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Search Results: 1 - 10 of 325220 matches for " Pritpal S Tamber "
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The World Trade Center Attack: Lessons for all aspects of health care
Pritpal S Tamber, Jean-Louis Vincent
Critical Care , 2001, DOI: 10.1186/cc1053
Abstract: The attack on the World Trade Center had the potential to overwhelm New York's health services. Initial estimates spoke of 10,000 people in each of the two towers, all of them either killed or injured. Local hospitals prepared for the worst, and in the first few hours there were hundreds of patients with crush injuries and burns. Sadly, however, the predicted thousands of treatable patients failed to materialize.Horror and sadness has now been replaced by anger, fear, and the determination to be better prepared next time. This determination not only exists in politics but also in health care, and as with all attempts to enforce change there needs to be a period of collecting opinions and data. In this issue of Critical Care, there is a series of nine articles offering varied perspectives of the events of 11 September 2001.The series begins like many disaster responses - with a paramedic. Louis Cook is an Advanced Life Support Coordinator with the Fire Department of New York. On page 301, he describes how the Fire Department of New York took charge, set up command and control, and then had to evacuate, replace lost personnel, and resume control after the tower collapsed. "This was a monumental task", writes Cook, "given the psychological impact of the event" [1].The command and control center was also staffed by the New York Police Department and, on page 304, the Deputy Chief Surgeon, Charles Martinez, describes his experiences, including the part he played in helping police to ensure surrounding buildings were not "used by terrorists to launch a subsequent attack ... with the specific aim of harming the rescue effort" [2]. The article, co-authored by Dario Gonzalez, Medical Director for Clinical Affairs of the Fire Department of New York, concludes that, while the incident was dramatic, the lessons to be learnt "are the same as those from previous disasters".On page 307, J David Roccaforte of Bellevue Hospital, only 2.5 miles (4 km) from the World Trade Center, tel
Critical Care: a good scientific citizen just got better
Pritpal S Tamber, Elizabeth Slade, Jean-Louis Vincent
Critical Care , 2003, DOI: 10.1186/cc2325
Abstract: The move to have only the abstracts of research articles in the print journal with open access to full text online was logical. Publishing research articles online as soon as they are ready means they are likely to be picked up by the most interested parties via searching well before they would have been available in print. Those that browse the print journal are unlikely to read every research article word-for-word on publication [1]. Instead, most readers tend to browse titles, abstracts or conclusions, preferring to read in detail only after searching databases like PubMed. When such a search leads to an article in Critical Care [2], the journal's online functionality will assist further – you can search PubMed for other articles by authors, email articles to colleagues, post and read comments, download references or read the abstracts in PubMed, and even link to the full text of a reference (if it's made available by its publisher). Presenting research articles as abstracts in the print journal and providing open access, full text versions online, then, satisfies both types of users – the print browsers and the online searchers.Our new way of publishing research articles will have a new citation system. Previously, research articles published online were cited as "in press" until they were included in the print journal, at which point the allotted page numbers were incorporated to make the final citation. In the new system the research articles will be paginated as soon as they are published online and separately from other types of articles. Their page numbers will have the prefix "R". The abstracts of these research articles will appear subsequently and sequentially in the print journal according to the page numbers. This system has been accepted by databases such as PubMed, and the ISI Web of Knowledge, the company that calculates impact factors.Making articles over two years old free to access online was also logical. Subscribers – whether they be personal o
Critical Care's move to fund open access
Elizabeth Slade, Pritpal S Tamber, Jean-Louis Vincent
Critical Care , 2003, DOI: 10.1186/cc2326
Abstract: Traditionally, readers pay to access research articles, either through subscriptions or by paying a fee each time they download an article (currently around US$20 per article [2]). Escalating journal subscription charges have resulted in libraries subscribing to fewer journals [3], and the range of research available to readers is therefore increasingly limited. Although traditional journals publish authors' work for free (unless there are page or colour charges), having to pay to access research articles limits how many can read, use and cite them.Critical Care's open access policy, as described in the BioMed Central Open Access Charter [4], changes the way in which research is published. First, all research articles become freely and universally accessible online, and so an author's work can be read by anyone at no cost. Second, the authors hold copyright for their work and may grant to anyone the right to reproduce and disseminate the article, provided that it is correctly cited and no errors are introduced [4]. Third, a copy of the full text of each open access article is immediately archived in an online repository separate from the journal; Critical Care's research articles are archived in PubMed Central [5] – the US National Library of Medicine's full-text repository of life science literature.Open access has four broad benefits for science and the general public. First, authors are assured that their work is disseminated to the widest possible audience, given that there are no barriers to access their work. This is accentuated by the authors being free to reproduce and distribute their work, for example by placing it on their institution's website. Second, the information available to researchers will not be limited by their library's budget, and the widespread availability of research articles will enhance literature searching and facilitate meta-analyses [6]. Third, the results of publicly funded research will be accessible to all taxpayers and not just th
