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Search Results: 1 - 10 of 201012 matches for " Puranik Manisha P "
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A validated HPTLC method for determination of ondansetron in combination with omeprazole or rabeprazole in solid dosage form
Raval P,Puranik Manisha,Wadher S,Yeole P
Indian Journal of Pharmaceutical Sciences , 2008,
Abstract: A simple, precise, accurate and rapid high performance thin layer chromatographic method has been developed for the simultaneous estimation of ondansetron combinations in solid dosage form with omeprazole and rabeprazole, respectively. The method involved separation of components by TLC on a precoated silica gel 60 F 254 using a mixture of dichloromethane:methanol (9:1) as a mobile phase. Detection of spots was carried out at 309 nm and 294 nm for ondansetron with omeprazole and ondansetron with rabeprazole combinations, respectively. The mean retardation factor for ondansetron and omeprazole were found to be 0.42±0.02, 0.54±0.03, respectively while for ondansetron and rabeprazole, 0.41± 0.02 and 0.51±0.02, respectively. The linearity and range was 0.1 to 0.5 μg/spot for three drugs. The method was validated for precision, accuracy and reproducibility.
Simultaneous estimation of valdecoxib and tizanidine hydrochloride in tablets by RP-HPLC
Puranik Manisha,Wadher S,Dhole Seema,Yeole P
Indian Journal of Pharmaceutical Sciences , 2006,
Abstract: A simple, fast, precise and accurate RP-HPLC method was developed for the simultaneous estimation of valdecoxib and tizanidine hydrochloride in tablet formulations. The separation was achieved by C18 Intersil column and acetonitrile: 0.02 M phosphate buffer (pH 3.5) (60:40 v/v) as mobile phase, at a flow rate of 1.5 ml/min. Detection was carried out at 240 nm. The retention time of valdecoxib and tizanidine hydrochloride was found to be 4.21 and 2.16 min respectively. The validation of the proposed method was also carried out for linearity, accuracy and precision. The linear dynamic range for valdecoxib and tizanidine hydrochloride was 0-100 μg/ml and 0-20 μg/ml respectively. The mean percentage recoveries obtained for valdecoxib and tizanidine hydrochloride were 99.10 and 100.19% respectively. The developed method was found to be accurate, precise, selective and rapid, and it can also be used for routine quality control analysis of these drugs in combination tablets.
Development and validation of spectrophotometric methods for simultaneous estimation of tramadol hydrochloride and chlorzoxazone in tablet dosage form
Puranik Manisha,Hirudkar A,Wadher S,Yeole P
Indian Journal of Pharmaceutical Sciences , 2006,
Abstract: Two simple, accurate, and precise methods for simultaneous estimation of tramadol hydrochloride and chlorzoxazone in combined dosage form have been described. The first method employs formation and solving of simultaneous equations using 272.20 and 248.30 nm as two analytical wavelengths. The second method is absorption ratio method, which uses 272.20 and 257.50 nm as two analytical wavelengths. Both the methods allow the simultaneous determination of tramadol hydrochloride and chlorzoxazone in concentration ranges employed for this purpose with the standard deviation of < 1.0% in the assay of tablet.
Determination of ethanol in Abhayarishta by gas chromatography
Wadher S,Puranik Manisha,Yeole P,Lokhande C
Indian Journal of Pharmaceutical Sciences , 2007,
Abstract: A simple, rapid, precise and accurate gas liquid chromatographic method was developed for the determination of ethanol in marketed preparation of abhayarishta using flame ionization detector. The separation was performed employing carbowax 20 M stainless steel column using nitrogen as a carrier gas at optimized conditions. The column was maintained at 90°, while injection port and detector were maintained at 110°. The system suitability parameters were studied throughout the study. The method has been applied successfully for the assay of ethanol in abhayarishta . The recovery values were found to be in the range of 98.14-104.54% with RSD values less then 0.800%. The proposed method can be used for the determination of generated ethanol content in abhayarishta preparation.
Simultaneous spectrophotometric estimation of paracetamol and metoclopramide hydrochloride in solid dosage form
Wadher S,Pathankar P,Puranik Manisha,Ganjiwale R
Indian Journal of Pharmaceutical Sciences , 2008,
Abstract: Two simple, accurate, rapid and economical spectrophotometric methods have been developed for the simultaneous determination of paracetamol and metoclopramide hydrochloride from tablet dosage form. The first method developed employs formation and solving simultaneous equations using 248.6 nm and 275.6 nm as two wavelengths for formation of equations. Second method is absorbance ratio in which wavelengths selected were 265.6 nm as isoabsorptive point and 275.6 nm as lmax of paracetamol. Both the drugs and their mixtures obey Beer-Lamberts law at selected wavelengths at given concentration range. The methods have been validated statistically and by recovery studies. The results of analysis have been validated statistically and by recovery studies.
