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Search Results: 1 - 10 of 2694 matches for " Priscila Yumiko Sakamoto "
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Da harmoniza o da legisla o tributária antievasiva no MERCOSUL
Priscila Yumiko Sakamoto
Scientia Iuris , 2004,
Abstract: Tax harmonization is an essential step to the concrete MERCOSUR's integration, and with this approach of tax legislations, appears a common necessity of a antievasion norm, as an important instrument to restrain evasion and to diminish fiscal competition between the State-parts. A harmoniza o tributária é um passo imprescindível para a concreta integra o do MERCOSUL, e dentro dessa aproxima o das legisla es tributárias, é que surge a necessidade de uma norma antievasiva em comum, como importante instrumento para coibir a evas o e diminuir a competi o fiscal entre os Estados-partes.
The constitutional limits to the tributary planning Os limites constitucionais ao planejamento tributário
Priscila Yumiko Sakamoto,Marlene Kempfer Bassoli
Scientia Iuris , 2005,
Abstract: Tax planning is a self-organization’s right of tax payers, due to that, they can organize its activities in the limits of legality, in order to reduce, to postpone or even to prevent rate of tributes. However, this right to self-organization is not, and cannot be, absolute. It has to find its limits in the respect to constitutional principles like: the fact’s precision with the hypothesis of the law, and strict legality. O planejamento tributário é o direito de auto-organiza o do contribuinte, para que, agindo nos limites da licitude, possa planejar suas atividades, de forma a reduzir, retardar, ou mesmo evitar o pagamento de tributos. Todavia, este direito de auto-organizar-se n o é, e nem pode ser absoluto, devendo encontrar os seus limites no respeito aos princípios da Tipicidade e da Estrita Legalidade.
A local anesthetic, ropivacaine, suppresses activated microglia via a nerve growth factor-dependent mechanism and astrocytes via a nerve growth factor-independent mechanism in neuropathic pain
Shigeru Toda, Atsushi Sakai, Yumiko Ikeda, Atsuhiro Sakamoto, Hidenori Suzuki
Molecular Pain , 2011, DOI: 10.1186/1744-8069-7-2
Abstract: Repetitive epidural administration of ropivacaine reduced the hyperalgesia induced by chronic constrictive injury of the sciatic nerve. Concomitantly with this analgesia, ropivacaine suppressed the increases in the immunoreactivities of CD11b and glial fibrillary acidic protein in the dorsal spinal cord, as markers of activated microglia and astrocytes, respectively. In addition, epidural administration of a TrkA-IgG fusion protein that blocks the action of nerve growth factor (NGF), which was upregulated by ropivacaine in the dorsal root ganglion, prevented the inhibitory effect of ropivacaine on microglia, but not astrocytes. The blockade of NGF action also abolished the analgesic effect of ropivacaine on neuropathic pain.Ropivacaine provides prolonged analgesia possibly by suppressing microglial activation in an NGF-dependent manner and astrocyte activation in an NGF-independent manner in the dorsal spinal cord. Local anesthetics, including ropivacaine, may represent a new approach for glial cell inhibition and, therefore, therapeutic strategies for neuropathic pain.Neuropathic pain is an extremely severe chronic pain caused by damage to the nervous system itself. In clinical practice, this pain syndrome remains a major issue because of the limited and variable effectiveness of existing analgesics [1]. Such poor effectiveness can be partly attributed to insufficient understanding of the analgesic mechanisms of existing drugs such as opioids, anticonvulsants and antidepressants. Systemic and epidural applications of local anesthetics relieve neuropathic pain in some cases, but the underlying mechanisms remain unclear because the effects occur at lower doses than the effective doses for blocking voltage-gated sodium channels, the primary targets of local anesthetics [2]. Furthermore, the analgesic effects of drugs persist for longer durations than those predicted on the basis of their pharmacokinetics [3-5]. It has been reported that local anesthetics affect other
The Acquisition of Complex Structures: The Case of Child ESL  [PDF]
Yumiko Yamaguchi
Open Journal of Modern Linguistics (OJML) , 2013, DOI: 10.4236/ojml.2013.33030

This study examines how complex linguistic structures are acquired in child English as a second language. The spontaneous speech producing by a Japanese primary school child, learning English in a naturalistic environment, was audio-recorded regularly over two years and the development of complex syntactic structures containing subordinate clauses was compared with the acquisition of other English morphosyntactic structures as represented within Processability Theory (PT) (Pienemann, 1998; Pienemann, Di Biase, & Kawaguchi, 2005). Although PT predicts that subordination is acquired at the highest stage in processability hierarchy, the results in this longitudinal study show that some of the subordinate constructions emerge at earlier stages in child ESL acquisition.

