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Search Results: 1 - 10 of 223636 matches for " R Oketcho "
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Epidemiological factors in admissions for diarrhoea in 6 - 60-month-old children admitted to Morogoro Regional Hospital, Tanzania
R Oketcho, ED Karimuribo, CNM Nyaruhucha, S Taybali
South African Journal of Child Health , 2012,
Abstract: Objectives. To describe the diarrhoea admissions and the influencing factors in 6 - 60-month-old children at Morogoro Regional Hospital. Design. A retrospective descriptive study of the type of diarrhoea, patient age, home address, nutritional status, diagnosed infection, month of admission, admission duration and outcome. Setting. A hospital-based study: paediatric admissions at Morogoro Regional Hospital. Subjects. All children aged 6 - 60 months admitted to the infectious diseases ward over the 60-month period from May 2006 to April 2011. Results. A total of 4 988 records were extracted, among which the prevalence of diarrhoea was 2 855 (57.2%). Among the 2 855 children with diarrhoea, the majority (2 536 (88.8%)), were 6 - 24 months old, with peak admissions at 7 months and 12 months. District of residence, season, undernutrition and infection were the factors significantly associated (p<0.001) with the age at which children were admitted with diarrhoea. Conclusions. There were increased numbers of admissions for diarrhoea at the ages of 7 months and 12 months, during the dry season and together with diagnosed infection, particularly malaria. However, further study on causes of childhood diarrhoea, given the identified risk factors, may better explain the epidemiology of diarrhoea in Morogoro.
Spatial Differentiation of Small Holder Farmers’ Vulnerability to Climate Change in the Kyoga Plains of Uganda  [PDF]
Oketcho Chombo, Shuaib Lwasa, Tenywa Moses Makooma
American Journal of Climate Change (AJCC) , 2018, DOI: 10.4236/ajcc.2018.74039
Abstract: The paper assessed the variation in the level of vulnerability to climate change among small holder farmers in the Kyoga plains of Uganda. It was hypothesized that there is no spatial variation in the level of vulnerability to climate change among the small holder farmers of different socioeconomic characteristics in the Kyoga plains. It improves the understanding of the different dimensions of vulnerability. This can help to design practical policies and intervention strategies that are specific to the communities’ spatial strata to reduce development imbalances and empower the most vulnerable small holder farmers. The conceptual framework is based on the three elements of vulnerability that is, exposure, sensitivity and adaptive capacity. The cross-sectional survey research design was used to collect both quantitative and qualitative data. Household data were acquired by using a structured questionnaire supported by focussed group discussions while meteorological data were collected using data base review. The study was done in the Kyoga plains agro ecological zone of Uganda comprising of several districts out of which Tororo and Pallisa were picked. Indicators for the components of vulnerability (Exposure, Sensitivity and Adaptive Capacity) were selected by Principle Component Analysis (PCA) and Vulnerability Indices constructed at household level then aggregated at sub county level for correlation using ANOVA. Inter sub county vulnerability index correlation revealed a spatial variation in the level of vulnerability between the different sub counties with Kasodo Sub County in Pallisa being the most vulnerable and Rubongi in Tororo being the least vulnerable. Policy measures and development efforts should therefore focus on place specific strategies of adapting to climate change rather nationwide or region wide strategies. There is also need to refocus policy to nonfarm activities which are less susceptible to climate change and enhance farmers’ income.
Tuberculin Skin Test Reversion following Isoniazid Preventive Therapy Reflects Diversity of Immune Response to Primary Mycobacterium tuberculosis Infection
Denise F. Johnson, LaShaunda L. Malone, Sarah Zalwango, Joy Mukisa Oketcho, Keith A. Chervenak, Bonnie Thiel, Harriet Mayanja-Kizza, Catherine M. Stein, W. Henry Boom, Christina L. Lancioni, for the Tuberculosis Research Unit
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0096613
Abstract: Rationale Healthy household contacts (HHC) of individuals with Tuberculosis (TB) with Tuberculin Skin Test (TST) conversions are considered to harbor latent Mycobacterium tuberculosis (Mtb), and at risk for TB. The immunologic, clinical, and public health implications of TST reversions that occur following Isoniazid preventive therapy (IPT) remain controversial. Objectives To measure frequency of TST reversion following IPT, and variation in interferon-gamma (IFN-γ) responses to Mtb, in healthy Ugandan TB HHC with primary Mtb infection evidenced by TST conversion. Methods Prospective cohort study of healthy, HIV-uninfected, TST-negative TB HHC with TST conversions. Repeat TST was performed 12 months following conversion (3 months following completion of 9 month IPT course) to assess for stable conversion vs. reversion. Whole blood IFN-γ responses to Mtb antigen 85B (MtbA85B) and whole Mtb bacilli (wMtb) were measured in a subset (n = 27 and n = 42, respectively) at enrollment and TST conversion, prior to initiation of IPT. Results Of 122 subjects, TST reversion was noted in 25 (20.5%). There were no significant differences in demographic, clinical, or exposure variables between reverters and stable converters. At conversion, reverters had significantly smaller TST compared to stable converters (13.7 mm vs 16.4 mm, respectively; p = 0.003). At enrollment, there were no significant differences in IFN-γ responses to MtbA85B or wMTB between groups. At conversion, stable converters demonstrated significant increases in IFN-γ responses to Ag85B and wMtb compared to enrollment (p = 0.001, p<0.001, respectively), while there were no significant changes among reverters. Conclusions TST reversion following IPT is common following primary Mtb infection and associated with unique patterns of Mtb-induced IFN-γ production. We have demonstrated that immune responses to primary Mtb infection are heterogeneous, and submit that prospective longitudinal studies of cell mediated immune responses to Mtb infection be prioritized to identify immune phenotypes protective against development of TB disease.
Power Aware Routing Protocol (PARP) for Wireless Sensor Networks  [PDF]
R. Prema, R. Rangarajan
Wireless Sensor Network (WSN) , 2012, DOI: 10.4236/wsn.2012.45019
Abstract: Several wireless sensor network applications ought to decide the intrinsic variance between energy efficient communication and the requirement to attain preferred quality of service (QoS) such as packet delivery ratio, delay and to reduce the power consumption of wireless sensor nodes. In order to address this challenge, we propose the Power Aware Routing Protocol (PARP), which attains application-specified communication delays at low energy cost by dynamically adapting transmission power and routing decisions. Extensive simulation results prove that the proposed PARP attains better QoS and reduced power consumption.
Studies on Dissolution Behaviour of Nanoparticulate Curcumin Formulation  [PDF]
R. Ravichandran
Advances in Nanoparticles (ANP) , 2013, DOI: 10.4236/anp.2013.21010
Abstract:

