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Search Results: 1 - 10 of 146240 matches for " Quirico-Santos T. "
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Modulation of fibronectin expression in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis
De-Carvalho, M.C.A.;Chimelli, L.M.C.;Quirico-Santos, T.;
Brazilian Journal of Medical and Biological Research , 1999, DOI: 10.1590/S0100-879X1999000500012
Abstract: fibronectin (fn), a large family of plasma and extracellular matrix (ecm) glycoproteins, plays an important role in leukocyte migration. in normal central nervous system (cns), a fine and delicate mesh of fn is virtually restricted to the basal membrane of cerebral blood vessels and to the glial limitans externa. experimental autoimmune encephalomyelitis (eae), an inflammatory cns demyelinating disease, was induced in lewis rats with a spinal cord homogenate. during the preclinical phase and the onset of the disease, marked immunolabelling was observed on the endothelial luminal surface and basal lamina of spinal cord and brainstem microvasculature. in the paralytic phase, a discrete labelling was evident in blood vessels of spinal cord and brainstem associated or not with an inflammatory infiltrate. conversely, intense immunolabelling was present in cerebral and cerebellar blood vessels, which were still free from inflammatory cuffs. shortly after clinical recovery minimal labelling was observed in a few blood vessels. brainstem and spinal cord returned to normal, but numerous inflammatory foci and demyelination were still evident near the ventricle walls, in the cerebral cortex and in the cerebellum. intense expression of fn in brain vessels ascending from the spinal cord towards the encephalon preceded the appearance of inflammatory cells but faded away after the establishment of the inflammatory cuff. these results indicate an important role for fn in the pathogenesis of cns inflammatory demyelinating events occurring during eae.
Modulation of fibronectin expression in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis
De-Carvalho M.C.A.,Chimelli L.M.C.,Quirico-Santos T.
Brazilian Journal of Medical and Biological Research , 1999,
Abstract: Fibronectin (FN), a large family of plasma and extracellular matrix (ECM) glycoproteins, plays an important role in leukocyte migration. In normal central nervous system (CNS), a fine and delicate mesh of FN is virtually restricted to the basal membrane of cerebral blood vessels and to the glial limitans externa. Experimental autoimmune encephalomyelitis (EAE), an inflammatory CNS demyelinating disease, was induced in Lewis rats with a spinal cord homogenate. During the preclinical phase and the onset of the disease, marked immunolabelling was observed on the endothelial luminal surface and basal lamina of spinal cord and brainstem microvasculature. In the paralytic phase, a discrete labelling was evident in blood vessels of spinal cord and brainstem associated or not with an inflammatory infiltrate. Conversely, intense immunolabelling was present in cerebral and cerebellar blood vessels, which were still free from inflammatory cuffs. Shortly after clinical recovery minimal labelling was observed in a few blood vessels. Brainstem and spinal cord returned to normal, but numerous inflammatory foci and demyelination were still evident near the ventricle walls, in the cerebral cortex and in the cerebellum. Intense expression of FN in brain vessels ascending from the spinal cord towards the encephalon preceded the appearance of inflammatory cells but faded away after the establishment of the inflammatory cuff. These results indicate an important role for FN in the pathogenesis of CNS inflammatory demyelinating events occurring during EAE.
Efeito inibidor do crescimento tumoral pela metionina-encefalina
Mascarenhas, Georgia;Quirico-Santos, Thereza;
Arquivos de Neuro-Psiquiatria , 1992, DOI: 10.1590/S0004-282X1992000100015
Abstract: methionine-enkephalin (met-enk) is an endogenous opioid pentapeptide derived from the prohormone proenkephalin a, present in neuroendocrine and hematopoietic cells. enkephalins are known to play an important role on the processes of induction, activation and control of immunomodulatory events. met-enk has been considered a potent antitumoral agent. the present study shows that met-enk exerts an inhibitory effect on the growth of a macrophage derived fibrous histiocytoma (mc-ii) inoculated intradermally into balb/cj mice. such effect was mainly influenced by the protocol, route of administration and concentration of met-enk used for treatment. neither higher doses of met-enk injected intracerebrally or subcutaneously, nor the use of various protocols of treatment, did modify the process of tumorigenesis. in contrast, low dose (0.25mg/kg) of met-enk injected intracerebrally together with tumor inoculation, significantly reduced tumor growth and prolonged survival rate.
Case of Advanced Recurrent Glioblastoma Successfully Treated with Monoterpene Perillyl Alcohol by Intranasal Administration  [PDF]
C. O. Da Fonseca, Raphael M. Teixeira, Ricardo Ramina, Giovana Kovaleski, Júlio Thome Silva, Janaína Nagel, Thereza Quirico-Santos
Journal of Cancer Therapy (JCT) , 2011, DOI: 10.4236/jct.2011.21003
Abstract: We report a case of recurrent glioblastoma (GBM) successfully treated with the Ras inhibitor monoterpene perillyl alcohol by intranasal administration. A 37-years-old white woman had been previously submitted to three neurosurgical procedures, in June 2000 for radical tumor excision of grade II astrocytoma; in July 2003 for first recurrence of type IV glioma and in August 2004 for GBM recurrence. After last surgery, patient started a new cycle of chemotherapy but was refractory to treatment, presented clinical adverse effects and resonance image scan showed no reduction of tumoral lesion. Patient was then considered out of therapeutic possibilities and indicated for supportive treatment. On March 2005 patient joined Phase I/II clinical trial for assess the efficacy of the monoterpene POH, a Ras inhibitor. POH was administered by intranasal route four times a day (268 mg daily) as single chemotherapy agent. Image scans performed 3 and 5 years later revealed marked reduction of enhancing lesion. This illustrative case demonstrates that intranasal administration of the monoterpene POH as a single agent was an effective therapeutic strategy capable to sustain long-term regression of recurrent glioma without clinical and laboratory toxicity.