Seasonal Mood and Behavioral Changes for Japanese Residents in the United Kingdom  [PDF]
Yumiko Kurata, Shinobu Nomura
Psychology (PSYCH) , 2012, DOI: 10.4236/psych.2012.329128
Abstract: The aim of this study was to investigate seasonal changes in mood and behavior for Japanese residents in UK A questionnaire survey was conducted with Japanese residents in the UK (n = 100) who participated both a combination winter and summer research. First, a longitudinal study comparing two surveys—one in summer and another in winter—was carried out to determine how the level of seasonal changes influenced depression among Japanese living in the UK. Then, we examined seasonal changes in mood and behavior over a 12-month period based on the degree of seasonal dependence. Paired t-tests on Global Seasonality Score (GSS score) and the Center for Epidemiologic Studies Depression Scale (CES-D) scores by winter and summer demonstrated that each score had a significant seasonal difference; individual scores were higher in winter than in summer. We examined the difference between high seasonality group, medium seasonal group, and non-seasonal group, regarding to the winter CES-D and summer CES-D scores. The ANOVA revealed a significant difference on the winter score (Winter: F(2,97) = 4.62, p < .01, Summer: F(2,97) = 3.24, p < .05). Although we did not find any interaction between seasonal change and season, the main effect was significant for season. The results showed fluctuations in which mood, social activity, and sleep all declined during the winter and then improved during the summer. It indicated that depressive symptoms among Japanese living in the UK fluctuate due to seasonality; over a period of 12 months, their mood and behavior declined during winter and improved during summer. As described, Japanese living in the UK experience environmental changes due to seasonality. This suggests that the environmental factor called seasonal change can partly explain why Japanese living in the UK suffer from mental and physical disorders. Mental health measures specific to the local environment are necessary to support individuals to adapt to and live under an environment different from home country.
Spitzer IRAC Colors of Nebulae Associated with Star-Forming Regions  [PDF]
Yoichi Itoh, Yumiko Oasa
International Journal of Astronomy and Astrophysics (IJAA) , 2019, DOI: 10.4236/ijaa.2019.91004
Abstract: Star-forming regions are often associated with nebulosity. In this study, we investigated infrared diffuse emission in Spitzer IRAC images. The infrared nebula L1527 traces outflows emanating from a low-mass protostar. The nebular color is consistent with the color of a stellar photosphere with large extinction. Nebulae around the HII region W5-East are bright in the infrared. These colors are consistent with the model color of dust containing polycyclic aromatic hydrocarbon (PAH). The strength of ultraviolet irradiation of the nebulae and the small dust fraction were deduced from the infrared colors of the nebulae. We found that the edges of the nebulae are irradiated by strong ultraviolet radiation and have abundant small dust. Dust at the surface of the molecular cloud is thought to be destroyed by ultraviolet radiation from an early-type star.
Transmedullary Decompression for Humeral Diaphysis Solitary Bone Cysts  [PDF]
Akio Sakamoto
Open Journal of Orthopedics (OJO) , 2013, DOI: 10.4236/ojo.2013.32015

Solitary bone cysts are benign, fluid-filled cavities that most often occur in childhood. Several minimally invasive decompression methods have been proposed; however, performing a surgical procedure through the thinned overlying cortex raises the risk of pathological fracture and neurovascular damage, especially in lesions located in the bone diaphysis. We describe a new technique that circumvents these problems: tunneling through the normal cortex and medullary space with a flexible reamer, placing a retrograde medullary nail for cyst decompression.

