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Six phenolic monomers (M1 - M6) have been synthesized, namely, potassium-3-(ortho,para)-hydroxy benzoyl dithiofor- mate (M1 and M2), (ortho,para)-(4-amino-5-mercapto-1,2,4 triazol-3-yl)-phenol (M3 and M4), (ortho,para)-hydroxy benzoic acid thiosemicarbazide (M5 and M6) and twelve novel chelating terpolymers (P1 - P12) were synthesized by ter- polymerization condensation reaction of these monomers with phenol or bis phenol-A and excess of formalin in basic medium. The monomers (M1 - M6) and their co-polymers (P1 - P12) were characterized by FT.IR, H1-NMR, elemental analysis and thermal analysis (TGA) and according to data obtained the structures of these compounds were proposed. Analytical evaluation of chelating selectivity of these polymers toward (Co2+, Cr3+, Cu2+, Cd2+, Pb2+) were achieved by batch equilibrium method, the results show that all synthetic resins have high efficiency toward (Cr3+) and less effi- ciency toward (Co2+, Cu2+, Cd2+ and Pb2+).
Tilmicosin was administered intravenously and
subcutaneously at a dose rate of 10 mg/kg bwt to determine its concentration in
blood and bronchial secretion as well as its kinetic behavior in healthy and Pasteurella
haemolytica type A1-infected calves. Sever acute bronchopneumonia was
induced in 10 calves by inoculating them intra-tracheally with P.
haemolytica type A1. The calves were treated with tilmicosin; 5 of these
received the drug intravenously and the other 5 were injected subcutaneously. After
a slow intravenous injection, the serum concentration-time curve indicated a
two compartment open model with a mean elimination half-lives (t1/2bs) of 22.09 and 22.14 hours before and after infection, respectively. The
mean residence time (MRT) corrected for a bolus injection was 2.25 and 2.20
hours and the mean MRTinf was 25.27 and 25.46 hours in healthy and P.
haemolytica-infected calves, respectively. After subcutaneous injection, the drug was
eliminated more slowly (before and after infection) from serum and bronchial
secretions, with t1/2bs of (24.60 and 25.85 hours) and (33.74 and 31.78
hours), respectively. The apparent volume of distribution (V