Simultaneous determination of ofloxacin and ornidazole in solid dosage form by RP-HPLC and HPTLC techniques
Puranik Manisha,Bhawsar D,Rathi Prachi,Yeole P
Indian Journal of Pharmaceutical Sciences , 2010,
Abstract: The objective of this work was to develop and validate simple, rapid and accurate chromatographic methods for simultaneous determination of ofloxacin and ornidazole in solid dosage form. The first method was based on reversed phase high performance liquid chromatography, on Intersil C 18 column (250 mm, 4.6 i.d.), using acetonitrile:methanol: 0.025M phosphate buffer, pH 3.0 (30:10:60 % v/v/v) as the mobile phase, at a flow rate of 1 ml/min at ambient temperature. Quantification was achieved with UV detection at 318 nm over a concentration range of 2-40 μg/ml for ofloxacin and 5-100 μg/ml for ornidazole. The mean retention time of ofloxacin and ornidazole was found to be 4.04 min and 5.83 min, 6.77 min (isomers), respectively. The amount of ofloxacin and ornidazole estimated as percentage of label claimed was found to be 100.23 and 99.61%, with mean percent recoveries 100.20 and 100.93%, respectively. The second method was based on TLC separation of these drugs using silica gel 60F 254 aluminium sheets and dichloromethane:methanol:25% ammonia solution (9.5:1:3 drops v/v) as mobile phase. Detection was carried out at 318 nm over the concentration range of 20-100 ng/spot for ofloxacin and 50-250 ng/spot for ornidazole. The mean R f value of ofloxacin and ornidazole was found to be 0.16 and 0.56, 0.78 (isomers), respectively. The amount of ofloxacin and ornidazole estimated as percentage of label claimed was found to be 100.23 and 99.61% with mean percent recoveries 100.47 and 99.32%, respectively. Both these methods were found to be simple, precise, accurate, selective and rapid and could be successfully applied for the determination of pure laboratory prepared mixtures and tablets.
SIMULTANEOUS DETERMINATION OF LAMIVUDINE, STAVUDINE AND NEVIRAPINE IN COMBINED DOSAGE FORM BY RP-HPLC
Puranik Manisha P,Bhawsar Dhiraj V,Kosarkar Ashish L,Jain Sapna P
International Research Journal of Pharmacy , 2011,
Abstract: A simple, sensitive and rapid reverse phase High Performance Liquid Chromatographic method was developed for the estimation of Lamivudine, Stavudine and Nevirapine in pure and in pharmaceutical dosage forms. A C8 Intersil column [4.6(i.d.) x250mm, 10 m] was used with a mobile phase containing a mixture of Phosphate Buffer: Acetonitrile (pH-3.5, adjusted with 1% Glacial acetic acid) in the ratio of 85: 15% v/v.The flow rate was 1.0 ml/min and effluents were monitored at 266.00 nm.The assay was validated for the parameters like accuracy, precision, robustness and system suitability parameters. The proposed method can be useful in the routine analysis for the determination of Lamivudine, Stavudine and Nevirapine in combined pharmaceutical dosage form.
RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF VALSARTAN AND HYDROCHLOROTHIAZIDE IN SOLID DOSAGE FORM
Sheikh Rahila J,Puranik Manisha P,Bavadkar Deepali N,Mali Prabha R
International Research Journal of Pharmacy , 2011,
Abstract: A simple, selective, rapid, precise and economical reverse phase HPLC method has been developed for the simultaneous estimation of Valsartan and Hydrochlorothiazide in solid dosage form. The method was carried out on a C18 Intersil (250 X 4.6 i.d., particle size 10μm) column with a mobile phase consisting of 0.02M Potassium dihydrogen orthophosphate:Methanol:Triethylamine [25:75:0.2 %v/v/v, pH 6.0]at a flow rate of 1.0 mL/min. Detection was carried out at 259 nm. The retention time of Valsartan and Hydrochlorothiazide was found to be 4.15 and 3.20 min, respectively. The developed method was validated in terms of accuracy, precision, linearity, limit of detection and limit of quantitation and can be used for the estimation of these drugs in combined pharmaceutical dosage forms.
Fuzzy based Color Image Segmentation using Comprehensive Learning Particle Swarm Optimization (CLPSO) - A Design Approach
Parag Puranik,P.R. Bajaj,P.M. Palsodkar
Lecture Notes in Engineering and Computer Science , 2009,
Abstract:
Particle Swarm Optimization with Genetic Operators for Vehicle Routing Problem
GAZALANAAZ QURESHI,DR. P. R. BAJAJ,P. V. PURANIK
International Journal of Engineering Science and Technology , 2012,
Abstract: Vehicle Routing Problem (VRP) is to find shortest route thereby minimizing total cost. VRP is a NP-hard and Combinatorial optimization problem. Such problems increase exponentially with the problem size. Various derivative based optimization techniques are employed for optimization. Derivative based optimization techniques are difficult to evaluate. Therefore parallel search algorithm emerged to solve VRP. In this work, a particle swarm optimization (PSO) algorithm and Genetic algorithm (GA) with crossover and mutation operator are applied to two typical functions to deal with the problem of VRP efficiently using MATLAB software. Before solving VRP, optimization of functions using PSO and GA are checked. In this paper capacitate VRP with time window (CVRPTW) is proposed. The computational result shows generation of input for VRP, optimization of Rastrigin function, Rosenbrock function using PSO and GA.
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