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Search Results: 1 - 10 of 53463 matches for " Qing Zhao "
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(E)-1-{6-[1-(2,6-Dimethylphenylimino)ethyl]pyridin-2-yl}ethanone
Qing Su,Qing Zhao
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536811056327
Abstract: In the title compound, C17H18N2O, the dijedral angle between the mean planes of the pyridine and benzene rings is 78.0 (1)°. In the crystal, pairs of C—H...O interactions with graph-set motif R22(10) form inversion dimers. Adjacent dimers are further connected into a three-dimensional network by C—H...O connections. There is also an interaction between the carbonyl groups in adjacent molecules with an O...C distance of 3.176 (2) .
Data Discrimination in Fault-Prone Sensor Networks  [PDF]
Xiaoning Cui, Qing Li, Baohua Zhao
Wireless Sensor Network (WSN) , 2010, DOI: 10.4236/wsn.2010.24039
Abstract: While sensor networks have been used in various applications because of the automatic sensing capability and ad-hoc organization of sensor nodes, the fault-prone characteristic of sensor networks has challenged the event detection and the anomaly detection which, to some extent, have neglected the importance of discriminating events and errors. Considering data uncertainty, in this article, we present the problem of data discrimination in fault-prone sensor networks, analyze the similarities and the differences between events and errors, and design a multi-level systematic discrimination framework. In each step, the framework filters erroneous data from the raw data and marks potential event samples for the next-step processing. The raw data set D is finally partitioned into three subsets, Devent, Derror and Dordinary. Both the scenario-based simulations and the experiments on real-sensed data are carried out. The statistical results of various discrimination metrics demonstrate high distinction ratio as well as the robustness in different cases of the network.
Genome-Based Studies of Marine Microorganisms to Maximize the Diversity of Natural Products Discovery for Medical Treatments
Xin-Qing Zhao
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1155/2011/384572
Abstract: Marine microorganisms are rich source for natural products which play important roles in pharmaceutical industry. Over the past decade, genome-based studies of marine microorganisms have unveiled the tremendous diversity of the producers of natural products and also contributed to the efficiency of harness the strain diversity and chemical diversity, as well as the genetic diversity of marine microorganisms for the rapid discovery and generation of new natural products. In the meantime, genomic information retrieved from marine symbiotic microorganisms can also be employed for the discovery of new medical molecules from yet-unculturable microorganisms. In this paper, the recent progress in the genomic research of marine microorganisms is reviewed; new tools of genome mining as well as the advance in the activation of orphan pathways and metagenomic studies are summarized. Genome-based research of marine microorganisms will maximize the biodiscovery process and solve the problems of supply and sustainability of drug molecules for medical treatments. 1. Introduction The marine environment covers more than 70% of the Earth’s surface and has been proven to be a rich source for both biological and chemical diversity. Marine natural products have become fascinating targets for biologists and chemists for discovery of lead compounds for clinical development for the past five decades [1–10]. Marine microorganisms comprise an important group of natural product producers, and the natural products isolated from marine microorganisms presented diverse activities, such as antibacterial, antifungal, anticancer, and antiviral activities. Of the major producers of useful natural products, marine actinobacteria are especially notable for the capability of producing diverse useful natural products [5–7], and marine cyanobacteria are also an important group of bioactive metabolites [5]. Currently 13 marine-derived compounds are reported in clinical development, and those belong to the authentic or derivatives of marine natural products of microbial origin and are listed in Table 1, and the structures are displayed in Figure 1. Of these compounds, soblidotin (TZT 1027), the synthetic derivative of dolastatin 10, was isolated from the marine cyanobacterium Symploca sp. VP642 from Palau, and the synthesis of plinabulin (NPI-2358) was inspired by halimide and phenylahistin, the former of which was isolated from a marine fungus Aspergillus sp. CNC-139. The structures of other interesting compounds with novel structures or potent activities can be retrieved from the recent
Effects of low frequency electromagnetic fields on osteoblasts proliferation and cell cycle
Qing Tang,Nanming Zhao
Chinese Science Bulletin , 1999, DOI: 10.1007/BF03182703
Abstract: After primary mouse osteoblasts and ROS osteo-like cells were exposed to 50 Hz low frequency electromagnetic fields (EMF), the MTT method and flow cytometry have been used to determine cell proliferation, cell cycle and apoptosis. The results show that, compared with the control, the cells after exposure are more abundant, have larger S phase ratios and lower apoptosis ratios. The results indicate that EMF has an important biological effect which influences cell proliferation and cell cycle.
Poly[[diaqua(ethanol)bis(μ3-pyridine-2,3-dicarboxylato)dimanganese(II)] monohydrate]
Yan-Qing Zhao
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809031948
Abstract: The title compound, {[Mn2(C7H3NO4)2(C2H5OH)(H2O)2]·H2O}n, is a three-dimensional polymer. There are two symmetry-independent MnII centres with different coordination environments: one MnII atom is coordinated by four O atoms from four ligands and two N atoms from two ligands, the other MnII atom is coordinated by three O atoms from two ligands, two water O atoms and the O atom of an ethanol molecule. The crystal structure is stabilized by O—H...O hydrogen bonds.
