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Entity-Specific Sentiment Classification of Yahoo News Comments
Prakhar Biyani,Cornelia Caragea,Narayan Bhamidipati
Computer Science , 2015,
Abstract: Sentiment classification is widely used for product reviews and in online social media such as forums, Twitter, and blogs. However, the problem of classifying the sentiment of user comments on news sites has not been addressed yet. News sites cover a wide range of domains including politics, sports, technology, and entertainment, in contrast to other online social sites such as forums and review sites, which are specific to a particular domain. A user associated with a news site is likely to post comments on diverse topics (e.g., politics, smartphones, and sports) or diverse entities (e.g., Obama, iPhone, or Google). Classifying the sentiment of users tied to various entities may help obtain a holistic view of their personality, which could be useful in applications such as online advertising, content personalization, and political campaign planning. In this paper, we formulate the problem of entity-specific sentiment classification of comments posted on news articles in Yahoo News and propose novel features that are specific to news comments. Experimental results show that our models outperform state-of-the-art baselines.
Formulation and in vitro evaluation of sustained release dosage form with taste masking of metformin hydrochloride
Bhoyar P,Biyani D
Indian Journal of Pharmaceutical Sciences , 2010,
Abstract: An attempt was made to sustain the release of metformin HCl as well as to mask the bitter taste by complexation technique using strong cation-exchange resins, indion 244 and indion 264. The drug loading onto ion-exchange resin was optimized for mixing time, activation, effect of pH, mode of mixing, ratio of drug:resin and temperature. The resinate was evaluated for micromeritic properties, taste masking and characterized using XRPD and IR. Using resinate sustained release tablets were formulated using hydoxypropylmethylcellulose K100M.The tablets were evaluated for hardness, thickness, friability, drug content, weight variation and in vitro drug release. Tablets thus formulated (Batch B-6) provided sustained release of drug over a period of 10 h with first order kinetics. The release of metformin HCl from resinate controls the diffusion of drug molecules through the polymeric material into aqueous medium. Results showed that metformin HCl was successfully taste masked and formulated into a sustained dosage form as an alternative to the conventional tablet.
Design, Formulation and Evaluation of Transdermal Drug Delivery System of Budesonide  [PDF]
Updesh B Lade, Yogesh M Amgaonkar, Rupesh V Chikhale, Dinesh M Biyani, Milind J Umekar
Pharmacology & Pharmacy (PP) , 2011, DOI: 10.4236/pp.2011.23029
Abstract: Budesonide is a highly potent synthetic, nonhalogenated corticosteroid. The mechanism of action of corticosteroids in allergic rhinitis remains unknown, but may involve reductions in number of various mediator cells such as basophils, eosinophils, T-helper cells, mast cells, and neutrophils. In the nasal mucosa, nasal reactivity to allergens, and release of inflammatory mediators and proteolytic enzymes. Budesonide is very effective and quikly acting as it is rapidly and almost completely absorbed after oral administration, but has poor systemic availability (about 10%) due to extensive first-pass metabolism in the liver, mainly by the cytochrome P450 isoenzyme CYP3A4.. The major metabolites, 6-β- hydroxybudesonide and 16-α-hydroxyprednisolone have less than 1% of the glucocorticoid activity of unchanged drug with a terminal half-life of about 2 - 4 hours. Polymeric films containing Eudragit RL 100: Eudragit RS: drug (7:3:1, 7: 2:1) and Ethyl cellulose: PVP: drug (7:3:1, 7:2:1) were selected for transdermal administration based on evaluation studies. These polymeric films were prepared by mercury substrate method employing PEG-400 as plasticizer. Two different penetration enhancers Urea and Dimethyl sulphoxide (DMSO) were employed in the study. The patches in each group were uniform in drug content, thickness. In Vitro drug permeation, moisture absorption and WVTR studies were carried out on these test patches. It was found that at all humidity condition the absorption increases which were linear to the moisture absorbed. In PVA and EUDRAGIT RL 100 patches the water vapor transmission rate was found to be higher at 75% RH, RT conditions. Therefore at both % RH, RT condition the PVA and EUDRAGIT RL 100 patches provides the best resistance to water vapor. Therefore, when applied to animals (in further studies) these patches may provide more occlusion to water vapor loss from skin thus making atmosphere beneath the skin more humid that aid in drug permeation.
Anaesthetic Challenges in Molar Pregnancy
Ghansham Biyani,Sadik Mohammed,Pradeep Bhatia
Indian Anaesthetists' Forum , 2013,
Abstract: Gestational Trophoblastic Disease (GTD) is a spectrum of tumours with a wide range of biologic behaviour and potential for metastases, which were often fatal in the past. However, with better understanding of patho-physiology in the last few years, most women can now be cured. A Hydatidiform Mole (or Molar Pregnancy) is a benign Gestational Trophoblastic Disease that originates from the placenta. Treatment consists of vacuum evacuation but rarely hysterectomy may be required. Anaesthetic management is often complicated by the associated derangements.
