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Computer-Aided Vaccine Design: A Brief Report
R Ghasemi Khorasgani,M Sanaei,M Mohammad Beigi
Tehran University Medical Journal , 2012,
Abstract: Background: Although the conventional vaccines have been instrumented in the incidence of many infectious diseases, the advances in genetic engineering and bioinformatics have provided the opportunity for developing improved and new vaccines.Methods: Reverse vaccinology was pioneered by a group of researchers investigating development of a vaccine against serogroup B Neisseria meningitidis. Reverse vaccinology analyzes the entire genome of a pathogen with the aid of computational programs to identify potentially antigenic extracellular proteins.Results: Using this method for Neisseria meningitidis genome analysis, 600 secretory or surface-exposed proteins were identified and, subsequently, 350 proteins were expressed and purified. Finally, seven proteins capable of activating the immune system against a range of strains were identified.Conclusion: Improved computational techniques are now able to provide researchers with high-confidence predictions for complex biological characteristics. This will herald a move to computer-aided biotechnology in which time-consuming and expensive large-scale experimental approaches are progressively replaced by functional bioinformatic investigations.
A Comparison of Healing Effects of Propolis and Silver Sulfadiazine on Full Thickness Skin Wounds in Rats
E. Moghtaday Khorasgani*, A. H. Karimi and M. R. Nazem
Pakistan Veterinary Journal , 2010,
Abstract: Healing effects of propolis and silver sulfadiazine (SS) on skin wounds in rats were compared using qualitative and quantitative parameters and histopathological findings. A total of 30 full thickness skin wounds were created on dorsal aspects of 10 rats; i.e., three wounds on each rat. Of these wounds, 10 each were allocated to group A (propolis), group B (SS) and group C (control). The skin wounds in the rats of groups A, B and C were covered daily for 14 days with 50% propolis cream, SS skin cream and bepanthane cream (control), respectively. Postoperatively, the wound surfaces were examined macroscopically and the healing process and the rates of wound expansion, contraction and epithelialization processes were quantitatively analyzed. As a result, propolis was found in general to have a better wound healing effect than others. At the 10th day of experiment histopathologically, there was inflammatory reaction with infiltration of lymphocytes, macrophages and neutrophils and proliferation of fibroblastic loose connective tissue in dermis of rats of all groups. The severity of these changes was lower in propolis treated group compared to other two groups.
Study of Tsunamis by Dimensional Analysis  [PDF]
S. Ghasemi
Engineering (ENG) , 2011, DOI: 10.4236/eng.2011.39111
Abstract: Tsunamis are among the most terrifying natural hazards known to man and have been responsible for tre-mendous loss of life and property throughout history. In this paper by means of dimensional analysis, important non-dimensional groups in Tsunamis was studied and an equation to calculate the power of tsunamis was obtained. Also by this method and using tsunami basic physics, the height of waves near the coastline was estimated and results were compared by reported values.
Application of Linear Model Predictive Control and Input-Output Linearization to Constrained Control of 3D Cable Robots  [PDF]
Ali Ghasemi
Modern Mechanical Engineering (MME) , 2011, DOI: 10.4236/mme.2011.12009
Abstract: Cable robots are structurally the same as parallel robots but with the basic difference that cables can only pull the platform and cannot push it. This feature makes control of cable robots a lot more challenging compared to parallel robots. This paper introduces a controller for cable robots under force constraint. The controller is based on input-output linearization and linear model predictive control. Performance of input-output linearizing (IOL) controllers suffers due to constraints on input and output variables. This problem is successfully tackled by augmenting IOL controllers with linear model predictive controller (LMPC). The effecttiveness of the proposed method is illustrated by numerical simulation.
Effect of anandamide in improving of the non-adrenergic non-cholinergic relaxation of the corpus cavernosum from diabetic rats
Ghasemi M,Dehpour A.R.
Tehran University Medical Journal , 2008,
Abstract: "nBackground: It is well known that erectile dysfunction is most commonly associated with diabetes, affecting 35% to 75% of men with diabetes mellitus. Several studies have been carried out to find appropriate strategies for treatment of diabetes-induced erectile dysfunction. The aim of the present study was to investigate the ability of acute administration of the endogenous cannabinoid anandamide in vitro to alter the NANC-mediated relaxation of corpus cavernosum from diabetic rats and the possible role of nitric oxide in this manner. "nMethods: Diabetes was induced by the administration of streptozotocin for eight weeks. Corpora cavernosa were isolated in organ baths for measurement of agonist-evoked or electrical field stimulation (EFS)-evoked smooth muscle tensions. "nResults: The neurogenic relaxation of phenylephrine (7.5 μM) precontracted isolated corporal strips was impaired in diabetic animals. Anandamide (0.3, 1 and 3 μM) enhanced the relaxant responses to EFS in diabetic strips in a dose-dependent manner. This effect was antagonized by either the selective cannabinoid CB1 receptor antagonist AM251 (1 μM) or the selective vanilloid receptor antagonist capsazepine (3 μM). Concurrent administration of partially effective doses of L-arginine (10 μM) and anandamide (0.3 μM) exerted a synergistic improvement in EFS-induced relaxation of diabetic strips (p<0.001). The relaxant responses to the nitric oxide donor sodium nitroprusside of the subjects in the diabetic and control groups were similar. "nConclusion: For the first time, we demonstrated that acute administration of an endogenous cannabinoid, alone or in combination with L-arginine could improve the NO-mediated relaxation of cavernosal smooth muscle in diabetic rats and this effect was mediated by cannabinoid CB1 and vanilloid VR1 receptors within the tissue."n"nKeywords: Diabetes mellitus; erectile dysfunction; anandamide; cannabinoid system; nitric oxide; corpus cavernosum.
