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Search Results: 1 - 10 of 223794 matches for " R. Duperrier "
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Toutatis, the Cea-Saclay RFQ code
R. Duperrier,R. Ferdinand,J. -M. Lagniel,N. Pichoff
Physics , 2000,
Abstract: A CW high power linear accelerator can only work with very low particles losses and structure activation. At low energy, the RFQ is a very sensitive element to losses. To design the RFQ, a good understanding of the beam dynamics is requested. Generally, the reference code PARMTEQM is enough to design the accelerator. TOUTATIS has been written with goals of cross-checking results and obtaining a more reliable dynamics. This paper relates the different numerical methods used in the code. It is time-based, using multigrids methods and adaptive mesh for a fine description of the forces without being time consuming. The field is accurately calculated through a Poisson solver and the vanes are fully described, allowing to properly simulate the coupling gaps and RFQs extremities. Differences with PARMTEQM and LIDOS.RFQ are shown.
Design of the Ess RFQs and Chopping Line
R. Duperrier,R. Ferdinand,P. Gros,J-M. Lagniel,N. Pichoff,D. Uriot,CEA-Saclay,DSM-DAPNIA-SEA
Physics , 2000,
Abstract: The chopping line is a critical part of the ESS linac in term of technical realisation of the choppers and preservation of the beam qualities. A new optimised design of the ESS RFQs and chopping lines is reported. The beam dynamics has been optimised with H- beam currents up to 100-mA to have safety margin with respect to the ESS goals. The first RFQ transmits almost 99.7% of the beam up to 2 MeV. The line with two choppers allows a perfect chopping between 2 bunches. The second RFQ accelerates the particles up to 5 MeV with a transmission close to 100%.
Status Report on the 5 Mev Iphi RFQ
R. Ferdinand,P-Y. Beauvais,R. Duperrier,A. France,J. Gaiffier,J-M. Lagniel,M. Painchault,F. Simoens,CEA-Saclay,DSM-DAPNIA-SEA,P. Balleyguier,CEA-Bruyeres le Chatel,DAM
Physics , 2000,
Abstract: A 5-MeV RFQ designed for a proton current up to 100-mA CW is now under construction as part of the High Intensity Proton Injector project (IPHI). Its computed transmission is greater than 99 %. The main goals of the project are to verify the accuracy of the design codes, to gain the know-how on fabrication, tuning procedures and operations, to measure the output beam characteristics in order to optimise the higher energy part of the linac, and to reach a high availability with minimum beam trips. A cold model has been built to develop the tuning procedure. The present status of the IPHI RFQ is presented.
NY-ESO-1-Specific Circulating CD4+ T Cells in Ovarian Cancer Patients Are Prevalently TH1 Type Cells Undetectable in the CD25+FOXP3+Treg Compartment
Nassima Redjimi, Karine Duperrier-Amouriaux, Isabelle Raimbaud, Immanuel Luescher, Danijel Dojcinovic, Jean-Marc Classe, Dominique Berton-Rigaud, Jean-Sébastien Frenel, Emmanuelle Bourbouloux, Danila Valmori, Maha Ayyoub
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0022845
Abstract: Spontaneous CD4+ T-cell responses to the tumor-specific antigen NY-ESO-1 (ESO) are frequently found in patients with epithelial ovarian cancer (EOC). If these responses are of effector or/and Treg type, however, has remained unclear. Here, we have used functional approaches together with recently developed MHC class II/ESO tetramers to assess the frequency, phenotype and function of ESO-specific cells in circulating lymphocytes from EOC patients. We found that circulating ESO-specific CD4+ T cells in EOC patients with spontaneous immune responses to the antigen are prevalently TH1 type cells secreting IFN-γ but no IL-17 or IL-10 and are not suppressive. We detected tetramer+ cells ex vivo, at an average frequency of 1:25000 memory cells, that is, significantly lower than in patients immunized with an ESO vaccine. ESO tetramer+ cells were mostly effector memory cells at advanced stages of differentiation and were not detected in circulating CD25+FOXP3+Treg. Thus, spontaneous CD4+ T-cell responses to ESO in cancer patients are prevalently of TH1 type and not Treg. Their relatively low frequency and advanced differentiation stage, however, may limit their efficacy, that may be boosted by immunogenic ESO vaccines.
