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Search Results: 1 - 10 of 223637 matches for " R.; Warning "
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Assessment of a pharmacist-driven point-of-care spirometry clinic within a primary care physicians office
Cawley MJ,Pacitti R,Warning W
Pharmacy Practice (Granada) , 2011,
Abstract: Objective: To assess value-added service of a pharmacist-driven point-of-care spirometry clinic to quantify respiratory disease abnormalities within a primary care physicians officeMethods: This retrospective, cohort study was an analysis of physician referred patients who attended our spirometry clinic during 2008-2010 due to pulmonary symptoms or disease. After spirometry testing, data was collected retrospectively to include patient demographics, spirometry results, and pulmonary pharmaceutical interventions. Abnormal spirometry was identified as an obstructive and/or restrictive defect.Results: Sixty-five patients with a primary diagnosis of cough, shortness of breath, or diagnosis of asthma or chronic obstructive pulmonary disease were referred to the spirometry clinic for evaluation. A total of 51 (32 patients with normal spirometry, 19 abnormal spirometry) completed their scheduled appointment. Calculated lung age was lower in normal spirometry (58.1; SD=20 yrs) than abnormal spirometry (78.2; SD=7.5 yrs, p<0.001). Smoking pack years was also lower in normal spirometry (14.4; SD=10.7 yrs) than abnormal spirometry (32.7; SD=19.5 yrs, p=0.004). Resting oxygen saturation of the arterial blood (SaO2) was higher in normal spirometry than abnormal spirometry (98.1% vs 96.5%, p=0.016). Mean change in the forced expiratory volume in one second (FEV1) after administration of bronchodilator was greater in patients with abnormal spirometry compared with normal spirometry (10.9% vs 4.1%, p<0.001). Spirometry testing assisted in addition, discontinuation or altering pulmonary drug regimens in 41/51 patients (80%) and the need for further diagnostic testing or physician referral in 14/51 patients (27.4%). Conclusion: Implementation of a pharmacist-driven spirometry clinic is a value-added service that can be integrated with other clinical pharmacy services within the ambulatory care setting. Further studies are needed to determine the role of pharmacists in performing spirometry testing and measuring performance outcomes of the pulmonary patient.
Assessment of a pharmacist-driven point-of-care spirometry clinic within a primary care physicians office
Cawley,M.J.; Pacitti,R.; Warning,W.;
Pharmacy Practice (Internet) , 2011, DOI: 10.4321/S1886-36552011000400007
Abstract: objective: to assess value-added service of a pharmacist-driven point-of-care spirometry clinic to quantify respiratory disease abnormalities within a primary care physicians office methods: this retrospective, cohort study was an analysis of physician referred patients who attended our spirometry clinic during 2008-2010 due to pulmonary symptoms or disease. after spirometry testing, data was collected retrospectively to include patient demographics, spirometry results, and pulmonary pharmaceutical interventions. abnormal spirometry was identified as an obstructive and/or restrictive defect. results: sixty-five patients with a primary diagnosis of cough, shortness of breath, or diagnosis of asthma or chronic obstructive pulmonary disease were referred to the spirometry clinic for evaluation. a total of 51 (32 patients with normal spirometry, 19 abnormal spirometry) completed their scheduled appointment. calculated lung age was lower in normal spirometry (58.1; sd=20 yrs) than abnormal spirometry (78.2; sd=7.5 yrs, p<0.001). smoking pack years was also lower in normal spirometry (14.4; sd=10.7 yrs) than abnormal spirometry (32.7; sd=19.5 yrs, p=0.004). resting oxygen saturation of the arterial blood (sao2) was higher in normal spirometry than abnormal spirometry (98.1% vs 96.5%, p=0.016). mean change in the forced expiratory volume in one second (fev1) after administration of bronchodilator was greater in patients with abnormal spirometry compared with normal spirometry (10.9% vs 4.1%, p<0.001). spirometry testing assisted in addition, discontinuation or altering pulmonary drug regimens in 41/51 patients (80%) and the need for further diagnostic testing or physician referral in 14/51 patients (27.4%). conclusion: implementation of a pharmacist-driven spirometry clinic is a value-added service that can be integrated with other clinical pharmacy services within the ambulatory care setting. further studies are needed to determine the role of pharmacists in performing sp
Some Are More Equal - A Comparative Study on Swab Uptake and Release of Bacterial Suspensions
Philipp Warnke, Liesa Warning, Andreas Podbielski
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0102215
Abstract: Objectives Swabs are widely used to collect samples for microbiological analyses from various clinical settings. They vary by material, size, and structure of the tip. This study investigates the uptake and release capacities for liquid and bacteria. Methods Five swabs were analyzed for their uptake and release capacities of Staphylococcus aureus and Staphylococcus epidermidis suspensions. Two approaches were investigated providing volume-restricted and unrestricted amounts of bacterial suspensions to mimic various clinical situations. Volume and bacterial uptake and release were measured in milligrams and by counting colony forming units (CFU), respectively. Results Volume uptake and release in the unrestricted setting varied highly significant between 239.6 mg and 88.7 mg (p<0.001) and between 65.2 mg and 2.2 mg (p<0.001), respectively. In the volume-restricted setting the complete volume was absorbed by all swabs, volume release could only be detected for flocked swabs (2.7 mg; p<0.001). Highest amount of CFU release was detected for the MWE Dryswab in the unrestricted setting for both S. aureus and S. epidermidis with 1544 CFU and 553 CFU, respectively, lowest release for the Sarstedt neutral swab with 32 CFU and 17 CFU, respectively (p<0.001). In the volume-restricted setting MWE Σ-Swab released the highest bacterial amount with 135 CFU S. aureus and 55 CFU S. epidermidis, respectively, the lowest amount was released by Mast Mastaswab with 2 CFU S. aureus and 1 CFU S. epidermidis, respectively (p<0.001). Within the range of the utilized bacterial concentrations, uptake/release ratios were identical for the particular swab types and independent of the bacterial species. Conclusions The influence of the swab type on subsequent diagnostic results is often underestimated. Uptake and release of the investigated bacteria vary significantly between different swab types and sampling conditions. For best diagnostic outcome swabs should be chosen according to the examined situation and the swab performance profile.
相控阵天线阵面两级备件优化配置模型
王永攀, 杨江平, 张宇, 侯晓东
(. Landbased Early Warning Equipment Department
, Air Force Early Warning Academy, Wuhan , China,. . The PLA Unit , Hohhot , China)