Caracteriza??o imunofenotípica das subpopula??es de linfócitos do lavado broncoalveolar de pacientes com silicose
FERREIRA, ?NGELA;MOREIRA, JOSE DA SILVA;CAETANO, REGINA;GABETTO, JOSé MANOEL;QUIRICO-SANTOS, THEREZA;
Jornal de Pneumologia , 2000, DOI: 10.1590/S0102-35862000000300002
Abstract: bronchoalveolar lavage is a safe and simple technique to evaluate lung disease related to exposure to mineral dusts. the aim of this study was to characterize the lymphocyte subsets in bronchoalveolar lavage of patients with silicosis. bronchoalveolar lavage was carried out in 26 workers with different forms of silicosis: simple form (n = 12), complicated (n = 13) and 1 patient with acute form of the disease. as a control group, 7 healthy individuals were included. compared to the control group, silicotic patients showed intense pleocytosis constituted mainly by alveolar macrophages with slight lymphocytosis. lymphocyte subsets present in the bronchoalveolar fluid (bal) of normal individuals were mature lymphocytes with phenotype cd2+tcrab (87.3%) and only 2.9% were cd2+tcrgd. cd4/cd8 ratio was 1.8 with few (16%) immature double negative t cells subsets (cd4-cd8-). in contrast, silicotic patients showed reduction of the more mature lymphocyte subset cd2+cd4+, cd2+cd8+ and a great increase (47%) of immature (cd4-cd8-) t cell subsets. no increase in the nk (cd56+) cell population was observed. biochemical analysis of protein contents and determination of the ig/albumin ratio characterized local immunoglobulin production within the pulmonary microenvironment. furthermore, lack of increase of plasma cells, as well as the maintenance of the percentage of b lymphocyte population (cd19+) in the bal of silicotic patients, favors the hypothesis that the cells responsible for ig production are possibly located in the interstitial space. altogether the results suggest development of lymphopoiesis and tertiary lymphoid tissue within the pulmonary microenvironment during the clinical course of silicosis.
Brain sweet brain: importance of sugars for the cerebral microenvironment and tumor development
Quirico-Santos, Thereza;Fonseca, Clovis O;Lagrota-Candido, Jussara;
Arquivos de Neuro-Psiquiatria , 2010, DOI: 10.1590/S0004-282X2010000500024
Abstract: the extracellular matrix (ecm) in the brain tissue is a complex network of glycoproteins and proteoglycans that fills the intercellular space serving as scaffolding to provide structural framework for the tissue and regulate the behavior of cells via specific receptors - integrins. there is enormous structural diversity among proteoglycans due to variation in the core protein, the number of glycosaminoglycans chains, the extent and position of sulfation. the lectican family of proteoglycans interacts with growth factors, hyaluronan and tenascin forming a complex structure that regulates neuronal plasticity and ion homeostasis around highly active neurons. in this review, we will discuss the latest insights into the roles of brain glycoproteins as modulators of cell adhesion, migration, neurite outgrowth and glial tumor invasion.
Study of polymorphisms in the interleukin-4 and IL-4 receptor genes in a population of Brazilian patients with multiple sclerosis
Quirico-Santos, Thereza;Suppiah, Vijayaprakash;Heggarty, Shirley;Caetano, Regina;Alves-Leon, Soniza;Vandenbroeck, Koen;
Arquivos de Neuro-Psiquiatria , 2007, DOI: 10.1590/S0004-282X2007000100005
Abstract: this study aimed to investigate in a population of brazilian patients with multiple sclerosis (ms) single-nucleotide polymorphisms (snp) in the promoter region of il4 (*33c-t) and receptor il4r (*q551r a-g) genes proposed to interfere with disease progression. no significant differences were observed in either of the snps investigated between healthy controls (n=135) and ms patients (n=129). however, the il4+33 tt genotype was significantly (p=0.039) higher in african descendants ms (af-ms= 9.09%) than in caucasian ms (ca-ms= 1.35%). it was also observed a significant (p=0.016) increase for the il4r* q551r cc genotype in af-ms compared to those of caucasian ethnicity (af-ms= 21.62%; ca-ms= 4.35%). these results suggest that il4+33 and il4r*q551 polymorphisms may have a disease-promoting role of th2 mediators in african ms descendants. additionally neither il4 nor il4r genes are susceptibility factors for brazilian ms but may be able to modify ethnicity-dependent disease risk and penetrance of susceptibility factors.
