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Search Results: 1 - 10 of 34449 matches for " Qiquan Zhou "
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Standardization of Methods for Early Diagnosis and On-Site Treatment of High-Altitude Pulmonary Edema
Qiquan Zhou
Pulmonary Medicine , 2011, DOI: 10.1155/2011/190648
Abstract: High-altitude pulmonary edema (HAPE) is a life-threatening disease of high altitude that often affects nonacclimatized apparently healthy individuals who rapidly ascend to high altitude. Early detection, early diagnosis, and early treatment are essential to maintain the safety of people who ascend to high altitude, such as construction workers and tourists. In this paper, I discuss various methods and criteria that can be used for the early diagnosis and prediction of HAPE. I also discuss the preventive strategies and options for on-site treatment. My objective is to improve the understanding of HAPE and to highlight the need for prevention, early diagnosis, and early treatment of HAPE to improve the safety of individuals ascending to high altitude. 1. Introduction High-altitude pulmonary edema (HAPE) is a specific disease of high altitude. It has a high incidence and is often serious because of its rapid progresses. It is also life-threatening if treatment is not started in a timely manner [1, 2]. Many studies [3, 4] have shown that HAPE is a major disease that often affects nonacclimatized healthy individuals who ascend to high altitudes. Therefore, early diagnosis of HAPE is essential to initiate early treatment of HAPE and maintain the safety of people who ascent to high altitude. Although international and Chinese criteria have been established for HAPE [5], its early detection and diagnosis are difficult, except in the presence of typical pulmonary edema. Following the magnitude 7.1 earthquake that struck Yushu (Yushu Tibetan Autonomous Prefecture, Qinghai Province, China) on April 14, 2010, approximately 50,000 rescuers assembled in the region. This region lies at an altitude ranging from 3700?m to 4900?m, the average altitude is 4,493?m. Although the incidence of HAPE is only 2–4%, the sudden influx of nonacclimatized rescuers to the region meant that HAPE was one of the most common life-threatening diseases at that time, even considering the effects of the earthquake, which caused 1944 deaths, with 216 people missing and 12,135 injured. HAPE can also induce psychological disorders in affected individuals. Therefore, it is essential to highlight the early diagnosis and on-site treatment of HAPE. Under the support of the National Science and Technology Program, we have conducted an extensive range of studies on HAPE intended to find effective methods for early diagnosis and clinical treatment of HAPE and, thus, improve the health and safety of individuals who rapidly ascend to high altitude. 2. Methods for the Early Diagnosis of HAPE It is
Role of TLR4/NF-κB in Damage to Intestinal Mucosa Barrier Function and Bacterial Translocation in Rats Exposed to Hypoxia
Han Luo, Ping Guo, Qiquan Zhou
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0046291
Abstract: The role of Toll-like receptor 4 (TLR4)/nuclear factor-kappa-B (NF-κB) in intestinal mucosal barrier damage and bacterial translocation under hypoxic exposure is unclear. Here, we investigated their role using an acute hypobaric hypoxia model. Adult Sprague-Dawley rats were divided into control (C), hypoxia (H), hypoxia+NF-κB inhibitor pyrrolidinedithiocarbamic acid (PDTC) (100 mg. kg) (HP), hypoxia+0.5 mg/kg lipopolysaccharide (HPL), and hypoxia+PDTC+LPS (HPL) group. Except control group, other four groups were placed in a hypobaric chamber set at 7000 m. Samples were collected at 72 h after pressure reduction. Damage in ultrastructure of the intestinal tract was examined by transmission electron microscopy and bacterial translocation was detected by cultivation. Kinetic turbidimetric assay was used to measure the serum LPS. ELISA was performed to detect TNF-α and IL-6 serum concentrations. Fluorescent quantitative RT-PCR was used to measure TLR4 mRNA levels was measured using quantitative RT-PCR and protein of NF-κB p65 was measured by western blotting. Different degrees of intestinal mucosa damage were observed in groups H and HL. The damage was significantly alleviated after blockage of the TLR4/NF-κB signaling pathway. PDTC- treatment also reversed hyoxia- and LPS-induced bacterial translocation rate and increased serum levels of LPS, TNF-α, and IL-6. TLR4 mRNA levels and NF-κB p65 expression were consistent with the serum factor results. This study suggested that TLR4 and NF-κB expression increased in rat intestinal tissues after acute hypoxia exposure. PDTC-treatment reversed TLR4 and NF-κB upregulation and alleviated damage to the intestinal tract and bacterial translocation. Thus, the TLR4/NF-κB signaling pathway may be critical to the mechanism underlying hypoxia-induced damage to intestinal barrier function and bacterial translocation.
Relationship between acute high altitude response, cardiac function injury, and high altitude de-adaptation response after returning to lower altitude*  [PDF]
Shengyue Yang, Qiquan Zhou, Zifu Shi, Enzhi Feng, Ziqiang Yan, Zhongxin Tian, He Yin, Yong Fan
Occupational Diseases and Environmental Medicine (ODEM) , 2013, DOI: 10.4236/odem.2013.11002
Abstract:

