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Search Results: 1 - 10 of 225298 matches for " R.Rajesh "
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Sodium Glucose Co transporter 2 (SGLT2) Inhibitors: A New Sword for the Treatment of Type 2 Diabetes Mellitus
R.Rajesh,,Patel Naren,Sudha vidyasagar,,Unnikrishnan
International Journal of Pharma Sciences and Research , 2010,
Abstract: The low affinity sodium glucose cotransporter (SGLT2) plays a major role in physiology of glucose reabsorption from proximal part of kidney. Almost all glucose excreted through glomerular filtration, isreabsorbed via SGLT2 until blood glucose level reaches to its hreshold value for glucose excretion i.e. ~180mg/dl. Increasing the glucose excretion by inhibiting the SGLT2 is the novel approach for the treatment of diabetes. Safe and normal life of patients having familial renal glucosuria due to SLC5A2 gene mutation is accelerating the development of SGLT2 inhibitors. Weight loss and very low risk of hypoglycemia are the potential benefits of these inhibitors. There are number of molecules in this class under the stage of development.
Safety Aspects of Antiretroviral Therapy for Management of HIV Infection
R.Rajesh,Sudha vidyasagar,Patel Naren,ManjuVarghese
Journal of Basic and Clinical Pharmacy , 2010,
Abstract: There are four classes of antiretroviral agents used in the treatment of HIV/AIDS. Adverse effects to Highly Active Antiretroviral Therapy (HAART) are common and often difficult to avoid. In many cases, research is not able to identify the exact cause of an adverse event. The severity of adverse reactions varies greatly and difficult to manage; typically prevention is more desirable than treatment. However, this is not always true. This paper will review safety aspect of class-wide Highly Active Antiretroviral Therapy, mechanism of action. A class-wide adverse effect for Reverse transcriptase inhibitors includes lactic acidosis, peripheral neuropathy and lipoatrophy. Class wide adverse effects to non-nucleoside reverse transcriptase inhibitors include rash and hepatotoxicity, while efavirenz has its own unique CNS reactions. Protease inhibitor side effects include hyperglycemia, lipoaccumulation, dyslipidemia, and gastrointestinal (GI) intolerance. Coreceptor CCR5 antagonists, which provide a novel mechanism of action, are a recent addition to the armamentarium of antiretroviral agents. Antiretroviral are an important break-through in the treatment of HIV/AIDS. However, adverse reactions from these drugs can range from mild to life-threatening, and determining which agent is the cause is frequently difficult to discern. Fortunately, side effects can be monitored, treated and in many cases, prevented.
Multi-Avalanche Correlations in Directed Sandpile Models
R. Rajesh
Physics , 2008, DOI: 10.1209/0295-5075/85/10001
Abstract: Multiple avalanches, initiated by simultaneously toppling neighbouring sites, are studied in three different directed sandpile models. It is argued that, while the single avalanche exponents are different for the three models, a suitably defined two-avalanche distribution has identical exponents. The origin of this universality is traced to particle conservation.
Nonequilibrium phase transitions in models of adsorption and desorption
R. Rajesh
Physics , 2004, DOI: 10.1103/PhysRevE.69.036128
Abstract: The nonequilibrium phase transition in a system of diffusing, coagulating particles in the presence of a steady input and evaporation of particles is studied. The system undergoes a transition from a phase in which the average number of particles is finite to one in which it grows linearly in time. The exponents characterizing the mass distribution near the critical point are calculated in all dimensions.
Software Selection in Manufacturing Industries Using a Fuzzy Multiple Criteria Decision Making Method, PROMETHEE  [PDF]
Intelligent Information Management (IIM) , 2009, DOI: 10.4236/iim.2009.13023
Abstract: This paper presents an effective decision making framework for software selection in manufacturing industries using a multiple criteria decision making method, Preference Ranking Organization Method for Enrichment Evaluations (PROMETHEE). The method is improved in the present work by integrating with analytic hierarchy process (AHP) and the fuzzy logic. Fuzzy logic is introduced to handle the imprecision of the human decision making process. The proposed decision making framework is practical for ranking competing software products in terms of their overall performance with respect to multiple criteria. An example is included to illustrate the approach.
