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Search Results: 1 - 10 of 223849 matches for " R. Ravichandran "
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Studies on Dissolution Behaviour of Nanoparticulate Curcumin Formulation  [PDF]
R. Ravichandran
Advances in Nanoparticles (ANP) , 2013, DOI: 10.4236/anp.2013.21010

Curcumin is the main biologically active phytochemical compound of turmeric that has been widely used by ancient cultures throughout Asia. However the dissolution rate limited absorption and pre-absorption degradation limits its use as a potential therapeutic. In this study an attempt has been made to overcome the above limitations by curcumin delivery through nanotechnology. Nanocurcumin solid dosage formulations were prepared and studied for its dissolution behaviour. Considerable improvement in the dissolution behavior was observed in the drug nanocrystal-loaded solid dosage forms. This is expected to enhance the bioavailability of poorly soluble medicinal herbs such as turmeric in the body.

Pharmacokinetic Study of Nanoparticulate Curcumin: Oral Formulation for Enhanced Bioavailability  [PDF]
R. Ravichandran
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2013, DOI: 10.4236/jbnb.2013.43037

Curcumin, a bioactive component of turmeric, which is a commonly used spice and nutritional supplement, is isolated from the rhizomes of Curcuma longa Linn. (Zingiberaceae). In recent years, the potential pharmacological actions of Curcumin in inflammatory disorders, cardiovascular disease, cancer, Alzheimer’s disease and neurological disorders have been shown. However, the clinical application of Curcumin is severely limited by its main drawbacks such as instability, low solubility, poor bioavailability and rapid metabolism. Multifarious nanotechnology-based drug delivery systems for Curcumin including liposomes, polymeric nanoparticles, solid lipid nanoparticles, micelles, nanogels, nanoemulsions, complexes and dendrimer/dimer, have been attempted to enhance the oral bioavailability, biological activity or tissue-targeting ability of Curcumin. We attempted the nanosuspensions based delivery of curcumin. Nanonisation renders curcumin completely dispersible in aqueous media. To enhance the curcumin absorption by oral administration, nanoparticulate solid oral formulation of curcumin was prepared by us and the resulting capsule was then examined for its efficiency on bioavailability in Male Wistar rats at a dose of 100 mg curcumin/kg body weight and the pharmacokinetic parameters were compared to those of normal curcumin powder and a commercial curcumin capsule CUR-500. The bio-distribution of curcumin in organs of rat was also studied. Nanoparticulation significantly raised the curcumin concentration in selective organs in the body. The results obtained provide promising results for nanoparticulate Curcumin to improve its biological activities. Enhanced bioavailability of curcumin in the form of nanoparticle is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease. The available information also strongly suggests that nano-formulation of ingredients such as curcumin may be used as a novel nutrient delivery system too.

