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Search Results: 1 - 10 of 1661 matches for " Preeti Chavan-Gautam "
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Effects of Altered Maternal Folic Acid, Vitamin B12 and Docosahexaenoic Acid on Placental Global DNA Methylation Patterns in Wistar Rats
Asmita Kulkarni,Kamini Dangat,Anvita Kale,Pratiksha Sable,Preeti Chavan-Gautam,Sadhana Joshi
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0017706
Abstract: Potential adverse effects of excess maternal folic acid supplementation on a vegetarian population deficient in vitamin B12 are poorly understood. We have previously shown in a rat model that maternal folic acid supplementation at marginal protein levels reduces brain omega-3 fatty acid levels in the adult offspring. We have also reported that reduced docosahexaenoic acid (DHA) levels may result in diversion of methyl groups towards DNA in the one carbon metabolic pathway ultimately resulting in DNA methylation. This study was designed to examine the effect of normal and excess folic acid in the absence and presence of vitamin B12 deficiency on global methylation patterns in the placenta. Further, the effect of maternal omega 3 fatty acid supplementation on the above vitamin B12 deficient diets was also examined. Our results suggest maternal folic acid supplementation in the absence of vitamin B12 lowers plasma and placental DHA levels (p<0.05) and reduces global DNA methylation levels (p<0.05). When this group was supplemented with omega 3 fatty acids there was an increase in placental DHA levels and subsequently DNA methylation levels revert back to the levels of the control group. Our results suggest for the first time that DHA plays an important role in one carbon metabolism thereby influencing global DNA methylation in the placenta.
Matrix Metalloproteinase-1 and -9 in Human Placenta during Spontaneous Vaginal Delivery and Caesarean Sectioning in Preterm Pregnancy
Deepali P. Sundrani, Preeti M. Chavan-Gautam, Hemlata R. Pisal, Savita S. Mehendale, Sadhana R. Joshi
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0029855
Abstract: Preterm birth is a major public health problem in terms of loss of life, long-term and short term disabilities worldwide. The process of parturition (both term and preterm) involves intensive remodelling of the extracellular matrix (ECM) in the placenta and fetal membranes by matrix metalloproteinases (MMPs). Our previous studies show reduced docosahexaenoic acid (DHA) in women delivering preterm. Further omega 3 fatty acids are reported to regulate MMP levels. This study was undertaken to examine the placental levels of MMPs and their association with placental DHA levels in women delivering preterm. The levels of MMP-1 and MMP-9 in 74 women delivering preterm (52 by spontaneous vaginal delivery and 22 by caesarean sectioning) and 75 women delivering at term (59 by spontaneous vaginal delivery and 16 by caesarean sectioning) were determined by enzyme-linked immunosorbent assay (ELISA) and their association with placental DHA was studied. Placental MMP-1 levels were higher (p<0.05) in women delivering preterm (both by spontaneous vaginal delivery and caesarean sectioning) as compared to those delivering at term. In contrast, placental MMP-9 levels in preterm pregnancies was higher (p<0.05) in women with spontaneous vaginal delivery while lower (p<0.05) in women delivering by caesarean sectioning. Low placental DHA was associated with higher placental MMP-9 levels. Our study suggests a differential effect of mode of delivery on the levels of MMPs from placenta. Further this study suggests a negative association of DHA and the levels of MMP-9 in human placenta although the mechanisms need further study.
On the study of phase-space analysis of fragments produced in heavy-ion collisions
Sakshi Gautam,Preeti Bansal
Physics , 2011,
Abstract: Effect of momentum-dependent interactions and broader Gaussian is investigated on the emission of various fragments formed in a heavy-ion reaction. We also study the corresponding structure details of those fragments for broader Gaussian and momentum-dependent interactions. We find that nucleons forming the fragments belong to same region of the phase space
Phase-space analysis of fragments formed in heavy-ion collisions
Sakshi Gautam,Preeti Bansal
Physics , 2011,
Abstract: We study the effect of momentum-dependent interactions and a broader Gaussian on multifragmentation. We also look into the details of the fragment structure for a broader Gaussian and momentum-dependent interactions. We find that nucleons forming the fragments belong to same region of the phase space.
