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Search Results: 1 - 10 of 42 matches for " Pratiksha Sable "
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Effects of Altered Maternal Folic Acid, Vitamin B12 and Docosahexaenoic Acid on Placental Global DNA Methylation Patterns in Wistar Rats
Asmita Kulkarni,Kamini Dangat,Anvita Kale,Pratiksha Sable,Preeti Chavan-Gautam,Sadhana Joshi
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0017706
Abstract: Potential adverse effects of excess maternal folic acid supplementation on a vegetarian population deficient in vitamin B12 are poorly understood. We have previously shown in a rat model that maternal folic acid supplementation at marginal protein levels reduces brain omega-3 fatty acid levels in the adult offspring. We have also reported that reduced docosahexaenoic acid (DHA) levels may result in diversion of methyl groups towards DNA in the one carbon metabolic pathway ultimately resulting in DNA methylation. This study was designed to examine the effect of normal and excess folic acid in the absence and presence of vitamin B12 deficiency on global methylation patterns in the placenta. Further, the effect of maternal omega 3 fatty acid supplementation on the above vitamin B12 deficient diets was also examined. Our results suggest maternal folic acid supplementation in the absence of vitamin B12 lowers plasma and placental DHA levels (p<0.05) and reduces global DNA methylation levels (p<0.05). When this group was supplemented with omega 3 fatty acids there was an increase in placental DHA levels and subsequently DNA methylation levels revert back to the levels of the control group. Our results suggest for the first time that DHA plays an important role in one carbon metabolism thereby influencing global DNA methylation in the placenta.
Comparison of the effect of post-instruction multiple-choice and short-answer tests on delayed retention learning
Ramraje SN,Sable PL
Australasian Medical Journal , 2011,
Abstract: BackgroundPeople forget much of what they learn, therefore studentscould benefit from learning strategies that yield long-lastingknowledge. Yet surprisingly, little is known about how longtermretention is most efficiently mastered. We studied thevalue of teacher made in class tests as learning aids andcompared two types of teacher-made tests (multiple choiceand short-answer tests) with a no test (control) todetermine their value as aids to retention learning.MethodThe study was conducted on two separate batches ofmedical undergraduate students. This study compared twotypes of tests [multiple choice questions (MCQs) and shortanswer questions (SAQs)] with a no test (control) group. Theinvestigation involved initial testing at the end of the lecture(post instruction), followed by an unannounced delayedretention test on the same material three weeks later. Theunannounced delayed test comprising of MCQs and SAQson the same material was given three weeks later to all thethree groups.ResultsIn batch I, the MCQ group had a higher mean delayedretention score of 10.97, followed by the SAQ group (8.42)and the control group (6.71). Analysis of variance (ANOVA)test and least significance difference (LSD) post hoc testrevealed statistically significant difference between themeans of the three groups. Similar results were obtained forbatch IIConclusionClassroom testing has a positive effect on retentionlearning; both short-answer and multiple-choice tests beingmore effective than no test in promoting delayed retentionlearning, however, multiple-choice tests are better.
Non-classical phase transitions at a sonic point
Monique Sable-Tougeron
Electronic Journal of Differential Equations , 2003,
Abstract: The relevant mathematical features of phase transition for a general hyperbolic nonlinear system near a sonic discontinuity are clarified. A well-posed Riemann's problem is obtained, including non-classical undercompressive shocks, defined by a geometrical kinetic relation. A counterpart is the geometrical rejection of some compressive shocks. The result is consistent with the structure profiles of the elasticity model of Shearer-Yang and the combustion model of Majda.