Antibody Responses to NY-ESO-1 in Primary Breast Cancer Identify a Subtype Target for Immunotherapy
Ahmed Hama?, Karine Duperrier-Amouriaux, Pascale Pignon, Isabelle Raimbaud, Lorenzo Memeo, Cristina Colarossi, Vincenzo Canzonieri, Tiziana Perin, Jean-Marc Classe, Mario Campone, Pascal Jézéquel, Lo?c Campion, Maha Ayyoub, Danila Valmori
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0021129
Abstract: The highly immunogenic human tumor antigen NY-ESO-1 (ESO) is a target of choice for anti-cancer immune therapy. In this study, we assessed spontaneous antibody (Ab) responses to ESO in a large cohort of patients with primary breast cancer (BC) and addressed the correlation between the presence of anti-ESO Ab, the expression of ESO in the tumors and their characteristics. We found detectable Ab responses to ESO in 1% of the patients. Tumors from patients with circulating Ab to ESO exhibited common characteristics, being mainly hormone receptor (HR)? invasive ductal carcinomas of high grade, including both HER2? and HER2+ tumors. In line with these results, we detected ESO expression in 20% of primary HR? BC, including both ESO Ab+ and Ab? patients, but not in HR+ BC. Interestingly, whereas expression levels in ESO+ BC were not significantly different between ESO Ab+ and Ab? patients, the former had, in average, significantly higher numbers of tumor-infiltrated lymph nodes, indicating that lymph node invasion may be required for the development of spontaneous anti-tumor immune responses. Thus, the presence of ESO Ab identifies a tumor subtype of HR? (HER2? or HER2+) primary BC with frequent ESO expression and, together with the assessment of antigen expression in the tumor, may be instrumental for the selection of patients for whom ESO-based immunotherapy may complement standard therapy.
Power Aware Routing Protocol (PARP) for Wireless Sensor Networks  [PDF]
R. Prema, R. Rangarajan
Wireless Sensor Network (WSN) , 2012, DOI: 10.4236/wsn.2012.45019
Abstract: Several wireless sensor network applications ought to decide the intrinsic variance between energy efficient communication and the requirement to attain preferred quality of service (QoS) such as packet delivery ratio, delay and to reduce the power consumption of wireless sensor nodes. In order to address this challenge, we propose the Power Aware Routing Protocol (PARP), which attains application-specified communication delays at low energy cost by dynamically adapting transmission power and routing decisions. Extensive simulation results prove that the proposed PARP attains better QoS and reduced power consumption.
An Innovative Low Cost EM Pollution Measurement System  [PDF]
R. Sittalatchoumy, R. Seetharaman
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.78176
Abstract: Mobile phones and other electronic devices are emitting radiations that will provide harmful effects to the human health. In order to measure the radiation, an innovative low cost measurement system is proposed in this paper. The ideology is to simplify the circuit’s value by converting a voltage detecting circuit to a field detecting circuit by finding an optimum resistance on trial and error basis. The requirement for a trial and error technique is to not allow too high or too low resistance which can be either short or open, resulting provides more damage to the circuit.
Ant Lion Optimization Approach for Load Frequency Control of Multi-Area Interconnected Power Systems  [PDF]
R. Satheeshkumar, R. Shivakumar
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.79206
Abstract: This work proposes a novel nature-inspired algorithm called Ant Lion Optimizer (ALO). The ALO algorithm mimics the search mechanism of antlions in nature. A time domain based objective function is established to tune the parameters of the PI controller based LFC, which is solved by the proposed ALO algorithm to reach the most convenient solutions. A three-area interconnected power system is investigated as a test system under various loading conditions to confirm the effectiveness of the suggested algorithm. Simulation results are given to show the enhanced performance of the developed ALO algorithm based controllers in comparison with Genetic Algorithm (GA), Particle Swarm Optimization (PSO), Bat Algorithm (BAT) and conventional PI controller. These results represent that the proposed BAT algorithm tuned PI controller offers better performance over other soft computing algorithms in conditions of settling times and several performance indices.
Obtaining Optimal Solution by Using Very Good Non-Basic Feasible Solution of the Transportation and Linear Programming Problem  [PDF]
R. R. K. Sharma
American Journal of Operations Research (AJOR) , 2017, DOI: 10.4236/ajor.2017.75021
Abstract: For the transportation problem, Sharma and Sharma [1] have given a very computationally efficient heuristic (runs in O(c*n2) time) to give very good dual solution to transportation problem. Sharma and Prasad [2] have given an efficient heuristic (complexity O(n3) procedure to give a very good primal solution (that is generally non-basic feasible solution) to transportation problem by using the very good dual solution given by Sharma and Sharma [2]. In this paper we use the solution given by Sharma and Prasad [2] to get a very good Basic Feasible Solution to transportation problem, so that network simplex (worst case complexity (O(n3*(log(n))) can be used to reach the optimal solution to transportation problem. In the second part of this paper, we give a simple heuristic procedure to get a very good BFS to linear programming problem from the solution given by Karmarkar [3] (that generally produces a very good non-basic feasible solution in polynomial time (O(n5.5)). We give a procedure to obtain a good BFS for LP by starting from the solution given by Karmarkar [3]. We note that this procedure (given here) is significantly different from the procedure given in [4].
Power Analysis of Sensor Node Using Simulation Tool  [PDF]
R. Sittalatchoumy, R. Kanthavel, R. Seetharaman
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.713348
Abstract: Power consumption of sensor node is analyzed in this paper. In order to analyze the energy consumption, the node model is simulated using Proteus Software tool. The proposed sensor nodes power characteristics are measured by using different combinations of microprocessors and sensors. Using this, the energy consumption of the node is calculated. This is a cost-effective method and provides appropriate power model for specific applications.
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