Curcumin is the main biologically active phytochemical compound of turmeric that has been widely used by ancient cultures throughout Asia. However the dissolution rate limited absorption and pre-absorption degradation limits its use as a potential therapeutic. In this study an attempt has been made to overcome the above limitations by curcumin delivery through nanotechnology. Nanocurcumin solid dosage formulations were prepared and studied for its dissolution behaviour. Considerable improvement in the dissolution behavior was observed in the drug nanocrystal-loaded solid dosage forms. This is expected to enhance the bioavailability of poorly soluble medicinal herbs such as turmeric in the body.

Pharmacokinetic Study of Nanoparticulate Curcumin: Oral Formulation for Enhanced Bioavailability  [PDF]
R. Ravichandran
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2013, DOI: 10.4236/jbnb.2013.43037
Abstract:

Curcumin, a bioactive component of turmeric, which is a commonly used spice and nutritional supplement, is isolated from the rhizomes of Curcuma longa Linn. (Zingiberaceae). In recent years, the potential pharmacological actions of Curcumin in inflammatory disorders, cardiovascular disease, cancer, Alzheimer’s disease and neurological disorders have been shown. However, the clinical application of Curcumin is severely limited by its main drawbacks such as instability, low solubility, poor bioavailability and rapid metabolism. Multifarious nanotechnology-based drug delivery systems for Curcumin including liposomes, polymeric nanoparticles, solid lipid nanoparticles, micelles, nanogels, nanoemulsions, complexes and dendrimer/dimer, have been attempted to enhance the oral bioavailability, biological activity or tissue-targeting ability of Curcumin. We attempted the nanosuspensions based delivery of curcumin. Nanonisation renders curcumin completely dispersible in aqueous media. To enhance the curcumin absorption by oral administration, nanoparticulate solid oral formulation of curcumin was prepared by us and the resulting capsule was then examined for its efficiency on bioavailability in Male Wistar rats at a dose of 100 mg curcumin/kg body weight and the pharmacokinetic parameters were compared to those of normal curcumin powder and a commercial curcumin capsule CUR-500. The bio-distribution of curcumin in organs of rat was also studied. Nanoparticulation significantly raised the curcumin concentration in selective organs in the body. The results obtained provide promising results for nanoparticulate Curcumin to improve its biological activities. Enhanced bioavailability of curcumin in the form of nanoparticle is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease. The available information also strongly suggests that nano-formulation of ingredients such as curcumin may be used as a novel nutrient delivery system too.