Importancia do camundongo mdx na fisiopatologia da distrofia muscular de Duchenne
Seixas, Sandra Lopes;Lagrota-Candido, Jussara;Savino, Wilson;Quirico-Santos, Thereza;
Arquivos de Neuro-Psiquiatria , 1997, DOI: 10.1590/S0004-282X1997000400017
Abstract: the mdx mouse develop an x-linked recessive muscular dystrophy (locus xp21.1) and lack dystrophin expression. despite showing less intense myofibrosis and scarce deposition of fatty tissue, mdx mice are considered an adequate animal model for studies on the pathogenesis of duchenne-type muscular dystrophy. marked histological alterations in the muscular tissues associated to myonecrosis and inflammatory mononuclear cell infiltrate (lymphocytes, monocytes/macrophages) suggest a participation of the immune system in this myopathy. modulation of the extracellular matrix (ecm) components in the muscular tissue during all phases (onset, myonecrosis and regeneration) of disease, indicate an important role for the ecm driving inflammatory cells to the foci of lesion. therefore mdx mice should be regarded as an important tool for studies on pathogenetic mechanisms of duchenne-type muscular dystrophy. such experimental model would allow development of new therapeutic approaches for increasing survival and clinical amelioration.
Evolu??o da pneumonia lipoide exógena em crian?as: aspectos clínicos e radiológicos e o papel da lavagem broncoalveolar
Sias, Selma Maria de Azevedo;Ferreira, Angela Santos;Daltro, Pedro Augusto;Caetano, Regina Lúcia;Moreira, José da Silva;Quirico-Santos, Thereza;
Jornal Brasileiro de Pneumologia , 2009, DOI: 10.1590/S1806-37132009000900004
Abstract: objective: to present aspects of the evolution of lipoid pneumonia in children, based on clinical, radiological and bronchoalveolar lavage fluid findings, emphasizing the importance of bronchoalveolar lavage for the diagnosis and treatment. methods: we included 28 children, with a mean age of 20 months (range, 1-108 months), diagnosed with chronic pneumonia refractory to antimicrobial therapy, with tb or with a combination of the two. most of the children had at least one risk factor for aspiration, and all of them had a history of mineral oil ingestion for intestinal constipation (23/28) or complicated ascaridiasis (5/28). clinical evaluations, tomographic evaluations and analyses of bronchoalveolar lavage fluid were carried out at the beginning of treatment and throughout a follow-up period of 24 months. results: tachypnea and cough were the most common symptoms. the most common radiological alterations were areas of consolidation (23/28), perihilar infiltrates (13/28) and hyperinflation (11/28). chest ct scans showed areas of consolidation with air bronchogram (24/28), decreased attenuation in the areas of consolidation (16/28), ground-glass opacities (3/28) and crazy-paving pattern (1/28). in the analysis of the bronchoalveolar lavage fluid, sudan staining revealed foamy macrophages, confirming the diagnosis of lipoid pneumonia. after treatment with multiple bronchoalveolar lavages (mean = 9.6), 20 children became asymptomatic, 18 of those presenting normal tomographic images. conclusions: a diagnosis of lipoid pneumonia should be considered in patients with chronic refractory pneumonia or tb, especially if there is a history of mineral oil ingestion. bronchoscopy with multiple bronchoalveolar lavages was an efficient treatment for the clearance of mineral oil from the lung parenchyma and the prevention of fibrosis. this strategy contributed to reducing the morbidity of lipoid pneumonia, which remains a rare diagnosis.
Acute disseminated encephalomyelitis: clinical features, HLA DRB1*1501, HLA DRB1*1503, HLA DQA1*0102, HLA DQB1*0602, and HLA DPA1*0301 allelic association study
Alves-Leon, Soniza Vieira;Veluttini-Pimentel, Maria Lucia;Gouveia, Maria Emmerick;Malfetano, Fabíola Rachid;Gaspareto, Emerson L.;Alvarenga, Marcos P.;Frugulhetti, Izabel;Quirico-Santos, Thereza;
Arquivos de Neuro-Psiquiatria , 2009, DOI: 10.1590/S0004-282X2009000400013
Abstract: we evaluated the frequency, demographic, clinical, disability evolution and genetic association of hla drb1*1501, drb1*1503, dqa1*0102, dqb1*0602 and dpa1*0301 alleles in patients diagnosed as acute disseminated encephalomyelitis (adem) among a population of cns demyelinating diseases. fifteen patients (8.4%) of our series were diagnosed as adem. the mean age onset was 35.23 years (range 12 to 77), 53.3% were male and follow-up range was 8.5 to 16 years. two cases (13.3%) had a preceding infection before neurological symptoms, one presented a parainfectious demyelinating, and one case had been submitted to hepatitis b vaccination four weeks before the clinical onset. the edss range was 3.0 to 9.5. eight patients (53.3%) presented mri with multiple large lesions. csf was normal in 73.3%. the severe disability observed at edss onset improved in 86.66% patients. the genetic susceptibility for adem was significantly associated with the hla dqb1*0602, drb1*1501 and drb1*1503 alleles (<0.05) in monophasic adem.
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