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Search Results: 1 - 10 of 371693 matches for " R. D’Ambrosio "
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Treatment of experienced and na ve patients with hepatitis C: focus on telaprevir
D'Ambrosio R, Aghemo A, Colombo M
Biologics: Targets and Therapy , 2012, DOI: http://dx.doi.org/10.2147/BTT.S20673
Abstract: eatment of experienced and na ve patients with hepatitis C: focus on telaprevir Review (1365) Total Article Views Authors: D'Ambrosio R, Aghemo A, Colombo M Published Date October 2012 Volume 2012:6 Pages 363 - 370 DOI: http://dx.doi.org/10.2147/BTT.S20673 Received: 17 April 2012 Accepted: 11 May 2012 Published: 18 October 2012 Roberta D’Ambrosio, Alessio Aghemo, Massimo Colombo Centro A.M. e A. Migliavacca, First Division of Gastroenterology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy Abstract: Telaprevir (TVR) is an orally available protease inhibitor of the hepatitis C virus that in association with pegylated interferon and ribavirin (PR) was shown to improve the rates of sustained virological response and potentially reduce treatment duration in adult patients with chronic hepatitis C genotype. Despite its robust activity in both treatment-na ve and experienced patients, the addition of TVR to PR is counterbalanced by increased costs and adverse events; moreover, there are still areas of uncertainty that regard treatment of patients with advanced liver disease, the role of patient stratification by genetic predictors, and the use/need for a lead-in phase with PR. Since TVR regimens have been associated with the risk of viral mutants that may cause treatment failure and jeopardize future therapeutic strategies with direct-acting antiviral agents, early stopping rules have been designed to protect patients with a poor virological response to TVR regimens against such a risk.
“COLATURA DI ALICI “ CETARESE: EVALUATION OF AMINIC PROFILE
R. Mercogliano,R. DAmbrosio,A. De Felice,C. Chirollo
Italian Journal of Food Safety , 2008, DOI: 10.4081/ijfs.2008.2.45
Abstract: “Colatura d’alici”is a speciality made in Cetara, a clear ,amber-coloured liquid that has sharp taste, prepared with the juice coming from the anchovy salting process. The anchovies are caught in the Gulf of Salerno between the mounths of March and July. The colatura is ready at the beginning of December. Histamine poisoning, a food-borne chemical intoxication caused by the consumption of food containing toxic levels of histamine, is a syndrome commonly associated with the consumption of seafood beloging to the Engraulidae and some fish families. Histamine and biogenic amine levels were determined in “colatura di alici di Cetara”. The amine was separated in a HPLC/FL system. Histamine level were lower than the law limits only in one of the examinated products. A reduction of the histamine and amine levels in colatura cetarese can be obtained using a determinate salt concentrations and changing way of seasoning.
Treatment of experienced and naïve patients with hepatitis C: focus on telaprevir
D'Ambrosio R,Aghemo A,Colombo M
Biologics: Targets and Therapy , 2012,
Abstract: Roberta D’Ambrosio, Alessio Aghemo, Massimo ColomboCentro A.M. e A. Migliavacca, First Division of Gastroenterology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, ItalyAbstract: Telaprevir (TVR) is an orally available protease inhibitor of the hepatitis C virus that in association with pegylated interferon and ribavirin (PR) was shown to improve the rates of sustained virological response and potentially reduce treatment duration in adult patients with chronic hepatitis C genotype. Despite its robust activity in both treatment-na ve and experienced patients, the addition of TVR to PR is counterbalanced by increased costs and adverse events; moreover, there are still areas of uncertainty that regard treatment of patients with advanced liver disease, the role of patient stratification by genetic predictors, and the use/need for a lead-in phase with PR. Since TVR regimens have been associated with the risk of viral mutants that may cause treatment failure and jeopardize future therapeutic strategies with direct-acting antiviral agents, early stopping rules have been designed to protect patients with a poor virological response to TVR regimens against such a risk.Keywords: protease inhibitor, pegylated interferon, ribavirin
Tuberculosis: an ancient and evergreen disease
G.B. Migliori,L. D'Ambrosio,R. Centis
European Respiratory Review , 2011,
Abstract:
Descompactación de suelos franco limosos en siembra directa: efectos sobre las propiedades edáficas y los cultivos
álvarez,Carina R; Torres Duggan,Martín; Chamorro,Enrique R; DAmbrosio,Diego; Taboada,Miguel A;
Ciencia del suelo , 2009,
Abstract: mechanical decompaction may improve the physical properties of no-tillage silty loam soils. the aims of this study were to: 1- evaluate the influence of mechanical tilling (e.g. paratill or cultivie) on soil physical (gravimetric water content, bulk density, penetration resistance and infiltration rate) and chemical (nitrate content) properties in no-tillage soils; 2- quantify the impact of soil decompaction on maize yield; and 3- evaluate the persistence of soil compaction alleviation on soil penetration resistance, root abundance and crop yields after maize. six field experiments were conducted in no-tillage maize plots in the rolling pampa region. paired plots were compared: continuous no tillage (test) vs. soil compaction alleviation by deep tillage (desc). soil penetration resistance decreased by 37and 24 % (p < 0.05) at the 0-25 cm and 0-40 cm soil layers, respectively, and the soil infiltration rate increased (p= 0.07) from test to desc at the v5-v6 maize growing stage. no deep tillage effect was observed on soil bulk density and nitrate content. maize yields were significantly augmented by soil compaction alleviation (p < 0.001) with an average response of 659 kg ha-1 (5.56%). all sites showed economic benefits. no residual effects were found in soil physical properties, root growth and yield in the following crops. the results indicate shortterm effects of soil decompaction by deep tillage on soil penetration resistance and maize yield, but no residual effects on subsequent crops.
