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Search Results: 1 - 10 of 44 matches for " Prathap Tharyan "
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Systematic reviews of randomized controlled trials and evidence informed palliative care
Tharyan Prathap,Jebaraj Prasanna
Indian Journal of Palliative Care , 2006,
How the Cochrane Collaboration Is Responding to the Asian Tsunami
Prathap Tharyan ,Mike Clarke,Sally Green
PLOS Medicine , 2005, DOI: 10.1371/journal.pmed.0020169
How the Cochrane collaboration is responding to the Asian tsunami.
Tharyan Prathap,Clarke Mike,Green Sally
PLOS Medicine , 2005,
Have Online International Medical Journals Made Local Journals Obsolete?
David Ofori-Adjei,Gerd Antes,Prathap Tharyan,Elizabeth Slade,Pritpal S Tamber
PLOS Medicine , 2006, DOI: 10.1371/journal.pmed.0030359
Abstract: Background to the Debate All of the major international medical journals are now available both in print and online. Being online increases the potential for these journals to have a more global distribution. With the rise of these online international journals, what functions do local journals serve?.
Randomised trials relevant to mental health conducted in low and middle-income countries: a survey
Rebecca Sheriff, Clive E Adams, Prathap Tharyan, Mahesh Jayaram, Lelia Duley, the PRACTIHC Mental Health Group
BMC Psychiatry , 2008, DOI: 10.1186/1471-244x-8-69
Abstract: 6107 electronic records, most with full text copies, were available following extensive searches for randomised or potentially randomised trials from low and middle-income countries published in 1991, 1995 and 2000. These records were searched to identify studies relevant to mental health. Data on study characteristics were extracted from the full text copies.Trials relevant to mental health were reported in only 3% of the records. 176 records reporting 177 trials were identified: 25 were published in 1991, 45 in 1995, and 106 in 2000. Participants from China were represented in 46% of trials described. 68% of trials had <100 participants. The method of sequence generation was described in less than 20% of reports and adequate concealment of allocation was described in only 12% of reports. Participants were most frequently adults with unipolar depression (36/177) or schizophrenia (36/177). 80% of studies evaluated pharmacological interventions, a third of which were not listed by WHO as essential drugs. 41% of reports were indexed on PubMed; this proportion decreased from 68% in 1991 to 32% in 2000.In terms of overall health burden, trial research activity from low and middle-income countries in mental health appears to be low, and in no area adequately reflects need.Most of the global burden of mental illness falls to the poorest nations, where 80% of world's population live [1]. On average low and middle-income countries devote less than 1% of their health expenditure to mental health and have poorly developed mental health policies and legislation. Treatment provision is often dismally under resourced [2]. Randomised trials are the gold-standard for evaluation of care, and systematic reviews of randomised trials increasingly provide the basis for health care practice and policy. Most trials, however, are conducted in high-income countries [3]. The interventions assessed may be unaffordable, unavailable or inappropriate for people in other cultures and settings [4
Randomised trials relevant to mental health conducted in low and middle-income countries: protocol for a survey of studies published in 1991, 1995 and 2000 and assessment of their relevance
Rebecca J Syed Sheriff, Mahesh Jayaram, Prathap Tharyan, Lelia Duley, Clive E Adams
BMC Psychiatry , 2006, DOI: 10.1186/1471-244x-6-40
Abstract: This project aims to survey the content, quality and accessibility of a sample of trials relevant to mental health conducted within low and middle-income countries; to compare these with studies conducted in high-income countries; and to assess their relevance for the needs of low and middle-income countries.An extensive search for all trials, or possible trials, published in 1991, 1995 and 2000 with participants in low and middle-income countries has already been conducted. Studies evaluating prevention or treatment of a mental health problem within these three years will be identified and further searches conducted to assess completeness of the initial search. Data on study quality and characteristics will be extracted from each report. Accessibility will be estimated based on whether each citation is available on MEDLINE. Trials relevant to schizophrenia will be compared with a random sample of schizophrenia trials from high-income countries in the same years. Topics covered by the trials will be compared with the estimated burden of disease.Trials and systematic reviews of trials are the gold standard of evaluation of care and increasingly provide the basis for recommendations to clinicians, to providers of care and to policy makers. Results from this study will present the first assessment of the scope, quality and accessibility of mental health trials in low and middle-income countries.Most of the global burden of mental illness falls to the poorest nations, where 80% of world's population live [1]. Major depression is now a leading cause of disability throughout the world and ranks fourth in the ten leading causes of the global burden of disease (measured using 'Disability Adjusted Life Years' – DALYS) [2,3].According to the World Health Organisation (WHO) "Most low/middle income countries devote less than 1% of their health expenditure to mental health. Health policies, legislation, community care facilities and treatments for mentally ill people are therefo
Communication in medical practice
Tharyan Anna
Indian Journal of Palliative Care , 2004,
Familial koilonychia
Prathap Priya,Asokan N
Indian Journal of Dermatology , 2010,
Prevalence and risk factors for female sexual dysfunction in women attending a medical clinic in south India
Singh J,Tharyan P,Kekre N,Singh G
Journal of Postgraduate Medicine , 2009,
Abstract: Background: Reports from India on the prevalence and determinants of female sexual dysfunction (FSD) are scant. Aims: To determine the prevalence and risk factors for FSD. Settings and Design: A cross-sectional survey in a medical outpatient clinic of a tertiary care hospital. Materials and Methods: We administered a Tamil version of the Female Sexual Function Index (FSFI) to 149 married women. We evaluated putative risk factors for FSD. We elicited participant′s attributions for their sexual difficulties. Statistical Analysis: We estimated the prevalence of possible FSD and sexual difficulties from published FSFI total and domain cut-off scores. We used logistic regression to identify risk factors for possible FSD. Results: FSFI total scores suggested FSD in two-thirds of the 149 women (73.2%; 95% confidence intervals [CI] 65.5% to 79.6%). FSFI domain scores suggested difficulties with desire in 77.2%; arousal in 91.3%; lubrication in 96.6%; orgasm in 86.6%, satisfaction in 81.2%, and pain in 64.4%. Age above 40 years (odds ratios [OR] 11.7; 95% CI 3.4 to 40.1) and fewer years of education (OR 1.2; 95% CI 1.0 to 1.3) were identified by logistic regression as contributory. Women attributed FSD to physical illness in participant or partner, relationship problems, and cultural taboos but none had sought professional help. Conclusions: Sexual problems suggestive of dysfunction, as suggested by FSFI total and domain scores, are highly prevalent in the clinic setting, particularly among women above 40 and those less educated, but confirmation using locally validated cut-off scores of the FSFI is needed.
Electro convulsive therapy in a pre-pubertal child with severe depression.
Russell P,Tharyan P,Arun Kumar K,Cherian A
Journal of Postgraduate Medicine , 2002,
Abstract: Electro Convulsive Therapy (ECT) in pre-pubertal children is a controversial and underreported treatment. Even though the effectiveness and side effects of ECT in adolescents are comparable with those in adults, there is a pervasive reluctance to use ECT in children and adolescents. We report the case of a pre-pubertal child in an episode of severe depression with catatonic features, where a protracted course of ECT proved life-saving in spite of prolonged duration of seizures and delayed response to treatment. The case illustrates the safety and efficacy of ECT in children. Relevant literature is also reviewed along with the case report.
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