Does the Nature of Chief Complaint, Gender, or Age Affect Time to Be Seen in the Emergency Room  [PDF]
Ayesha Sattar, Kenneth Sable, Antonios Likourezos, Christian Fromm, John Marshall
Open Journal of Emergency Medicine (OJEM) , 2014, DOI: 10.4236/ojem.2014.22006

Objectives: EM physicians may be biased in seeing patients presenting with nonspecific complaints or requiring more extensive work-ups. The goal of our study was to ascertain if chief complaint affected time to be seen (TTBS) in the ED. Methods: A retrospective report was generated from the EMR for all moderate acuity patients who visited the ED from January 2005 to December 2010 at a large urban teaching hospital. Abdominal pain, alcohol intoxication, back pain, chest pain, cough, dyspnea, dizziness, fall, fever, flank pain, headache, infection, pain (nonspecific), psychiatric evaluation, “sent by MD”, vaginal bleeding, vomiting, and weakness were the most common complaints. Non-Parametric Independent Sample Tests assessed median TTBS between complaints, gender, and age. Chisquare testing assessed for differences in the distribution of arrival times. Results: We obtained data from 116,194 patients. Patients presenting with weakness and dizziness waited the longest time of 35 minutes and patients with flank pain waited the shortest with 24 minutes. Males waited 30 minutes and females waited 32 minutes. Younger females between the ages of 18 - 50 waited significantly longer when presenting with a chief complaint of abdominal pain, chest pain, or flank pain. There was no difference in the distribution of arrival times for these complaints. Conclusion: There is a significant bias toward seeing young male patients more quickly than women or older males. Patients might benefit from efforts to educate EM physicians on the delays and potential quality issues associated with this bias in an attempt to move toward more egalitarian patient selection.

Frailty Prevalence and Characteristics in Older Patients with Type 2 Diabetes  [PDF]
Takahisa Tanikawa, Sayuri Sable-Morita, Haruhiko Tokuda, Hidenori Arai
Journal of Diabetes Mellitus (JDM) , 2019, DOI: 10.4236/jdm.2019.92004
Abstract: Background: Older diabetic patients are more likely to be frail than those who do not have diabetes. Frailty is an important risk factor for both mortality and disability in older patients with type 2 diabetes. However, the mechanism of frailty in diabetes mellitus is not fully understood. Aims: The aim of this study was to identify the prevalence of frailty and associated factors in older patients with type 2 diabetes in Japan. Methods: A cross-sectional study was conducted with a total of 178 outpatients who were over 65 years old with type 2 diabetes. We used the Obu Study Health Promotion for the Elderly definition of frailty to divided subjects into a non-frail and a frail group. We investigated the association between frailty and various patient characteristics. Results: In the study, 21.4% of the older patients with type 2 diabetes were considered frail. There were no significant differences in the duration of diabetes, BMI, proportion of microvascular complications, or HbA1c values between the frail and non-frail group. However, serum albumin and IGF-1 levels were lower in the frail group than the non-frail group as were the Mini-Mental State Examination scores. The frail group had a higher number of medications than the non-frail group. In a multivariable analysis, frailty was positively associated with the number of medications and, lower levels of both serum albumin and IGF-1. Conclusion: Our study suggests that diabetes accelerates the aging process and frailty is associated with low albumin, polypharmacy and low levels of IGF-1.
Design of LVDT Based Digital Weighing System
Pratiksha Sarma,P. K. Bordoloi
International Journal of Electronics and Computer Science Engineering , 2012,
Abstract: - Linear variable differential transformer (LVDT) has evolved into a highly accurate and reliable form of displacement transducer and has found widespread application in industry for the measurement of displacement, force or pressure. This paper discusses the design consideration of an LVDT based digital weighing system capable of weighing up to 1000 grams (1 kilogram). Atmel 89S52 microcontroller is used to acquire, process and display the weight into 16x2 LCD. The system has been designed and calibrated using standard weights and is found to be simple and of low cost.
Simulation Tool for Queuing Models: QSIM
Dr. Pratiksha Saxena,Lokesh Sharma
International Journal of Computers & Technology , 2013,
Abstract: This paper proposes simulation software QSIM (Queuing Simulation) to simulate queuing models. QSIM is a tool which simulates and compares the results of different queuing models. This tool is programmed in JAVA and is based on analytical approach to guide optimization strategy. In Qsim, Simulation is carried out by providing the inputs for arrival rate, service rate and number of servers and using these values the performance measurement of a particular model is stored in the database for further comparisons and study. Simulation results are stored in excel file and it also provides graphical results to compare the outcome.
Rupali Shirsat, Pratiksha Kokate, and Subhash Surdakar
Bioscience Discovery , 2012,
Abstract: The present paper is focused on morphological and anatomical characterization of Salvia plebeia collected from Chikhaldara forest ranges (MS) India. The study includes morphological description, anatomy of stem and surface features like hairs and trichomes. All the results are supported with the respective photographs, drawings and tables. The specific odor of the plant, characteristic quadrangular and hairy stem and simple as well as glandular hairs are the prominent features of the plant.