Descompactación de suelos franco limosos en siembra directa: efectos sobre las propiedades edáficas y los cultivos Decompaction of no-tillage soils: effects on soil properties and crops
Carina R álvarez,Martín Torres Duggan,Enrique R Chamorro,Diego DAmbrosio
Ciencia del Suelo , 2009,
Abstract: La descompactación mecánica puede mejorar las condiciones físicas de suelos franco limosos que sufren compactación en siembra directa. Los objetivos del presente trabajo fueron: 1-evaluar la influencia de la descompactación mecánica (e.g. paratill o cultivie) sobre algunas propiedades físicas y químicas de suelos manejados bajo siembra directa; 2- cuantificar el impacto de la descompactación sobre el rendimiento de maíz; 3-evaluar la perdurabilidad de la descompactación sobre variables físicas edáficas, desarrollo de raíces y rendimiento de los cultivos implantados luego del maíz. Durante la campa a 2006/07 se condujeron seis ensayos de campo en lotes de producción de maíz ubicados en la Pampa Ondulada. Se compararon parcelas apareadas en siembra directa continua (TEST) vs. parcelas con pasaje de equipo descompactador a 30 cm (DESC). La resistencia a la penetración disminuyó 37 y 24% (p < 0,05) en las capas de 0-25 cm y 0-40 cm, respectivamente, y la tasa de infiltración aumentó (p= 0,07) de TEST a DESC en el estado V5-V6 de maíz. No se encontraron efectos de la descompactación sobre la densidad aparente y disponibilidad de nitratos. La decompactación aumentó significativamente (p < 0,001) el rendimiento de maíz con una respuesta media de 659 kg ha-1 (5,56%) y beneficios económicos positivos en todos los sitios. No se observaron efectos residuales de la descompactación sobre la resistencia a la penetración y el rendimiento de los cultivos subsiguientes al maíz. Los resultados indican que la descompactación produjo efectos positivos de corto plazo sobre la resistencia a la penetración y el rendimiento maíz pero no se observó efecto residual sobre el/ los cultivo/ s subsiguientes. Mechanical decompaction may improve the physical properties of no-tillage silty loam soils. The aims of this study were to: 1- evaluate the influence of mechanical tilling (e.g. paratill or cultivie) on soil physical (gravimetric water content, bulk density, penetration resistance and infiltration rate) and chemical (nitrate content) properties in no-tillage soils; 2- quantify the impact of soil decompaction on maize yield; and 3- evaluate the persistence of soil compaction alleviation on soil penetration resistance, root abundance and crop yields after maize. Six field experiments were conducted in no-tillage maize plots in the Rolling Pampa region. Paired plots were compared: continuous no tillage (TEST) vs. soil compaction alleviation by deep tillage (DESC). Soil penetration resistance decreased by 37and 24 % (p < 0.05) at the 0-25 cm and 0-40 cm soil layers, respectively, an
Model of Thermal Wavefront Distortion in Interferometric Gravitational-Wave Detectors I: Thermal Focusing
R. G. Beausoleil,E. D'Ambrosio,W. Kells,J. Camp,E K. Gustafson,M. M. Fejer
Physics , 2002, DOI: 10.1364/JOSAB.20.001247
Abstract: We develop a steady-state analytical and numerical model of the optical response of power-recycled Fabry-Perot Michelson laser gravitational-wave detectors to thermal focusing in optical substrates. We assume that the thermal distortions are small enough that we can represent the unperturbed intracavity field anywhere in the detector as a linear combination of basis functions related to the eigenmodes of one of the Fabry-Perot arm cavities, and we take great care to preserve numerically the nearly ideal longitudinal phase resonance conditions that would otherwise be provided by an external servo-locking control system. We have included the effects of nonlinear thermal focusing due to power absorption in both the substrates and coatings of the mirrors and beamsplitter, the effects of a finite mismatch between the curvatures of the laser wavefront and the mirror surface, and the diffraction by the mirror aperture at each instance of reflection and transmission. We demonstrate a detailed numerical example of this model using the MATLAB program Melody for the initial LIGO detector in the Hermite-Gauss basis, and compare the resulting computations of intracavity fields in two special cases with those of a fast Fourier transform field propagation model. Additional systematic perturbations (e.g., mirror tilt, thermoelastic surface deformations, and other optical imperfections) can be included easily by incorporating the appropriate operators into the transfer matrices describing reflection and transmission for the mirrors and beamsplitter.
