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Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity
Klawitter Marina,Quero Lilian,Klasen Juergen,Gloess Alexia N
Journal of Inflammation , 2012, DOI: 10.1186/1476-9255-9-29
Abstract: Background As proinflammatory cytokines seem to play a role in discogenic back pain, substances exhibiting anti-inflammatory effects on intervertebral disc cells may be used as minimal-invasive therapeutics for intradiscal/epidural injection. The purpose of this study was to investigate the anti-inflammatory and anti-catabolic potential of curcuma, which has been used in the Indian Ayurvedic medicine to treat multiple ailments for a long time. Methods Human disc cells were treated with IL-1β to induce an inflammatory/catabolic cascade. Different extracts of curcuma as well as curcumin (= a component selected based on results with curcuma extracts and HPLC/MS analysis) were tested for their ability to reduce mRNA expression of proinflammatory cytokines and matrix degrading enzymes after 6 hours (real-time RT-PCR), followed by analysis of typical inflammatory signaling mechanisms such as NF-κB (Western Blot, Transcription Factor Assay), MAP kinases (Western Blot) and Toll-like receptors (real-time RT-PCR). Quantitative data was statistically analyzed using a Mann Whitney U test with a significance level of p < 0.05 (two-tailed). Results Results indicate that the curcuma DMSO extract significantly reduced levels of IL-6, MMP1, MMP3 and MMP13. The DMSO-soluble component curcumin, whose occurrence within the DMSO extract was verified by HPLC/MS, reduced levels of IL-1β, IL-6, IL-8, MMP1, MMP3 and MMP13 and both caused an up-regulation of TNF-α. Pathway analysis indicated that curcumin did not show involvement of NF-κB, but down-regulated TLR2 expression and inhibited the MAP kinase JNK while activating p38 and ERK. Conclusions Based on its anti-inflammatory and anti-catabolic effects, intradiscal injection of curcumin may be an attractive treatment alternative. However, whether the anti-inflammatory properties in vitro lead to analgesia in vivo will need to be confirmed in an appropriate animal model.
De la ley de la calle a la ley de las élites: la sociedad civil en la encrucijada de la gubernamentalidad en América Latina
Morgan Quero
Economía, sociedad y territorio , 2004,
Abstract: En la sociedad del riesgo, la aceleración y multiplicación de las crisis políticas y la incertidumbre producida por efectos de la modernización democrática genera vacíos políticos, que son ocupados por actores de la sociedad civil al asumir responsabilidades de gobierno. Pero se pueden rastrear rasgos autoritarios, reflejos de las continuidades de la cultura política latinoamericana, donde las élites reaparecen con un papel de liderazgo. Así el autoritarismo con rostro democrático se originaría, no tanto en la supuesta separación teórica entre Estado y sociedad civil, sino más bien en su compenetración, en su batalla por definir la gubernamentalidad, expresada a través de la sobre-representación de las élites y la paulatina desaparición de la auto-representación de los sectores populares.