Are reviewers suggested by authors as good as those chosen by editors? Results of a rater-blinded, retrospective study
Elizabeth Wager, Emma C Parkin, Pritpal S Tamber
BMC Medicine , 2006, DOI: 10.1186/1741-7015-4-13
Abstract: Our objective was to compare the performance of author-nominated reviewers (ANR) with that of editor-chosen reviewers (ECR) in terms of review quality and recommendations about submissions in an online-only medical journal.Pairs of reviews from 100 consecutive submissions to medical journals in the BMC series (with one author-nominated and one editor-chosen reviewer and a final decision) were assessed by two raters, blinded to reviewer type, using a validated review quality instrument (RQI) which rates 7 items on 5-point Likert scales. The raters discussed their ratings after the first 20 pairs (keeping reviewer type masked) and resolved major discrepancies in scoring and interpretation to improve inter-rater reliability. Reviewers' recommendations were also compared.Reviewer source had no impact on review quality (mean RQI score (± SD) 2.24 ± 0.55 for ANR, 2.34 ± 0.54 for ECR) or tone (mean scores on additional question 2.72 ANR vs 2.82 ECR) (maximum score = 5 in both cases). However author-nominated reviewers were significantly more likely to recommend acceptance (47 vs 35) and less likely to recommend rejection (10 vs 23) than editor-chosen reviewers after initial review (p < 0.001). However, by the final review stage (i.e. after authors had responded to reviewer comments) ANR and ECR recommendations were similar (65 vs 66 accept, 10 vs 14 reject, p = 0.47). The number of reviewers unable to decide about acceptance was similar in both groups at both review stages.Author-nominated reviewers produced reviews of similar quality to editor-chosen reviewers but were more likely to recommend acceptance during the initial stages of peer review.Identifying peer reviewers is an important part of an editor's job. This task is especially difficult for general journals that cover a wide range of subject areas, many of which will be outside the editor's own area of expertise. If reviewers are unsuitable (e.g. do not know enough about the subject or are biased) this might affec
Have Online International Medical Journals Made Local Journals Obsolete?
David Ofori-Adjei,Gerd Antes,Prathap Tharyan,Elizabeth Slade,Pritpal S Tamber
PLOS Medicine , 2006, DOI: 10.1371/journal.pmed.0030359
Abstract: Background to the Debate All of the major international medical journals are now available both in print and online. Being online increases the potential for these journals to have a more global distribution. With the rise of these online international journals, what functions do local journals serve?.
Weather based prediction model for forcasting cotton leaf curl disease in American cotton
Indian Phytopathology , 2011,
Abstract: Cotton is one of the most important cash crops of India . The productivity of cotton in the last decade has suffered to a great set back due to cotton leaf curl disease (CLCuD) in Punjab. Results indicated that the best fitted equations were Y=63.96+0.809Tmax - 4.550*Tmin +0.488RHmax +0.699*RHmin-0.453*RF of year 2002-2003 with R2 (78.0%) and showed 9.4% error (when validated with 2001 data) and 15.2% error (when validated with 2004 data) . Linear regression analysis also revealed that two week lag meteorological parameters i.e. temperature, relative humidity along with vector of CLCuD has played a significant role in the appearance of disease over the years as compared to one week lag and current week meteorological parameters. It can also be concluded that the previous week’s meteorological weather parameters played a significant role in the appearance of disease in subsequent weeks. As the value of R 2 was 0.68 for the best fitted linear regression equation for two week lags meteorological weather parameters, whereas the corresponding value of R2 for the current week meteorological weather parameters was 0.52. The disease intensity increases exponentially on an average up to first ten weeks from the appearance of disease (i.e. from 21st standard week to 30th standard week). The exponential equation was found to be Y= 0.081e 0.608X R2=0.98, where X=weeks. Therefore based on this equation the major meteorological parameters i.e. temperature, relative humidity and rainfall played a significant role in the appearance of CLCuD over the years. This prediction model gave fairly close estimation to the observed values.
Offline Handwritten Gurmukhi Numeral Recognition using Wavelet Transforms
Pritpal Singh,Sumit Budhiraja
International Journal of Modern Education and Computer Science , 2012,
Abstract: This paper presents an OCR (optical character recognition) system for the handwritten Gurmukhi numerals. A lot of work has been done in recognition of characters and numerals of various languages like English, Chinese, and Arabic etc. But in case of handwritten Gurmukhi script very less work has been reported. Different Wavelet transforms are used in this work for feature extraction. Also zonal densities of different zones of an image have been used in the feature set. In this work, 100 samples of each numeral character have been used. The back propagation neural network has been used for classification. An average recognition accuracy of 88.83% has been achieved.
