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Search Results: 1 - 10 of 297550 matches for " Piush J. Mandhane "
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The Association Between Community Stressors and Asthma Prevalence of School Children in Winnipeg, Canada
Tyler P. Pittman,Candace I. J. Nykiforuk,Javier Mignone,Piush J. Mandhane,Allan B. Becker,Anita L. Kozyrskyj
International Journal of Environmental Research and Public Health , 2012, DOI: 10.3390/ijerph9020579
Abstract: It is generally surmised that community stressors have an incubating effect for a variety of diagnoses on maternal and child health. This is of public health significance, as children of mothers facing long-term distress were found to have a 60% higher risk for asthma diagnosis at age 7 in Manitoba, Canada. Our objective was to determine the association of community stressors with childhood asthma prevalence in Winnipeg, Canada from participants who completed the Study of Asthma, Genes and the Environment (SAGE) survey administered in 2002–2003 to a birth cohort from 1995. Measures of community socioeconomic makeup and community disorder with rank ordinalized by quintile at the census tract level were obtained from the 1996 Canada Census. Crime data (annual incidence per 10,000 persons) by neighbourhood profile for 2001 was provided by the Winnipeg Police Service. Dichotomous caregiver report of child asthma along with other indicators from the geocoded SAGE survey allowed linkage to 23 neighbourhood profiles. Multilevel logistic regression analyses were performed to estimate the effect of community stressors on childhood asthma prevalence for birth and non-birth home children ( N = 1472) and children resident of birth homes at age 7 or 8 ( N = 698). After adjusting for individual risk factors, children resident of birth homes in a high thefts over $5,000 neighbourhood profile were twice as likely (Adjusted OR, 2.05; 95% CI, 1.11–3.81) to have report of asthma compared to children in a lower thefts over $5,000 profile, with community thefts over $5,000 explaining over half of the observed neighbourhood variation in asthma.
Factors affecting exhaled nitric oxide measurements: the effect of sex
D Robin Taylor, Piush Mandhane, Justina M Greene, Robert J Hancox, Sue Filsell, Christene R McLachlan, Avis J Williamson, Jan O Cowan, Andrew D Smith, Malcolm R Sears
Respiratory Research , 2007, DOI: 10.1186/1465-9921-8-82
Abstract: Data were obtained from 895 members of the Dunedin Multidisciplinary Health and Development Study at age 32. The effects of sex, height, weight, lung function indices, smoking, atopy, asthma and rhinitis on FENO were explored by unadjusted and adjusted linear regression analyses.The effect of sex on FENO was both statistically and clinically significant, with FENO levels approximately 25% less in females. Overall, current smoking reduced FENO up to 50%, but this effect occurred predominantly in those who smoked on the day of the FENO measurement. Atopy increased FENO by 60%. The sex-related differences in FENO remained significant (p < 0.001) after controlling for all other significant factors affecting FENO.Even after adjustment, FENO values are significantly different in males and females. The derivation of reference values and the interpretation of FENO in the clinical setting should be stratified by sex. Other common factors such as current smoking and atopy also require to be taken into account.Measurement of exhaled nitric oxide (FENO) is increasingly recognised as an important addition to pulmonary function testing in clinical practice [1]. FENO may be used as a surrogate marker for airway eosinophilia [2], and as an alternative to other more invasive or time-consuming assessments of airway pathology such as induced sputum, [2,3] bronchial lavage fluid, [4] or mucosal biopsy. [5-7] Against this background, FENO measurements are increasingly being used to clarify the aetiology of non-specific respiratory symptoms as well as monitor levels of inflammation in conditions characterised by airway eosinophilia [8].There are a number of demographic and biological factors which cause variation in FENO levels. The commonest are cigarette smoking [9,10] and atopy [11-13] with or without allergic rhinitis. [13,14] Others include age [15,16], and IgE levels [17]. However, conflicting results concerning the importance of these factors has precluded a clear definition of so
Qualitative and Quantitative Estimation of Acyclovir in Human Plasma by Using LC-MS/MS
P. SusantaKumar*,Ajay Gaur,Piush Sharma
Biomirror , 2011,
Abstract: Acyclovir is used orally for the treatment and prophylaxis of initialsand recurrent episodes of genital and labial herps and varicells in immunocompetent individuals. A simple, sensitive, high throughout liquid chromatography Tandem Mass Spectrometry-Waters Quattro Premier XE method (LC-MS/MS) method has been developed for the simultaneous estimation of acyclovir in human plasma using ganciclovir as internal standard. The method involved solid phase extraction of the analytes and IS from 0.5 mL human plasma with no reconstitution and drying steps (direct injection of eluate). The chromatographic separation was achieved on a Hypersil GOLD C18 analytical column using isocratic mobile phase, consisting of mobile phase containing ammonium acetate and acetonitrile (25:75%, v/v) were used. The retention time for internal standard and acyclovir were 1.14 min and 1.81 min respectively and overall chromatography run time was 2.26 minutes. Lower limit of detection and lower limit of quantification (LLOQ) were identifiable and reproducible at 5.0ng/mL and 30.0ng/mL. This method was used successfully to a bioequivalence or pharmacokinetic study in 36 healthy human subjects after single oral estimation of 200mg acyclovir capsule formulation under fasting and non-fasting conditions.