Human MMP28 expression is unresponsive to inflammatory stimuli and does not correlate to the grade of intervertebral disc degeneration
Marina Klawitter, Lilian Quero, Alessando Bertolo, Marco Mehr, Jivko Stoyanov, Andreas G Nerlich, Juergen Klasen, Nikolaus Aebli, Norbert Boos, Karin Wuertz
Journal of Negative Results in BioMedicine , 2011, DOI: 10.1186/1477-5751-10-9
Abstract: While MMP28 expression was increased in individual cases with trauma or disc degeneration, there was no significant correlation between the grade of disease and MMP28 expression. Stimulation with LPS, IL-1β, TNF-α or trichostatin A did not alter MMP28 gene expression at any investigated time point or any concentration.Our results demonstrate that gene expression of MMP28 in the IVD is not regulated by inflammatory mechanisms, is donor-dependent and cannot be positively or negatively linked to the grade of degeneration and only weakly to the occurrence of trauma. New hypotheses and future studies are needed to find the role of MMP28 in the intervertebral disc.Proteins of the matrix metalloproteinase (MMP) family play an essential role in tissue homeostasis by initiating breakdown and reorganization of the extracellular matrix. While being tightly regulated in normal physiological processes (e.g. via tissue inhibitors of metalloproteases TIMPs), dysregulation of MMPs has been implicated in many diseases. During intervertebral disc (IVD) degeneration, the expression and activity of a number of MMPs is increased, including MMPs 1, 3, 7, 9 and 13 [1]. Proinflammatory cytokines such as IL-1β and TNF-α as well as bacterial endotoxins (e.g. lipopolysaccharide LPS) can stimulate expression of various MMPs (e.g. MMPs 1, 3, 9 and 13) in the IVD, as well as in cartilage [2-10].During the recent past, five new members in the MMP family have been identified: MMP24 to MMP28. MMP28, also known as epilysin and most closely related to MMP19, is a soluble MMP that contains an activation sequence recognized by the furin endoprotease following the pro-domain [11]. It is a well-conserved MMP, with great similarity (97%) in the catalytic domain between human and mouse and overall 85% identical amino acids [12]. MMP28 is strongly expressed in testis, as well as in bone, kidneys, lung, heart, colon, intestines, brain, skin and carcinomas [12-17]. It is also expressed in cartilage, synovium
Educación, capacitación para el trabajo y proyección social
Quero,Luis Edgardo;
Cuadernos de la Facultad de Humanidades y Ciencias Sociales. Universidad Nacional de Jujuy , 2008,
Abstract: the possibilities for professional advancement of those who completed work training courses depends, on the achieved qualification and the abilities, managerial and social competencies, level of preparation for continuing education and their skills to adapt learning to a changing society. educational formation becomes ever more important when considering that many youngsters in this society are unemployment or in low income activities that fail to contribute significantly to their learning and development of new skills and competencies. therefore, it is important to discover the significance it is given to the completion of a training program or to the obtaining of a certificate given by those who completed an educational program (pre or post graduate alike). even labor competencies and training become more significant. we can list the above mentioned competencies and training as know-how, which relates to carrying out work related tasks, know-know, which have to do with cross functional competencies such as reading, writing, arithmetic, oral and written expression, social skills, and concepts and methodologies specific to a certain specialty or trade, and finally know-learn, which will provide subjects with a competitive advantage when facing personal and social challenges. when this group of competencies are not developed or are not properly valued, opportunities for work advancement and social insertion are significantly limited. to understand the make up of the educational institutions as far as educators and students is concerned, will allow many citizens to overcome their inability to progress professionally, and thus, improving their social situation knowing that training is the need that will more and more define their access and permanence in the labor market.
SADIE como herramienta de cuantificación de la heterogeneidad espacial: casos prácticos en el Parque Nacional de Sierra Nevada (Granada, Espa a)
J.L. Quero
Ecosistemas , 2006,
Abstract: SADIE como herramienta de cuantificación de la heterogeneidad espacial: casos prácticos en el Parque Nacional de Sierra Nevada (Granada, Espa a). SADIE es una herramienta de análisis espacial basado en índices de distancia. Su sencilla metodología, cuantifica el patrón espacial de una variable objeto de estudio, detecta los agregados locales de la variable y cuantifica el grado de asociación o disociación espacial entre pares de variables. SADIE genera estadísticos continuos para cada punto de muestro con lo que las diferentes facetas del patrón espacial que SADIE detecta, puede ser representadas mediante mapas. Otra de las ventajas de SADIE es su baja exigencia con datos de diferente naturaleza aunque también se describen diferentes limitaciones de la metodología. El creador de SADIE también ha dise ado un sencillo programa informático, bajo entorno Windows, que facilita la utilización de esta herramienta. A modo de ejemplo, se presentan resultados de un estudio sobre la variación espacial a peque a escala de factores abióticos en la heterogénea Sierra Nevada (Granada). La versatilidad y sencillez de uso, han hecho que esta herramienta de análisis espacial se haya extendido considerablemente en los últimos tiempos.
