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Search Results: 1 - 10 of 149805 matches for " Pudjo H. Widjajanto "
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Dexamethasone versus Prednisone in Childhood Acute Lymphoblastic Leukemia Treatment: Results of the Indonesian Randomized Trial  [PDF]
Pudjo H. Widjajanto, Eddy Supriyadi, Ignatius Purwanto, Jacqueline Cloos, Peter M. vdVen, Sutaryo ?, Anjo JP. Veerman
Journal of Cancer Therapy (JCT) , 2017, DOI: 10.4236/jct.2017.88064
Abstract:
Background: Randomized trials report that, compared to prednisone, dexamethasone has reduced CNS relapse and improved event-free survival (EFS), despite a trend toward a higher risk for induction death. Because toxic death is a specific problem in the Indonesian setting, this study compares the outcome of dexamethasone versus prednisone. Methods: In the period 2006 - 2011, 196 patients with childhood acute lymphoblastic leukemia (ALL) treated on the Indonesia-ALL-2006 protocol [first standard risk (SR) and later high risk (HR) patients] were randomized to receive dexamethasone or prednisone as steroid. Patients in the dexamethasone arm (n = 102: 68 SR, 34 HR) received dexamethasone 4 mg/m2/day (SR) or 6 mg/m2/day (HR), while the prednisone arm (n = 94: 66 SR, 28 HR) received prednisone 40 mg/m2/day (SR and HR). Results: Patients in the dexamethasone arm showed no significant difference compared to the prednisone arm in abandonment rate (24.5% vs. 25.5%, P = 0.91), death rate (17.7% vs. 14.9%, P = 0.54), or leukemic events (13.7 vs. 11.7%, P = 0.59). After stratification for risk group, a trend towards a higher death rate was found in the dexamethasone arm of SR patients (16.2 vs. 6.1%, P = 0.06). The 3-year survival for EFS in SR and HR patients for dexamethasone versus prednisone was 31.5% ± 6.6% vs. 41.5% ± 5.9% (P = 0.51), for leukemia-free survival (LFS) it was 63.7% ± 9.3% vs. 74.5% ± 7.6% (P = 0.47), and for overall survival (OS) it was 49.5% ± 7.7% vs. 69.3% ± 6.1% (P = 0.09). Conclusions: In our setting, a trend toward higher induction deaths was observed in the dexamethasone arm of SR patients and the 3-year EFS; LFS and OS rates were lower in the dexamethasone group; however, these differences were not significant.
Early Response to Dexamethasone as Prognostic Factor: Result from Indonesian Childhood WK-ALL Protocol in Yogyakarta
Pudjo H. Widjajanto,Sutaryo Sutaryo,Ignatius Purwanto,Peter M. vd Ven,Anjo J. P. Veerman
Journal of Oncology , 2012, DOI: 10.1155/2012/417941
Abstract: Early response to treatment has been shown to be an important prognostic factor of childhood acute lymphoblastic leukemia (ALL) patients in Western studies. We studied this factor in the setting of a low-income province in 165 patients treated on Indonesian WK-ALL-2000 protocol between 1999 and 2006. Poor early response, defined as a peripheral lymphoblasts count of ≥1000/μL after 7 days of oral dexamethasone plus one intrathecal methotrexate (MTX), occurred in 19.4% of the patients. Poor responders showed a higher probability of induction failures compared to good responders (53.1% versus 23.3%, <0.01), higher probability of resistant disease (15.6% versus 4.5%, =0.02), shorter disease-free survival (=0.034; 5-year DFS: 24.9% ± 12.1% versus 48.6% ± 5.7%), and shorter event-free survival (=0.002; 5-year EFS: 9.7% ± 5.3% versus 26.3% ± 3.8%). We observed that the percentage of poor responders in our setting was higher than reported for Western countries with prednisone or prednisolone as the steroids. The study did not demonstrate a significant additive prognostic value of early response over other known risk factors (age and white blood cell count) for DFS and only a moderately added value for EFS.
Transforming Indonesia's Armed Forces
Andi Widjajanto
UNISCI Discussion Papers , 2007,
Abstract: This article describes the process of military reform in Indonesia initiated in 1998. First, it is a political reform that tries to promote legitimate civilian control over military as implementation of democracy principles. Second, the political nexus of military reform is also accompanied by systematic attempts to strengthening Indonesia's military capability. Third, military reform evolves in the context of the military's collective perceptions and institutional interest. Fourth, military reform in Indonesia has been supported by a working network created between Civil Society Organizations, political leaders, and civilian military experts.
