the identification of the first gene predisposing to a familial cardiac disease. It is expected that our knowledge of cardiac disease will grow exponentially in the next few years thanks to the advances in the Human Genome Project. The reality, though, is that the technology has not yet evolved enough to be able to complete a genetic screen in a few days.Among the different diseases which are genetically determined, Brugada syndrome has benefited tremendously from the developments in molecular biology. The diagnosis is based on a clinical-electrocardiographic criteria consisting of syncopal or aborted sudden death episodes occurring in patients with a structurally normal heart, who also present with a characteristic ECG pattern of right bundle branch block and ST segment elevation in leads V1 to V3. The episodes of syncope and sudden death (aborted) are caused by fast polymorphic ventricular tachycardias [1].The first case series showing
Directed cell migration in the presence of obstacles
Ramon Grima
Theoretical Biology and Medical Modelling , 2007, DOI: 10.1186/1742-4682-4-2
Abstract: We propose that cells can sense the presence of obstacles and avoid them because obstacles interfere with the chemical field. We build a model to test this hypothesis and find that this naturally enables efficient at-a-distance sensing to be achieved with no need for a specific and active obstacle-sensing mechanism. We find that (i) the efficiency of obstacle avoidance depends strongly on whether the chemotactic chemical reacts or remains unabsorbed at the obstacle surface. In particular, it is found that chemotactic cells generally avoid absorbing barriers much more easily than non-absorbing ones. (ii) The typically low noise in a cell's motion hinders the ability to avoid obstacles. We also derive an expression estimating the typical distance traveled by chemotactic cells in a 3D random distribution of obstacles before capture; this is a measure of the distance over which chemotaxis is viable as a means of directing cells from one point to another in vivo.Chemotactic cells, in many cases, can avoid obstacles by simply following the spatially perturbed chemical gradients around obstacles. It is thus unlikely that they have developed specialized mechanisms to cope with environments having low to moderate concentrations of obstacles.Directed cell motion is a common feature of many cells and micro-organisms; this movement can be induced by a number of factors including light (phototaxis), gravity (gravitotaxis) and various chemicals (chemotaxis). The last of these is the most pervasive natural form of taxis. The bacteria Escherichia coli and Salmonella typhimurium, the slime mould Dictyostelium discoideum, and neutrophils [1] are a few of the many well studied examples of chemotactic life-forms. Chemotaxis involves the detection of a local chemical gradient and the subsequent movement of the organism up (positive chemotaxis) or down (negative chemotaxis) the gradient. For example, Dictyostelium discoideum follows trails of folic acid secreted by its food source, bacte
Latinos(as) y la descolonización del imperio estadounidense en el siglo XXI
Tabula Rasa , 2007,
Abstract: despite appearances, the united states empire finds itself in an accelerated decay. there are many fights, such as anti-capitalist, anti-imperialist, and anti-patriarchic taking place in the interior of this empire, invisible to the peoples that live through the ominous consequences in latin america, africa, asia and middle east. this article presents the dilemmas that the united states empire faces related to the growth of the latin populations and the decolonialization from its interior. in a few decades, white people in the united states will be a demographic minority. current racial minorities will be the majorities; latinos will be the majority of the minority groups. the empire is struggling with new forms of apartheid (neoapartheid) and de-colonization of white supremacy. because of their strategic importance, the upcoming fights will be acute and defining for the future of all humanity.
Hacia un pluri-versalismo transmoderno decolonial
Tabula Rasa , 2008,
Abstract: this article discusses the concept of the universal in the western philosophical tradition and proposes other, decolonial ways to think about uni-versality as pluri-versality, based on the thinking of aimé cesaire, enrique dussel and the zapatistas. the first part discusses the concept of “universal” from descartes to marx, covering kant and hegel. the second part discusses the other concept of universal which is proposed by aimé cesaire from an afro-caribbean decolonial perspective. the third part analyzes the concept of universal implied in the notion of transmodernity proposed by enrique dussel. the fourth part discusses the difference between postmodernity and transmodernity using as an example the postmodern notion of hegemony proposed by laclau and the transmodern and pluriversal notion of politics proposed by the zapatistas in the other campaign. finally, the article discusses the implications of all this for the leftist debate about the vanguard party versus the rearguard movement.
Tachyon-Chaplygin inflation on the brane
Herrera, Ramon
High Energy Physics - Phenomenology , 2008, DOI: 10.1007/s10714-008-0703-8
Abstract: Tachyon-Brane inflationary universe model in the context of a Chaplygin gas equation of state is studied. General conditions for this model to be realizable are discussed. In the high-energy limit and by using an exponential potential we describe in great details the characteristic of this model. Recent observational data from the Wilkinson Microwave Anisotropy Probe experiment are employed to restrict the parameters of the model.
Hacia un pluri-versalismo transmoderno decolonial
Tabula Rasa , 2008,
Abstract: Este artículo discute el concepto de Universal en la tradición filosófica occidental y propone maneras otras, decoloniales, de pensar la Uni-versalidad como Pluri-versalidad a partir del pensamiento de Aimé Césaire, Enrique Dussel y los zapatistas. La primera parte discute el concepto de Universal desde Descartes hasta Marx pasando por Kant y Hegel. La segunda parte discute el concepto otro de universal que desde una perspectiva decolonial afro-caribe a propone Aimé Césaire. La tercera parte analiza el concepto de universal implicado en la noción de transmodernidad propuesto por Enrique Dussel. La cuarta parte discute la diferencia entre posmodernidad y transmodernidad usando como ejemplo la noción posmoderna de hegemonía propuesta por Laclau y la noción transmoderna y pluriversal de la política propuesta por los Zapatistas en la Otra Campa a. Finalmente, se discuten las implicaciones de todo esto para el debate de la izquierda acerca del partido de vanguardia vs. movimiento de retaguardia.
SPECIAL REPORT: Socialism is Dead! Long Live Socialism! Reflections on the Communist Manifesto
Ramon Casiple
Kasarinlan : Philippine Journal of Third World Studies , 2000,
Abstract: The relevance of the Communist Manifesto in the era of global capitalism was questioned following the collapse of the Soviet model of socialism and the failure of socialism elsewhere. The masterwork of Karl Marx and Friedrich Engels foresaw the divergent paths which capitalism will take economies as well as the resulting inequality and poverty amid plenty. In the past 150 years, the correctness of the Manifesto's analysis of the capitalist system and its flaws, the periodic crises of overproduction, its tendencies towards concetration of capital and towards alienation of labor, its devaluation and destruction of every social nexus, and the revolutionary role of the proletarian class has been proven and refuted. Despite its imperfections, the Manifesto is the standard by which all alternative paradigms are measured. If the socialists and socialism can keep up, the Manifesto may yet liberate humankind from capitalism, perhaps within the next 150 years.
On a class of continous flow
Ramon Mogollon
International Journal of Mathematics and Mathematical Sciences , 1980, DOI: 10.1155/s0161171280000191
Abstract: This paper involves characterizations of a class of continuous flows. The flows considered are those in which the positive prolongation of each point coincides with the trajectory through the point. The characterizations are based on the theory of prolongation.
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