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Search Results: 1 - 10 of 226631 matches for " R. Lawrence "
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Comments on ALLHAT and doxazosin
Lawrence R Krakoff
Trials , 2001, DOI: 10.1186/cvm-2-6-254
Abstract: In April 2000, the first results of the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) were published summarizing the comparison between two of the four drugs studied (chlorthalidone and doxazosin) as initial monotherapy for hypertension [1]. This prospective, randomized trial was designed to compare a diuretic (chlorthalidone) with long-acting (once-a-day) drugs among different classes: angiotensin-converting enzyme inhibitor (lisinopril); calcium-channel blocker (amlodipine); and alpha blocker (doxazosin). The diuretic had been the mainstay of several previous trials, particularly the Systolic Hypertension in the Elderly Program (SHEP) study [2].During the first three years of the trial, the Data Safety and Monitoring Committee became aware of different event rates between two groups and, after considerable deliberation, made the decision to discontinue the arm assigned to doxazosin for two stated reasons. One reason was an extremely low likelihood that doxazosin would prove superior to chlorthalidone when the study would be completed as planned. The second reason was a pattern of increased morbid events in comparing doxazosin to the diuretic, which was highly significant on statistical analysis. This pattern is shown in Table 1. While event rates for fatal cardiovascular disease were similar, there was a disturbing tendency for stroke and a definite trend for heart failure to occur more often in the doxazosin group, than in the group taking chlorthalidone. For heart failure, the curves for event rates diverged quite early in the trial, within the first year, but continued to separate over the three-year period of analysis. ALLHAT continues with ongoing comparisons for amlodipine, lisinopril, and chlorthalidone.The results of ALLHAT regarding doxazosin were first made public by a presentation at the meeting of the American College of Cardiology, March 2000, and the subsequent publication. Several news agencies published report
The Solifugae, Scorpions and Pedipalpi of the Kruger National Park
R. F. Lawrence
Koedoe : African Protected Area Conservation and Science , 1964, DOI: 10.4102/koedoe.v7i1.797
Abstract: The Solifugae, Scorpions and Pedipalpi of the Kruger National Park
Woodlice (crustacea, isopoda, terrestria) recorded by the late K. H. Barnard from the Kruger National Park and its neighbourhood
R.F. Lawrence
Koedoe : African Protected Area Conservation and Science , 1977, DOI: 10.4102/koedoe.v20i1.945
Abstract: This short paper represents a list of the woodlice known from the Kruger National Park, Republic of South Africa, up to the present time, most of them having been collected by R. F. Lawrence in 1962 and 1963. Much more intensive collecting will eventually be carried out in the Park and until this has been done the list of Isopoda given here must of necessity be regarded as incomplete and of a temporary nature. The number of species living in the Park may eventually prove to amount to twice the number known at the present time but in the meanwhile the paper should serve a useful purpose for indicating the genera and families which can be looked for by future collectors.
Supplementary list of the Solifugae,scorpions and Pepipalpi of the Kruger National Park
R. F. Lawrence
Koedoe : African Protected Area Conservation and Science , 1967, DOI: 10.4102/koedoe.v10i1.765
Abstract: Supplementary list of the Solifugae,scorpions and Pepipalpi of the Kruger National Park
Island Biogeography: Paradigm Lost?
Lawrence R. Heaney
Frontiers of Biogeography , 2011,
Abstract:
The Pseudoscorpions (False-Scorpions) of the Kruger National Park
R. F. Lawrence
Koedoe : African Protected Area Conservation and Science , 1967, DOI: 10.4102/koedoe.v10i1.766
Abstract: The Pseudoscorpions (False-Scorpions) of the Kruger National Park
Conflicts of Interest and Quality Care
Huntoon, Lawrence R.
Journal of American Physicians and Surgeons , 2007,
Abstract:
APPLICATIONS OF BIOTECHNOLOGY TO THE STUDY OF NEMATODES
Lawrence R. Ash
Bulletin of Health Research , 2012,
Abstract: A brief review is given of the application of some of the newer biotechnological methods to the study of nematodes. Within the area of biochemistry, the application of nuclear magnetic resonance spectroscopy to the studies of parasite metabolism, and the continued use of isoenzyme analysis for understanding infraspeciric variation in parasites are discussed. Aspects of the molecular characterization of nematodes are described, including methodologies for extraction of DNA, and the identification of specific parasite antigens. The use of in vitro DNA amplification by the polymerase chain reaction for diagnostic purposes is considered.
Molecular Theory of Hydrophobic Effects: ``She is too mean to have her name repeated.''
Lawrence R. Pratt
Physics , 2001, DOI: 10.1146/annurev.physchem.53.090401.093500
Abstract: This paper reviews the molecular theory of hydrophobic effects relevant to biomolecular structure and assembly in aqueous solution. Recent progress has resulted in simple, validated molecular statistical thermodynamic theories and clarification of confusing theories of decades ago. Current work is resolving effects of wider variations of thermodynamic state, e.g. pressure denaturation of soluble proteins, and more exotic questions such as effects of surface chemistry in treating stability of macromolecular structures in aqueous solution
An Innovative Approach to Balancing Chemical-Reaction Equations: A Simplified Matrix-Inversion Technique for Determining The Matrix Null Space
Lawrence R. Thorne
Physics , 2011,
Abstract: I propose a novel approach to balancing equations that is applicable to all chemical-reaction equations; it is readily accessible to students via scientific calculators and basic computer spreadsheets that have a matrix-inversion application. The new approach utilizes the familiar matrix-inversion operation in an unfamiliar and innovative way; its purpose is not to identify undetermined coefficients as usual, but, instead, to compute a matrix null space (or matrix kernel). The null space then provides the coefficients that balance the equation. Indeed, the null space contains everything there is to know about balancing any chemical-reaction equation!
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