The relationship between acute high altitude response (AHAR), cardiac function injury, and high altitude de-adaptation response (HADAR) was assessed. Cardiac function indicators were assessed for 96 men (18 - 35 years old) deployed into a high altitude (3700 - 4800 m) environment requiring intense physical activity. The subjects were divided into 3 groups based on AHAR at high altitude: severe AHAR (n = 24), mild to moderate AHAR (Group B, n = 47) and non-AHAR (Group C, 25); and based on HADAR: severe HADAR (Group E, n = 19), mild to moderate HADAR (Group F, n = 40) and non-HADAR (Group G, n = 37) after return to lower altitude (1,500 m). Cardiac function indicators were measured after 50 days at high altitude and at 12 h, 15 days, and 30 days after return to lower altitude. Controls were 50 healthy volunteers (Group D, n = 50) at 1500 m. Significant differences were observed in cardiac function indicators among groups A, B, C, and D. AHAR score was positively correlated with HADAR score (r = 0.863, P < 0.001). Significant differ- ences were also observed in cardiac function indicators among groups D, E, F, and G, 12 h and15 days after return to lower altitude. There were no significant differences in cardiac function indicators among the groups, 30 days after return to lower altitude, compared to group D. The results indicated that the severity of HADAR is associated with the severity of AHAR and cardiac injury, and prolonged recovery.

Observetion of major organs deadaptation change after returning to lower altitude in Qinghai-Tibet railway construction population  [PDF]
Qiquan Zhou, Zhencai Yuan, Xuefeng Zhang, Yahong Zhang, Quansheng Peng, Han Luo, Ping Guo
Occupational Diseases and Environmental Medicine (ODEM) , 2014, DOI: 10.4236/odem.2014.21001
Abstract:

High altitude deadaptation affects the health of population returned to the plain. We examined major physiological functions in 348 healthy control subjects and 626 Qinghai-Tibet railway construction workers who returned to the plain from the Qinghai-Tibet plateau. Blood indices, such as hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin concentration and platelet larger cell ratio, of the returned group that had stayed at high altitude more than 3 years were significantly higher than those of the control group. Red blood cell distribution width and platelet were significantly lower in the returned group than in the control group. Compared to the control group, five years after returning to the plain, the returned group had higher mean corpuscular hemoglobin and lower red blood cell distribution width. Detection rate of hypotension and low pulse pressure were significantly higher in the returned group than in the control group at 20 months after the return, and cardiothoracic ratio was significantly higher in the returned group than in the control group at 40 months after the return. Short-term memory function was significantly lower in the returned group than in the control group. Total triiodothyronine and thyroid-stimulating hormone were significantly lower, but total thyroxine and free triiodothyronine were significantly higher in the returned group than in the control group. Sex hormones level returned to normal level in the returned group. Superoxide dismutase was significantly higher and malondialdehyde was significantly lower in the returned group than in the control group. Fatty acid binding protein was significantly higher in the returned group than in the control group, and this difference maintained with time after the return. We conclude that physiological functions of most organs in returned population after exposed to high altitude can not be completely restored to the normal level in a short period of time.

Effects of CIITA antisense RNA on the expression of HLA class II molecules
Caihong Zhou,Daru Lu,Qiquan Zhu,Xinfang Qiu,Jinglun Xue
Chinese Science Bulletin , 2000, DOI: 10.1007/BF03183528
Abstract: To study the effect of the major histocompatibility complex class II (MHC II) transactivator (CIITA) antisense RNA on the expression of the human leukemia (HLA) class II molecules, 5′ end cDNA sequence of CIITA gene was cloned, and antisense RNA expression vector pcDNA-II was constructed. HeLa cells transfected with pcDNA-II and pcDNA3 were induced by IFN-γ for 3 d. The expression of HLA class II molecules on HeLa/pcDNA-II cells was significantly decreased, while it has no effect on the expression of HLA class I molecules. This result suggests that the CIITA antisense RNA can inhibit the expression of HLA class II molecules in HeLa cells. It also implies a promising approach to generate immune tolerance in graft transplantation.
Boundedness of Hyper-Singular Parametric Marcinkiewicz Integrals with Variable Kernels  [PDF]
Qiquan Fang, Xianliang Shi
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.411A3005
Abstract:

In this article, we consider the boundedness of  \"\" on Hardy type space  \"\". Where  \"\" \"\"