Gabapentin for the treatment of behavioral and psychological symptoms of dementia  [PDF]
Rajesh R. Tampi, Banu Ozkan, Deena Williamson
Advances in Alzheimer's Disease (AAD) , 2012, DOI: 10.4236/aad.2012.12002
Abstract: Objective: To examine the efficacy of gabapentin for the treatment of behavioral and psychological symptoms of dementia (BPSD). Design: A retrospective chart review. Settings: Tertiary care geriatric psychiatry inpatient unit. Participants: 230 patients with BPSD. Measurements: The socio-demographic information, type of behaviors, co-morbid psychiatric and medical diagnoses, daily doses of medications and side-effects were recorded. Results: Of the 230 patients, 22 were treated with gabapentin. Twenty of these patients were on a combination of gabapentin and an antipsychotic medication while two patients were treated with gabapentin monotherapy. Eighteen of the 20 patients in the combination group tolerated the treatments with little or no side effects as did the two patients in the monotherapy group. Conclusions: Gabapentin may be a safe option for the treatment of BPSD in combination with antipsychotic medications. Gabapentin may also be effective as monotherapy in certain patients with BPSD.
Why is Schr?dinger's equation linear?
Parwani, Rajesh R.;
Brazilian Journal of Physics , 2005, DOI: 10.1590/S0103-97332005000300021
Abstract: information-theoretic arguments are used to obtain a link between the accurate linearity of schr¨odinger's equation and lorentz invariance: a possible violation of the latter at short distances would imply the appearance of nonlinear corrections to quantum theory. nonlinear corrections can also appear in a lorentz invariant theory in the form of higher derivative terms that are determined by a length scale, possibly the planck length. it is suggested that the best place to look for evidence of such quantum nonlinear effects is in neutrino physics and cosmology.
Simultaneous Design of T-S Fuzzy Controllers and Observers Using GA
R. Rajesh,T. Sureshkumar
International Journal of Soft Computing , 2012,
Abstract: Fuzzy control can be used to improve existing controller systems by adding an extra layer of intelligence to the current control method. But most of the cases it is very difficult to measure the state variables. Various design methods are available to design fuzzy observers which can be used to estimate the state variables. But simultaneous design of fuzzy controllers and observers using genetic algorithm is not reported so far. This study presents the Simultaneous Design of Takagi-Sugeno Fuzzy Controllers and Observers using Genetic Algorithm. Benchmarking control problem, namely the inverted pendulum system is simulated with the designed fuzzy controller and observer and the results are promising.
Pyridoxine Dependent Seizures-Report Of A Case And Brief Review Of Literature
Rajesh R,Girija AS
Annals of Indian Academy of Neurology , 2002,
Abstract: Pyridoxine-dependent seizure is a rare autosornal recessive disorder that usually presents as neonatal intractable seizures. This syndrome is due to an inborn abnormality of the enzyme glutamic acid decarboxylase, which results in reduced pyridoxine-dependent synthesis of the inhibitory neurotransmitter gamma amino butyric acid. We report a girl child who had seizures on the second post natal day which was controlled with oral pyridoxine. She had status epilepticus twice when the drug was stopped at the age of 3 months and 21 months. The neurological development was normal. There was normalization of EEG abnormalities on intravenous administration of 100 mg pyridoxine. A brief review of the literature is also included.
Classification of a Class of Agricultural Images Using Multi Guided Multicolor Coherence Feature
P. Balamurugan,R. Rajesh
Journal of Applied Sciences , 2012,
Abstract: Classification of particular group of agricultural images into semantically meaningful categories is a challenging task. Recently color coherence vector has become popular for image mining. This study makes use of multicolor coherence feature with multiple guide images (MGMCF) for classification of agricultural images like coconut and palm trees. The classification results using neural network is promising. Hence, image mining/image retrieval tasks can be done at good precision/recall by using MGMCF features.
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