VARIOUS TYPES AND MANAGEMENT OF BREAST CANCER: AN OVERVIEW
Ganesh N. Sharma,Rahul Dave,Jyotsana Sanadya,Piush Sharma
Journal of Advanced Pharmaceutical Technology & Research , 2010,
Abstract: Now days, breast cancer is the most frequently diagnosed life-threatening cancer in women and the leading cause of cancer death among women. Since last two decades, researches related to the breast cancer has lead to extraordinary progress in our understanding of the disease, resulting in more efficient and less toxic treatments. Increased public awareness and improved screening have led to earlier diagnosis at stages amenable to complete surgical resection and curative therapies. Consequently, survival rates for breast cancer have improved significantly, particularly in younger women. This article addresses the types, causes, clinical symptoms and various approach both non- drug (such as surgery and radiation) and drug treatment (including chemotherapy, gene therapy etc.) of breast cancer.
Infection control strategy in orthodontic office
Shalaj Bhatnagar,Dinesh K Bagga,Payal Sharma,Piush Kumar
European Journal of General Dentistry , 2013, DOI: doi:10.4103/2278-9626.106793
Abstract: Effective and efficient infection control in the orthodontic office is essential for the safety of patients. A comprehensive infection control strategy must be implemented by the orthodontist without compromising on cost-effectiveness and time factor, that safeguards not only his own health but also of the auxiliary staff and even the community. It is also important to follow manufacturer's instructions for dental instruments and devices regarding sterilization to avoid damage to these items.
Thoracoscopic splanchnicectomy as a palliative procedure for pain relief in carcinoma pancreas
Prasad Arun,Choudhry Piush,Kaul Sunil,Srivastava Gaurav
Journal of Minimal Access Surgery , 2009,
Abstract: Thoracoscopic splanchnicectomy has been used for the management of upper abdominal pain syndromes as an alternative to celiac plexus block for conditions such as chronic pancreatitis or supramesocolic malignant neoplasms, including unresectable pancreatic cancer. This procedure is similar to the percutaneous block with a higher degree of precision and avoids the side effects associated with the local diffusion of neurolytic solutions. Thoracoscopic splanchnicectomy appears to be a better treatment in such cases as the procedure is done under direct vision and less dependent on anatomical variations.
Earthing of High Voltage Laboratory
Jashandeep Singh,Y.R. Sood,R.K. Jarial,Piush Verrma
International Journal of Electrical and Power Engineering , 2012,
Abstract: The study discusses salient points about development of a typical earthing mat installation that has been designed for meeting safety requirement for users of a high voltage laboratory. The details of the earthing practice followed and pattern of earthing mat resistivity variation under different conditions are discussed. The effectiveness of a good earthing system demands not only sound knowledge of design of the earthing mat system but also need experienced personals to implement the design during earth digging, filling soft soil, laying earth electrodes their interconnection and proper maintenance and upkeep at regular interval during all atmospheric conditions.
New components of the mercury’s perihelion precession  [PDF]
J. J. Smulsky
Natural Science (NS) , 2011, DOI: 10.4236/ns.2011.34034
Abstract: The velocity of perihelion rotation of Mercury's orbit relatively motionless space is computed. It is prove that it coincides with that calculated by the Newtonian interaction of the planets and of the compound model of the Sun’s rotation.
Simple General Purpose Ion Beam Deceleration System Using a Single Electrode Lens  [PDF]
J. Lopes, J. Rocha
World Journal of Engineering and Technology (WJET) , 2015, DOI: 10.4236/wjet.2015.33014
Abstract: Ion beam deceleration properties of a newly developed low-energy ion beam implantation system were studied. The objective of this system was to produce general purpose low-energy (5 to 15 keV) implantations with high current beam of hundreds of μA level, providing the most wide implantation area possible and allowing continuously magnetic scanning of the beam over the sample(s). This paper describes the developed system installed in the high-current ion implanter at the Laboratory of Accelerators and Radiation Technologies of the Nuclear and Technological Cam-pus, Sacavém, Portugal (CTN).
Constraints on velocity anisotropy of spherical systems with separable augmented densities
J. An
Physics , 2011, DOI: 10.1088/0004-637X/736/2/151
Abstract: If the augmented density of a spherical anisotropic system is assumed to be multiplicatively separable to functions of the potential and the radius, the radial function, which can be completely specified by the behavior of the anisotropy parameter alone, also fixes the anisotropic ratios of every higher-order velocity moment. It is inferred from this that the non-negativity of the distribution function necessarily limits the allowed behaviors of the radial function. This restriction is translated into the constraints on the behavior of the anisotropy parameter. We find that not all radial variations of the anisotropy parameter satisfy these constraints and thus that there exist anisotropy profiles that cannot be consistent with any separable augmented density.
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