El vano: una nueva localidad paleo-india en el noroccidente de Venezuela
Jaimes Quero Arturo
Maguaré , 2003,
Abstract: N.A
Comment expliquer la signification des particules discursives d’une langue étrangère ? How to explain the meaning of discursive particles of a foreign language ?
Carlos Meléndez?Quero
Recherche et Pratiques Pédagogiques en Langues de Spécialité : Cahiers de l'APLIUT , 2011, DOI: 10.4000/apliut.994
Abstract: L’usage adéquat des marqueurs du discours constitue un aspect complexe dans l’acquisition d’une deuxième langue. D’abord, nous allons présenter les problèmes que les équivalences et les définitions synonymiques proposées dans les dictionnaires unilingues et bilingues traditionnels génèrent pour l’apprentissage d’une langue étrangère. Ensuite, nous proposerons un modèle d’explication de la signification des adverbes espagnols afortunadamente et felizmente, basé notamment sur les intentions argumentatives des locuteurs. Enfin, nous proposerons des exercices qui pourraient servir d’outil de travail dans les classes. The adequate usage of discourse markers constitutes a complicated aspect in the acquisition of a second language. First of all, we are going to present the problems that the equivalences and the synonymic definitions available in traditional unilingual or bilingual dictionaries generate for the learning of a foreign language. Then, we will suggest a model to explain for the meaning of the Spanish adverbs afortunadamente and felizmente, based in particular on the speakers’ argumentative intentions. Finally, we will suggest some exercises which could serve as working tool in the classes.
Aproximación crítica a la crisis económica mundial: Sistema capitalista, política monetaria y globalización financiera
García Quero, Fernando J.
Pecunia : Revista de la Facultad de Ciencias Económicas y Empresariales , 2010,
Abstract: Para comprender las verdaderas causas de la crisis económica mundial en la que aún estamos inmersos, es necesario abordarla dentro del proceso de integración del sistema financiero internacional, entendido como la evolución del régimen económico capitalista contemporáneo. El presente trabajo analiza la crisis actual desde esa perspectiva, mostrándola como una causa directa al modelo de expansión capitalista cuyos inicios se remontan a la década de los 70. Esta orientación nos ayudará a vislumbrar otra serie de problemas fuera de la esfera financiera e inherentes al modelo de crecimiento de los últimos 30 a os.This paper aims to analyse the true causes of the current global economic crisis. In order to get a good understanding of the problem, this crisis needs to be considered as a consequence of the integration of the international financial system, the last evolution of the contemporary capitalist regime. By dealing with the subject in this way, it becomes possible to discern new problems, which are inherent in the capitalist model of expansion which began 30 years ago, known as post-fordism.
La Seguridad Nacional y la política antinarcóticos en la transición política de México
Silvia E. Vélez Quero
El Cotidiano , 2001,
Abstract: Algo debemos tener en cuenta: aunque muchas cosas han cambiado en México, el problema del narcotráfico está ahí y los altos beneficios también. Tampoco parece posible variar la política antidrogas con que México y Estados Unidos pretenden acabar con el narcotráfico y que tan ineficaz ha sido en su propósito manifiesto, pero que se ha revelado dinamizadora para alentar el agravamiento del problema, local e internacionalmente. Los cambios surgidos en México por el triunfo de la oposición anuncian, además, algún impulso en la Guerra contra las drogas. Cuál será ahora su dirección? se continuará actuando dentro del mismo equivocado paradigma represivo?
Globalización y narcotráfico:El dúo dinámico de la Posguerra Fría
Silvia Elena Vélez Quero
El Cotidiano , 2000,
Abstract: Los cambios ocurridos con el fin de la guerra fría, liberan de obstáculos y avivan la fluidez de cada uno de los pasos de la secuencia del narcotráfico; todos ellos se han visto beneficiados y no se percibe ninguna acción concreta que los detenga y todo indica que seguirán creciendo. En estas condiciones, pueden pronosticarse da os económicos, políticos, sociales y geoestratégicos.
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