PENETAPAN STANDAR NASIONAL VAKSIN DIFTERI, PERTUSSIS, TETANUS: Penetapan Standar Nasional Toksoid Serap Difteri
Muljati Prijanto,Sumarno Sumarno,Pudjo Prajitno
Bulletin of Health Research , 2012,
Abstract: To check the potency of DPT vaccine, standard preparations of the components, namely Adsorbed Diphtheria Toxoid, Pertussis Vaccine and Adsorbed Tetanus Toxoid, are needed. Since WHO International Standard Preparations are distributed only in limited amounts, WHO has suggested that each member country should develop a National Standard, which is matched against In-ternational Standard Preparation. An Indonesian National Standard of DPT vaccine (lot 1) has been prepared and lyophilized at the National Institute of Health in Tokyo. The potency of the National Standard of Adsorbed Diphtheria Toxoid is determined by antibody ti-tration in guinea pigs. Antitoxin titres are determined by cell culture method. After several experiments, the potency of the National Standard of Adsorbed Diphtheria Toxoid has been decided of being 59 IU/ml. Using the same standard preparations, namely the National Standards, it is hoped that from the same lot of DPT vaccine, similar results of potency could be achieved when determined by the Government Vaccine Quality Control laboratory and the Manufacturer's laboratory.
Nitrogen Dynamics in Komatsuna (Brassica rapa) Cultivation Due to Incorporation of Water Hyacinth Residues into the System
Didik Wisnu Widjajanto,Terumasa Honmura,Nobufumi Miyauchi
Pakistan Journal of Biological Sciences , 2003,
Abstract: Nitrogen derived (Ndev) from water hyacinth (WH) residues and recovered (Nrec) in Komatsuna (Brassica rapa L.) was measured to evaluate the effect of different amounts of water hyacinth residues (0, 30, 45, 60 and 100%) added during komatsuna cultivation on the performance of the crop and amount of N released from WH residues into the system. There were no significant differences on dry matter production among treatments both in the 1st and 2nd sampling. N yield of Komatsuna decreased as the amounts of added WH residues increased in the 1st sampling but no significant differences were observed in N yield among treatments in the 2nd sampling. The Ndev from WH residues was significantly increased as amounts of added WH residues increased. In contrast, there were no significant differences found in Nrec from Komatsuna both in the 1st and 2nd sampling. In conclusion different quantities of added WH residues influenced the performance of Komatsuna, and the N dynamics in the soil-Komatsuna systems. The combination of 30% WH residues: 70% ammonium sulphate seems to be the most appropriate ratio that may be applied in the field.
Nitrogen Release from Green Manure of Water Hyacinth in Rice Cropping Systems
Didik Wisnu Widjajanto,Terumasa Honmura,Nobufumi Miyauchi
Pakistan Journal of Biological Sciences , 2002,
Abstract: Nitrogen derived from water hyacinth and recovered in rice crops was measured to evaluate the effect of different amounts of added water hyacinth residues into rice cultivation on the performance of rice crop, N derived (Ndev) from residues and N recovery (Nrec) in rice crop. Dry matter production and N yield of rice crop decreased significantly as the amounts of added water hyacinth increased. The Ndev from water hyacinth was significantly increased as amounts of added water hyacinth increased. In contrast, the Nrec in rice crop was significantly decreased as amounts of added water hyacinth increased. In conclusion different quantities of added water hyacinth residues influenced the performance of rice, and the N dynamics of soil-rice systems.
Oil Production Optimization in a Cluster of Gas Lift Wells System
Deni Saepudin,Pudjo Sukarno,Edy Soewono,Kuntjoro Adji Sidarto
Journal of Applied Sciences , 2010,
Abstract: In this study, optimization problems for a cluster of gas lift wells system, which are coupled with a production and gas injection manifold, are discussed. The main goal is to determine the optimum gas injection rate for each well that maximizing the total oil production rate. The total gas for injection is constrained by the maximum availability and the total liquid production rate is constrained by separator capacity. The mathematical model for gas lift problem could be written as a boundary value problem, where the two parameter family non linear differential equation of the boundary value problem represents steady flow equation along the tubing, satisfying wellhead pressure and bottom hole pressure as boundary conditions. Oil production rate is a non-linear function of gas injection rate, which is given implicitly from the gas lift model. A computation scheme based on genetic algorithms is developed to solve the constrained optimization problem with and without considering separator capacity. Our results show quite good estimation for optimum solution. This approach is also flexible to accommodate separator capacity constraints.