Analysis and correction of the magnetic field effects in the Hybrid Photo-Detectors of the RICH2 Ring Imaging Cherenkov detector of LHCb
R. Cardinale,C. D'Ambrosio,R. Forty,C. Frei,T. Gys,A. Petrolini,D. Piedigrossi,B. Storaci,M. Villa
Physics , 2011, DOI: 10.1088/1748-0221/6/06/P06010
Abstract: The Ring Imaging Cherenkov detectors of the LHCb experiment at the Large Hadron Collider at CERN are equipped with Hybrid Photo-Detectors. These vacuum photo-detectors are affected by the stray magnetic field of the LHCb magnet, which degrades their imaging properties. This effect increases the error on the Cherenkov angle measurement and would reduce the particle identification capabilities of LHCb. A system has been developed for the RICH2 Ring Imaging Cherenkov detector to perform a detailed characterisation of the magnetic distortion effects. It is described, along with the methods implemented to correct for these effects, restoring the optimal resolution.
Wood Polymer Composites Technology Supporting the Recovery and Protection of Tropical Forests: The Amazonian Phoenix Project
Marcia C. Branciforti,Alessandra L. Marinelli,Marcio Kobayashi,Jose D. Ambrosio,Marcos R. Monteiro,Antonio D. Nobre
Sustainability , 2009, DOI: 10.3390/su1041431
Abstract: The Amazon Rain Forest has attracted worldwide attention due its large scale services to climate and also due to the green house gas emissions arising from deforestation. Contributing to the later and detrimental to the former, timber logging in the region has very low efficiency (only 16% in the production chain). Such timber extraction, often referred to as selective logging, has been claimed as a sustainable extractive industry, because the forest is said to restore itself through regenerative growth. But forest regeneration in the Amazon occurs naturally only in a very limited scale, resulting that large scale, low efficiency logging poses a big treat to the functional integrity of the biome, supplying to the market only a fraction of what it could if done differently. So, instead of extracting big centennial logs from the forests, the Amazonian Phoenix project proposes that large expanses of degraded lands be reforested using pioneer plants species from the forest itself. These plants have the capacity to heal gaps in the canopy, being able to grow and produce woody biomass in very extreme conditions. The idea is to mimic the regenerative dynamics of the natural ecosystem in short cycle agrosilvicultural production areas, utilizing a variety of technologies to transform raw fibers from these fast growth native plants into a variety of materials with high aggregated value. This communication presents the research on natural fibers by the Polymeric Composites Group within the Amazonian Phoenix Project. Sustainable technologies employing materials with good and responsible ecological footprints are important and necessary stimulus for a change in the destructive economical activities present in the Amazon frontiers. The relatively well established wood polymer composites technology, for example, is a good candidate solution. Two research and development fields are proposed: the first one considers production systems with simple and cheap machinery, to facilitate technology assimilation by rural communities in the Amazon. The second one aims at developing composite materials with advanced production technology, like profile and sheet extrusion and injection molding. The source of the fibers would be both the short cycle agrosilviculture with softwood species, on already deforested lands, and the hardwood residues from operating sawmills. Preliminary results show that softwood fibers act as potentially important reinforcement for synthetic plastics.
Obsolescência institucional e degrada??o ambiental e social
D'Ambrosio, Ubiratan;
Cadernos de Saúde Pública , 1992, DOI: 10.1590/S0102-311X1992000400012
Abstract: although military crises continue to be a major concern for all of mankind, it is clear that ongoing problems such as disparities between rich and poor, among nations and within societies, other forms of violation of human rights and regional and global environmental aggression jeopardize the future of civilization on earth. quality of life continues to defy improvement in the less developed countries and at the same time plunges dizzily in the industrialized countries. such issues call for a cooperative effort, bringing developed and less developed nations together in long-range projects in education, health, sustainable agriculture and energy supply. clearly, the population problem is of equal concern. we are talking not only of quantitative aspects, but mainly of qualitative ones. although there are scientific and technological instruments to correct these distortions in modern civilization, a concerted effort by all nations in the world towards peace in its various dimensions is an absolute necessity.
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