- , 2017, DOI: 10.11887/j.cn.201703026
Abstract: 针对相控阵天线阵面备件配置存在的冗余性强、批量送修、多级维修等现实问题,综合考虑备件费用、维修能力以及库存策略之间的关系,建立了基于定期补给的两级备件优化配置模型。给出了系统的故障件维修周转过程和维修备件的定期补给过程,在分析备件、库存、维修能力之间关系的基础上,结合成批到达的排队理论,建立了系统的供应可用度模型。以备件配置费用最小为目标、以系统供应可用度为约束条件,建立了系统的备件优化配置模型,并通过边际效益分析法对模型进行了求解。通过算例仿真与分析对模型进行了验证。结果表明:构建的备件配置能够较好地解决相控阵天线阵面的备件配置问题,具有一定的优越性。
Three problems are normally found in the spare parts configuration of phased array antenna, namely, the strong redundancy, the batch delivery maintenance and the multi-echelon maintenance. Aiming at these problems, through analyzing the relations among spare parts cost, repair capacity and inventory strategies, an optimal configuration model was established based on the periodic review strategies. Firstly, the repair circulation process of fault component and the periodic supply process of maintenance spare parts were given, and then the system supply availability model was built by analyzing the relations among spare parts, inventories and repair capacity, and the batch arrival queuing theory was also used. Secondly, an optimal configuration model of spare parts was built, which takes minimum spare parts costs as the object and the system availability as the subject. Next, solution algorithm based on the margin analysis theory to the model was also given. Finally, simulations and analysis of an instance were conducted to verify the proposed model, and results show that the model can solve the spare parts allocation problems of phased array antenna well, and has a high superiority. 
Power Aware Routing Protocol (PARP) for Wireless Sensor Networks  [PDF]
R. Prema, R. Rangarajan
Wireless Sensor Network (WSN) , 2012, DOI: 10.4236/wsn.2012.45019
Abstract: Several wireless sensor network applications ought to decide the intrinsic variance between energy efficient communication and the requirement to attain preferred quality of service (QoS) such as packet delivery ratio, delay and to reduce the power consumption of wireless sensor nodes. In order to address this challenge, we propose the Power Aware Routing Protocol (PARP), which attains application-specified communication delays at low energy cost by dynamically adapting transmission power and routing decisions. Extensive simulation results prove that the proposed PARP attains better QoS and reduced power consumption.
Studies on Dissolution Behaviour of Nanoparticulate Curcumin Formulation  [PDF]
R. Ravichandran
Advances in Nanoparticles (ANP) , 2013, DOI: 10.4236/anp.2013.21010
Abstract:

Curcumin is the main biologically active phytochemical compound of turmeric that has been widely used by ancient cultures throughout Asia. However the dissolution rate limited absorption and pre-absorption degradation limits its use as a potential therapeutic. In this study an attempt has been made to overcome the above limitations by curcumin delivery through nanotechnology. Nanocurcumin solid dosage formulations were prepared and studied for its dissolution behaviour. Considerable improvement in the dissolution behavior was observed in the drug nanocrystal-loaded solid dosage forms. This is expected to enhance the bioavailability of poorly soluble medicinal herbs such as turmeric in the body.