Has the time come for doing away with Cobalt-60 teletherapy for cancer treatments
Ravichandran R
Journal of Medical Physics , 2009,
Text Book of Radiological Safety
Ravichandran R
Journal of Medical Physics , 2010,
Seasonal Variation on the Proximate Composition of Turbo brunneus
R. Ramesh,S. Ravichandran
International Journal of Zoological Research , 2008,
Abstract: This study is to find out the nutritive value of the meat of T. brunneus and to ascertain the relationship between seasonal variations in biochemical components and reproductive cycle. The monthly variations in the biochemical constituents were estimated in different body organs such as foot, gonad, digestive gland and mantle for both male and female gastropods. Carbohydrate content of gonad is high during May 2002 in males (5.30%) and females (6.14%). The percentage of lipid is high (4.85%) in ovary during May 2002 and low in October 2002 (3.10%). In testis, the values range from 3.0 (September 2002) to 4.20% (May 2002), respectively. The gonadal tissues show major variations in lipid values, whereas the percentage variation is negligible in mantle, which ranges from 1.64-1.74% in males and 1.59-1.78% in females. The lipid valued decreases from June to October and the values showed little fluctuations from the minimum value until December. But, in the digestive gland, the percentage is higher in September 2002 in males (3.06%) and October 2003 in females (2.96%) and low in May 2003 (2.4 and 2.12%) in both the sexes. The protein contents of the digestive gland shows a clear seasonal variation, which is negatively correlated with that of other body organs.
Uniformly Convex and Uniformly Starlike Functions
R. M. Ali,V. Ravichandran
Mathematics , 2011,
Abstract: A normalized univalent function is uniformly convex if it maps every circular arc contained in the open unit disk with center in it into a convex curve. This article surveys recent results on the class of uniformly convex functions and on an analogous class of uniformly starlike functions.
Antitumour Activity of Methanolic Extract of Plumeria alba L. Leaves Against Dalton Lymphoma Ascites in Mice
R Radha, S Kavimani, V Ravichandran
International Journal of Health Research , 2008,
Abstract: Purpose: To evaluate Plumeria alba leaves for antitumor activity against Ehrlich ascites carcinoma (EAC) and Dalton lymphoma ascites (DLA) bearing Swiss albino mice. Method: The antitumour activity of the methanolic extract of Plumeria alba leaves (MPA) was evaluated against EAC and DLA using in-vitro cytotoxic and mean survival time, a decrease in the tumour volume and viable cell count in the DLA tumour hosts. The animal was observed for improvement in the haematological parameters (e.g., heamoglobin content, red and white blood cells count, and differential cell count) following MPA treatment of the tumour bearing mice. Results: MPA was found to be cytotoxic in the invitro model. Intraperitoneal administration of MPA increased the survival time, dead cell count haematological parameters and solid tumour mass was also significantly reduced. Conclusion: MPA possesses significant antitumour activity.
Surface buoyancy flux in Bay of Bengal and Arabian Sea
G. Anitha, M. Ravichandran,R. Sayanna
Annales Geophysicae (ANGEO) , 2008,
Abstract: The seasonal variation of thermal, haline, net surface buoyancy flux, the Monin-Obukhov length (M-O length, L) and stability parameter, i.e. the ratio of M-O length to mixed layer depth (h) were studied in the Bay of Bengal (BoB) and the Arabian Sea (AS) for the years 2003 and 2004 using Argo temperature and salinity profiles. The relative quantitative influence of winds to surface buoyancy and the applicability of scaling mixed layer using M-O length in BoB and AS was brought out. Rotation and light penetration modify the mixed layer depth from M-O length during shoaling in spring giving L/h<1.
On certain applications of differential subordinations for $Phi$-like functions
V. Ravichandran,N. Magesh,R. Rajalakshmi
Tamkang Journal of Mathematics , 2005, DOI: 10.5556/j.tkjm.36.2005.137-142
Abstract: Let $ f(z) $ be a normalized analytic function in $ Delta={z | zin{Bbb C} mbox{ and } |z| <1} $ satisfying $ f(0)=0 $ and $ f'(0)=1 $. Let $ Phi $ be an analytic function in a domain containing $ f(Delta) $, with $ Phi(0) = 0 $, $ Phi^{'}(0) = 1 $ and $ Phi(omega) eq 0 $ for $ omegain f(Delta) - { 0 } $. Let $ q(z) $ be a fixed analytic function in $ Delta$, $q(0)=1 $. The function $ f $ is called $Phi$-like with respect to $ q $ if $$ frac{zf^{'}(z)}{Phi(f(z))} prec q(z) quad (zinDelta). $$ In this paper, we obtain some sufficient conditions for functions to be $ Phi $-like with respect to $ q(z) $.
An application of Stochastic Models - Grading system in Manpower planning
S Parthasarathy,M K Ravichandran,R Vinoth
International Business Research , 2010, DOI: 10.5539/ibr.v3n2p79
Abstract: The expected time to cross the threshold level of cumulative loss of manpower and its variance are obtained under the assumption that an organisation has two grades of personnel and that the loss of manpower in one category is compensated by utilisation of manpower available in the order to sustain the activities intact. In this paper we made an attempt that the threshold follows the special case of Exponentiated exponential distribution is used, to study the two grade system with numerical illustration.
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