A draft of the genome and four transcriptomes of a medicinal and pesticidal angiosperm Azadirachta indica
Krishnan Neeraja M,Pattnaik Swetansu,Jain Prachi,Gaur Prakhar
BMC Genomics , 2012, DOI: 10.1186/1471-2164-13-464
Abstract: Background The Azadirachta indica (neem) tree is a source of a wide number of natural products, including the potent biopesticide azadirachtin. In spite of its widespread applications in agriculture and medicine, the molecular aspects of the biosynthesis of neem terpenoids remain largely unexplored. The current report describes the draft genome and four transcriptomes of A. indica and attempts to contextualise the sequence information in terms of its molecular phylogeny, transcript expression and terpenoid biosynthesis pathways. A. indica is the first member of the family Meliaceae to be sequenced using next generation sequencing approach. Results The genome and transcriptomes of A. indica were sequenced using multiple sequencing platforms and libraries. The A. indica genome is AT-rich, bears few repetitive DNA elements and comprises about 20,000 genes. The molecular phylogenetic analyses grouped A. indica together with Citrus sinensis from the Rutaceae family validating its conventional taxonomic classification. Comparative transcript expression analysis showed either exclusive or enhanced expression of known genes involved in neem terpenoid biosynthesis pathways compared to other sequenced angiosperms. Genome and transcriptome analyses in A. indica led to the identification of repeat elements, nucleotide composition and expression profiles of genes in various organs. Conclusions This study on A. indica genome and transcriptomes will provide a model for characterization of metabolic pathways involved in synthesis of bioactive compounds, comparative evolutionary studies among various Meliaceae family members and help annotate their genomes. A better understanding of molecular pathways involved in the azadirachtin synthesis in A. indica will pave ways for bulk production of environment friendly biopesticides.
Time Evolution of Temperature Fluctuation in a Non-Equilibrated System
Trambak Bhattacharyya,Prakhar Garg,Raghunath Sahoo,Prasant Samantray
Physics , 2015,
Abstract: The evolution equation for inhomogeneous and anisotropic temperature fluctuation inside a medium is derived within the ambit of Boltzmann Transport Equation (BTE) for a hot gas of massless particles. Also, specializing to a situation created after heavy-ion collision (HIC), we analyze the Fourier space variation of temperature fluctuation of the medium using its temperature profile. The effect of viscosity on the variation of fluctuations in the latter case is investigated and possible implications for early universe cosmology, and its connection with HICs are also explored.
Role of mechanical factors in the evaluation of pedicle screw type spinal fixation devices
Goel V,Ebraheim N,Biyani A,Rengachary S
Neurology India , 2005,
Abstract: Prior to implantation, spinal implants are subjected to rigorous testing to ensure safety and efficacy. A full battery of tests for the devices may include many steps ranging from biocompatibility tests to in vivo animal studies. This paper describes some of the essential tests from a mechanical engineering perspective (e.g., motion, load sharing, bench type tests, and finite element model analyses). These protocols reflect the research experience of the past decade or so.
Pediatric cerebellar pilocytic astrocytoma presenting with hemorrhage
Kumar Ashish,Deopujari Chandrashekhar,Biyani Naresh,Mhatre Mayur
Neurology India , 2010,
An Adaptive parameter free data mining approach for healthcare application
Prof. Dipti Patil,Bhagyashree Agrawal,Snehal Andhalkar,Richa Biyani
International Journal of Advanced Computer Sciences and Applications , 2012,
Abstract: In today’s world, healthcare is the most important factor affecting human life. Due to heavy work load it is not possible for personal healthcare. The proposed system acts as a preventive measure for determining whether a person is fit or unfit based on his/her historical and real time data by applying clustering algorithms viz. K-means and D-stream. Both clustering algorithms are applied on patient’s biomedical historical database. To check the correctness of both the algorithms, we apply them on patient’s current biomedical data. The Density-based clustering algorithm i.e. the D-stream algorithm overcomes drawbacks of K-means algorithm. By calculating their performance measures we finally find out effectiveness and efficiency of both the algorithms
Peptide-Modulated Activity Enhancement of Acidic Protease Cathepsin E at Neutral pH
Masayuki Komatsu,Madhu Biyani,Sunita Ghimire Gautam,Koichi Nishigaki
International Journal of Peptides , 2012, DOI: 10.1155/2012/316432
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