The Arithmetic Mean Standard Deviation Distribution: A Geometrical Framework  [PDF]
R. Caimmi
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.411A4001
Abstract:

The current attempt is aimed to outline the geometrical framework of a well known statistical problem, concerning the explicit expression of the arithmetic mean standard deviation distribution. To this respect, after a short exposition, three steps are performed as 1) formulation of the arithmetic mean standard deviation, \"\", as a function of the errors, \"\", which, by themselves, are statistically independent; 2) formulation of the arithmetic mean standard deviation distribution, \"\", as a function of the errors, \"\"; 3) formulation of the arithmetic mean standard deviation distribution, \"\", as a function of the arithmetic mean standard deviation, \"\", and the arithmetic mean rms error, \"\". The integration domain can be expressed in canonical form after a change of reference frame in the n-space, which is recognized as an infinitely thin n-cylindrical corona where the symmetry axis coincides with a coordinate axis. Finally, the solution is presented and a number of (well known) related parameters are inferred for sake of completeness.

Optimized Parameter Combinations of Hydraulic Damper Modules  [PDF]
R. Sonnenburg
Journal of Transportation Technologies (JTTs) , 2014, DOI: 10.4236/jtts.2014.43025
Abstract:

This paper is devoted to the problem of finding optimized parameter combinations of automotive damper modules. Different cost functions using the amplitude spectrum of the excitation and the frequency response function of the car model will be investigated and it is shown that for three different arbitrary road excitations there exists a parameter combination of top mount stiffness, piston rod mass and damping constant that provides an optimum for the dynamic wheel load fluctuation. The achieved advantage of the optimized damper module regarding the dynamic wheel load fluctuation compared to a simple damper in a two mass vibration system can reach up to 20 percent.

CSA Discounting: Impacts on Pricing and Risk of Commodity Derivatives  [PDF]
R. Abbate
Journal of Financial Risk Management (JFRM) , 2014, DOI: 10.4236/jfrm.2014.33011
Abstract: The global financial crisis of 2007-2008 caused market practitioners to reassess the way in which financial derivative contracts had been priced during the preceding thirty years. The purpose of this paper is to examine the evolving practice of pricing and hedging commodity derivative contracts according to the terms of the Credit Support Annex (CSA). Using a series of case studies, we price crude oil swaps and Asian options in the pre-crisis, peak-crisis, post-crisis and recent market environments under two different frameworks: LIBOR discounting and CSA discounting (also referred to in a less general form as “OIS discounting”, which incorporates nearly risk-free interest rates). We also compute the widely used first-order and second-order Greek sensitivities. In each market environment, we shift the forward prices and implied volatilities crude oil and re-compute the trades’ valuation and Greek sensitivities at each incremental increase or decrease in price or implied volatility. Under each discounting framework, we quantify the change in trade valuation and Greek sensitivities that results from switching from LIBOR discounting to CSA discounting. The impact on the valuation and Greek sensitivities of a swap and an Asian option as the result of adopting CSA discounting can be significant under certain market conditions. There is likely to be larger impact on directional portfolios containing transactions that hedge either consumption or production (e.g. end users). Ceteris paribus, the impact on portfolio valuation and risk is likely to be limited for market participants (e.g. banks) with hedged portfolios that contain a large number of offsetting positions. Even though we focus our analysis on crude oil derivative contracts, the results easily extend to other asset classes such as natural gas, refined products, agriculture, metals, etc.
The Weighted Mean Standard Deviation Distribution: A Geometrical Framework  [PDF]
R. Caimmi
Applied Mathematics (AM) , 2015, DOI: 10.4236/am.2015.63049
Abstract: The current attempt is aimed to extend previous results, concerning the explicit expression of the arithmetic mean standard deviation distribution, to the general case of the weighted mean standard deviation distribution. To this respect, the integration domain is expressed in canonical form after a change of reference frame in the n-space, which is recognized as an infinitely thin n-cylindrical corona where the axis coincides with a coordinate axis and the orthogonal section is an infinitely thin, homotetic (n-1)-elliptical corona. The semiaxes are formulated in two different ways, namely in terms of (1) eigenvalues, via the eigenvalue equation, and (2) leading principal minors of the matrix of a quadratic form, via the Jacobi formulae. The distribution and related parameters have the same formal expression with respect to their counterparts in the special case where the weighted mean coincides with the arithmetic mean. The reduction of some results to ordinary geometry is also considered.
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