Leak Detection Modeling and Simulation for Oil Pipeline with Artificial Intelligence Method
Pudjo Sukarno,Kuntjoro Adji Sidarto,Amoranto Trisnobudi,Delint Ira Setyoadi
ITB Journal of Engineering Science , 2007,
Abstract: Leak detection is always interesting research topic, where leak location and leak rate are two pipeline leaking parameters that should be determined accurately to overcome pipe leaking problems. In this research those two parameters are investigated by developing transmission pipeline model and the leak detection model which is developed using Artificial Neural Network. The mathematical approach needs actual leak data to train the leak detection model, however such data could not be obtained from oil fields. Therefore, for training purposes hypothetical data are developed using the transmission pipeline model, by applying various physical configuration of pipeline and applying oil properties correlations to estimate the value of oil density and viscosity. The various leak locations and leak rates are also represented in this model. The prediction of those two leak parameters will be completed until the total error is less than certain value of tolerance, or until iterations level is reached. To recognize the pattern, forward procedure is conducted. The application of this approach produces conclusion that for certain pipeline network configuration, the higher number of iterations will produce accurate result. The number of iterations depend on the leakage rate, the smaller leakage rate, the higher number of iterations are required. The accuracy of this approach is clearly determined by the quality of training data. Therefore, in the preparation of training data the results of pressure drop calculations should be validated by the real measurement of pressure drop along the pipeline. For the accuracy purposes, there are possibility to change the pressure drop and fluid properties correlations, to get the better results. The results of this research are expected to give real contribution for giving an early detection of oil-spill in oil fields.
Studies on the Release of N from Water Hyacinth Incorporated into Soil-Crop Systems Using 15N-labeling Techniques
Didik Wisnu Widjajanto,Kozo Matsushita,Terumasa Honmura,Nobufumi Miyauchi
Pakistan Journal of Biological Sciences , 2001,
Abstract: Nitrogen derived from water hyacinth and recovered in rice crops was measured by employing 15N-labeling techniques. Either 15N-labeled water hyacinth or 15N-ammonium sulphate was incorporated into soil separately. Derived N was significantly detected in shoot of rice at all stages (Tillering Stage, TS; Panicle Initiation Stage, PIS; Heading Stage, HS; and Harvesting Stage, HVS), while there was non-significant difference between treatments in derived N to root throughout the growth season. On the other hand, N was significantly recovered in shoot of rice at TS and PIS only. There were no significant differences between treatments in recovering N at all stages in root of rice crop. About 8.2 39.6% and 30.2 38.9% of N from water hyacinth and fertilizer, was recovered from the shoot of rice, respectively, whereas, only 1.1 5.7% and 2.2 5.9% from root of rice crop. It was proved that fertilizer derived more N than that derived by water hyacinth. N recovery of water hyacinth in rice crop in early stage was lower than that of fertilizer, however, in the late stages the figure was similar between the two
Effects of Combined Inhalation of Coal Dust and Cigarette Smoking on Haematobiochemical Parameters
Nia Kania,Bambang Setiawan,Edi Widjajanto,M Aris Widodo
Cukurova Medical Journal , 2013,
Abstract: Aim of this study was have to known an effect of inhaled particulate matter coal dust and smoking on hematobiochemical profile of worker in coal analysis laboratoy. Twenty nine workers, were randomly divided into three groups, one control group (n=5), one group who exposed to coal dust but non smoking (CDNS) (n=15), and one group exposed to coal dust and smoking (CDS) (n=9). Control group are subject who working in administrative division which none exposed to coal dust. Exposed group are subject who working in coal dust material analysis who divided into smoker and non smoker. The duration of working are less than 10 years. Mean of eosinofil and monocytes counts were decreased significantly in both of coal dust exposure compared to control group (p<0.05). Segmental neutrophil counts was increase significantly in coal dust exposure group with or without smoking compared to control group (p<0.05). The level of erythocytre sedimentation rate (ESR) was decreased significantly in CDNS group compared to control group (p<0.05). Combined inhalation of coal dust and cigarette smoking changes cellular imune system such as decreasing of eosinophil and monocytes counts also increasing of segmental neutrophil. Beside that, this exposure also induces acute phase process of inflammation. [Cukurova Med J 2013; 38(4.000): 547-552]
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