DNA Microarrays in Herbal Drug Research
Preeti Chavan,Kalpana Joshi,Bhushan Patwardhan
Evidence-Based Complementary and Alternative Medicine , 2006, DOI: 10.1093/ecam/nel075
Abstract: Natural products are gaining increased applications in drug discovery and development. Being chemically diverse they are able to modulate several targets simultaneously in a complex system. Analysis of gene expression becomes necessary for better understanding of molecular mechanisms. Conventional strategies for expression profiling are optimized for single gene analysis. DNA microarrays serve as suitable high throughput tool for simultaneous analysis of multiple genes. Major practical applicability of DNA microarrays remains in DNA mutation and polymorphism analysis. This review highlights applications of DNA microarrays in pharmacodynamics, pharmacogenomics, toxicogenomics and quality control of herbal drugs and extracts.
Florid manifestions of recurrent herpes genitalis in seronegative patient
Nisarg Chavan,Manjyot Gautam,Sharmila Patil
Indian Journal of Sexually Transmitted Diseases , 2008,
Familial distal renal tubular acidosis presenting as acute quadriparesis
Zaki Syed,Chavan Vishal,Nagotkar Leena,Shanbag Preeti
Saudi Journal of Kidney Diseases and Transplantation , 2010,
Synthesis and Characterization of Cholesteric Thermotropic Liquid Crystalline Polyesters Based on Isosorbide  [PDF]
Nayaku N. Chavan
Materials Sciences and Applications (MSA) , 2011, DOI: 10.4236/msa.2011.210205
Abstract: BACKGROUND: Generally main chain cholesteric thermotropic liquid crystalline polymers are prepared form chiral diacid or diol monomer. But these monomers are costly. Isosorbide is chiral cycloaliphatic diol accessible from renewable resources in the form of pure enantiomers. Thus it is used to synthesize main chain cholesteric thermotropic liquid crystalline polymers. Incorporation of phenyl hydroquinone into the backbone of the main chain frustrates chain packing, thus lowering the crystallinity and depressing the melting point below the degradation temperature, also improves the solubility due to disruption of packing and maintains the mechanical and thermal performance. RESULTS: Optical microscopy study reveals that more than 50% of isosorbide content with phenyl hydroquinone and terephthalic acid showed “yellow iridescent oily streaks” with a background of mosaic/marble texture. These are the typical textures of cholesteric liquid crystalline phase. Copolyesters based on phenyl hydroquinone, isosorbide and terephthalic acid are soluble in aprotic solvents like N,N-dimethylacetamide (DMAC), dimethyl sulfoxide (DMSO), N,N-dimethylformamide (DMF), and N-methyl-2-pyrrolidone (NMP). Solubility increases with the content of isosorbide percent. Thermal stability of all copolyesters was more than 300?C on the basis of 10% wt loss. CONCLUSIONS: It was found that main chain cholesteric thermotropic liquid crystalline polymers can be prepared form chiral cycloaliphatic diol such as isosorbide. Main chain cholesteric thermotropic liquid crystalline polyesters are prepared from phenyl hydroquinone, isosorbide and terephthalic acid showed thermal stability more than 300?C. Main chain cholesteric thermotropic liquid crystalline polymers are soluble in aprotic solvents like DMAC, DMSO, DMF and NMP.
Tessier 30 Facial Cleft Associated with Complete Duplication of Tongue: A Rare Entity  [PDF]
Jayanto Tapadar, Preeti Tiwari
International Journal of Otolaryngology and Head & Neck Surgery (IJOHNS) , 2015, DOI: 10.4236/ijohns.2015.42029
Abstract: Background: Median cleft of mandible and lower lip is a rare anomaly [1]. Only a few cases have been reported in literature with different variations till now. Herein we report a patient with Tessier 30 cleft associated with complete duplication of tongue. Aim: We herein report this rare variant as it posed special challenges for its management by virtue of its uniqueness, late presentation and limited affordability of patient for standard treatment. Case Report: A 12 years old female reported to us with a chief complaint of a midline gap in the lower lip and mandible since birth. On examination under anaesthesia, we found that tongue was not bifid. There was complete duplication of the tongue. The case was planned for staged repair of the defect. In the same sitting, a repair of the soft tissues in the midline was performed. Conclusion: There are no specific guidelines in literature for management of such cases. This makes all these cases worth for reporting in order to guide treating surgeons.
Coupled Fixed Point for (α, Ψ)-Contractive in Partially Ordered Metric Spaces Using Compatible Mappings  [PDF]
  Preeti, Sanjay Kumar
Applied Mathematics (AM) , 2015, DOI: 10.4236/am.2015.68130
Abstract: In this paper, first we introduce notions of (α, Ψ)-contractive and (α)-admissible for a pair of map and prove a coupled coincidence point theorem for compatible mappings using these notions. Our work extends and generalizes the results of Mursaleen et al. [1]. At the end, we will provide an example in support of our result.
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