A Method to Evaluate an Urban Area by Using the Model That Calculates a Number of Facilities from an Area and a Population  [PDF]
Noriaki Sakamoto
Current Urban Studies (CUS) , 2016, DOI: 10.4236/cus.2016.44028
Abstract: This paper presents 1) a new mathematical model improved from a conventional model that calculates a number of facility from an area and a population in a town and, 2) by using this model, a method to evaluate the enrichment (in other words, convenience or enough) of facilities in the town where many high-rise apartments have been built (the area is hereinafter referred to as the high-rise apartment town). The conventional model uses only a nighttime population, but this paper considers a daytime population in addition to the nighttime population. Also, there has not been the method to evaluate the enrichment of facilities in a town, but we can evaluate it using this model. We apply this method to 23 special wards in Tokyo and the highrise apartment towns, the results prove the effectiveness of the proposed method.
Direct and Specific Effect of Sevoflurane Anesthesia on rat Per2 Expression in the Suprachiasmatic Nucleus
Megumi Anzai, Norio Iijima, Shimpei Higo, Ken Takumi, Izumi Matsuo, Keisuke Mori, Yumiko Ohe, Kana Kadota, Toshio Akimoto, Atsuhiro Sakamoto, Hitoshi Ozawa
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0059454
Abstract: Background Our previous studies revealed that application of the inhalation anesthetic, sevoflurane, reversibly repressed the expression of Per2 in the mouse suprachiasmatic nucleus (SCN). We aimed to examine whether sevoflurane directly affects the SCN. Methods We performed in vivo and in vitro experiments to investigate rat Per2 expression under sevoflurane-treatment. The in vivo effects of sevoflurane on rPer2 expression were examined by quantitative in situ hybridization with a radioactively-labeled cRNA probe. Additionally, we examined the effect of sevoflurane anesthesia on rest/activity rhythms in the rat. In the in vitro experiments, we applied sevoflurane to SCN explant cultures from Per2-dLuc transgenic rats, and monitored luciferase bioluminescence, representing Per2 promoter activity. Bioluminescence from two peripheral organs, the kidney cortex and the anterior pituitary gland, were also analyzed. Results Application of sevoflurane in rats significantly suppressed Per2 expression in the SCN compared with untreated animals. We observed no sevoflurane-induced phase-shift in the rest/activity rhythms. In the in vitro experiments, the intermittent application of sevoflurane repressed the increase of Per2-dLuc luminescence and led to a phase delay in the Per2-dLuc luminescence rhythm. Sevoflurane treatment did not suppress bioluminescence in the kidney cortex or the anterior pituitary gland. Conclusion The suppression of Per2-dLuc luminescence by sevoflurane in in vitro SCN cultures isolated from peripheral inputs and other nuclei suggest a direct action of sevoflurane on the SCN itself. That sevoflurane has no such effect on peripheral organs suggests that this action might be mediated through a neuron-specific cellular mechanism or a regulation of the signal transduction between neurons.
Reflection on the GIM Level I
Yumiko Sato
Voices: A World Forum for Music Therapy , 2013,
Abstract: “When I close my eyes and listen to music, images come to me. And they take me to a place where I feel open in a way I never felt before,” said Rick, dying from lung cancer at the age of 59. I never suggested or encouraged Rick to use imagery while listening to music, yet it seemed to come to him naturally and spontaneously. During the course of music therapy that lasted nearly a year, Rick, who had kept his feelings inside throughout his life became a man whose heart was open to sharing his feelings. To witness his transformation was humbling and mystifying at the same time. I thought to myself: How did music and imagery transform Rick? The answer came while attending The Bonny Method of Guided Imagery & Music (GIM) Level I training. During the four intense days filled with powerful imagery, vivid dreams, and new insights, I began to understand the power of music and imagery Rick experienced. All identifying information has been changed to protect patient confidentiality.
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