Intramedullary Chondrosarcoma of Proximal Humerus
Pratiksha Yadav,Dolly Thakkar,S. S. Thind
Case Reports in Radiology , 2012, DOI: 10.1155/2012/642062
Abstract: Primary chondrosarcoma is the third most frequent primary malignancy of bone after myeloma and osteosarcoma. It is ranging from slow growing nonmetastasising lesions to highly aggressive lesions. We report a case of primary intramedullary chondrosarcoma of proximal humerus. A 60-year-old female presented with pain and hard swelling involving the left arm for 5 months. Radiograph showed a lucent expansile intramedullary lesion with matrix calcification and associated soft tissue mass. CT confirmed the finding. MRI showed a lobulated lesion which is hyperintense on T2WI with low signal fibrous septae. Increased tracer uptake was seen on bone scan. Histopathology confirmed the radiology diagnosis. The patient underwent wide resection and endoprosthetic reconstruction of proximal humerus. 1. Case Report Primary chondrosarcoma is the third most common primary malignant tumor of bone after myeloma and osteosarcoma. It is most commonly seen between 30 and 70 years of age. We report a case of a sixty-year-old female who presented with gradually progressive pain and swelling over the proximal part of left arm since 5 months associated with restricted flexion, extension, and abduction of left shoulder. On inspection, loss of normal contour of left shoulder due to a diffuse swelling and asymmetric pectoral girdle (Figure 1). Skin over the surface was normal, with mild prominence of the veins. On palpation, it is tender and measuring approximately 6?cm in length and 4?cm in breadth. It was bony hard in consistency and fixed in nature with immobile skin over the swelling. Clinical diagnosis was of a neoplastic musculoskeletal pathology. Radiographs of left shoulder showed an ill defined, expansile, and osteolytic lesion involving the cortical and medullary region of neck and proximal shaft of left humerus with a wide zone of transition (Figures 2 and 3). Few specks of calcifications were seen within it. It shows endosteal scalloping with cortical break and adjacent soft tissue component. In addition, a calcified nodular opacity was seen in the peripheral left lung mid zone. As computed tomography (CT) is useful in defining the bony anatomy, integrity of the cortex surrounding a lesion, and calcifications within, a helical CT scan of 5?mm thickness was done from the superior margin of left shoulder to mid arm level. It revealed that the osteolytic expansile lesion was seen with endosteal scalloping and cortical thinning. It contains matrix calcification, break in cortices at multiple sites with adjacent anterolateral soft tissue component, and specks of calcification
A Study Of Psychiatric Morbidty Amongst Children Attending A Child Guidance Clinic At A Tertiary Level Teaching Hospital In Nepal
Manisha Chapagai,Kabin Man Dangol,Pratiksha Tulachan
Journal of Nobel Medical College , 2013, DOI: 10.3126/jonmc.v2i1.7677
Abstract: Background: Mental health and its related problems are growing concerns over the world. The early onset of emotional and behavioral problem in the young children is related to a variety of health and behavior problems in adolescence. It is a challenging all over the world to determine the epidemiology of childhood mental disorders. Objective : The aim of this study is to sort out the prevalence and predominance of mental illness and their onset of age and sex among the child and adolescent who attended in the child guidance clinic in TUTH. Methodology: A retrospective study of a total of 539 consecutive cases of child and adolescent attended in Child Guidance Clinic TUTH. Diagnosis was made according to the criteria of Diagnostic and Statistical Manual of Mental Disorders, 4th edition, Text Revision. Result: T he cases from the age of 0.4 year to 21 years with mean age 8.85±4.08 years. Significantly majority were boys ( n= 343, 63.6%) and most of from out of the Kathmandu valley ( n= 300, 53.2%). Significantly most case referred from ENT OPD of TUTH ( n =97, 18%) and mental retardation was the commonest ( n =81, 15%) followed by conversion disorder ( n =77, 14.3%) and anxiety spectrum disorder ( n =63, 11.7%) Conclusion : Boys are common in mental illness among child and adolescents. The common diagnoses among child and adolescent are mental retardation, conversion disorder, anxiety spectrum disorders and Autism spectrum disorder. Journal of Nobel Medical College Vol. 2, No.1 Issue 3 Nov.-April 2013 Page 55-63 DOI: http://dx.doi.org/10.3126/jonmc.v2i1.7677
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