Curative effects of Fuzheng Huayu Capsules on hepatic fibrosis and the functional mechanisms: a review
Chang-Qing ZHAO
Zhong Xi Yi Jie He Xue Bao , 2006,
Abstract: Deficiency of Qi (healthy energy) and blood stasis are the basic pathological changes of hepatic fibrosis according to the theories of traditional Chinese medicine. Fuzheng Huayu Capsule, a compound Chinese herbal medicine for hepatic fibrosis, is produced in the light of this pathological mechanism. More than a decade of clinical studies and experimental researches show that this medicine has effects of protecting hepatic cells, relieving liver injury, and controlling the development of hepatic fibrosis. It has definite functional mechanisms on anti-hepatic fibrosis. It is a safe and effective medicine for hepatic fibrosis, and deserves to be well introduced to clinic.
Opportunistic Carrier Sensing for Energy-Efficient Information Retrieval in Sensor Networks
Zhao Qing,Tong Lang
EURASIP Journal on Wireless Communications and Networking , 2005,
Abstract: We consider distributed information retrieval for sensor networks with cluster heads or mobile access points. The performance metric used in the design is energy efficiency defined as the ratio of the average number of bits reliably retrieved by the access point to the total amount of energy consumed. A distributed opportunistic transmission protocol is proposed using a combination of carrier sensing and backoff strategy that incorporates channel state information (CSI) of individual sensors. By selecting a set of sensors with the best channel states to transmit, the proposed protocol achieves the upper bound on energy efficiency when the signal propagation delay is negligible. For networks with substantial propagation delays, a backoff function optimized for energy efficiency is proposed. The design of this backoff function utilizes properties of extreme statistics and is shown to have mild performance loss in practical scenarios. We also demonstrate that opportunistic strategies that use CSI may not be optimal when channel acquisition at individual sensors consumes substantial energy. We show further that there is an optimal sensor density for which the opportunistic information retrieval is the most energy efficient. This observation leads to the design of the optimal sensor duty cycle.
Component Dynamic Behavioral Compatibility Analysis of ScudWare Middleware for Ubiquitous Computing
Qing Wu,Chunbo Zhao
Journal of Software , 2010, DOI: 10.4304/jsw.5.12.1417-1424
Abstract: In ubiquitous computing environments, the software component dynamic behavior and its compatibility analysis are two important issues in middleware dynamic adaptation. In this paper, we firstly present an adaptive middleware architecture called ScudWare for a smart vehicle space. Then a semantic component model is given in detail. Next, for ScudWare middleware, we propose a semantic component dynamic behavior formalization and component behavior compatibility verification based on the higher-order calculus. Next, a case study is given to evaluate our model and methods. Finally, we draw a conclusion and give our next work.
Opportunistic Carrier Sensing for Energy-Efficient Information Retrieval in Sensor Networks
Zhao Qing,Tong Lang
EURASIP Journal on Wireless Communications and Networking , 2005,
Abstract: We consider distributed information retrieval for sensor networks with cluster heads or mobile access points. The performance metric used in the design is energy efficiency defined as the ratio of the average number of bits reliably retrieved by the access point to the total amount of energy consumed. A distributed opportunistic transmission protocol is proposed using a combination of carrier sensing and backoff strategy that incorporates channel state information (CSI) of individual sensors. By selecting a set of sensors with the best channel states to transmit, the proposed protocol achieves the upper bound on energy efficiency when the signal propagation delay is negligible. For networks with substantial propagation delays, a backoff function optimized for energy efficiency is proposed. The design of this backoff function utilizes properties of extreme statistics and is shown to have mild performance loss in practical scenarios. We also demonstrate that opportunistic strategies that use CSI may not be optimal when channel acquisition at individual sensors consumes substantial energy. We show further that there is an optimal sensor density for which the opportunistic information retrieval is the most energy efficient. This observation leads to the design of the optimal sensor duty cycle.
Striking a Balance: Modulation of Host Cell Death Pathways by Legionella Pneumophila
Zhao-Qing Luo
Frontiers in Microbiology , 2011, DOI: 10.3389/fmicb.2011.00036
Abstract: Programmed cell death is considered the ultimate solution for the host to eliminate infected cells, leading to the abolishment of the niche for microbial replication and the ablation of infection. Thus, it is not surprising that successful pathogens have evolved diverse strategies to reprogram the cell death pathways for their proliferation. Using effector proteins translocated by the Dot/Icm type IV secretion system, the facultative intracellular pathogen Legionella pneumophila manipulates multiple host cellular processes to create a niche within host cells to support its replication. Investigation in the past decade has established that in mammalian cells this bacterium actively modulates two host cell death pathways, namely the canonical apoptotic pathway controlled by the mitochondrion and the pyroptotic pathway controlled by the Nod-like receptor Naip5 and the Ipaf inflammasome. In this review, I will discuss the recent progress in understanding the mechanisms the bacterium employs to interfere with these host cell death pathways and how such modulation contribute to the intracellular life cycle of the pathogen.
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