Pharmacokinetic Study of Nanoparticulate Curcumin: Oral Formulation for Enhanced Bioavailability  [PDF]
R. Ravichandran
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2013, DOI: 10.4236/jbnb.2013.43037
Abstract:

Curcumin, a bioactive component of turmeric, which is a commonly used spice and nutritional supplement, is isolated from the rhizomes of Curcuma longa Linn. (Zingiberaceae). In recent years, the potential pharmacological actions of Curcumin in inflammatory disorders, cardiovascular disease, cancer, Alzheimer’s disease and neurological disorders have been shown. However, the clinical application of Curcumin is severely limited by its main drawbacks such as instability, low solubility, poor bioavailability and rapid metabolism. Multifarious nanotechnology-based drug delivery systems for Curcumin including liposomes, polymeric nanoparticles, solid lipid nanoparticles, micelles, nanogels, nanoemulsions, complexes and dendrimer/dimer, have been attempted to enhance the oral bioavailability, biological activity or tissue-targeting ability of Curcumin. We attempted the nanosuspensions based delivery of curcumin. Nanonisation renders curcumin completely dispersible in aqueous media. To enhance the curcumin absorption by oral administration, nanoparticulate solid oral formulation of curcumin was prepared by us and the resulting capsule was then examined for its efficiency on bioavailability in Male Wistar rats at a dose of 100 mg curcumin/kg body weight and the pharmacokinetic parameters were compared to those of normal curcumin powder and a commercial curcumin capsule CUR-500. The bio-distribution of curcumin in organs of rat was also studied. Nanoparticulation significantly raised the curcumin concentration in selective organs in the body. The results obtained provide promising results for nanoparticulate Curcumin to improve its biological activities. Enhanced bioavailability of curcumin in the form of nanoparticle is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease. The available information also strongly suggests that nano-formulation of ingredients such as curcumin may be used as a novel nutrient delivery system too.

The Arithmetic Mean Standard Deviation Distribution: A Geometrical Framework  [PDF]
R. Caimmi
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.411A4001
Abstract:

The current attempt is aimed to outline the geometrical framework of a well known statistical problem, concerning the explicit expression of the arithmetic mean standard deviation distribution. To this respect, after a short exposition, three steps are performed as 1) formulation of the arithmetic mean standard deviation, \"\", as a function of the errors, \"\", which, by themselves, are statistically independent; 2) formulation of the arithmetic mean standard deviation distribution, \"\", as a function of the errors, \"\"; 3) formulation of the arithmetic mean standard deviation distribution, \"\", as a function of the arithmetic mean standard deviation, \"\", and the arithmetic mean rms error, \"\". The integration domain can be expressed in canonical form after a change of reference frame in the n-space, which is recognized as an infinitely thin n-cylindrical corona where the symmetry axis coincides with a coordinate axis. Finally, the solution is presented and a number of (well known) related parameters are inferred for sake of completeness.

Optimized Parameter Combinations of Hydraulic Damper Modules  [PDF]
R. Sonnenburg
Journal of Transportation Technologies (JTTs) , 2014, DOI: 10.4236/jtts.2014.43025
Abstract:

This paper is devoted to the problem of finding optimized parameter combinations of automotive damper modules. Different cost functions using the amplitude spectrum of the excitation and the frequency response function of the car model will be investigated and it is shown that for three different arbitrary road excitations there exists a parameter combination of top mount stiffness, piston rod mass and damping constant that provides an optimum for the dynamic wheel load fluctuation. The achieved advantage of the optimized damper module regarding the dynamic wheel load fluctuation compared to a simple damper in a two mass vibration system can reach up to 20 percent.

CSA Discounting: Impacts on Pricing and Risk of Commodity Derivatives  [PDF]
R. Abbate
Journal of Financial Risk Management (JFRM) , 2014, DOI: 10.4236/jfrm.2014.33011
Abstract: The global financial crisis of 2007-2008 caused market practitioners to reassess the way in which financial derivative contracts had been priced during the preceding thirty years. The purpose of this paper is to examine the evolving practice of pricing and hedging commodity derivative contracts according to the terms of the Credit Support Annex (CSA). Using a series of case studies, we price crude oil swaps and Asian options in the pre-crisis, peak-crisis, post-crisis and recent market environments under two different frameworks: LIBOR discounting and CSA discounting (also referred to in a less general form as “OIS discounting”, which incorporates nearly risk-free interest rates). We also compute the widely used first-order and second-order Greek sensitivities. In each market environment, we shift the forward prices and implied volatilities crude oil and re-compute the trades’ valuation and Greek sensitivities at each incremental increase or decrease in price or implied volatility. Under each discounting framework, we quantify the change in trade valuation and Greek sensitivities that results from switching from LIBOR discounting to CSA discounting. The impact on the valuation and Greek sensitivities of a swap and an Asian option as the result of adopting CSA discounting can be significant under certain market conditions. There is likely to be larger impact on directional portfolios containing transactions that hedge either consumption or production (e.g. end users). Ceteris paribus, the impact on portfolio valuation and risk is likely to be limited for market participants (e.g. banks) with hedged portfolios that contain a large number of offsetting positions. Even though we focus our analysis on crude oil derivative contracts, the results easily extend to other asset classes such as natural gas, refined products, agriculture, metals, etc.
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