Comparative Genomic Analyses of Streptococcus pseudopneumoniae Provide Insight into Virulence and Commensalism Dynamics
Dea Shahinas, Christina S. Thornton, Gurdip Singh Tamber, Gitanjali Arya, Andrew Wong, Frances B. Jamieson, Jennifer H. Ma, David C. Alexander, Donald E. Low, Dylan R. Pillai
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0065670
Abstract: Streptococcus pseudopneumoniae (SPPN) is a recently described species of the viridans group streptococci (VGS). Although the pathogenic potential of S. pseudopneumoniae remains uncertain, it is most commonly isolated from patients with underlying medical conditions, such as chronic obstructive pulmonary disease. S. pseudopneumoniae can be distinguished from the closely related species, S. pneumoniae and S. mitis, by phenotypic characteristics, including optochin resistance in the presence of 5% CO2, bile insolubility, and the lack of the pneumococcal capsule. Previously, we reported the draft genome sequence of S. pseudopneumoniae IS7493, a clinical isolate obtained from an immunocompromised patient with documented pneumonia. Here, we use comparative genomics approaches to identify similarities and key differences between S. pseudopneumoniae IS7493, S. pneumoniae and S. mitis. The genome structure of S. pseudopneumoniae IS7493 is most closely related to that of S. pneumoniae R6, but several recombination events are evident. Analysis of gene content reveals numerous unique features that distinguish S. pseudopneumoniae from other streptococci. The presence of loci for competence, iron transport, pneumolysin production and antimicrobial resistance reinforce the phylogenetic position of S. pseudopneumoniae as an intermediate species between S. pneumoniae and S. mitis. Additionally, the presence of several virulence factors and antibiotic resistance mechanisms suggest the potential of this commensal species to become pathogenic or to contribute to increasing antibiotic resistance levels seen among the VGS.
Integrated Functional, Gene Expression and Genomic Analysis for the Identification of Cancer Targets
Elizabeth Iorns, Christopher J. Lord, Anita Grigoriadis, Sarah McDonald, Kerry Fenwick, Alan MacKay, Charles A. Mein, Rachael Natrajan, Kay Savage, Narinder Tamber, Jorge S. Reis-Filho, Nicholas C. Turner, Alan Ashworth
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0005120
Abstract: The majority of new drug approvals for cancer are based on existing therapeutic targets. One approach to the identification of novel targets is to perform high-throughput RNA interference (RNAi) cellular viability screens. We describe a novel approach combining RNAi screening in multiple cell lines with gene expression and genomic profiling to identify novel cancer targets. We performed parallel RNAi screens in multiple cancer cell lines to identify genes that are essential for viability in some cell lines but not others, suggesting that these genes constitute key drivers of cellular survival in specific cancer cells. This approach was verified by the identification of PIK3CA, silencing of which was selectively lethal to the MCF7 cell line, which harbours an activating oncogenic PIK3CA mutation. We combined our functional RNAi approach with gene expression and genomic analysis, allowing the identification of several novel kinases, including WEE1, that are essential for viability only in cell lines that have an elevated level of expression of this kinase. Furthermore, we identified a subset of breast tumours that highly express WEE1 suggesting that WEE1 could be a novel therapeutic target in breast cancer. In conclusion, this strategy represents a novel and effective strategy for the identification of functionally important therapeutic targets in cancer.
Measurement properties of the Dizziness Handicap Inventory by cross-sectional and longitudinal designs
Anne-Lise Tamber, Kjersti T Wilhelmsen, Liv Strand
Health and Quality of Life Outcomes , 2009, DOI: 10.1186/1477-7525-7-101
Abstract: Two samples (n = 92 and n = 27) included participants with dizziness of mainly vestibular origin. A cross-sectional design was used to examine the factor structure (exploratory factor analysis), internal consistency (Cronbach's α), concurrent validity (Pearson's product moment correlation r), and discriminate ability (ROC curve analysis). Longitudinal designs were used to examine test-retest reliability (intraclass correlation coefficient (ICC) statistics, smallest detectable difference (SDD)), and responsiveness (Pearson's product moment correlation, ROC curve analysis; area under the ROC curve (AUC), and minimally important change (MIC)). The DHI scores range from 0 to 100.Factor analysis revealed a different factor structure than the original DHI, resulting in dismissal of subscale scores in the DHI-N. Acceptable internal consistency was found for the total scale (α = 0.95). Concurrent correlations between the DHI-N and other related measures were moderate to high, highest with Vertigo Symptom Scale-short form-Norwegian version (r = 0.69), and lowest with preferred gait (r = - 0.36). The DHI-N demonstrated excellent ability to discriminate between participants with and without 'disability', AUC being 0.89 and best cut-off point = 29 points. Satisfactory test-retest reliability was demonstrated, and the change for an individual should be ≥ 20 DHI-N points to exceed measurement error (SDD). Correlations between change scores of DHI-N and other self-report measures of functional health and symptoms were high (r = 0.50 - 0.57). Responsiveness of the DHI-N was excellent, AUC = 0.83, discriminating between self-perceived 'improved' versus 'unchanged' participants. The MIC was identified as 11 DHI-N points.The DHI-N total scale demonstrated satisfactory measurement properties. This is the first study that has addressed and demonstrated responsiveness to important change of the DHI, and provided values of SDD and MIC to help interpret change scores.The Dizziness Handicap
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