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Regular Observation of De-Acclimatization and Randomized Controlled Research of Diagnostic Criteria of High Altitude De-Acclimatization Syndrome among Different Plateau Migrants Crowd after Their Return to the Plain  [PDF]
Qiquan Zhou, Shengyue Yang, Zhencai Yuan, Yinhu Wang, Xuefeng Zhang, Wei Gao, Zifu Shi, Youli Yang, Yunhong Wu, Yong Fan, Fuling Wang, Guansong Wang
Occupational Diseases and Environmental Medicine (ODEM) , 2014, DOI: 10.4236/odem.2014.24010
Abstract: Objective: The objective of this study was to investigate the diagnostic methods of high altitude de-acclimatization syndrome and to formulate diagnostic criteria. Methods: This study was conducted using epidemiological surveys and a multi-center randomized controlled clinical trial. A total of 3011 subjects were studied, and the following indices were collected after their return to low altitude areas from the plateau: general health status, blood, urine and stool samples, myo-cardial enzyme levels, liver and kidney function, nerve function, sex hormone levels, microalbuminuria, electrocardiogram (ECG), echocardiography, pulmonary function, and hemorheological markers. These data were compared to those of randomized healthy subjects in the same age range who lived at the same altitude to determine the characteristics of high altitude de-acclimatization syndrome. Based on these characteristics, diagnostic criteria for high altitude de-acclimatization syndrome were formulated. Results: This study demonstrated that the incidence of high altitude de-acclimatization syndrome was 84.36%. Sixty percent of the cases were mild, 30% were medium, and 10% were severe. The incidence was higher among those who returned to a place of lower altitude, resided at a high altitude for a longer period of time, or engaged in heavy labor while at high altitude. Patients with high altitude de-acclimatization syndrome manifested hematological abnormalities and abnormal ventricular function, notably a right ventricular diastolic function, which recovered to baseline function after one to five years. Exposure to long-term hypoxia often caused obvious changes in cardiac morphology, i.e., left and right ventricular hypertrophy, particularly within the right ventricle. In addition, patients with high altitude de-acclimatization syndrome often presented with low blood pressure, low pulse pressure, and microalbuminuria. A few patients presented with occult blood in their feces. The diagnosis of high altitude de-acclimatization syndrome can be made if a patient who recently returns to the plain from the plateau complains of dizziness, weakness, sleepiness, chest tightness, edema, memory loss, and other symptoms and signs that do not alleviate under short-term rehabilitation or symptomatic treatment, and if organic diseases of the heart, lung, kidney, and other organs have been excluded. Conclusion: The diagnosis of high altitude de-acclimatization syndrome should be made after a comprehensive analysis of the patient’s clinical symptoms and signs.
A Randomly-Controlled Study on the Cardiac Function at the Early Stage of Return to the Plains after Short-Term Exposure to High Altitude
Qiquan Zhou, Shengyue Yang, Yongjun Luo, Yushu Qi, Ziqiang Yan, Zifu Shi, Yong Fan
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0031097
Abstract: High altitude acclimatization and adaptation mechanisms have been well clarified, however, high altitude de-adaptation mechanism remains unclear. In this study, we conducted a controlled study on cardiac functions in 96 healthy young male who rapidly entered the high altitude (3700 m) and returned to the plains (1500 m) after 50 days. Ninety eight healthy male who remained at low altitude were recruited as control group. The mean pulmonary arterial pressure (mPAP), left ventricular ejection fraction (LVEF), left ventricular fraction shortening (LVFS), cardiac function index (Tei index) were tested. Levels of serum creatine kinase isoform MB (CK-MB), lactate dehydrogenase isoenzyme-1 (LDH-1), endothelin-1 (ET-1), nitrogen oxide (NO), serum hypoxia-inducible factor-1α (HIF-1α), 8-iso-prostaglandin F2α (8-iso PGF2α), superoxide dismutase (SOD) and malonaldehyde (MDA) were measured at an altitude of 3700 m and 1500 m respectively. The results showed that after short-term exposure to high altitude mPAP and Tei index increased significantly, while LVEF and LVFS decreased significantly. These changes were positively correlated with altitude. On the 15th day after the subjects returned to low altitude, mPAP, LVEF and LVFS levels returned to the same level as those of the control subjects, but the Tei index in the returned subjects was still significantly higher than that in the control subjects (P<0.01). We also found that changes in Tei index was positively correlated with mPAP, ET-1, HIF-1α and 8-iso PGF2α levels, and negatively correlated with the level of NO, LVEF, LVFS, CK-MB and LDH-1. These findings suggest that cardiac function de-adapts when returning to the plains after short-term exposure to high altitude and the function recovery takes a relatively long time.
Auto CAD R12 Parametric Design System Based on the Detained Auxiliary Line
基于辅助线滞生法的AutoCADR12参数化设计系统

Guo Qiquan,Zhou Kesheng,
郭启全
,周克绳

中国图象图形学报 , 1996,
Abstract: 本文提出了一种在AutoCAD12环境下,用C语言(基于ADS)开发二维图形参数化设计的新方法--辅助线滞生法,解决了辅助线滞生法与ADS具体结合中的技术难题;阐述了实元素悬挂在辅助元素上的新思想,实现了尺寸驱动;为用户众多的AutoCADR12增加了新功能。基于该方法的AutoCADR12参数化设计系统(AutoCADR12Parametric Design System-APDS)已用于悬挂灌
Necessity of Oversampling Theorem for Affine Frames  [PDF]
Qiquan Fang, Xianliang Shi, Weicai Li
Journal of Applied Mathematics and Physics (JAMP) , 2014, DOI: 10.4236/jamp.2014.22003
Abstract:

In this paper we prove that n is relatively prime to a which is also necessary.

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