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Search Results: 1 - 10 of 223852 matches for " R. Hey "
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What's So Hot about Recombination Hotspots?
Jody Hey
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0020190
Abstract:
On the Number of New World Founders: A Population Genetic Portrait of the Peopling of the Americas
Jody Hey
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0030193
Abstract: The founding of New World populations by Asian peoples is the focus of considerable archaeological and genetic research, and there persist important questions on when and how these events occurred. Genetic data offer great potential for the study of human population history, but there are significant challenges in discerning distinct demographic processes. A new method for the study of diverging populations was applied to questions on the founding and history of Amerind-speaking Native American populations. The model permits estimation of founding population sizes, changes in population size, time of population formation, and gene flow. Analyses of data from nine loci are consistent with the general portrait that has emerged from archaeological and other kinds of evidence. The estimated effective size of the founding population for the New World is fewer than 80 individuals, approximately 1% of the effective size of the estimated ancestral Asian population. By adding a splitting parameter to population divergence models it becomes possible to develop detailed portraits of human demographic history. Analyses of Asian and New World data support a model of a recent founding of the New World by a population of quite small effective size.
Universal Human Rights and Cultural Diversity
Hilde Hey
Human Rights & Human Welfare , 2001,
Abstract:
On the Number of New World Founders: A Population Genetic Portrait of the Peopling of the Americas
Jody Hey
PLOS Biology , 2005, DOI: 10.1371/journal.pbio.0030193
Abstract: The founding of New World populations by Asian peoples is the focus of considerable archaeological and genetic research, and there persist important questions on when and how these events occurred. Genetic data offer great potential for the study of human population history, but there are significant challenges in discerning distinct demographic processes. A new method for the study of diverging populations was applied to questions on the founding and history of Amerind-speaking Native American populations. The model permits estimation of founding population sizes, changes in population size, time of population formation, and gene flow. Analyses of data from nine loci are consistent with the general portrait that has emerged from archaeological and other kinds of evidence. The estimated effective size of the founding population for the New World is fewer than 80 individuals, approximately 1% of the effective size of the estimated ancestral Asian population. By adding a splitting parameter to population divergence models it becomes possible to develop detailed portraits of human demographic history. Analyses of Asian and New World data support a model of a recent founding of the New World by a population of quite small effective size.
What's So Hot about Recombination Hotspots?
Jody Hey
PLOS Biology , 2004, DOI: 10.1371/journal.pbio.0020190
Abstract:
A comparison of massively parallel nucleotide sequencing with oligonucleotide microarrays for global transcription profiling
James R Bradford, Yvonne Hey, Tim Yates, Yaoyong Li, Stuart D Pepper, Crispin J Miller
BMC Genomics , 2010, DOI: 10.1186/1471-2164-11-282
Abstract: We found a high degree of correspondence between the two platforms in terms of exon-level fold changes and detection. For example, over 80% of exons detected as expressed in RNA-Seq were also detected on the Exon array, and 91% of exons flagged as changing from Absent to Present on at least one platform had fold-changes in the same direction. The greatest detection correspondence was seen when the read count threshold at which to flag exons Absent in the SOLiD data was set to t<1 suggesting that the background error rate is extremely low in RNA-Seq. We also found RNA-Seq more sensitive to detecting differentially expressed exons than the Exon array, reflecting the wider dynamic range achievable on the SOLiD platform. In addition, we find significant evidence of novel protein coding regions outside known exons, 93% of which map to Exon array probesets, and are able to infer the presence of thousands of novel transcripts through the detection of previously unreported exon-exon junctions.By focusing on exon-level expression, we present the most fine-grained comparison between RNA-Seq and microarrays to date. Overall, our study demonstrates that data from a SOLiD RNA-Seq experiment are sufficient to generate results comparable to those produced from Affymetrix Exon arrays, even using only a single replicate from each platform, and when presented with a large genome.Massively Parallel Nucleotide Sequencing (MPNS) allows the rapid generation of gigabases of sequence data at a relatively low cost per residue. A variety of platforms exist, but all rely on the generation of a large number of relatively short sequences, known as 'tags' or 'reads' that can then be aligned to a target database, or assembled de novo into contiguous sequences. In many MPNS experiments, it is possible to treat the set of reads generated during a sequencing run as an unbiased sampling of the total nucleotide complement of the cells, making it possible to use the number of reads aligning to a given
A family of improved ZVT PWM converters using an auxiliary resonant source
Martins, M. L.;Pinheiro, H.;Pinheiro, J. R.;Gründling, H. A.;Hey, H. L.;
Sba: Controle & Automa??o Sociedade Brasileira de Automatica , 2003, DOI: 10.1590/S0103-17592003000400009
Abstract: this paper presents a novel family of zero voltage transition (zvt) dc-dc pwm converters that uses a resonant circuit as auxiliary commutation source to control the current through the auxiliary switch without additional current stresses on main devices. the improved zvt commutation cell enables the main switch to be turned on and off at zero voltage switching (zvs) and the auxiliary switch to be turned on and off at zero current switching (zcs) from zero to full-load.
Uma metodologia de projeto generalizada para inversores multiníveis híbridos
Rech, Cassiano;Gründling, Hilton A.;Hey, Hélio L.;Pinheiro, Humberto;Pinheiro, José R.;
Sba: Controle & Automa??o Sociedade Brasileira de Automatica , 2004, DOI: 10.1590/S0103-17592004000200008
Abstract: with the use of hybrid multilevel inverters it is possible to reduce the number of series-connected cells for a given number of levels, to minimize the thd of the output voltage and, consequently, to reduce or even eliminate the output filter. therefore, this paper develops a detailed analysis and proposes a generalized design methodology for hybrid multilevel inverters. with the proposed design methodology it is possible to define the number of series-connected cells, the value of the dc voltage source of each cell, to minimize the circulating energy among the series-connected inverters, and the switching frequency of the lowest power cell.
Resonant Rayleigh Scattering in Ordered and Intentionally Disordered Semiconductor Superlattices
V. Bellani,M. Amado,E. Diez,C. Koerdt,M. Potemski,R. Hey
Physics , 2007, DOI: 10.1103/PhysRevB.76.075349
Abstract: We report the experimental study of resonant Rayleigh scattering in GaAs-AlGaAs superlattices with ordered and intentionally disordered potential profiles (correlated and uncorrelated) in the growth direction z. We show that the intentional disorder along z modify markedly the energy dispersion of the dephasing rates of the excitons. The application of an external magnetic field in the same direction allows the continuous tuning of the in plane exciton localization and to study the interplay between the in plane and vertical disorder.
Mesoscopic spin confinement during acoustically induced transport
J. A. H. Stotz,P. V. Santos,R. Hey,K. H. Ploog
Physics , 2007,
Abstract: Long coherence lifetimes of electron spins transported using moving potential dots are shown to result from the mesoscopic confinement of the spin vector. The confinement dimensions required for spin control are governed by the characteristic spin-orbit length of the electron spins, which must be larger than the dimensions of the dot potential. We show that the coherence lifetime of the electron spins is independent of the local carrier densities within each potential dot and that the precession frequency, which is determined by the Dresselhaus contribution to the spin-orbit coupling, can be modified by varying the sample dimensions resulting in predictable changes in the spin-orbit length and, consequently, in the spin coherence lifetime.
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