Investigation into the Translucency of Tooth-Colored Restorative Materials
H. Torabzadeh,R. Aminian,A. Ghasemi
Journal of Dentistry of Tehran University of Medical Sciences , 2009,
Abstract: Objective: The aim of this study was to investigate the translucency of resin-modified glass-ionomer cements (RMGIC) and polyacid-modified composite resin (PCMR) over a period of one year.Materials and Methods: The study was done on three RMGIC (Fuji II LC, Photac-Fil Aplicap and Vitremer) and one PCMR (Dyract). A conventional GIC (Fuji Cap II) and two composite resins (Tetric and Z 100) were used for comparison. Five discs approximately 5 mm in diameter and 1.5 mm thick were made from each material using a Perspex mould. The specimens were kept in distilled water at 37°C during the test period. The optical density/mm (inverse of translucency) of each material was measured using a special photometric set up after preparation and after one week, six months, and one year.Means and standard deviations were calculated and subjected to Two-way ANOVA, Oneway ANOVA and Scheffe tests.Results: The results indicated that all of the materials, except Dyract, showed an increase of translucency over the test period. After one year, the conventional GIC was the least translucent material.Conclusion: The translucency of the resin-modified GICs and Dyract was equivalent to that of the composite resins Tetric and Z 100.
A collocation method for the solution of nonlinear one-dimensional parabolic equations
J. Rashidinia,M. Ghasemi,R. Jalilian
Mathematical Sciences Quarterly Journal , 2010,
Abstract: In this paper, we develop a collocation method based on cubic B-spline to the solution of nonlinear parabolic equation $varepsilon u_{xx}=a(x,t)u_{t}+phi(x,t,u,u_{x})$ subject to appropriate initial, and Dirichlet boundary conditions, where $varepsilon >0$ is a small constant. We developed a new two-level three-point scheme of order $O(k^2+h^2)$. The convergence analysis of the method is proved. Numerical results are given to illustrate the efficiency of our method computationally.
A Case Report of Infectious Mononucleosis after Curettage
M. Movahedi,R. Sabahi,M. Ghasemi
Qom University of Medical Sciences Journal , 2008,
Abstract: Background and Objectives Epstein Barr Virus (EBV) infection leading to Infectious Mononucleosis (IM) is one of the etiologies of fever in women after curettage. EBV is a virus that can be transferred from carrier to the recipient through contact. The focus of this article is to bring more awareness to EBV as a rare cause of infection and fever after curettage procedure.Case ReportThis is a case of a woman who developed fever after curettage procedure. After a series of medical tests, the cause of her fever was found to be IM from an EBV infection. The emphasis of this report is to bring medical team’s attention to both common and uncommon etiologies of fever after an abortion procedure for better diagnosis and treatment of patients. Keywords: Infections mononucleosis; Curettage; fever.
Six-cold-month Precipitation over Southwestern and Central Iran and its Relation to E1 Ninio Southern Oscillation
M. J. Nazemosadat,A. R. Ghasemi
Journal of Science and Technology of Agriculture and Natural Resources , 2003,
Abstract: The present study evaluates the influence of the El Ninio Southern Oscillation (ENSO) phenomenon on the cold season precipitation over Isfahan, Fars, Khuzestan, Chaharmahal-Bakhtyari, Bushehr and Kohgiluyeh-Boyerahmad provinces. The results indicate that the occurrence of La Nina events caused a 20% to 50% reduction in precipitation over Bushehr, Chaharmahal-Bakhtyari and southern Fars. The cold event did not change the total precipitation over the other parts of the region. In contrast to La Nina episodes, the occurrence of El Ninio events caused a 20% to 70% increase in rainfall in most of the study area. While the most highly wet conditions are related to the El Ninio events, the occurrence probability of the severe droughts has found to be low during such events. In association with La Nina events, the occurrence probability of severe drought was found to be low. Only in Khuzestan and southern parts of the Fars Provinces, this probability has increased to about 0.5.
Economic Evaluation of Every-Other Furrow Irrigation for Sorghum with Real and Subsidized Irrigation Water Prices
M. M. Ghasemi,A. R. Sepaskhah
Journal of Science and Technology of Agriculture and Natural Resources , 2003,
Abstract: In this study, the effect of deficit irrigation with every–other furrow irrigation method, which is an innovated method in farm irrigation management, was examined on sorghum (Sorghum durra L.) in Bajgah and Kooshkak areas of Fars Province. The experimental design was split plot with three main plots of irrigation interval (10, 15 and 20 days), three subplots of irrigation methods (ordinary furrow, fixed and variable every–other furrow), and 4 replications. Considering the crop production cost with real and subsidized prices of water in both areas, the net benefit per unit volume of irrigation water and benefit–cost ratio were calculated. The results showed that these economic parameters for the fixed and alternative furrow irrigation methods of 10-day intervals in both areas did not differ much with those of the ordinary furrow irrigation with 10-day intervals and were even higher in Bajgah area. Furthermore, the relationship between the amount of irrigation water, water application efficiency (Ea), water price per unit volume (Cw) and the net benefit per unit volume of irrigation water (B) with different conveyance efficiencies (Ec) were determined by multiple linear regression procedure. The regression coefficients of linear fit equation between the costs and irrigation water were determined. The results indicated that with higher price of water, the farmer should increase the farm irrigation application efficiency to avoid the economic losses.
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